Dynamics of insulin secretion and the clinical implications for obesity and diabetes von Seino, Susumu, Shibasaki, Tadao, Minami, Kohtaro

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PKA-Dependent and PKA-Independent Pathways for cAMP-Regulated Exocytosis von Seino, Susumu, Shibasaki, Tadao

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GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure von Kim, Minsuk, Platt, Mathew J, Shibasaki, Tadao, Quaggin, Susan E, Backx, Peter H, Seino, Susumu, Simpson, Jeremy A, Drucker, Daniel J

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Evaluation of cerebrospinal fluid heparan sulfate as a biomarker of neuropathology in a murine model of mucopolysaccharidosis type II using high-sensitivity LC/MS/MS von Tanaka, Noboru, Kida, Sachiho, Kinoshita, Masafumi, Morimoto, Hideto, Shibasaki, Tadao, Tachibana, Katsuhiko, Yamamoto, Ryuji

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Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP von Shibasaki, Tadao, Takahashi, Harumi, Miki, Takashi, Sunaga, Yasuhiro, Matsumura, Kimio, Yamanaka, Mami, Zhang, Changliang, Tamamoto, Atsuko, Satoh, Takaya, Miyazaki, Jun-ichi, Seino, Susumu

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Glutamate Acts as a Key Signal Linking Glucose Metabolism to Incretin/cAMP Action to Amplify Insulin Secretion von Gheni, Ghupurjan, Ogura, Masahito, Iwasaki, Masahiro, Yokoi, Norihide, Minami, Kohtaro, Nakayama, Yasumune, Harada, Kazuo, Hastoy, Benoit, Wu, Xichen, Takahashi, Harumi, Kimura, Kazushi, Matsubara, Toshiya, Hoshikawa, Ritsuko, Hatano, Naoya, Sugawara, Kenji, Shibasaki, Tadao, Inagaki, Nobuya, Bamba, Takeshi, Mizoguchi, Akira, Fukusaki, Eiichiro, Rorsman, Patrik, Seino, Susumu

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The cAMP Sensor Epac2 Is a Direct Target of Antidiabetic Sulfonylurea Drugs von Zhang, Chang-Liang, Katoh, Megumi, Shibasaki, Tadao, Minami, Kohtaro, Sunaga, Yasuhiro, Takahashi, Harumi, Yokoi, Norihide, Iwasaki, Masahiro, Miki, Takashi, Seino, Susumu

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GLP-1 Inhibits and Adrenaline Stimulates Glucagon Release by Differential Modulation of N- and L-Type Ca2+ Channel-Dependent Exocytosis von De Marinis, Yang Z., Salehi, Albert, Ward, Caroline E., Zhang, Quan, Abdulkader, Fernando, Bengtsson, Martin, Braha, Orit, Braun, Matthias, Ramracheya, Reshma, Amisten, Stefan, Habib, Abdella M., Moritoh, Yusuke, Zhang, Enming, Reimann, Frank, Rosengren, Anders H., Shibasaki, Tadao, Gribble, Fiona, Renström, Erik, Seino, Susumu, Eliasson, Lena, Rorsman, Patrik

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Role of Epac2A/Rap1 signaling in interplay between incretin and sulfonylurea in insulin secretion von Takahashi, Harumi, Shibasaki, Tadao, Park, Jae-Hyung, Hidaka, Shihomi, Takahashi, Toshimasa, Ono, Aika, Song, Dae-Kyu, Seino, Susumu

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Critical role of the N-terminal cyclic AMP-binding domain of Epac2 in its subcellular localization and function von Niimura, Manabu, Miki, Takashi, Shibasaki, Tadao, Fujimoto, Wakako, Iwanaga, Toshihiko, Seino, Susumu

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Actin Dynamics Regulated by the Balance of Neuronal Wiskott-Aldrich Syndrome Protein (N-WASP) and Cofilin Activities Determines the Biphasic Response of Glucose-induced Insulin Sec... von Uenishi, Eita, Shibasaki, Tadao, Takahashi, Harumi, Seki, Chihiro, Hamaguchi, Hitomi, Yasuda, Takao, Tatebe, Masao, Oiso, Yutaka, Takenawa, Tadaomi, Seino, Susumu

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Antidiabetic sulfonylureas and cAMP cooperatively activate Epac2A von Takahashi, Toshimasa, Shibasaki, Tadao, Takahashi, Harumi, Sugawara, Kenji, Ono, Aika, Inoue, Naoko, Furuya, Toshio, Seino, Susumu

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Elucidation of the function and role of cAMP sensor Epac2A in insulin secretion von Shibasaki, Tadao

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Rab11 and its effector Rip11 participate in regulation of insulin granule exocytosis von Sugawara, Kenji, Shibasaki, Tadao, Mizoguchi, Akira, Saito, Tetsuya, Seino, Susumu

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Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1 von Seino, Susumu, Miki, Takashi, Suzuki, Masashi, Shibasaki, Tadao, Uemura, Hiroko, Sato, Toshiaki, Yamaguchi, Kaori, Koseki, Haruhiko, Iwanaga, Toshihiko, Nakaya, Haruaki

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Critical Role of cAMP-GEFII·Rim2 Complex in Incretin-potentiated Insulin Secretion von Kashima, Yasushige, Miki, Takashi, Shibasaki, Tadao, Ozaki, Nobuaki, Miyazaki, Masaru, Yano, Hideki, Seino, Susumu

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Interaction of ATP Sensor, cAMP Sensor, Ca2+ Sensor, and Voltage-dependent Ca2+ Channel in Insulin Granule Exocytosis von Shibasaki, Tadao, Sunaga, Yasuhiro, Fujimoto, Kei, Kashima, Yasushige, Seino, Susumu

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cAMP-GEFII is a direct target of cAMP in regulated exocytosis von Seino, Susumu, Ozaki, Nobuaki, Shibasaki, Tadao, Kashima, Yasushige, Miki, Takashi, Takahashi, Kazuo, Ueno, Hiroaki, Sunaga, Yasuhiro, Yano, Hideki, Matsuura, Yoshiharu, Iwanaga, Toshihiko, Takai, Yoshimi

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Pancreatic β-cell signaling: toward better understanding of diabetes and its treatment von SEINO, Susumu, SHIBASAKI, Tadao, MINAMI, Kohtaro

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Regulation of Ca2+ channel expression at the cell surface by the small G-protein kir/Gem von BEGUIN, Pascal, NAGASHIMA, Kazuaki, GONOI, Tohru, SHIBASAKI, Tadao, TAKAHASHI, Kazuo, KASHIMA, Yasushige, OZAKI, Nobuaki, GEERING, Käthi, IWANAGA, Toshihiko, SELNO, Susumu

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