A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death von Scott, Duncan E., Francis-Newton, Nicola J., Marsh, May E., Coyne, Anthony G., Fischer, Gerhard, Moschetti, Tommaso, Bayly, Andrew R., Sharpe, Timothy D., Haas, Kalina T., Barber, Lorraine, Valenzano, Chiara R., Srinivasan, Rajavel, Huggins, David J., Lee, Miyoung, Emery, Amy, Hardwick, Bryn, Ehebauer, Matthias, Dagostin, Claudio, Esposito, Alessandro, Pellegrini, Luca, Perrior, Trevor, McKenzie, Grahame, Blundell, Tom L., Hyvönen, Marko, Skidmore, John, Venkitaraman, Ashok R., Abell, Chris

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Sensitive, High Throughput Detection of Proteins in Individual, Surfactant-Stabilized Picoliter Droplets Using Nanoelectrospray Ionization Mass Spectrometry von Smith, Clive A, Li, Xin, Mize, Todd H, Sharpe, Timothy D, Graziani, Edmund I, Abell, Chris, Huck, Wilhelm T. S

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General Structural Motifs of Amyloid Protofilaments von Ferguson, Neil, Becker, Johanna, Tidow, Henning, Tremmel, Sandra, Sharpe, Timothy D., Krause, Gerd, Flinders, Jeremy, Petrovich, Miriana, Berriman, John, Oschkinat, Hartmut, Fersht, Alan R.

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Distinguishing between Cooperative and Unimodal Downhill Protein Folding von Huang, Fang, Sato, Satoshi, Sharpe, Timothy D., Ying, Liming, Fersht, Alan R.

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Structural Basis for Par-4 Recognition by the SPRY Domain- and SOCS Box-Containing Proteins SPSB1, SPSB2, and SPSB4 von Filippakopoulos, Panagis, Low, Andrew, Sharpe, Timothy D., Uppenberg, Jonas, Yao, Shenggen, Kuang, Zhihe, Savitsky, Pavel, Lewis, Rowena S., Nicholson, Sandra E., Norton, Raymond S., Bullock, Alex N.

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CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function von Canning, Peter, Park, Kwangjin, Gonçalves, João, Li, Chunmei, Howard, Conor J., Sharpe, Timothy D., Holt, Liam J., Pelletier, Laurence, Bullock, Alex N., Leroux, Michel R.

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Ultra-fast Barrier-limited Folding in the Peripheral Subunit-binding Domain Family von Ferguson, Neil, Sharpe, Timothy D., Schartau, Pamela J., Sato, Satoshi, Allen, Mark D., Johnson, Christopher M., Rutherford, Trevor J., Fersht, Alan R.

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p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)–fold structure von Adams, Cassandra J, Pike, Ashley C. W, Maniam, Sandra, Sharpe, Timothy D, Coutts, Amanda S, Knapp, Stefan, La Thangue, Nicholas B, Bullock, Alex N

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The Folding Mechanism of BBL: Plasticity of Transition-State Structure Observed within an Ultrafast Folding Protein Family von Neuweiler, Hannes, Sharpe, Timothy D., Rutherford, Trevor J., Johnson, Christopher M., Allen, Mark D., Ferguson, Neil, Fersht, Alan R.

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Downhill versus Barrier-Limited Folding of BBL 2: Mechanistic Insights from Kinetics of Folding Monitored by Independent Tryptophan Probes von Neuweiler, Hannes, Sharpe, Timothy D., Johnson, Christopher M., Teufel, Daniel P., Ferguson, Neil, Fersht, Alan R.

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Structure and inhibitor specificity of the PCTAIRE-family kinase CDK16 von Dixon-Clarke, Sarah E, Shehata, Saifeldin N, Krojer, Tobias, Sharpe, Timothy D, von Delft, Frank, Sakamoto, Kei, Bullock, Alex N

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Rapid Amyloid Fiber Formation from the Fast-Folding WW Domain FBP28 von Ferguson, Neil, Berriman, John, Petrovich, Miriana, Sharpe, Timothy D., Finch, John T., Fersht, Alan R.

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Carboxyl pK(a) values and acid denaturation of BBL von Arbely, Eyal, Rutherford, Trevor J, Neuweiler, Hannes, Sharpe, Timothy D, Ferguson, Neil, Fersht, Alan R

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Downhill versus Barrier-Limited Folding of BBL 1: Energetic and Structural Perturbation Effects upon Protonation of a Histidine of Unusually Low pKa von Arbely, Eyal, Rutherford, Trevor J., Sharpe, Timothy D., Ferguson, Neil, Fersht, Alan R.

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Structural Biology Analysis of 'downhill' protein folding von Schartau, Pamela J, Fersht, Alan R, Sharpe, Timothy D, Johnson, Christopher M, Ferguson, Neil

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Conservation of Transition State Structure in Fast Folding Peripheral Subunit-Binding Domains von Sharpe, Timothy D., Ferguson, Neil, Johnson, Christopher M., Fersht, Alan R.

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One-state Downhill versus Conventional Protein Folding von Ferguson, Neil, Schartau, Pamela J., Sharpe, Timothy D., Sato, Satoshi, Fersht, Alan R.

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The human peripheral subunit‐binding domain folds rapidly while overcoming repulsive Coulomb forces von Arbely, Eyal, Neuweiler, Hannes, Sharpe, Timothy D., Johnson, Christopher M., Fersht, Alan R.

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The Transition State for Folding of a Peripheral Subunit-binding Domain Contains Robust and Ionic-strength Dependent Characteristics von Ferguson, Neil, Sharpe, Timothy D., Johnson, Christopher M., Fersht, Alan R.

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Carboxyl pKa Values and Acid Denaturation of BBL von Arbely, Eyal, Rutherford, Trevor J., Neuweiler, Hannes, Sharpe, Timothy D., Ferguson, Neil, Fersht, Alan R.

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