RADX Promotes Genome Stability and Modulates Chemosensitivity by Regulating RAD51 at Replication Forks von Dungrawala, Huzefa, Bhat, Kamakoti P., Le Meur, Rémy, Chazin, Walter J., Ding, Xia, Sharan, Shyam K., Wessel, Sarah R., Sathe, Aditya A., Zhao, Runxiang, Cortez, David

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Replication fork stability confers chemoresistance in BRCA-deficient cells von Ray Chaudhuri, Arnab, Callen, Elsa, Ding, Xia, Gogola, Ewa, Duarte, Alexandra A., Lee, Ji-Eun, Wong, Nancy, Lafarga, Vanessa, Calvo, Jennifer A., Panzarino, Nicholas J., John, Sam, Day, Amanda, Crespo, Anna Vidal, Shen, Binghui, Starnes, Linda M., Ruiter, Julian R. de, Daniel, Jeremy A., Konstantinopoulos, Panagiotis A., Cortez, David, Cantor, Sharon B., Fernandez-Capetillo, Oscar, Ge, Kai, Jonkers, Jos, Rottenberg, Sven, Sharan, Shyam K., Nussenzweig, André

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Recombineering: a homologous recombination-based method of genetic engineering von Sharan, Shyam K, Thomason, Lynn C, Kuznetsov, Sergey G, Court, Donald L

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Genetically engineered mouse models for hereditary cancer syndromes von Biswas, Kajal, Mohammed, Altaf, Sharan, Shyam K., Shoemaker, Robert H.

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Translating Embryogenesis to Generate Organoids: Novel Approaches to Personalized Medicine von Sahu, Sounak, Sharan, Shyam K.

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Intragenic DNA methylation and BORIS-mediated cancer-specific splicing contribute to the Warburg effect von Singh, Smriti, Narayanan, Sathiya Pandi, Biswas, Kajal, Gupta, Amit, Ahuja, Neha, Yadav, Sandhya, Panday, Rajendra Kumar, Samaiya, Atul, Sharan, Shyam K., Shukla, Sanjeev

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RAD52 S346X variant reduces breast cancer risk in BRCA2 mutation carriers von Biswas, Kajal, Sharan, Shyam K.

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Identification PMS1 and PMS2 as potential meiotic substrates of CDK2 activity von Palmer, Nathan, Talib, S Zakiah A, Goh, Christine M F, Biswas, Kajal, Sharan, Shyam K, Kaldis, Philipp

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Saturation genome editing of 11 codons and exon 13 of BRCA2 coupled with chemotherapeutic drug response accurately determines pathogenicity of variants von Sahu, Sounak, Sullivan, Teresa L, Mitrophanov, Alexander Y, Galloux, Mélissa, Nousome, Darryl, Southon, Eileen, Caylor, Dylan, Mishra, Arun Prakash, Evans, Christine N, Clapp, Michelle E, Burkett, Sandra, Malys, Tyler, Chari, Raj, Biswas, Kajal, Sharan, Shyam K

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WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells von Datta, Arindam, Biswas, Kajal, Sommers, Joshua A., Thompson, Haley, Awate, Sanket, Nicolae, Claudia M., Thakar, Tanay, Moldovan, George-Lucian, Shoemaker, Robert H., Sharan, Shyam K., Brosh, Robert M.

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Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies von Ding, Xia, Chaudhuri, Arnab Ray, Callen, Elsa, Pang, Yan, Biswas, Kajal, Klarmann, Kimberly D., Martin, Betty K., Burkett, Sandra, Cleveland, Linda, Stauffer, Stacey, Sullivan, Teresa, Dewan, Aashish, Marks, Hanna, Tubbs, Anthony T., Wong, Nancy, Buehler, Eugen, Akagi, Keiko, Martin, Scott E., Keller, Jonathan R., Nussenzweig, André, Sharan, Shyam K.

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Interferon restores replication fork stability and cell viability in BRCA-defective cells via ISG15 von Moro, Ramona N., Biswas, Uddipta, Kharat, Suhas S., Duzanic, Filip D., Das, Prosun, Stavrou, Maria, Raso, Maria C., Freire, Raimundo, Chaudhuri, Arnab Ray, Sharan, Shyam K., Penengo, Lorenza

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Bypass of premature stop codons and generation of functional BRCA2 by exon skipping von Stauffer, Stacey, Biswas, Kajal, Sharan, Shyam K

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The epigenetic regulator LSH maintains fork protection and genomic stability via MacroH2A deposition and RAD51 filament formation von Xu, Xiaoping, Ni, Kai, He, Yafeng, Ren, Jianke, Sun, Chongkui, Liu, Yie, Aladjem, Mirit I., Burkett, Sandra, Finney, Richard, Ding, Xia, Sharan, Shyam K., Muegge, Kathrin

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Interaction with PALB2 Is Essential for Maintenance of Genomic Integrity by BRCA2 von Hartford, Suzanne A, Chittela, Rajanikant, Ding, Xia, Vyas, Aradhana, Martin, Betty, Burkett, Sandra, Haines, Diana C, Southon, Eileen, Tessarollo, Lino, Sharan, Shyam K

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Growth factor dependency in mammary organoids regulates ductal morphogenesis during organ regeneration von Sahu, Sounak, Albaugh, Mary E., Martin, Betty K., Patel, Nimit L., Riffle, Lisa, Mackem, Susan, Kalen, Joseph D., Sharan, Shyam K.

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BRE/BRCC45 regulates CDC25A stability by recruiting USP7 in response to DNA damage von Biswas, Kajal, Philip, Subha, Yadav, Aditya, Martin, Betty K., Burkett, Sandra, Singh, Vaibhav, Babbar, Anav, North, Susan Lynn, Chang, Suhwan, Sharan, Shyam K.

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BRCA2-DSS1 interaction is dispensable for RAD51 recruitment at replication-induced and meiotic DNA double strand breaks von Mishra, Arun Prakash, Hartford, Suzanne A., Sahu, Sounak, Klarmann, Kimberly, Chittela, Rajani Kant, Biswas, Kajal, Jeon, Albert B., Martin, Betty K., Burkett, Sandra, Southon, Eileen, Reid, Susan, Albaugh, Mary E., Karim, Baktiar, Tessarollo, Lino, Keller, Jonathan R., Sharan, Shyam K.

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handcuff model for the cohesin complex von Zhang, Nenggang, Kuznetsov, Sergey G, Sharan, Shyam K, Li, Kaiyi, Rao, Pulivarthi H, Pati, Debananda

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Characterization of BRCA2 R3052Q variant in mice supports its functional impact as a low-risk variant von Mishra, Arun Prakash, Hartford, Suzanne, Chittela, Rajani Kant, Sahu, Sounak, Kharat, Suhas S., Alvaro-Aranda, Lucia, Contreras-Perez, Aida, Sullivan, Teresa, Martin, Betty K., Albaugh, Mary, Southon, Eileen, Burkett, Sandra, Karim, Baktiar, Carreira, Aura, Tessarollo, Lino, Sharan, Shyam K.

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