Development and Application of Regenerative Medicine in Inflammatory Bowel Disease von Okamoto, Ryuichi, Mizutani, Tomohiro, Shimizu, Hiromichi

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Single cell analysis of Crohn’s disease patient-derived small intestinal organoids reveals disease activity-dependent modification of stem cell properties von Suzuki, Kohei, Murano, Tatsuro, Shimizu, Hiromichi, Ito, Go, Nakata, Toru, Fujii, Satoru, Ishibashi, Fumiaki, Kawamoto, Ami, Anzai, Sho, Kuno, Reiko, Kuwabara, Konomi, Takahashi, Junichi, Hama, Minami, Nagata, Sayaka, Hiraguri, Yui, Takenaka, Kento, Yui, Shiro, Tsuchiya, Kiichiro, Nakamura, Tetsuya, Ohtsuka, Kazuo, Watanabe, Mamoru, Okamoto, Ryuichi

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Organoids transplantation as a new modality to design epithelial signature to create a membrane-protective sulfomucin-enriched segment von Watanabe, Satoshi, Ogasawara, Nobuhiko, Kobayashi, Sakurako, Kirino, Sakura, Inoue, Masami, Hiraguri, Yui, Nagata, Sayaka, Shimizu, Hiromichi, Ito, Go, Mizutani, Tomohiro, Nemoto, Yasuhiro, Tsuchiya, Kiichiro, Okamoto, Ryuichi, Watanabe, Mamoru, Yui, Shiro

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Higher concentrations of cytokine blockers are needed to obtain small bowel mucosal healing during maintenance therapy in Crohn's disease von Takenaka, Kento, Kawamoto, Ami, Hibiya, Shuji, Suzuki, Kohei, Fujii, Toshimitsu, Motobayashi, Maiko, Shimizu, Hiromichi, Nagahori, Masakazu, Saito, Eiko, Okamoto, Ryuichi, Watanabe, Mamoru, Ohtsuka, Kazuo

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A20 and ABIN-1 synergistically preserve intestinal epithelial cell survival von Kattah, Michael G, Shao, Ling, Rosli, Yenny Y, Shimizu, Hiromichi, Whang, Michael I, Advincula, Rommel, Achacoso, Philip, Shah, Sanjana, Duong, Bao H, Onizawa, Michio, Tanbun, Priscilia, Malynn, Barbara A, Ma, Averil

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Organoid-based regenerative medicine for inflammatory bowel disease von Okamoto, Ryuichi, Shimizu, Hiromichi, Suzuki, Kohei, Kawamoto, Ami, Takahashi, Junichi, Kawai, Mao, Nagata, Sayaka, Hiraguri, Yui, Takeoka, Sayaka, Sugihara, Hady Yuki, Yui, Shiro, Watanabe, Mamoru

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Salmonella type III effector SpvC, a phosphothreonine lyase, contributes to reduction in inflammatory response during intestinal phase of infection von Haneda, Takeshi, Ishii, Yuta, Shimizu, Hiromichi, Ohshima, Keiko, Iida, Naoyuki, Danbara, Hirofumi, Okada, Nobuhiko

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Transmural Remission Characterized by High Biologic Concentrations Demonstrates Better Prognosis in Crohn’s Disease von Takenaka, Kento, Kawamoto, Ami, Kitazume, Yoshio, Fujii, Toshimitsu, Udagawa, Yumi, Shimizu, Hiromichi, Hibiya, Shuji, Nagahori, Masakazu, Ohtsuka, Kazuo, Watanabe, Mamoru, Okamoto, Ryuichi

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5‐aminosalicylate–intolerant patients are at increased risk of colectomy for ulcerative colitis von Hibiya, Shuji, Matsuyama, Yusuke, Fujii, Toshimitsu, Maeyashiki, Chiaki, Saito, Eiko, Ito, Kimiko, Shimizu, Hiromichi, Kawamoto, Ami, Motobayashi, Maiko, Takenaka, Kento, Nagahori, Masakazu, Kurosaki, Masayuki, Yauchi, Tsunehito, Ohtsuka, Kazuo, Fujiwara, Takeo, Okamoto, Ryuichi, Watanabe, Mamoru

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Stem cell-based therapy for inflammatory bowel disease von Shimizu, Hiromichi, Suzuki, Kohei, Watanabe, Mamoru, Okamoto, Ryuichi

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Functional analysis of isoflavones using patient-derived human colonic organoids von Tsuchiya, Mao, Ito, Go, Hama, Minami, Nagata, Sayaka, Kawamoto, Ami, Suzuki, Kohei, Shimizu, Hiromichi, Anzai, Sho, Takahashi, Junichi, Kuno, Reiko, Takeoka, Sayaka, Hiraguri, Yui, Sugihara, Hady Yuki, Mizutani, Tomohiro, Yui, Shiro, Oshima, Shigeru, Tsuchiya, Kiichiro, Watanabe, Mamoru, Okamoto, Ryuichi

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Deep neural network for video colonoscopy of ulcerative colitis: a cross-sectional study von Takenaka, Kento, Fujii, Toshimitsu, Kawamoto, Ami, Suzuki, Kohei, Shimizu, Hiromichi, Maeyashiki, Chiaki, Yamaji, Osamu, Motobayashi, Maiko, Igarashi, Akira, Hanazawa, Ryoichi, Hibiya, Shuji, Nagahori, Masakazu, Saito, Eiko, Okamoto, Ryuichi, Ohtsuka, Kazuo, Watanabe, Mamoru

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PGE2 is a direct and robust mediator of anion/fluid secretion by human intestinal epithelial cells von Fujii, Satoru, Suzuki, Kohei, Kawamoto, Ami, Ishibashi, Fumiaki, Nakata, Toru, Murano, Tatsuro, Ito, Go, Shimizu, Hiromichi, Mizutani, Tomohiro, Oshima, Shigeru, Tsuchiya, Kiichiro, Nakamura, Tetsuya, Araki, Akihiro, Ohtsuka, Kazuo, Okamoto, Ryuichi, Watanabe, Mamoru

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Contribution of ATOH1+ Cells to the Homeostasis, Repair, and Tumorigenesis of the Colonic Epithelium von Ishibashi, Fumiaki, Shimizu, Hiromichi, Nakata, Toru, Fujii, Satoru, Suzuki, Kohei, Kawamoto, Ami, Anzai, Sho, Kuno, Reiko, Nagata, Sayaka, Ito, Go, Murano, Tatsuro, Mizutani, Tomohiro, Oshima, Shigeru, Tsuchiya, Kiichiro, Nakamura, Tetsuya, Watanabe, Mamoru, Okamoto, Ryuichi

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Mucosal healing of small intestinal stricture is associated with improved prognosis post-dilation in Crohn's disease von Hibiya, Shuji, Ohtsuka, Kazuo, Takenaka, Kento, Kawamoto, Ami, Matsuyama, Yusuke, Udagawa, Yumi, Motobayashi, Maiko, Shimizu, Hiromichi, Fujii, Toshimitsu, Saito, Eiko, Nagahori, Masakazu, Okamoto, Ryuichi, Watanabe, Mamoru

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Combination of leucine-rich alpha-2 glycoprotein and fecal markers detect Crohn’s disease activity confirmed by balloon-assisted enteroscopy von Kawamoto, Ami, Takenaka, Kento, Hibiya, Shuji, Kitazume, Yoshio, Shimizu, Hiromichi, Fujii, Toshimitsu, Saito, Eiko, Ohtsuka, Kazuo, Okamoto, Ryuichi

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Collagen type I-mediated mechanotransduction controls epithelial cell fate conversion during intestinal inflammation von Kobayashi, Sakurako, Ogasawara, Nobuhiko, Watanabe, Satoshi, Yoneyama, Yosuke, Kirino, Sakura, Hiraguri, Yui, Inoue, Masami, Nagata, Sayaka, Okamoto-Uchida, Yoshimi, Kofuji, Satoshi, Shimizu, Hiromichi, Ito, Go, Mizutani, Tomohiro, Yamauchi, Shinichi, Kinugasa, Yusuke, Kano, Yoshihito, Nemoto, Yasuhiro, Watanabe, Mamoru, Tsuchiya, Kiichiro, Nishina, Hiroshi, Okamoto, Ryuichi, Yui, Shiro

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Long-term efficacy and safety of tofacitinib in patients with ulcerative colitis: 3-year results from a real-world study von Shimizu, Hiromichi, Aonuma, Yuko, Hibiya, Shuji, Kawamoto, Ami, Takenaka, Kento, Fujii, Toshimitsu, Saito, Eiko, Nagahori, Masakazu, Ohtsuka, Kazuo, Okamoto, Ryuichi

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Intravenous tacrolimus is a superior induction therapy for acute severe ulcerative colitis compared to oral tacrolimus von Shimizu, Hiromichi, Fujii, Toshimitsu, Kinoshita, Kenji, Kawamoto, Ami, Hibiya, Shuji, Takenaka, Kento, Saito, Eiko, Nagahori, Masakazu, Ohtsuka, Kazuo, Watanabe, Mamoru, Okamoto, Ryuichi

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Hemorrhagic gastric ulcer in a patient with Behcet's disease successfully treated with infliximab von Fujiwara, Shun, Kawamoto, Ami, Motobayashi, Maiko, Hibiya, Shuji, Takenaka, Kento, Shimizu, Hiromichi, Saito, Eiko, Fujii, Toshimitsu, Nagahori, Masakazu, Kawata, Daisuke, Umezawa, Natsuka, Hosoya, Tadashi, Yasuda, Shinsuke, Ohtsuka, Kazuo, Okamoto, Ryuichi

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