Small molecule allosteric inhibitors of RORγt block Th17-dependent inflammation and associated gene expression in vivo von Saenz, Steven A, Local, Andrea, Carr, Tiffany, Shakya, Arvind, Koul, Shivsmriti, Hu, Haiqing, Chourb, Lisa, Stedman, Justin, Malley, Jenna, D'Agostino, Laura Akullian, Shanmugasundaram, Veerabahu, Malona, John, Schwartz, C Eric, Beebe, Lisa, Clements, Meghan, Rajaraman, Ganesh, Cho, John, Jiang, Lan, Dubrovskiy, Alex, Kreilein, Matt, Shimanovich, Roman, Hamann, Lawrence G, Escoubet, Laure, Ellis, J Michael

Volltext

Discovery of Potent and Selective 8‑Fluorotriazolopyridine c‑Met Inhibitors von Peterson, Emily A, Teffera, Yohannes, Albrecht, Brian K, Bauer, David, Bellon, Steven F, Boezio, Alessandro, Boezio, Christiane, Broome, Martin A, Choquette, Deborah, Copeland, Katrina W, Dussault, Isabelle, Lewis, Richard, Lin, Min-Hwa Jasmine, Lohman, Julia, Liu, Jingzhou, Potashman, Michele, Rex, Karen, Shimanovich, Roman, Whittington, Douglas A, Vaida, Karina R, Harmange, Jean-Christophe

Volltext

Discovery and Optimization of Triazolopyridazines as Potent and Selective Inhibitors of the c-Met Kinase von Albrecht, Brian K, Harmange, Jean-Christophe, Bauer, David, Berry, Loren, Bode, Christiane, Boezio, Alessandro A, Chen, April, Choquette, Deborah, Dussault, Isabelle, Fridrich, Cary, Hirai, Satoko, Hoffman, Doug, Larrow, Jay F, Kaplan-Lefko, Paula, Lin, Jasmine, Lohman, Julia, Long, Alexander M, Moriguchi, Jodi, O’Connor, Anne, Potashman, Michele H, Reese, Monica, Rex, Karen, Siegmund, Aaron, Shah, Kavita, Shimanovich, Roman, Springer, Stephanie K, Teffera, Yohannes, Yang, Yajing, Zhang, Yihong, Bellon, Steven F

Volltext

In Silico Prediction of Pharmaceutical Degradation Pathways: A Benchmarking Study von Kleinman, Mark H, Baertschi, Steven W, Alsante, Karen M, Reid, Darren L, Mowery, Mark D, Shimanovich, Roman, Foti, Chris, Smith, William K, Reynolds, Dan W, Nefliu, Marcela, Ott, Martin A

Volltext

Mechanisms of Peroxynitrite Decomposition Catalyzed by FeTMPS, a Bioactive Sulfonated Iron Porphyrin von Shimanovich, Roman, Groves, John T.

Volltext

Structural characterization and developability assessment of sustained release hydrogels for rapid implementation during preclinical studies von Agarwal, Prashant, Greene, Daniel G., Sherman, Scott, Wendl, Kaitlyn, Vega, Leonela, Park, Hyunsoo, Shimanovich, Roman, Reid, Darren L.

Volltext

Inhibition of CDC7 with Sgr-2921 in AML Models Results in Enhanced DNA Damage and Anti-Leukemic Activity As Monotherapy and in Combination with Standard of Care Agents von Tsvetkov, Lyuben, Pittsenbarger, Janét, Atsriku, Christian, Devine, Paul, Dingley, Karen, Levinson, Adam, Mondal, Sayan, Piccotti, Joseph, Shimanovich, Roman, Tang, Lin, Weiss, Daniel, Woo, Jacky, Ye, Min, Yin, Wu, Akinsanya, Karen, Tang, Wayne, Wright, Hamish, Traer, Elie, Jensen, Kristian

Volltext

Abstract IA20: Unlocked groove—developing covalent inhibitors of KRASG12C von Lipford, J. Russell, Cee, Victor, Lanman, Brian, Saiki, Anne, Rex, Karen, Volak, Laurie, Shimanovich, Roman, Hinkle, Beth

Volltext

Discovery of pyridyl urea sulfonamide inhibitors of NaV1.7 von Butler, John R., Rescourio, Gwenaella, Milgram, Benjamin C., Foti, Robert S., Kornecook, Thomas, Ligutti, Joseph, Moyer, Bryan D., Taborn, Kristin, Youngblood, Beth D., Yu, Violeta, Shimanovich, Roman, Boezio, Alessandro, Weiss, Matthew

Volltext

Characterization of Potent Paracaspase MALT1 Inhibitors for Hematological Malignancies von Yin, Wu, Nie, Zhe, Dingley, Karen, Trzoss, Michael, Krilov, Goran, Marshall, Netonia, Feng, Shulu, Pelletier, Robert, Bell, Jeff, Devine, Paul, Skrdla, Peter, Shimanovich, Roman, Ye, Min, Calkins, David, Grimes, Mary, Tang, Wayne, Placzek, Andrew, Lawrenz, Morgan, McRobb, Fiona, Gerasyuto, Aleksey, Feher, Victoria, Mondal, Sayan, Jensen, Kristian, Wright, Hamish, Weiss, Daniel, Akinsanya, Karen

Volltext

Small molecule allosteric inhibitors of ROR[gamma]t block Th17-dependent inflammation and associated gene expression in vivo von Saenz, Steven A, Local, Andrea, Carr, Tiffany, Shakya, Arvind, Koul, Shivsmriti, Hu, Haiqing, Chourb, Lisa, Stedman, Justin, Malley, Jenna, D'Agostino, Laura Akullian, Shanmugasundaram, Veerabahu, Malona, John, Schwartz, C. Eric, Beebe, Lisa, Clements, Meghan, Rajaraman, Ganesh, Cho, John, Jiang, Lan, Dubrovskiy, Alex, Kreilein, Matt, Shimanovich, Roman, Hamann, Lawrence G, Escoubet, Laure, Ellis, J. Michael

Volltext

A rapid approach to the preliminary assessment of the physical stability of pharmaceutical hydrates von Shimanovich, Roman, Cooke, Melanie, Peterson, Matthew L.

Volltext

Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in Viv... von Graceffa, Russell F, Boezio, Alessandro A, Able, Jessica, Altmann, Steven, Berry, Loren M, Boezio, Christiane, Butler, John R, Chu-Moyer, Margaret, Cooke, Melanie, DiMauro, Erin F, Dineen, Thomas A, Feric Bojic, Elma, Foti, Robert S, Fremeau, Robert T, Guzman-Perez, Angel, Gao, Hua, Gunaydin, Hakan, Huang, Hongbing, Huang, Liyue, Ilch, Christopher, Jarosh, Michael, Kornecook, Thomas, Kreiman, Charles R, La, Daniel S, Ligutti, Joseph, Milgram, Benjamin C, Lin, Min-Hwa Jasmine, Marx, Isaac E, Nguyen, Hanh N, Peterson, Emily A, Rescourio, Gwen, Roberts, John, Schenkel, Laurie, Shimanovich, Roman, Sparling, Brian A, Stellwagen, John, Taborn, Kristin, Vaida, Karina R, Wang, Jean, Yeoman, John, Yu, Violeta, Zhu, Dawn, Moyer, Bryan D, Weiss, Matthew M

Volltext

Discovery of (R)‑6-(1-(8-Fluoro-6-(1-methyl‑1H‑pyrazol-4-yl)-[1,2,4]triazolo[4,3‑a]pyridin-3-yl)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)‑one (AMG 337), a Potent and Select... von Boezio, Alessandro A, Copeland, Katrina W, Rex, Karen, K. Albrecht, Brian, Bauer, David, Bellon, Steven F, Boezio, Christiane, Broome, Martin A, Choquette, Deborah, Coxon, Angela, Dussault, Isabelle, Hirai, Satoko, Lewis, Richard, Lin, Min-Hwa Jasmine, Lohman, Julia, Liu, Jingzhou, Peterson, Emily A, Potashman, Michele, Shimanovich, Roman, Teffera, Yohannes, Whittington, Douglas A, Vaida, Karina R, Harmange, Jean-Christophe

Volltext

Discovery of a Potent, Selective, and Orally Bioavailable c-Met Inhibitor: 1-(2-Hydroxy-2-methylpropyl)-N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-di... von Liu, Longbin, Siegmund, Aaron, Xi, Ning, Kaplan-Lefko, Paula, Rex, Karen, Chen, April, Lin, Jasmine, Moriguchi, Jodi, Berry, Loren, Huang, Liyue, Teffera, Yohannes, Yang, Yajing, Zhang, Yihong, Bellon, Steven F, Lee, Matthew, Shimanovich, Roman, Bak, Annette, Dominguez, Celia, Norman, Mark H, Harmange, Jean-Christophe, Dussault, Isabelle, Kim, Tae-Seong

Volltext

Sulfonamides as Selective Na V 1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in V... von Graceffa, Russell F, Boezio, Alessandro A, Able, Jessica, Altmann, Steven, Berry, Loren M, Boezio, Christiane, Butler, John R, Chu-Moyer, Margaret, Cooke, Melanie, DiMauro, Erin F, Dineen, Thomas A, Feric Bojic, Elma, Foti, Robert S, Fremeau, Jr, Robert T, Guzman-Perez, Angel, Gao, Hua, Gunaydin, Hakan, Huang, Hongbing, Huang, Liyue, Ilch, Christopher, Jarosh, Michael, Kornecook, Thomas, Kreiman, Charles R, La, Daniel S, Ligutti, Joseph, Milgram, Benjamin C, Lin, Min-Hwa Jasmine, Marx, Isaac E, Nguyen, Hanh N, Peterson, Emily A, Rescourio, Gwen, Roberts, John, Schenkel, Laurie, Shimanovich, Roman, Sparling, Brian A, Stellwagen, John, Taborn, Kristin, Vaida, Karina R, Wang, Jean, Yeoman, John, Yu, Violeta, Zhu, Dawn, Moyer, Bryan D, Weiss, Matthew M

Volltext

Part I: pathogenetic role of peroxynitrite in the development of diabetes and diabetic vascular complications: studies with FP15, a novel potent peroxynitrite decomposition catalys... von Szabó, Csaba, Mabley, Jon G, Moeller, Suzanne M, Shimanovich, Roman, Pacher, Pál, Virag, László, Soriano, Francisco G, Van Duzer, John H, Williams, William, Salzman, Andrew L, Groves, John T

Volltext

Small molecule allosteric inhibitors of RORγt block Th17-dependent inflammation and associated gene expression in vivo von Steven A. Saenz, Andrea Local, Tiffany Carr, Arvind Shakya, Shivsmriti Koul, Haiqing Hu, Lisa Chourb, Justin Stedman, Jenna Malley, Laura Akullian D’Agostino, Veerabahu Shanmugasundaram, John Malona, C. Eric Schwartz, Lisa Beebe, Meghan Clements, Ganesh Rajaraman, John Cho, Lan Jiang, Alex Dubrovskiy, Matt Kreilein, Roman Shimanovich, Lawrence G. Hamann, Laure Escoubet, J. Michael Ellis

Volltext

Correction to Discovery of Potent and Selective 8‑Fluorotriazolopyridine c‑Met Inhibitors von Peterson, Emily A, Teffera, Yohannes, Albrecht, Brian K, Bauer, David, Bellon, Steven F, Boezio, Alessandro, Boezio, Christiane, Broome, Martin A, Choquette, Deborah, Copeland, Katrina W, Dussault, Isabelle, Lewis, Richard, Lin, Min-Hwa Jasmine, Lohman, Julia, Liu, Jingzhou, Potashman, Michele, Rex, Karen, Shimanovich, Roman, Whittington, Douglas A, Vaida, Karina R, Harmange, Jean-Christophe

Volltext

Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors von Boezio, Alessandro A., Berry, Loren, Albrecht, Brian K., Bauer, David, Bellon, Steven F., Bode, Christiane, Chen, April, Choquette, Deborah, Dussault, Isabelle, Hirai, Satoko, Kaplan-Lefko, Paula, Larrow, Jay F., Lin, Min-Hwa Jasmine, Lohman, Julia, Potashman, Michele H., Rex, Karen, Santostefano, Michael, Shah, Kavita, Shimanovich, Roman, Springer, Stephanie K., Teffera, Yohannes, Yang, Yajing, Zhang, Yihong, Harmange, Jean-Christophe

Volltext