Novel qualitative aspects of tissue fatty acids related to metabolic regulation: Lessons from Elovl6 knockout von Shimano, Hitoshi

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Homozygous Familial Hypercholesterolemia von Nohara, Atsushi, Tada, Hayato, Ogura, Masatsune, Okazaki, Sachiko, Ono, Koh, Shimano, Hitoshi, Daida, Hiroyuki, Dobashi, Kazushige, Hayashi, Toshio, Hori, Mika, Matsuki, Kota, Minamino, Tetsuo, Yokoyama, Shinji, Harada-Shiba, Mariko

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Comparative Binding Analysis of Dipeptidyl Peptidase IV (DPP-4) with Antidiabetic Drugs - An Ab Initio Fragment Molecular Orbital Study von Arulmozhiraja, Sundaram, Matsuo, Naoya, Ishitsubo, Erika, Okazaki, Seiji, Shimano, Hitoshi, Tokiwa, Hiroaki

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The Peroxisome Proliferator-Activated Receptor α (PPARα) Agonist Pemafibrate Protects against Diet-Induced Obesity in Mice von Araki, Masaya, Nakagawa, Yoshimi, Oishi, Asayo, Han, Song-Iee, Wang, Yunong, Kumagai, Kae, Ohno, Hiroshi, Mizunoe, Yuhei, Iwasaki, Hitoshi, Sekiya, Motohiro, Matsuzaka, Takashi, Shimano, Hitoshi

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SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism von Oishi, Yumiko, Spann, Nathanael J., Link, Verena M., Muse, Evan D., Strid, Tobias, Edillor, Chantle, Kolar, Matthew J., Matsuzaka, Takashi, Hayakawa, Sumio, Tao, Jenhan, Kaikkonen, Minna U., Carlin, Aaron F., Lam, Michael T., Manabe, Ichiro, Shimano, Hitoshi, Saghatelian, Alan, Glass, Christopher K.

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ELOVL5‐mediated fatty acid elongation promotes cellular proliferation and invasion in renal cell carcinoma von Nitta, Satoshi, Kandori, Shuya, Tanaka, Ken, Sakka, Shotaro, Siga, Masanobu, Nagumo, Yoshiyuki, Negoro, Hiromitsu, Kojima, Takahiro, Mathis, Bryan J., Shimazui, Toru, Miyamoto, Takafumi, Matsuzaka, Takashi, Shimano, Hitoshi, Nishiyama, Hiroyuki

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Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in Macrophages von Karasawa, Tadayoshi, Kawashima, Akira, Usui-Kawanishi, Fumitake, Watanabe, Sachiko, Kimura, Hiroaki, Kamata, Ryo, Shirasuna, Koumei, Koyama, Yutaro, Sato-Tomita, Ayana, Matsuzaka, Takashi, Tomoda, Hiroshi, Park, Sam-Yong, Shibayama, Naoya, Shimano, Hitoshi, Kasahara, Tadashi, Takahashi, Masafumi

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New perspective on type 2 diabetes, dyslipidemia and non‐alcoholic fatty liver disease von Matsuzaka, Takashi, Shimano, Hitoshi

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HbA1c 5·7–6·4% and impaired fasting plasma glucose for diagnosis of prediabetes and risk of progression to diabetes in Japan (TOPICS 3): a longitudinal cohort study von Heianza, Yoriko, RD, Hara, Shigeko, MD, Arase, Yasuji, MD, Saito, Kazumi, MD, Fujiwara, Kazuya, MD, Tsuji, Hiroshi, MD, Kodama, Satoru, MD, Hsieh, Shiun Dong, MD, Mori, Yasumichi, MD, Shimano, Hitoshi, Prof, Yamada, Nobuhiro, Prof, Kosaka, Kinori, Prof, Sone, Hirohito, Prof

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Effects of K-877, a novel selective PPARα modulator, on small intestine contribute to the amelioration of hyperlipidemia in low-density lipoprotein receptor knockout mice von Takei, Kenta, Nakagawa, Yoshimi, Wang, Yunong, Han, Song-iee, Satoh, Aoi, Sekiya, Motohiro, Matsuzaka, Takashi, Shimano, Hitoshi

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SREBP-1c and TFE3, energy transcription factors that regulate hepatic insulin signaling von SHIMANO, Hitoshi

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Obesity-induced metabolic imbalance allosterically modulates CtBP2 to inhibit PPAR-alpha transcriptional activity von Saito, Kenji, Sekiya, Motohiro, Kainoh, Kenta, Yoshino, Ryunosuke, Hayashi, Akio, Han, Song-Iee, Araki, Masaya, Ohno, Hiroshi, Takeuchi, Yoshinori, Tsuyuzaki, Tomomi, Yamazaki, Daichi, Wanpei, Chen, Hada, Lisa, Watanabe, Sho, Paramita Adi Putri, Putu Indah, Murayama, Yuki, Sugano, Yoko, Osaki, Yoshinori, Iwasaki, Hitoshi, Yahagi, Naoya, Suzuki, Hiroaki, Miyamoto, Takafumi, Matsuzaka, Takashi, Shimano, Hitoshi

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CREBH regulation of lipid metabolism through multifaceted functions that improve arteriosclerosis von Nakagawa, Yoshimi, Matsuzaka, Takashi, Shimano, Hitoshi

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The selective peroxisome proliferator-activated receptor alpha modulator (SPPARMα) paradigm: conceptual framework and therapeutic potential von Jean-Charles Fruchart, Santos, Raul D, Aguilar-Salinas, Carlos, Aikawa, Masanori, Khalid Al Rasadi, Amarenco, Pierre, Barter, Philip J, Ceska, Richard, Corsini, Alberto, Després, Jean-Pierre, Duriez, Patrick, Eckel, Robert H, Ezhov, Marat V, Farnier, Michel, Ginsberg, Henry N, Hermans, Michel P

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Effects of Branched-Chain Amino Acids on Skeletal Muscle, Glycemic Control, and Neuropsychological Performance in Elderly Persons with Type 2 Diabetes Mellitus: An Exploratory Rand... von Matsuda, Takaaki, Suzuki, Hiroaki, Sugano, Yoko, Suzuki, Yasuhiro, Yamanaka, Daisuke, Araki, Risa, Yahagi, Naoya, Sekiya, Motohiro, Kawakami, Yasushi, Osaki, Yoshinori, Iwasaki, Hitoshi, Hashimoto, Koichi, Takahashi, Shin-Ichiro, Hada, Yasushi, Shimano, Hitoshi

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Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood von Yuan, Xunmei, Tsujimoto, Kazutaka, Hashimoto, Koshi, Kawahori, Kenichi, Hanzawa, Nozomi, Hamaguchi, Miho, Seki, Takami, Nawa, Makiko, Ehara, Tatsuya, Kitamura, Yohei, Hatada, Izuho, Konishi, Morichika, Itoh, Nobuyuki, Nakagawa, Yoshimi, Shimano, Hitoshi, Takai-Igarashi, Takako, Kamei, Yasutomi, Ogawa, Yoshihiro

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Hepatocyte- or macrophage-specific SREBP-1a deficiency in mice exacerbates methionine- and choline-deficient diet-induced nonalcoholic fatty liver disease von Araki, Masaya, Nakagawa, Yoshimi, Saito, Hodaka, Yamada, Yasunari, Han, Song-Iee, Mizunoe, Yuhei, Ohno, Hiroshi, Miyamoto, Takafumi, Sekiya, Motohiro, Matsuzaka, Takashi, Sone, Hirohito, Shimano, Hitoshi

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CREB3L3 controls fatty acid oxidation and ketogenesis in synergy with PPARα von Nakagawa, Yoshimi, Satoh, Aoi, Tezuka, Hitomi, Han, Song-iee, Takei, Kenta, Iwasaki, Hitoshi, Yatoh, Shigeru, Yahagi, Naoya, Suzuki, Hiroaki, Iwasaki, Yasumasa, Sone, Hirohito, Matsuzaka, Takashi, Yamada, Nobuhiro, Shimano, Hitoshi

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Octacosanol and policosanol prevent high-fat diet-induced obesity and metabolic disorders by activating brown adipose tissue and improving liver metabolism von Sharma, Rahul, Matsuzaka, Takashi, Kaushik, Mahesh K., Sugasawa, Takehito, Ohno, Hiroshi, Wang, Yunong, Motomura, Kaori, Shimura, Takuya, Okajima, Yuka, Mizunoe, Yuhei, Ma, Yang, Saber, Zahara M., Iwasaki, Hitoshi, Yatoh, Shigeru, Suzuki, Hiroaki, Aita, Yuichi, Han, Song-iee, Takeuchi, Yoshinori, Yahagi, Naoya, Miyamoto, Takafumi, Sekiya, Motohiro, Nakagawa, Yoshimi, Shimano, Hitoshi

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Deranged fatty acid composition causes pulmonary fibrosis in Elovl6-deficient mice von Sunaga, Hiroaki, Matsui, Hiroki, Ueno, Manabu, Maeno, Toshitaka, Iso, Tatsuya, Syamsunarno, Mas Rizky A. A., Anjo, Saki, Matsuzaka, Takashi, Shimano, Hitoshi, Yokoyama, Tomoyuki, Kurabayashi, Masahiko

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