Nonproteasomal Targets of the Proteasome Inhibitors Bortezomib and Carfilzomib: a Link to Clinical Adverse Events von ARASTU-KAPUR, Shirin, ANDERL, Janet L, KIRK, Christopher J, KRAUS, Marianne, PARLATI, Francesco, SHENK, Kevin D, LEE, Susan J, MUCHAMUEL, Tony, BENNETT, Mark K, DRIESSEN, Christoph, BALL, Andrew J

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Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome von Parlati, Francesco, Lee, Susan J., Aujay, Monette, Suzuki, Erika, Levitsky, Konstantin, Lorens, James B., Micklem, David R., Ruurs, Paulina, Sylvain, Catherine, Lu, Yan, Shenk, Kevin D., Bennett, Mark K.

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Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma von Kuhn, Deborah J., Chen, Qing, Voorhees, Peter M., Strader, John S., Shenk, Kevin D., Sun, Congcong M., Demo, Susan D., Bennett, Mark K., van Leeuwen, Fijs W.B., Chanan-Khan, Asher A., Orlowski, Robert Z.

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Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome von DEMO, Susan D, KIRK, Christopher J, SHENK, Kevin D, SMYTH, Mark S, SUN, Congcong M, VALLONE, Marcy K, WOO, Tina M, MOLINEAUX, Christopher J, BENNETT, Mark K, AUJAY, Monette A, BUCHHOLZ, Tonia J, DAJEE, Maya, HO, Mark N, JING JIANG, LAIDIG, Guy J, LEWIS, Evan R, PARLATI, Francesco

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Design and Synthesis of an Orally Bioavailable and Selective Peptide Epoxyketone Proteasome Inhibitor (PR-047) von Zhou, Han-Jie, Aujay, Monette A, Bennett, Mark K, Dajee, Maya, Demo, Susan D, Fang, Ying, Ho, Mark N, Jiang, Jing, Kirk, Christopher J, Laidig, Guy J, Lewis, Evan R, Lu, Yan, Muchamuel, Tony, Parlati, Francesco, Ring, Eileen, Shenk, Kevin D, Shields, Jamie, Shwonek, Peter J, Stanton, Timothy, Sun, Congcong M, Sylvain, Catherine, Woo, Tina M, Yang, Jinfu

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CVT-4325: a potent fatty acid oxidation inhibitor with favorable oral bioavailability von Elzein, Elfatih, Ibrahim, Prabha, Koltun, Dmitry O., Rehder, Ken, Shenk, Kevin D., Marquart, Timothy A., Jiang, Bob, Li, Xiaofen, Natero, Reina, Li, Yuan, Nguyen, Marie, Kerwar, Suresh, Chu, Nancy, Soohoo, Daniel, Hao, Jia, Maydanik, Victoria Y., Lustig, David A., Zeng, Dewan, Leung, Kwan, Zablocki, Jeff A.

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New fatty acid oxidation inhibitors with increased potency lacking adverse metabolic and electrophysiological properties von Koltun, Dmitry O., Marquart, Timothy A., Shenk, Kevin D., Elzein, Elfatih, Li, Yuan, Nguyen, Marie, Kerwar, Suresh, Zeng, Dewan, Chu, Nancy, Soohoo, Daniel, Hao, Jia, Maydanik, Victoria Y., Lustig, David A., Ng, Khing-Jow, Fraser, Heather, Zablocki, Jeffery A.

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Structure-affinity relationships of 5'-aromatic ethers and 5'-aromatic sulfides as partial A1 adenosine agonists, potential supraventricular anti-arrhythmic agents von MORRISON, Christopher F, ELZEIN, Elfatih, YUZHI WU, DEWAN ZENG, IRVING FONG, LUSTIG, David, KWAN LEUNG, ZABLOCKI, Jeff A, JIANG, Bob, IBRAHIM, Prabha N, MARQUART, Timothy, PALLE, Venkata, SHENK, Kevin D, VARKHEDKAR, Vaibhav, TENNING MAA, LIN WU

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Non-Proteasomal Targets of Proteasome Inhibitors Bortezomib and Carfilzomib von Arastu-Kapur, Shirin, Shenk, Kevin, Parlati, Francesco, Bennett, Mark K

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Anti-Tumor Activity of Immunoproteasome Selective Inhibitors von Parlati, Francesco, Aujay, Monette, Bedringaas, Siv Lise, Demo, Susan, Gjertsen, Bjorn, Goldstein, Eileen, Jiang, Jing, Kirk, Christopher, Laidig, Guy, Lorens, James, Lu, Yan, Micklem, David, Ruurs, Paulina, Shenk, Kevin, Sylvain, Catherine, Sun, Congcong, Woo, Tina, Zhou, Han-Jie, Bennett, Mark

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The Proteasome Inhibitor PR-171 Inhibits Cell Growth, Induces Apoptosis, and Overcomes De Novo and Acquired Drug Resistance in Human Multiple Myeloma Cells von Ivancsits, Douglas, Nimmanapali, Rama, Sun, Megan, Shenk, Kevin, Demo, Susan D., Bennett, Mark K., Dalton, William S., Alsina, Melissa

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FIBER COMPOSITE STRUCTURE von BERNARDIS, Alessandro, WEI, Shuzhen, SHENK, Kevin, THEODORE, Shakeel, THAKKAR, Rahul, BERGIN, Connor, SWAMINATHAN, Bharath, MODI, Harsh

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FIBER COMPOSITE STRUCTURE von Thakkar, Rahul, Modi, Harsh, Bergin, Connor, Shenk, Kevin, Swaminathan, Bharath, Wei, Shuzhen, Theodore, Shakeel, Bernardis, Alessandro

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Immunoproteasome-Selective Keto-Epoxide Inhibitors: Potential Therapeutic Agents for the Treatment of Hematological Disorders von Parlati, Francesco, Aujay, Monette A., Demo, Susan D., Goldstein, Eileen D., Jiang, Jing, Kirk, Christopher J., Laidig, Guy J., Lu, Yan, Muchamuel, Tony, Shenk, Kevin D., Sylvain, Catherine, Sun, Congcong M., Woo, Tina M., Zhou, Han-Jie, Bennett, Mark K.

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Identification of Peptide Epoxy-Ketone Proteasome Inhibitors with Differential Active Site Selectivity von Demo, Susan D., Aujay, Monette A., Goldstein, Eileen, Laidig, Guy J., Parlati, Francesco, Lu, Yan, Shenk, Kevin D., Sun, Congcong M., Sylvain, Catherine, Woo, Tina M., Zhou, Hanjie, Bennett, Mark K.

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The Novel, Irreversible Proteasome Inhibitor PR-171 Demonstrates Potent Anti-Tumor Activity in Pre-Clinical Models of Multiple Myeloma, and Overcomes Bortezomib Resistance von Kuhn, Deborah J., Chen, Qing, Voorhees, Peter M., Strader, John S., Shenk, Kevin D., Sun, Congcong M., Demo, Susan D., Bennett, Mark K., van Leeuwen, Fred W., Orlowski, Robert Z.

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Potent Activity of a Novel, Irreversible Inhibitor of the Ubiquitin-Proteasome Pathway Against Pre-Clinical Models of Multiple Myeloma von Kuhn, Deborah J., Voorhees, Peter M., Strader, John S., Shenk, Kevin D., Sun, Congcong M., Demo, Susan D., Bennett, Mark K., Orlowski, Robert Z.

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Synthesis of conformationally restricted substance P antagonists von Howard, Harry R., Shenk, Kevin D., Coffman, Karen C., Bryce, Dianne K., Crawford, Rosemary T., McLean, Stafford A.

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Pharmacokinetics, Pharmacodynamics and Anti-Tumor Efficacy of PR-171, a Novel Inhibitor of the 20S Proteasome von Kirk, Christopher J., Bennett, Mark K., Buchholz, Tonia J., Demo, Susan D., Ho, Mark N., Jiang, Jing, Laidig, Guy J., Lewis, Evan R., Shenk, Kevin D., Smyth, Mark S., Sun, Congcong M., Vallone, Marcy K., Woo, Tina M., Molineaux, Christopher J.

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Biochemical and Cellular Characterization of the Novel Proteasome Inhibitor PR-171 von Demo, Susan D., Buchholz, Tonia J., Laidig, Guy J., Parlati, Francesco, Shenk, Kevin D., Smyth, Mark S., Sullivan, Carol M., Sun, Congcong M., Vallone, Marcy K., Woo, Tina, Bennett, Mark K.

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