Broadening the Spectrum of β-Lactam Antibiotics through Inhibition of Signal Peptidase Type I von THERIEN, Alex G, HUBER, Joann L, XIN GU, KEVIN, Nancy J, LAFLEUR, Josiane, LEAVITT, Penny S, LEBEAU-JACOB, Christian, LEE, Suzy S, LIN, Molly M, MICHELS, Anna A, OGAWA, Aimie M, PAINTER, Ronald E, WILSON, Kenneth E, PARISH, Craig A, PARK, Young-Whan, BENTON-PERDOMO, Liliana, PETCU, Mihai, PHILLIPS, John W, POWLES, Mary Ann, SKOREY, Kathryn I, TAM, John, TAN, Christopher M, YOUNG, Katherine, BEAULIEU, Patrick, WONG, Simon, WADDELL, Sherman T, MIESEL, Lynn, CARON, Alexandre, CLAVEAU, David, DESCHAMPS, Kathleen, DONALD, Robert G. K, GALGOCI, Andrew M, GALLANT, Michel

Volltext

Design and Synthesis of Piperazine Sulfonamide Cores Leading to Highly Potent HIV‑1 Protease Inhibitors von Bungard, Christopher J, Williams, Peter D, Schulz, Jurgen, Wiscount, Catherine M, Holloway, M. Katharine, Loughran, H. Marie, Manikowski, Jesse J, Su, Hua-Poo, Bennett, David J, Chang, Lehua, Chu, Xin-Jie, Crespo, Alejandro, Dwyer, Michael P, Keertikar, Kartik, Morriello, Gregori J, Stamford, Andrew W, Waddell, Sherman T, Zhong, Bin, Hu, Bin, Ji, Tao, Diamond, Tracy L, Bahnck-Teets, Carolyn, Carroll, Steven S, Fay, John F, Min, Xu, Morris, William, Ballard, Jeanine E, Miller, Michael D, McCauley, John A

Volltext

Fluorogenic substrates for high-throughput measurements of endothelial lipase activity von Mitnaul, Lyndon J., Tian, Jenny, Burton, Charlotte, Lam, My-Hanh, Zhu, Yuping, Olson, Steve H., Schneeweis, Jonathan E., Zuck, Paul, Pandit, Shilpa, Anderson, Matt, Maletic, Milana M., Waddell, Sherman T., Wright, Samuel D., Sparrow, Carl P., Lund, Erik G.

Volltext

Selective Formation of Functionalized α‑Quaternary Malononitriles toward 5,5-Disubstituted Pyrrolopyrimidinones von Whitehead, Alan, Zhang, Yong, McCabe Dunn, Jamie, Sherer, Edward C, Lam, Yu-hong, Stelmach, John, Sun, Aaron, Shiroda, Melisa, Orr, Robert K, Waddell, Sherman T, Raghavan, Subharekha

Volltext

Evaluation of selective inhibitors of 11β-HSD1 for the treatment of hypertension von Bauman, David R., Whitehead, Alan, Contino, Lisa C., Cui, Jisong, Garcia-Calvo, Margarita, Gu, Xin, Kevin, Nancy, Ma, Xiuying, Pai, Lee-yuh, Shah, Kashmira, Shen, Xiaolan, Stribling, Sloan, Zokian, Hratch J., Metzger, Joe, Shevell, Diane E., Waddell, Sherman T.

Volltext

Substituted phenyl triazoles as selective inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 von Sun, Wanying, Maletic, Milana, Mundt, Steven S., Shah, Kashmira, Zokian, Hratch, Lyons, Kathy, Waddell, Sherman T., Balkovec, James

Volltext

11β-HSD1 inhibition reduces atherosclerosis in mice by altering proinflammatory gene expression in the vasculature von Luo, Mingjuan J, Thieringer, Rolf, Springer, Martin S, Wright, Samuel D, Hermanowski-Vosatka, Anne, Plump, Andrew, Balkovec, James M, Cheng, Kang, Ding, Gloria J, Kawka, Douglas W, Koo, Gloria C, Grand, Cheryl B Le, Luo, Qi, Maletic, Milana M, Malkowitz, Lorraine, Shah, Kashmira, Singer, Irwin, Waddell, Sherman T, Wu, Kenneth K, Yuan, Jeffrey, Zhu, Jun, Stepaniants, Serguei, Yang, Xia, Lum, Pek Yee, Wang, I-Ming

Volltext

Bicyclo[2.2.2]octyltriazole inhibitors of 11β-hydoxysteroid dehydrogenase type 1. Pharmacological agents for the treatment of metabolic syndrome von Maletic, Milana, Leeman, Aaron, Szymonifka, Michael, Mundt, Steven S., Zokian, Hratch J., Shah, Kashmira, Dragovic, Jasminka, Lyons, Kathy, Thieringer, Rolf, Vosatka, Anne H., Balkovec, James, Waddell, Sherman T.

Volltext

Discovery of 4-heteroarylbicyclo[2.2.2]octyltriazoles as potent and selective inhibitors of 11β-HSD1: Novel therapeutic agents for the treatment of metabolic syndrome von Gu, Xin, Dragovic, Jasminka, Koo, Gloria C., Koprak, Sam L., LeGrand, Cheryl, Mundt, Steven S., Shah, Kashmira, Springer, Marty S., Tan, Eugene Y., Thieringer, Rolf, Hermanowski-Vosatka, Anne, Zokian, Hratch J., Balkovec, James M., Waddell, Sherman T.

Volltext

Reactions of [1.1.1]propellane von Wiberg, Kenneth B, Waddell, Sherman T

Volltext

Inhibitors of the bacterial cell wall biosynthesis enzyme Mur D von Gegnas, Laura D., Waddell, Sherman T., Chabin, Renee M., Reddy, Sreelatha, Wong, Kenny K.

Volltext

Preparative Enzymatic Synthesis and Characterization of the Cytoplasmic Intermediates of Murein Biosynthesis von Reddy, Sreelatha G, Waddell, Sherman T, Kuo, David W, Wong, Kenny K, Pompliano, David L

Volltext

Engineering a Cell-Free Murein Biosynthetic Pathway:  Combinatorial Enzymology in Drug Discovery von Wong, Kenny K, Kuo, David W, Chabin, Renee M, Fournier, Carole, Gegnas, Laura D, Waddell, Sherman T, Marsilio, Frank, Leiting, Barbara, Pompliano, David L

Volltext

Artificial transaminases linking pyridoxamine to binding cavities: controlling the geometry von Breslow, Ronald, Canary, James W, Varney, Michael, Waddell, Sherman T, Yang, Dan

Volltext

11 beta -HSD1 inhibition reduces atherosclerosis in mice by altering proinflammatory gene expression in the vasculature von Luo, Mingjuan J, Thieringer, Rolf, Springer, Martin S, Wright, Samuel D, Hermanowski-Vosatka, Anne, Plump, Andrew, Balkovec, James M, Cheng, Kang, Ding, Gloria J, Kawka, Douglas W

Volltext

Vibrational spectrum, structure, and energy of [1.1.1]propellane von Wiberg, Kenneth B, Dailey, William P, Walker, Frederick H, Waddell, Sherman T, Crocker, Louis S, Newton, Marshall

Volltext

Evaluation of selective inhibitors of 11[beta]-HSD1 for the treatment of hypertension von Bauman, David R, Whitehead, Alan, Contino, Lisa C, Cui, Jisong, Garcia-Calvo, Margarita, Gu, Xin, Kevin, Nancy, Ma, Xiuying, Pai, Lee-yuh, Shah, Kashmira, Shen, Xiaolan, Stribling, Sloan, Zokian, Hratch J, Metzger, Joe, Shevell, Diane E, Waddell, Sherman T

Volltext

Infrared intensities: bicyclo[1.1.0]butane. A normal coordinate analysis and comparison with cyclopropane and [1.1.1]propellane von Wiberg, Kenneth B, Waddell, Sherman T, Rosenberg, Robert E

Volltext

[1.1.1]Propellane: Reaction with electron deficient alkenes and alkynes von Wiberg, Kenneth B, Waddell, Sherman T

Volltext

Infrared intensities: bicyclo[1.1.1]pentane. A normal-coordinate analysis and comparison with [1.1.1]propellane von Wiberg, Kenneth B, Rosenberg, Robert E, Waddell, Sherman T

Volltext