Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity von Stockton, Rebecca A, Shenkar, Robert, Awad, Issam A, Ginsberg, Mark H

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PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism von Ren, Aileen A., Snellings, Daniel A., Su, Yourong S., Hong, Courtney C., Castro, Marco, Tang, Alan T., Detter, Matthew R., Hobson, Nicholas, Girard, Romuald, Romanos, Sharbel, Lightle, Rhonda, Moore, Thomas, Shenkar, Robert, Benavides, Christian, Beaman, M. Makenzie, Müller-Fielitz, Helge, Chen, Mei, Mericko, Patricia, Yang, Jisheng, Sung, Derek C., Lawton, Michael T., Ruppert, J. Michael, Schwaninger, Markus, Körbelin, Jakob, Potente, Michael, Awad, Issam A., Marchuk, Douglas A., Kahn, Mark L.

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Endothelial TLR4 and the microbiome drive cerebral cavernous malformations von Tang, Alan T., Choi, Jaesung P., Kotzin, Jonathan J., Yang, Yiqing, Hong, Courtney C., Hobson, Nicholas, Girard, Romuald, Zeineddine, Hussein A., Lightle, Rhonda, Moore, Thomas, Cao, Ying, Shenkar, Robert, Chen, Mei, Mericko, Patricia, Yang, Jisheng, Li, Li, Tanes, Ceylan, Kobuley, Dmytro, Võsa, Urmo, Whitehead, Kevin J., Li, Dean Y., Franke, Lude, Hart, Blaine, Schwaninger, Markus, Henao-Mejia, Jorge, Morrison, Leslie, Kim, Helen, Awad, Issam A., Zheng, Xiangjian, Kahn, Mark L.

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Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations von Lopez-Ramirez, Miguel Alejandro, Fonseca, Gregory, Zeineddine, Hussein A, Girard, Romuald, Moore, Thomas, Pham, Angela, Cao, Ying, Shenkar, Robert, de Kreuk, Bart-Jan, Lagarrigue, Frederic, Lawler, Jack, Glass, Christopher K, Awad, Issam A, Ginsberg, Mark H

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Fasudil Decreases Lesion Burden in a Murine Model of Cerebral Cavernous Malformation Disease von MCDONALD, David A, SHI, Changbin, SHENKAR, Robert, STOCKTON, Rebecca A, FEIFEI LIU, GINSBERG, Mark H, MARCHUK, Douglas A, AWAD, Issam A

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Evaluation of Iron Content in Human Cerebral Cavernous Malformation Using Quantitative Susceptibility Mapping von Tan, Huan, Liu, Tian, Wu, Ying, Thacker, Jon, Shenkar, Robert, Mikati, Abdul Ghani, Shi, Changbin, Dykstra, Conner, Wang, Yi, Prasad, Pottumarthi V, Edelman, Robert R, Awad, Issam A

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Permissive microbiome characterizes human subjects with a neurovascular disease cavernous angioma von Polster, Sean P., Sharma, Anukriti, Tanes, Ceylan, Tang, Alan T., Mericko, Patricia, Cao, Ying, Carrión-Penagos, Julián, Girard, Romuald, Koskimäki, Janne, Zhang, Dongdong, Stadnik, Agnieszka, Romanos, Sharbel G., Lyne, Seán B., Shenkar, Robert, Yan, Kimberly, Lee, Cornelia, Akers, Amy, Morrison, Leslie, Robinson, Myranda, Zafar, Atif, Bittinger, Kyle, Kim, Helen, Gilbert, Jack A., Kahn, Mark L., Shen, Le, Awad, Issam A.

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Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican von Hong, Courtney C., Tang, Alan T., Detter, Matthew R., Choi, Jaesung P., Wang, Rui, Yang, Xi, Guerrero, Andrea A., Wittig, Carl F., Hobson, Nicholas, Girard, Romuald, Lightle, Rhonda, Moore, Thomas, Shenkar, Robert, Polster, Sean P., Goddard, Lauren M., Ren, Aileen A., Leu, N. Adrian, Sterling, Stephanie, Yang, Jisheng, Li, Li, Chen, Mei, Mericko-Ishizuka, Patricia, Dow, Lukas E., Watanabe, Hideto, Schwaninger, Markus, Min, Wang, Marchuk, Douglas A., Zheng, Xiangjian, Awad, Issam A., Kahn, Mark L.

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Propranolol as therapy for cerebral cavernous malformations: a cautionary note von Shenkar, Robert, Moore, Thomas, Benavides, Christian, Lightle, Rhonda, Detter, Matthew R, Hobson, Nicholas, Girard, Romuald, DeBiasse, Dorothy, Patrucco, Mary, Gallione, Carol, Zabramski, Joseph M, Marchuk, Douglas A, Awad, Issam A

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Neutrophils as early immunologic effectors in hemorrhage- or endotoxemia-induced acute lung injury von Abraham, Edward, Carmody, Aaron, Shenkar, Robert, Arcaroli, John

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Brain tumor like vascular anomaly: Pragmatic management von Biro, Daniel, Warnke, Peter, Shenkar, Robert, Pytel, Peter, Awad, Issam A.

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Transcriptomic signatures of individual cell types in cerebral cavernous malformation von Li, Ying, Girard, Romuald, Srinath, Abhinav, Cruz, Diana Vera, Ciszewski, Cezary, Chen, Chang, Lightle, Rhonda, Romanos, Sharbel, Sone, Je Yeong, Moore, Thomas, DeBiasse, Dorothy, Stadnik, Agnieszka, Lee, Justine J, Shenkar, Robert, Koskimäki, Janne, Lopez-Ramirez, Miguel A, Marchuk, Douglas A, Ginsberg, Mark H, Kahn, Mark L, Shi, Changbin, Awad, Issam A

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Genomics of Human Intracranial Aneurysm Wall von SHI, Changbin, AWAD, Issam A, BENDOK, Bernard R, JAFARI, Nadereh, LIN, Simon, PAN DU, HAGE, Ziad A, SHENKAR, Robert, GETCH, Christopher C, BREDEL, Markus, HUNT BATJER, H

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Micro-computed tomography in murine models of cerebral cavernous malformations as a paradigm for brain disease von Girard, Romuald, Zeineddine, Hussein A., Orsbon, Courtney, Tan, Huan, Moore, Thomas, Hobson, Nick, Shenkar, Robert, Lightle, Rhonda, Shi, Changbin, Fam, Maged D., Cao, Ying, Shen, Le, Neander, April I., Rorrer, Autumn, Gallione, Carol, Tang, Alan T., Kahn, Mark L., Marchuk, Douglas A., Luo, Zhe-Xi, Awad, Issam A.

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Inflammatory Mechanisms in a Neurovascular Disease: Cerebral Cavernous Malformation von Li, Ying, Srinath, Abhinav, Alcazar-Felix, Roberto J, Hage, Stephanie, Bindal, Akash, Lightle, Rhonda, Shenkar, Robert, Shi, Changbin, Girard, Romuald, Awad, Issam A

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Pathobiology of human cerebrovascular malformations: basic mechanisms and clinical relevance von Gault, Judith, Sarin, Hemant, Awadallah, Nabil A, Shenkar, Robert, Awad, Issam A

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Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations von Koskimäki, Janne, Zhang, Dongdong, Li, Yan, Saadat, Laleh, Moore, Thomas, Lightle, Rhonda, Polster, Sean P, Carrión-Penagos, Julián, Lyne, Seán B, Zeineddine, Hussein A, Shi, Changbin, Shenkar, Robert, Romanos, Sharbel, Avner, Kenneth, Srinath, Abhinav, Shen, Le, Detter, Matthew R, Snellings, Daniel, Cao, Ying, Lopez-Ramirez, Miguel A, Fonseca, Gregory, Tang, Alan T, Faber, Pieter, Andrade, Jorge, Ginsberg, Mark, Kahn, Mark L, Marchuk, Douglas A, Girard, Romuald, Awad, Issam A

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Comprehensive transcriptome analysis of cerebral cavernous malformation across multiple species and genotypes von Koskimäki, Janne, Girard, Romuald, Li, Yan, Saadat, Laleh, Zeineddine, Hussein A, Lightle, Rhonda, Moore, Thomas, Lyne, Seán, Avner, Kenneth, Shenkar, Robert, Cao, Ying, Shi, Changbin, Polster, Sean P, Zhang, Dongdong, Carrión-Penagos, Julián, Romanos, Sharbel, Fonseca, Gregory, Lopez-Ramirez, Miguel A, Chapman, Eric M, Popiel, Evelyn, Tang, Alan T, Akers, Amy, Faber, Pieter, Andrade, Jorge, Ginsberg, Mark, Derry, W Brent, Kahn, Mark L, Marchuk, Douglas A, Awad, Issam A

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Involvement of Phosphoinositide 3-Kinases in Neutrophil Activation and the Development of Acute Lung Injury von Yum, Ho-Kee, Arcaroli, John, Kupfner, John, Shenkar, Robert, Penninger, Josef M, Sasaki, Takehiko, Yang, Kuang-Yao, Park, Jong Sung, Abraham, Edward

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Plasma metabolites with mechanistic and clinical links to the neurovascular disease cavernous angioma von Srinath, Abhinav, Xie, Bingqing, Li, Ying, Sone, Je Yeong, Romanos, Sharbel, Chen, Chang, Sharma, Anukriti, Polster, Sean, Dorrestein, Pieter C., Weldon, Kelly C., DeBiasse, Dorothy, Moore, Thomas, Lightle, Rhonda, Koskimäki, Janne, Zhang, Dongdong, Stadnik, Agnieszka, Piedad, Kristina, Hagan, Matthew, Shkoukani, Abdallah, Carrión-Penagos, Julián, Bi, Dehua, Shen, Le, Shenkar, Robert, Ji, Yuan, Sidebottom, Ashley, Pamer, Eric, Gilbert, Jack A., Kahn, Mark L., D’Souza, Mark, Sulakhe, Dinanath, Awad, Issam A., Girard, Romuald

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