Targeting the lysosome in cancer von Piao, Shengfu, Amaravadi, Ravi K.

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Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency von McAfee, Quentin, Zhang, Zhihui, Samanta, Arabinda, Levi, Samuel M, Ma, Xiao-Hong, Piao, Shengfu, Lynch, John P, Uehara, Takeshi, Sepulveda, Antonia R, Davis, Lisa E, Winkler, Jeffrey D, Amaravadi, Ravi K

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Measurements of Tumor Cell Autophagy Predict Invasiveness, Resistance to Chemotherapy, and Survival in Melanoma von MA, Xiao-Hong, SHENGFU PIAO, DAN WANG, MCAFEE, Quentin W, NATHANSON, Katherine L, LUM, Julian J, LI, Lin Z, AMARAVADI, Ravi K

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PPT1 inhibition enhances the antitumor activity of anti-PD-1 antibody in melanoma von Sharma, Gaurav, Ojha, Rani, Noguera-Ortega, Estela, Rebecca, Vito W, Attanasio, John, Liu, Shujing, Piao, Shengfu, Lee, Jennifer J, Nicastri, Michael C, Harper, Sandra L, Ronghe, Amruta, Jain, Vaibhav, Winkler, Jeffrey D, Speicher, David W, Mastio, Jerome, Gimotty, Phyllis A, Xu, Xiaowei, Wherry, E John, Gabrilovich, Dmitry I, Amaravadi, Ravi K

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Ascorbate Attenuates Atrial Pacing-Induced Peroxynitrite Formation and Electrical Remodeling and Decreases the Incidence of Postoperative Atrial Fibrillation von Carnes, Cynthia A, Chung, Mina K, Nakayama, Tomohiro, Nakayama, Hitomi, Baliga, Reshma S, Piao, Shengfu, Kanderian, Anne, Pavia, Steven, Hamlin, Robert L, McCarthy, Patrick M, Bauer, John A, Van Wagoner, David R

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PPT1 inhibition enhances the antitumor activity of anti-PD-1 antibody in melanoma von Sharma, Gaurav, Ojha, Rani, Noguera-Ortega, Estela, Rebecca, Vito W, Attanasio, John, Liu, Shujing, Piao, Shengfu, Lee, Jennifer J, Nicastri, Michael C, Harper, Sandra L, Ronghe, Amruta, Jain, Vaibhav, Winkler, Jeffrey D, Speicher, David W, Mastio, Jerome, Gimotty, Phyllis A, Xu, Xiaowei, Wherry, E John, Gabrilovich, Dmitry I, Amaravadi, Ravi K

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Molecular evolution in the Drosophila melanogaster species subgroup: frequent parameter fluctuations on the timescale of molecular divergence von Akashi, Hiroshi, Ko, Wen-Ya, Piao, Shengfu, John, Anoop, Goel, Piyush, Lin, Chiao-Feng, Vitins, Alexa P

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PPT1 Promotes Tumor Growth and Is the Molecular Target of Chloroquine Derivatives in Cancer von Rebecca, Vito W, Nicastri, Michael C, Fennelly, Colin, Chude, Cynthia I, Barber-Rotenberg, Julie S, Ronghe, Amruta, McAfee, Quentin, McLaughlin, Noel P, Zhang, Gao, Goldman, Aaron R, Ojha, Rani, Piao, Shengfu, Noguera-Ortega, Estela, Martorella, Alessandra, Alicea, Gretchen M, Lee, Jennifer J, Schuchter, Lynn M, Xu, Xiaowei, Herlyn, Meenhard, Marmorstein, Ronen, Gimotty, Phyllis A, Speicher, David W, Winkler, Jeffrey D, Amaravadi, Ravi K

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Combined autophagy and proteasome inhibition: A phase 1 trial of hydroxychloroquine and bortezomib in patients with relapsed/refractory myeloma von Vogl, Dan T, Stadtmauer, Edward A, Tan, Kay-See, Heitjan, Daniel F, Davis, Lisa E, Pontiggia, Laura, Rangwala, Reshma, Piao, Shengfu, Chang, Yunyoung C, Scott, Emma C, Paul, Thomas M, Nichols, Charles W, Porter, David L, Kaplan, Janeen, Mallon, Gayle, Bradner, James E, Amaravadi, Ravi K

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A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme von Rosenfeld, Myrna R, Ye, Xiaobu, Supko, Jeffrey G, Desideri, Serena, Grossman, Stuart A, Brem, Steven, Mikkelson, Tom, Wang, Daniel, Chang, Yunyoung C, Hu, Janice, McAfee, Quentin, Fisher, Joy, Troxel, Andrea B, Piao, Shengfu, Heitjan, Daniel F, Tan, Kay-See, Pontiggia, Laura, O'Dwyer, Peter J, Davis, Lisa E, Amaravadi, Ravi K

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Phase I trial of hydroxychloroquine with dose-intense temozolomide in patients with advanced solid tumors and melanoma von Rangwala, Reshma, Leone, Robert, Chang, Yunyoung C, Fecher, Leslie A, Schuchter, Lynn M, Kramer, Amy, Tan, Kay-See, Heitjan, Daniel F, Rodgers, Glenda, Gallagher, Maryann, Piao, Shengfu, Troxel, Andrea B, Evans, Tracey L, DeMichele, Angela M, Nathanson, Katherine L, O'Dwyer, Peter J, Kaiser, Jonathon, Pontiggia, Laura, Davis, Lisa E, Amaravadi, Ravi K

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A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles von Rebecca, Vito W, Nicastri, Michael C, McLaughlin, Noel, Fennelly, Colin, McAfee, Quentin, Ronghe, Amruta, Nofal, Michel, Lim, Chun-Yan, Witze, Eric, Chude, Cynthia I, Zhang, Gao, Alicea, Gretchen M, Piao, Shengfu, Murugan, Sengottuvelan, Ojha, Rani, Levi, Samuel M, Wei, Zhi, Barber-Rotenberg, Julie S, Murphy, Maureen E, Mills, Gordon B, Lu, Yiling, Rabinowitz, Joshua, Marmorstein, Ronen, Liu, Qin, Liu, Shujing, Xu, Xiaowei, Herlyn, Meenhard, Zoncu, Roberto, Brady, Donita C, Speicher, David W, Winkler, Jeffrey D, Amaravadi, Ravi K

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Identification of secreted proteins that reflect autophagy dynamics within tumor cells von Kraya, Adam A., Piao, Shengfu, Xu, Xiaowei, Zhang, Gao, Herlyn, Meenhard, Gimotty, Phyllis, Levine, Beth, Amaravadi, Ravi K, Speicher, David W

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ER Translocation of the MAPK Pathway Drives Therapy Resistance in BRAF-Mutant Melanoma von Ojha, Rani, Leli, Nektaria M, Onorati, Angelique, Piao, Shengfu, Verginadis, Ioannis I, Tameire, Feven, Rebecca, Vito W, Chude, Cynthia I, Murugan, Sengottuvelan, Fennelly, Colin, Noguera-Ortega, Estela, Chu, Charleen T, Liu, Shujing, Xu, Xiaowei, Krepler, Clemens, Xiao, Min, Xu, Wei, Wei, Zhi, Frederick, Dennie T, Boland, Genevieve, Mitchell, Tara C, Karakousis, Giorgos C, Schuchter, Lynn M, Flaherty, Keith T, Zhang, Gao, Herlyn, Meenhard, Koumenis, Constantinos, Amaravadi, Ravi K

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ALDH1A1 and HLTF modulate the activity of lysosomal autophagy inhibitors in cancer cells von Piao, Shengfu, Ojha, Rani, Rebecca, Vito W., Samanta, Arabinda, Ma, Xiao-hong, Mcafee, Quentin, Nicastri, Michael C., Buckley, Meghan, Brown, Eric, Winkler, Jeffrey D., Gimotty, Phyllis A., Amaravadi, Ravi K.

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Abstract 310: Identification of secreted proteins that reflect intracellular autophagy dynamics in melanoma von Akl, Adam, Xu, Xiaowei, Piao, Shengfu, Amaravadi, Ravi K., Speicher, David W.

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Abstract 1024: Expression pattern of ALDH1A1 and HLTF predicts sensitivity to lysosomal autophagy inhibitors in cancer cells von Piao, Shengfu, Samanta, Arabinda, Ma, Xiaohong, Mcafee, Quentin W., Rebecca, Vito W., Buckley, Meghan, Brown, Eric J., Gimotty, Phyllis A., Amaravadi, Ravi K.

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Abstract 1018: Structural features of novel dimeric quinacrines that have single-agent antitumor activity determine the mechanism of action: destabilization of mTORC1lysosomal inte... von Rebecca, Vito W, Nicastri, Michael, McGlaughlin, Noel, McAfee, Quentin, Zhang, Gao, Alicea, Gretchen M, Piao, Shengfu, Fennelly, Colin, Murugan, Sengottuvelan, Wei, Zhi, Mills, Gordon B, Lu, Yiling, Herlyn, Meenhard, Winkler, Jeffrey D, Amaravadi, Ravi K

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Abstract 1018: Structural features of novel dimeric quinacrines that have single-agent antitumor activity determine the mechanism of action: destabilization of mTORC1/lysosomal int... von Rebecca, Vito W., Nicastri, Michael, McGlaughlin, Noel, McAfee, Quentin, Zhang, Gao, Alicea, Gretchen M., Piao, Shengfu, Fennelly, Colin, Murugan, Sengottuvelan, Wei, Zhi, Mills, Gordon B., Lu, Yiling, Herlyn, Meenhard, Winkler, Jeffrey D., Amaravadi, Ravi K.

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Preparation, Structure Characterization and Hydrodesulfurization Performance of B-Ni2P/SBA-15/Cordierite Monolithic Catalysts von Wu, Pingyi, Li, Qingyuan, Lan, Ling, Liu, Hongfei, Ju, Yana, Piao, Jiarui, Ji, Shengfu

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