AIRE-Deficient Patients Harbor Unique High-Affinity Disease-Ameliorating Autoantibodies von Meyer, Steffen, Woodward, Martin, Hertel, Christina, Vlaicu, Philip, Haque, Yasmin, Kärner, Jaanika, Macagno, Annalisa, Onuoha, Shimobi C., Fishman, Dmytro, Peterson, Hedi, Metsküla, Kaja, Uibo, Raivo, Jäntti, Kirsi, Hokynar, Kati, Wolff, Anette S.B., Meloni, Antonella, Kluger, Nicolas, Husebye, Eystein S., Podkrajsek, Katarina Trebusak, Battelino, Tadej, Bratanic, Nina, Peet, Aleksandr, Krohn, Kai, Ranki, Annamari, Peterson, Pärt, Kisand, Kai, Hayday, Adrian

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Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies von Maciocia, Paul M, Wawrzyniecka, Patrycja A, Philip, Brian, Ricciardelli, Ida, Akarca, Ayse U, Onuoha, Shimobi C, Legut, Mateusz, Cole, David K, Sewell, Andrew K, Gritti, Giuseppe, Somja, Joan, Piris, Miguel A, Peggs, Karl S, Linch, David C, Marafioti, Teresa, Pule, Martin A

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CAR T cells with dual targeting of CD19 and CD22 in pediatric and young adult patients with relapsed or refractory B cell acute lymphoblastic leukemia: a phase 1 trial von Cordoba, Shaun, Onuoha, Shimobi, Thomas, Simon, Pignataro, Daniela Soriano, Hough, Rachael, Ghorashian, Sara, Vora, Ajay, Bonney, Denise, Veys, Paul, Rao, Kanchan, Lucchini, Giovanna, Chiesa, Robert, Chu, Jan, Clark, Liz, Fung, Mei Mei, Smith, Koval, Peticone, Carlotta, Al-Hajj, Muhammad, Baldan, Vania, Ferrari, Mathieu, Srivastava, Saket, Jha, Ram, Arce Vargas, Frederick, Duffy, Kevin, Day, William, Virgo, Paul, Wheeler, Lucy, Hancock, Jeremy, Farzaneh, Farzin, Domning, Sabine, Zhang, Yiyun, Khokhar, Nushmia Z., Peddareddigari, Vijay G. R., Wynn, Robert, Pule, Martin, Amrolia, Persis J.

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Prediction of protein biophysical traits from limited data: a case study on nanobody thermostability through NanoMelt von Ramon, Aubin, Ni, Mingyang, Predeina, Olga, Gaffey, Rebecca, Kunz, Patrick, Onuoha, Shimobi, Sormanni, Pietro

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Going with the flow: harnessing the power of the vasculature for targeted therapy in rheumatoid arthritis von Ferrari, Mathieu, Onuoha, Shimobi C., Pitzalis, Costantino

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Characterization of a Novel ACE2-Based Therapeutic with Enhanced Rather than Reduced Activity against SARS-CoV-2 Variants von Ferrari, Mathieu, Mekkaoui, Leila, Ilca, F Tudor, Akbar, Zulaikha, Bughda, Reyisa, Lamb, Katarina, Ward, Katarzyna, Parekh, Farhaan, Karattil, Rajeev, Allen, Christopher, Wu, Philip, Baldan, Vania, Mattiuzzo, Giada, Bentley, Emma M, Takeuchi, Yasuhiro, Sillibourne, James, Datta, Preeta, Kinna, Alexander, Pule, Martin, Onuoha, Shimobi C

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Tunable control of CAR T cell activity through tetracycline mediated disruption of protein–protein interaction von Hotblack, Alastair, Kokalaki, Evangelia K., Palton, Morgan J., Cheung, Gordon Weng-Kit, Williams, Iwan P., Manzoor, Somayya, Grothier, Thomas I., Piapi, Alice, Fiaccadori, Valeria, Wawrzyniecka, Patrycja, Roddy, Harriet A., Agliardi, Giulia, Roddie, Claire, Onuoha, Shimobi, Thomas, Simon, Cordoba, Shaun, Pule, Martin

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Rational Design of Antirheumatic Prodrugs Specific for Sites of Inflammation von Onuoha, Shimobi C., Ferrari, Mathieu, Sblattero, Daniele, Pitzalis, Costantino

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Combining phage display with SMRTbell next-generation sequencing for the rapid discovery of functional scFv fragments von Nannini, Francesco, Senicar, Lenart, Parekh, Farhaan, Kong, Khai J, Kinna, Alexander, Bughda, Reyisa, Sillibourne, James, Hu, Xihao, Ma, Biao, Bai, Yuchen, Ferrari, Mathieu, Pule, Martin A, Onuoha, Shimobi C

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Novel Bispecific Antibody for Synovial-Specific Target Delivery of Anti-TNF Therapy in Rheumatoid Arthritis von Ferrari, Mathieu, Onuoha, Shimobi C, Fossati-Jimack, Liliane, Nerviani, Alessandra, Alves, Pedro L, Pagani, Sara, Deantonio, Cecilia, Colombo, Federico, Santoro, Claudio, Sblattero, Daniele, Pitzalis, Costantino

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Structure-guided engineering of immunotherapies targeting TRBC1 and TRBC2 in T cell malignancies von Ferrari, Mathieu, Righi, Matteo, Baldan, Vania, Wawrzyniecka, Patrycja, Bulek, Anna, Kinna, Alexander, Ma, Biao, Bughda, Reyisa, Akbar, Zulaikha, Srivastava, Saket, Gannon, Isaac, Robson, Mathew, Sillibourne, James, Jha, Ram, El-Kholy, Mohamed, Amin, Oliver Muhammad, Kokalaki, Evangelia, Banani, Mohammed Amin, Hussain, Rehan, Day, William, Lim, Wen Chean, Ghongane, Priyanka, Hopkins, Jade R., Jungherz, Dennis, Herling, Marco, Welin, Martin, Surade, Sachin, Dyson, Michael, McCafferty, John, Logan, Derek, Cordoba, Shaun, Thomas, Simon, Sewell, Andrew, Maciocia, Paul, Onuoha, Shimobi, Pule, Martin

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A primer set for the rapid isolation of scFv fragments against cell surface antigens from immunised rats von Nannini, Francesco, Parekh, Farhaan, Wawrzyniecka, Patrycja, Mekkaoui, Leila, Righi, Matteo, Dastjerdi, Fatemeh V., Yeung, Jenny, Roddie, Claire, Bai, Yuchen, Ma, Biao, Ferrari, Mathieu, Onuoha, Shimobi, Chester, Kerry, Pule, Martin

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Limited efficacy of APRIL CAR in patients with multiple myeloma indicate challenges in the use of natural ligands for CAR T-cell therapy von Lee, Lydia, Lim, Wen Chean, Galas-Filipowicz, Daria, Fung, Kent, Taylor, Julia, Patel, Dominic, Akbar, Zulaikha, Alvarez Mediavilla, Elena, Wawrzyniecka, Patrycja, Shome, Debarati, Reijmers, Rogier M, Gregg, Trillian, Wood, Leigh, Day, William, Cerec, Virginie, Ferrari, Mathieu, Thomas, Simon, Cordoba, Shaun, Onuoha, Shimobi, Khokhar, Nushmia, Peddareddigari, Vijay, Al-Hajj, Muhammad, Cavet, Jim, Zweegman, Sonja, Rodriguez-Justo, Manuel, Yong, Kwee, Pule, Martin, Popat, Rakesh

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Knotted Fusion Proteins Reveal Unexpected Possibilities in Protein Folding von Mallam, Anna L., Onuoha, Shimobi C., Grossmann, J. Günter, Jackson, Sophie E.

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Optimised Method for the Production and Titration of Lentiviral Vectors Pseudotyped with the SARS-CoV-2 Spike von Mekkaoui, Leila, Bentley, Emma M, Ferrari, Mathieu, Lamb, Katarina, Ward, Katarzyna, Karattil, Rajeev, Akbar, Zulaikha, Bughda, Reyisa, Sillibourne, James, Onuoha, Shimobi, Mattiuzzo, Giada, Takeuchi, Yasuhiro, Pule, Martin

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Enhanced CAR T cell expansion and prolonged persistence in pediatric patients with ALL treated with a low-affinity CD19 CAR von Ghorashian, Sara, Kramer, Anne Marijn, Onuoha, Shimobi, Wright, Gary, Bartram, Jack, Richardson, Rachel, Albon, Sarah J., Casanovas-Company, Joan, Castro, Fernanda, Popova, Bilyana, Villanueva, Krystle, Yeung, Jenny, Vetharoy, Winston, Guvenel, Aleks, Wawrzyniecka, Patrycja A., Mekkaoui, Leila, Cheung, Gordon Weng-Kit, Pinner, Danielle, Chu, Jan, Lucchini, Giovanna, Silva, Juliana, Ciocarlie, Oana, Lazareva, Arina, Inglott, Sarah, Gilmour, Kimberly C., Ahsan, Gulrukh, Ferrari, Mathieu, Manzoor, Somayya, Champion, Kim, Brooks, Tony, Lopes, Andre, Hackshaw, Allan, Farzaneh, Farzin, Chiesa, Robert, Rao, Kanchan, Bonney, Denise, Samarasinghe, Sujith, Goulden, Nicholas, Vora, Ajay, Veys, Paul, Hough, Rachael, Wynn, Robert, Pule, Martin A., Amrolia, Persis J.

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An APRIL-based chimeric antigen receptor for dual targeting of BCMA and TACI in multiple myeloma von Lee, Lydia, Draper, Benjamin, Chaplin, Neil, Philip, Brian, Chin, Melody, Galas-Filipowicz, Daria, Onuoha, Shimobi, Thomas, Simon, Baldan, Vania, Bughda, Reyisa, Maciocia, Paul, Kokalaki, Eva, Neves, Margarida P., Patel, Dominic, Rodriguez-Justo, Manuel, Francis, James, Yong, Kwee, Pule, Martin

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A Rapamycin-Activated Caspase 9-Based Suicide Gene von Stavrou, Maria, Philip, Brian, Traynor-White, Charlotte, Davis, Christopher G., Onuoha, Shimobi, Cordoba, Shaun, Thomas, Simon, Pule, Martin

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Dual targeting of CD19 and CD22 against B-ALL using a novel high-sensitivity aCD22 CAR von Kokalaki, Evangelia, Ma, Biao, Ferrari, Mathieu, Grothier, Thomas, Hazelton, Warren, Manzoor, Somayya, Costu, Eren, Taylor, Julia, Bulek, Anna, Srivastava, Saket, Gannon, Isaac, Jha, Ram, Gealy, Rosalind, Stanczuk, Lukas, Rizou, Tatiana, Robson, Mathew, El-Kholy, Mohamed, Baldan, Vania, Righi, Matteo, Sillibourne, James, Thomas, Simon, Onuoha, Shimobi, Cordoba, Shaun, Pule, Martin

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Anti-CD21 Chimeric Antigen Receptor (CAR)-T Cells for T Cell Acute Lymphoblastic Leukaemia (T-ALL) von Maciocia, Nicola C, Burley, Amy, Nannini, Francesco, Wawrzyniecka, Patrycja, Neves, Margarida, Karpanasamy, Thaneswari, Ferrari, Mathieu, Marafioti, Teresa, Onuoha, Shimobi, Khwaja, Asim, Maciocia, Paul M, Pule, Martin

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