Selective small-molecule inhibition of an RNA structural element von Howe, John A., Wang, Hao, Fischmann, Thierry O., Balibar, Carl J., Xiao, Li, Galgoci, Andrew M., Malinverni, Juliana C., Mayhood, Todd, Villafania, Artjohn, Nahvi, Ali, Murgolo, Nicholas, Barbieri, Christopher M., Mann, Paul A., Carr, Donna, Xia, Ellen, Zuck, Paul, Riley, Dan, Painter, Ronald E., Walker, Scott S., Sherborne, Brad, de Jesus, Reynalda, Pan, Weidong, Plotkin, Michael A., Wu, Jin, Rindgen, Diane, Cummings, John, Garlisi, Charles G., Zhang, Rumin, Sheth, Payal R., Gill, Charles J., Tang, Haifeng, Roemer, Terry

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Mechanism of Action and Epitopes of Clostridium difficile Toxin B-neutralizing Antibody Bezlotoxumab Revealed by X-ray Crystallography von Orth, Peter, Xiao, Li, Hernandez, Lorraine D., Reichert, Paul, Sheth, Payal R., Beaumont, Maribel, Yang, Xiaoyu, Murgolo, Nicholas, Ermakov, Grigori, DiNunzio, Edward, Racine, Fred, Karczewski, Jerzy, Secore, Susan, Ingram, Richard N., Mayhood, Todd, Strickland, Corey, Therien, Alex G.

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Structural basis for selectivity and diversity in angiotensin II receptors von Zhang, Haitao, Han, Gye Won, Batyuk, Alexander, Ishchenko, Andrii, White, Kate L., Patel, Nilkanth, Sadybekov, Anastasiia, Zamlynny, Beata, Rudd, Michael T., Hollenstein, Kaspar, Tolstikova, Alexandra, White, Thomas A., Hunter, Mark S., Weierstall, Uwe, Liu, Wei, Babaoglu, Kerim, Moore, Eric L., Katz, Ryan D., Shipman, Jennifer M., Garcia-Calvo, Margarita, Sharma, Sujata, Sheth, Payal, Soisson, Stephen M., Stevens, Raymond C., Katritch, Vsevolod, Cherezov, Vadim

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Chemical Genetic Analysis and Functional Characterization of Staphylococcal Wall Teichoic Acid 2-Epimerases Reveals Unconventional Antibiotic Drug Targets von Mann, Paul A, Müller, Anna, Wolff, Kerstin A, Fischmann, Thierry, Wang, Hao, Reed, Patricia, Hou, Yan, Li, Wenjin, Müller, Christa E, Xiao, Jianying, Murgolo, Nicholas, Sher, Xinwei, Mayhood, Todd, Sheth, Payal R, Mirza, Asra, Labroli, Marc, Xiao, Li, McCoy, Mark, Gill, Charles J, Pinho, Mariana G, Schneider, Tanja, Roemer, Terry

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Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40 von Lu, Jun, Byrne, Noel, Wang, John, Bricogne, Gerard, Brown, Frank K, Chobanian, Harry R, Colletti, Steven L, Di Salvo, Jerry, Thomas-Fowlkes, Brande, Guo, Yan, Hall, Dawn L, Hadix, Jennifer, Hastings, Nicholas B, Hermes, Jeffrey D, Ho, Thu, Howard, Andrew D, Josien, Hubert, Kornienko, Maria, Lumb, Kevin J, Miller, Michael W, Patel, Sangita B, Pio, Barbara, Plummer, Christopher W, Sherborne, Bradley S, Sheth, Payal, Souza, Sarah, Tummala, Srivanya, Vonrhein, Clemens, Webb, Maria, Allen, Samantha J, Johnston, Jennifer M, Weinglass, Adam B, Sharma, Sujata, Soisson, Stephen M

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Direct Analysis from Phase-Separated Liquid Samples using ADE-OPI-MS: Applicability to High-Throughput Screening for Inhibitors of Diacylglycerol Acyltransferase 2 von Wen, Xiujuan, Liu, Chang, Ghislain, Lucien, Tovar, Kiersten, Shah, Vinit, Stout, Steven J, Cifelli, Steven, Satapati, Santhosh, O’Donnell, Gregory, Sheth, Payal R, Wildey, Mary Jo, Datwani, Sammy S, Covey, Thomas R, Bateman, Kevin P, McLaren, David G

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Structural basis of CX-4945 binding to human protein kinase CK2 von Ferguson, Andrew D., Sheth, Payal R., Basso, Andrea D., Paliwal, Sunil, Gray, Kimberly, Fischmann, Thierry O., Le, Hung V.

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Epitopes and Mechanism of Action of the Clostridium difficile Toxin A-Neutralizing Antibody Actoxumab von Hernandez, Lorraine D., Kroh, Heather K., Hsieh, Edward, Yang, Xiaoyu, Beaumont, Maribel, Sheth, Payal R., DiNunzio, Edward, Rutherford, Stacey A., Ohi, Melanie D., Ermakov, Grigori, Xiao, Li, Secore, Susan, Karczewski, Jerzy, Racine, Fred, Mayhood, Todd, Fischer, Paul, Sher, Xinwei, Gupta, Pulkit, Lacy, D. Borden, Therien, Alex G.

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Antianemic activity of polyherbal formulation, Raktavardhak Kadha, against phenylhydrazine-induced anemia in rats von Sheth, Payal A., Pawar, Anil T., Mote, Chandrashekhar S., More, Chandrakant

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Broad coverage of genetically diverse strains of Clostridium difficile by actoxumab and bezlotoxumab predicted by in vitro neutralization and epitope modeling von Hernandez, Lorraine D, Racine, Fred, Xiao, Li, DiNunzio, Edward, Hairston, Nichelle, Sheth, Payal R, Murgolo, Nicholas J, Therien, Alex G

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Examining Targeted Protein Degradation from Physiological and Analytical Perspectives: Enabling Translation between Cells and Subjects von Daurio, Natalie A., Zhou, Haihong, Chen, Ying, Sheth, Payal R., Imbriglio, Jason E., McLaren, David G., Tawa, Paul, Rachdaoui, Nadia, Previs, Michael J., Kasumov, Takhar, O’Neil, Jennifer, Previs, Stephen F.

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Phytochemical Content and Antioxidant Property of Polyherbal Formulation, Raktavardhak Kadha von Sheth, Payal A, Pawar, Anil T, Choudhari, Ganesh B, More, Chandrakant S

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Quantitation of wall teichoic acid in Staphylococcus aureus by direct measurement of monomeric units using LC-MS/MS von Berejnaia, Olga, Wang, Hao, Labroli, Marc, Yang, Christine, Gill, Charles, Xiao, Jianying, Hesk, David, DeJesus, Reynalda, Su, Jing, Tan, Christopher M., Sheth, Payal R., Kavana, Michael, McLaren, David G.

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Benzimidazole analogs as WTA biosynthesis inhibitors targeting methicillin resistant Staphylococcus aureus von Yang, Shu-Wei, Pan, Jianping, Yang, Christine, Labroli, Marc, Pan, Weidong, Caldwell, John, Ha, Sookhee, Koseoglu, Sandra, Xiao, Jing C., Mayhood, Todd, Sheth, Payal R., Garlisi, Charles G., Wu, Jin, Lee, Sang Ho, Wang, Hao, Tan, Christopher M., Roemer, Terry, Su, Jing

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Using measures of metabolic flux to align screening and clinical development: Avoiding pitfalls to enable translational studies von Satapati, Santhosh, Downes, Daniel P., Metzger, Daniel, Shankaran, Harish, Talukdar, Saswata, Zhou, Yingjiang, Ren, Zhao, Chen, Michelle, Lim, Yeon-Hee, Hatcher, Nathan G., Wen, Xiujuan, Sheth, Payal R., McLaren, David G., Previs, Stephen F.

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Antibacterial small molecules targeting the conserved TOPRIM domain of DNA gyrase von Walker, Scott S, Labroli, Marc, Painter, Ronald E, Wiltsie, Judyann, Sherborne, Brad, Murgolo, Nicholas, Sher, Xinwei, Mann, Paul, Zuck, Paul, Garlisi, Charles G, Su, Jing, Kargman, Stacia, Xiao, Li, Scapin, Giovanna, Salowe, Scott, Devito, Kristine, Sheth, Payal, Buist, Nichole, Tan, Christopher M, Black, Todd A, Roemer, Terry

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Novel Benzimidazole Inhibitors Bind to a Unique Site in the Kinesin Spindle Protein Motor Domain von Sheth, Payal R, Shipps, Gerald W, Seghezzi, Wolfgang, Smith, Catherine K, Chuang, Cheng-Chi, Sanden, David, Basso, Andrea D, Vilenchik, Lev, Gray, Kimberly, Annis, D. Allen, Nickbarg, Elliott, Ma, Yao, Lahue, Brian, Herbst, Ronald, Le, Hung V

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Fully Activated MEK1 Exhibits Compromised Affinity for Binding of Allosteric Inhibitors U0126 and PD0325901 von Sheth, Payal R, Liu, Yuqi, Hesson, Thomas, Zhao, Jia, Vilenchik, Lev, Liu, Yan-Hui, Mayhood, Todd W, Le, Hung V

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Isotope Fractionation during Gas Chromatography Can Enhance Mass Spectrometry-Based Measures of 2H-Labeling of Small Molecules von Downes, Daniel P., Kasumov, Takhar, Daurio, Natalie A., Wood, Neil B., Previs, Michael J., Sheth, Payal R., McLaren, David G., Previs, Stephen F.

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Affinity characterization–mass spectrometry methodology for quantitative analyses of small molecule protein binding in solution von Vilenchik, Lev Z., Sheth, Payal R., Chuang, Cheng-Chi, Le, Hung V.

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