Ocular Inflammatory Response to Intravitreal Injection of Adeno-Associated Virus Vector: Relative Contribution of Genome and Capsid von Timmers, Adrian M, Newmark, Judith A, Turunen, Heikki T, Farivar, Tanaz, Liu, Jilin, Song, Chunjuan, Ye, Guo-Jie, Pennock, Steven, Gaskin, Chantelle, Knop, David R, Shearman, Mark S

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Pathway-based analysis of genome-wide siRNA screens reveals the regulatory landscape of APP processing von Camargo, Luiz Miguel, Zhang, Xiaohua Douglas, Loerch, Patrick, Caceres, Ramon Miguel, Marine, Shane D, Uva, Paolo, Ferrer, Marc, de Rinaldis, Emanuele, Stone, David J, Majercak, John, Ray, William J, Yi-An, Chen, Shearman, Mark S, Mizuguchi, Kenji

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A highly efficient transgene knock-in technology in clinically relevant cell types von Allen, Alexander G., Khan, Samia Q., Margulies, Carrie M., Viswanathan, Ramya, Lele, Swarali, Blaha, Laura, Scott, Sean N., Izzo, Kaitlyn M., Gerew, Alexandra, Pattali, Rithu, Cochran, Nadire R., Holland, Carl S., Zhao, Amy H., Sherman, Stephen E., Jaskolka, Michael C., Wu, Meng, Wilson, Aaron C., Sun, Xiaoqi, Ciulla, Dawn M., Zhang, Deric, Nelson, Jacqueline D., Zhang, Peisheng, Mazzucato, Patrizia, Huang, Yan, Giannoukos, Georgia, Marco, Eugenio, Nehil, Michael, Follit, John A., Chang, Kai-Hsin, Shearman, Mark S., Wilson, Christopher J., Zuris, John A.

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The Impact of Inherited Retinal Diseases in the United States of America (US) and Canada from a Cost-of-Illness Perspective von Gong, Jennifer, Cheung, Simone, Fasso-Opie, Alivia, Galvin, Orla, Moniz, Larissa S, Earle, Doug, Durham, Todd, Menzo, Jason, Li, Nan, Duffy, Stephanie, Dolgin, Jill, Shearman, Mark S, Fiorani, Chiara, Banhazi, Judit, Daly, Avril

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Increased O-GlcNAcylation reduces pathological tau without affecting its normal phosphorylation in a mouse model of tauopathy von Graham, Danielle L., Gray, Audrey J., Joyce, John A., Yu, Dongzi, O'Moore, Jill, Carlson, George A., Shearman, Mark S., Dellovade, Tammy L., Hering, Heike

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Optimization of Retinal Gene Therapy for X-Linked Retinitis Pigmentosa Due to RPGR Mutations von Beltran, William A., Cideciyan, Artur V., Boye, Shannon E., Ye, Guo-Jie, Iwabe, Simone, Dufour, Valerie L., Marinho, Luis Felipe, Swider, Malgorzata, Kosyk, Mychajlo S., Sha, Jin, Boye, Sanford L., Peterson, James J., Witherspoon, C. Douglas, Alexander, John J., Ying, Gui-Shuang, Shearman, Mark S., Chulay, Jeffrey D., Hauswirth, William W., Gamlin, Paul D., Jacobson, Samuel G., Aguirre, Gustavo D.

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Dose Range Finding Studies with Two RPGR Transgenes in a Canine Model of X-Linked Retinitis Pigmentosa Treated with Subretinal Gene Therapy von Song, Chunjuan, Dufour, Valérie L, Cideciyan, Artur V, Ye, Guo-Jie, Swider, Malgorzata, Newmark, Judith A, Timmers, Adrian M, Robinson, Paulette M, Knop, David R, Chulay, Jeffrey D, Jacobson, Samuel G, Aguirre, Gustavo D, Beltran, William A, Shearman, Mark S

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Toxicity and Efficacy Evaluation of an Adeno-Associated Virus Vector Expressing Codon-Optimized RPGR Delivered by Subretinal Injection in a Canine Model of X-linked Retinitis Pigme... von Dufour, Valérie L, Cideciyan, Artur V, Ye, Guo-Jie, Song, Chunjuan, Timmers, Adrian, Habecker, Perry L, Pan, Wei, Weinstein, Nicole M, Swider, Malgorzata, Durham, Amy C, Ying, Gui-Shuang, Robinson, Paulette M, Jacobson, Samuel G, Knop, David R, Chulay, Jeffrey D, Shearman, Mark S, Aguirre, Gustavo D, Beltran, William A

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Fenton chemistry and oxidative stress mediate the toxicity of the β-amyloid peptide in a Drosophila model of Alzheimer's disease von Rival, Thomas, Page, Richard M., Chandraratna, Dhianjali S., Sendall, Timothy J., Ryder, Edward, Liu, Beinan, Lewis, Huw, Rosahl, Thomas, Hider, Robert, Camargo, L. M., Shearman, Mark S., Crowther, Damian C., Lomas, David A.

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Correction: Pathway-Based Analysis of Genome-Wide siRNA Screens Reveals the Regulatory Landscape of App Processing von Camargo, Luiz Miguel, Zhang, Xiaohua Douglas, Loerch, Patrick, Caceres, Ramon Miguel, Marine, Shane D, Uva, Paolo, Ferrer, Marc, de Rinaldis, Emanuele, Stone, David J, Majercak, John, Ray, William J, Yi-An, Chen, Shearman, Mark S, Mizuguchi, Kenji

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Glu-333 of Nicastrin Directly Participates in γ-Secretase Activity von Dries, Daniel R., Shah, Sanjiv, Han, Yu-Hong, Yu, Cong, Yu, Sophie, Shearman, Mark S., Yu, Gang

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Presenilin-Dependent γ-Secretase Activity Modulates Thymocyte Development von Doerfler, Petra, Shearman, Mark S., Perlmutter, Roger M.

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Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1 von Gardell, Stephen J, Li, Yue-Ming, Xu, Min, Lai, Ming-Tain, Huang, Qian, Castro, José L, DiMuzio-Mower, Jillian, Harrison, Timothy, Lellis, Colin, Nadin, Alan, Neduvelil, Joseph G, Register, R. Bruce, Sardana, Mohinder K, Shearman, Mark S, Smith, Adrian L, Shi, Xiao-Ping, Yin, Kuo-Chang, Shafer, Jules A

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Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism von Beher, Dirk, Clarke, Earl E, Wrigley, Jonathan D J, Martin, Agnes C L, Nadin, Alan, Churcher, Ian, Shearman, Mark S

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L-685,458, an Aspartyl Protease Transition State Mimic, Is a Potent Inhibitor of Amyloid β-Protein Precursor γ-Secretase Activity von Shearman, Mark S, Beher, Dirk, Clarke, Earl E, Lewis, Huw D, Harrison, Tim, Hunt, Peter, Nadin, Alan, Smith, Adrian L, Stevenson, Graeme, Castro, José L

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C‐terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation von Wang, Jun, Beher, Dirk, Nyborg, Andrew C., Shearman, Mark S., Golde, Todd E., Goate, Alison

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Generation and characterization of a rabbit monoclonal antibody site-specific for tau O-GlcNAcylated at serine 400 von Cameron, Andrew, Giacomozzi, Brandy, Joyce, John, Gray, Audrey, Graham, Danielle, Ousson, Solenne, Neny, Maud, Beher, Dirk, Carlson, George, O’Moore, Jill, Shearman, Mark, Hering, Heike

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Oral treatment with a gamma-secretase inhibitor improves long-term potentiation in a mouse model of Alzheimer's disease von Townsend, Matthew, Qu, Yujie, Gray, Audrey, Wu, Zhenhua, Seto, Tiffany, Hutton, Mike, Shearman, Mark S, Middleton, Richard E

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Acute gamma-secretase inhibition of nonhuman primate CNS shifts amyloid precursor protein (APP) metabolism from amyloid-beta production to alternative APP fragments without amyloid... von Cook, Jacquelynn J, Wildsmith, Kristin R, Gilberto, David B, Holahan, Marie A, Kinney, Gene G, Mathers, Parker D, Michener, Maria S, Price, Eric A, Shearman, Mark S, Simon, Adam J, Wang, Jennifer X, Wu, Guoxin, Yarasheski, Kevin E, Bateman, Randall J

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Safety and Efficacy Evaluation of rAAV2tYF-PR1.7-hCNGA3 Vector Delivered by Subretinal Injection in CNGA3 Mutant Achromatopsia Sheep von Gootwine, Elisha, Ofri, Ron, Banin, Eyal, Obolensky, Alexey, Averbukh, Edward, Ezra-Elia, Raaya, Ross, Maya, Honig, Hen, Rosov, Alexander, Yamin, Esther, Ye, Guo-Jie, Knop, David R, Robinson, Paulette M, Chulay, Jeffrey D, Shearman, Mark S

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