Learning versus confirming in clinical drug development von Sheiner, Lewis B.

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Pharmacokinetic/pharmacodynamic modeling in drug development von Sheiner, L B, Steimer, J L

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Evaluating pharmacokinetic/pharmacodynamic models using the posterior predictive check von Yano, Y, Beal, S L, Sheiner, L B

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Population pharmacokinetics/pharmacodynamics of docetaxel in phase II studies in patients with cancer von BRUNO, R, HILLE, D, RIGAS, J. R, SEIDMAN, A. D, CHEVALLIER, B, FUMOLEAU, P, BURRIS, H. A, RAVDIN, P. M, SHEINER, L. B, RIVA, A, VIVIER, N, TEN BOKKEL HUINNINK, W. W, VAN OOSTEROM, A. T, KAYE, S. B, VERWEIJ, J, FOSSELLA, F. V, VALERO, V

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Quantitative characterization of therapeutic index: Application of mixed‐effects modeling to evaluate oxybutynin dose–efficacy and dose–side effect relationships von Gupta, Suneel K., Sathyan, Gayatri, Lindemulder, Elizabeth A., Ho, Pai‐Ling, Sheiner, Lewis B., Aarons, Leon

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Characterizing patterns of drug-taking behavior with a multiple drug regimen in an AIDS clinical trial von KASTRISSIOS, H, SUAREZ, J.-R, KATZENSTEIN, D, GIRARD, P, SHEINER, L. B, BLASCHKE, T. F

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Population Pharmacokinetics of Nevirapine, Zidovudine, and Didanosine in Human Immunodeficiency Virus-Infected Patients von ZHOU, X.-J, SHEINER, L. B, D'AQUILA, R. T, HUGHES, M. D, HIRSCH, M. S, FISCHL, M. A, JOHNSON, V. A, MYERS, M, SOMMADOSSI, J.-P

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A Markov mixed effect regression model for drug compliance von Girard, Pascal, Blaschke, Terrence F., Kastrissios, Helen, Sheiner, Lewis B.

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A Population Pharmacokinetic-Pharmacodynamic Analysis of Repeated Measures Time-to-Event Pharmacodynamic Responses: The Antiemetic Effect of Ondansetron von Cox, Eugène H, Veyrat-follet, Christine, Beal, Stuart L, Fuseau, Eliane, Kenkare, Saraswati, Sheiner, Lewis B

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Population Pharmacokinetics and Pharmacodynamics of Efavirenz, Nelfinavir, and Indinavir: Adult AIDS Clinical Trial Group Study 398 von PFISTER, Marc, LABBE, Line, HAMMER, Scott M, MELLORS, John, BENNETT, Kara K, ROSENKRANZ, Susan, SHEINER, Lewis B

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The need for mixed-effects modeling with population dichotomous data von Yano, I, Beal, S L, Sheiner, L B

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Exposure-response relationships for saquinavir, zidovudine, and zalcitabine in combination therapy von VANHOVE, G. F, GRIES, J.-M, VEROTTA, D, SHEINER, L. B, COOMBS, R, COLLIER, A. C, BLASCHKE, T. F

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A simulation study comparing designs for dose ranging von Sheiner, Lewis B., Hashimoto, Yukiya, Beal, Stuart L.

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Pharmacokinetics of saquinavir, zidovudine, and zalcitabine in combination therapy von VANHOVE, G. F, KASTRISSIOS, H, GRIES, J.-M, VEROTTA, D, PARK, K, COLLIER, A. C, SQUIRES, K, SHEINER, L. B, BLASCHKE, T. F

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Comparison of twitch depression of the adductor pollicis and the respiratory muscles : pharmacodynamic modeling without plasma concentrations von BRAGG, P, FISHER, D. M, JUN SHI, DONATI, F, MEISTELMAN, C, LAU, M, SHEINER, L. B

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Selecting reliable pharmacokinetic data for explanatory analyses of clinical trials in the presence of possible noncompliance von Lu, J, Gries, J M, Verotta, D, Sheiner, L B

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Modeling a bivariate control system: LH and testosterone response to the GnRH antagonist antide von Fattinger, K. E, Verotta, D, Porchet, H. C, Munafo, A, Le Cotonnec, J. Y, Sheiner, L. B

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Population pharmacokinetics/dynamics von Sheiner, L B, Ludden, T M

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Semiparametric approach to pharmacokinetic-pharmacodynamic data von Verotta, D, Beal, S. L, Sheiner, L. B

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Use of a Pharmacokinetic/Pharmacodynamic Model to Design an Optimal Dose Input Profile von Park, Kyungsoo, Verotta, Davide, Gupta, Suneel K, Sheiner, Lewis B

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