PARP Inhibition Elicits STING-Dependent Antitumor Immunity in Brca1-Deficient Ovarian Cancer von Ding, Liya, Kim, Hye-Jung, Wang, Qiwei, Kearns, Michael, Jiang, Tao, Ohlson, Carolynn E., Li, Ben B., Xie, Shaozhen, Liu, Joyce F., Stover, Elizabeth H., Howitt, Brooke E., Bronson, Roderick T., Lazo, Suzan, Roberts, Thomas M., Freeman, Gordon J., Konstantinopoulos, Panagiotis A., Matulonis, Ursula A., Zhao, Jean J.

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STING agonism reprograms tumor-associated macrophages and overcomes resistance to PARP inhibition in BRCA1-deficient models of breast cancer von Wang, Qiwei, Bergholz, Johann S., Ding, Liya, Lin, Ziying, Kabraji, Sheheryar K., Hughes, Melissa E., He, Xiadi, Xie, Shaozhen, Jiang, Tao, Wang, Weihua, Zoeller, Jason J., Kim, Hye-Jung, Roberts, Thomas M., Konstantinopoulos, Panagiotis A., Matulonis, Ursula A., Dillon, Deborah A., Winer, Eric P., Lin, Nancy U., Zhao, Jean J.

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Drug Resistance in HER2-Positive Breast Cancer Brain Metastases: Blame the Barrier or the Brain? von Kabraji, Sheheryar, Ni, Jing, Lin, Nancy U, Xie, Shaozhen, Winer, Eric P, Zhao, Jean J

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p16INK4A-deficiency predicts response to combined HER2 and CDK4/6 inhibition in HER2+ breast cancer brain metastases von Ni, Jing, Kabraji, Sheheryar, Xie, Shaozhen, Wang, Yanzhi, Pan, Peichen, He, Xiaofang, Liu, Zongming, Leone, Jose Palbo, Long, Henry W., Brown, Myles A., Winer, Eric P., Dillon, Deborah A. R., Lin, Nancy U., Zhao, Jean J.

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Improving orthotopic mouse models of patient-derived breast cancer brain metastases by a modified intracarotid injection method von Liu, Zongming, Wang, Yanzhi, Kabraji, Sheheryar, Xie, Shaozhen, Pan, Peichen, Liu, Zhenning, Ni, Jing, Zhao, Jean J.

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The role of the PIK3CA gene in the development and aging of the brain von Xie, Shaozhen, Ni, Jing, Guo, Hanbing, Luu, Victor, Wang, Yanzhi, Zhao, Jean J., Roberts, Thomas M.

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Rac1-mediated membrane raft localization of PI3K/p110β is required for its activation by GPCRs or PTEN loss von Cizmecioglu, Onur, Ni, Jing, Xie, Shaozhen, Zhao, Jean J, Roberts, Thomas M

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Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases von Ni, Jing, Ramkissoon, Shakti H, Xie, Shaozhen, Goel, Shom, Stover, Daniel G, Guo, Hanbing, Luu, Victor, Marco, Eugenio, Ramkissoon, Lori A, Kang, Yun Jee, Hayashi, Marika, Nguyen, Quang-De, Ligon, Azra H, Du, Rose, Claus, Elizabeth B, Alexander, Brian M, Yuan, Guo-Cheng, Wang, Zhigang C, Iglehart, J Dirk, Krop, Ian E, Roberts, Thomas M, Winer, Eric P, Lin, Nancy U, Ligon, Keith L, Zhao, Jean J

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STING agonism overcomes STAT3-mediated immunosuppression and adaptive resistance to PARP inhibition in ovarian cancer von Ding, Liya, Wang, Qiwei, Martincuks, Antons, Kearns, Michael J, Jiang, Tao, Lin, Ziying, Cheng, Xin, Qian, Changli, Xie, Shaozhen, Kim, Hye-Jung, Launonen, Inga-Maria, Färkkilä, Anniina, Roberts, Thomas M, Freeman, Gordon J, Liu, Joyce F, Konstantinopoulos, Panagiotis A, Matulonis, Ursula, Yu, Hua, Zhao, Jean J

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TR4 nuclear receptor functions as a fatty acid sensor to modulate CD36 expression and foam cell formation von Xie, Shaozhen, Lee, Yi-Fen, Kim, Eungseok, Chen, Lu-Min, Ni, Jing, Fang, Lei-Ya, Liu, Su, Lin, Shin-Jen, Abe, Jun-ichi, Berk, Bradford, Ho, Feng-Ming, Chang, Chawnshang

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Induction of Androgen Receptor Expression by Phosphatidylinositol 3-Kinase/Akt Downstream Substrate, FOXO3a, and Their Roles in Apoptosis of LNCaP Prostate Cancer Cells von Yang, Lin, Xie, Shaozhen, Jamaluddin, Md. Saha, Altuwaijri, Saleh, Ni, Jing, Kim, Eungseok, Chen, Yei-Tsung, Hu, Yueh-Chiang, Wang, Liang, Chuang, Kuang-Hsiang, Wu, Chun-Te, Chang, Chawnshang

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Tocopherol-associated protein suppresses prostate cancer cell growth by inhibition of the phosphoinositide 3-kinase pathway von JING NI, XINGQIAO WEN, DI SANT'AGNESE, Anthony, MESSING, Edward M, YEH, Shuyuan, YAO, Jorge, CHANG, Hong-Chiang, YI YIN, MIN ZHANG, SHAOZHEN XIE, MING CHEN, SIMONS, Brenna, CHANG, Philip

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CDK4/6 inhibition triggers anti-tumour immunity von Goel, Shom, DeCristo, Molly J., Watt, April C., BrinJones, Haley, Sceneay, Jaclyn, Li, Ben B., Khan, Naveed, Ubellacker, Jessalyn M., Xie, Shaozhen, Metzger-Filho, Otto, Hoog, Jeremy, Ellis, Matthew J., Ma, Cynthia X., Ramm, Susanne, Krop, Ian E., Winer, Eric P., Roberts, Thomas M., Kim, Hye-Jung, McAllister, Sandra S., Zhao, Jean J.

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CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer von Wang, Yubao, Zhang, Tinghu, Kwiatkowski, Nicholas, Abraham, Brian J., Lee, Tong Ihn, Xie, Shaozhen, Yuzugullu, Haluk, Von, Thanh, Li, Heyuan, Lin, Ziao, Stover, Daniel G., Lim, Elgene, Wang, Zhigang C., Iglehart, J. Dirk, Young, Richard A., Gray, Nathanael S., Zhao, Jean J.

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APPL Suppresses Androgen Receptor Transactivation via Potentiating Akt Activity von Yang, Lin, Lin, Hui-Kuan, Altuwaijri, Saleh, Xie, Shaozhen, Wang, Liang, Chang, Chawnshang

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PI3Kβ controls immune evasion in PTEN-deficient breast tumours von Bergholz, Johann S., Wang, Qiwei, Wang, Qi, Ramseier, Michelle, Prakadan, Sanjay, Wang, Weihua, Fang, Rong, Kabraji, Sheheryar, Zhou, Qian, Gray, G. Kenneth, Abell-Hart, Kayley, Xie, Shaozhen, Guo, Xiaocan, Gu, Hao, Von, Thanh, Jiang, Tao, Tang, Shuang, Freeman, Gordon J., Kim, Hye-Jung, Shalek, Alex K., Roberts, Thomas M., Zhao, Jean J.

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In vitro and In vivo Anticancer Effects of the Novel Vitamin E Ether Analogue RRR-α-Tocopheryloxybutyl Sulfonic Acid in Prostate Cancer von JING NI, TIEJUN MAI, YEH, Shuyuan, PANG, See-Tong, HAQUE, Imranul, HUANG, Kaohsing, DIMAGGIO, MatthewA, SHAOZHEN XIE, JAMES, Nadine S, KASI, Dhanalakshmi, CHEMLER, Sherry R

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Functional characterization of an isoform-selective inhibitor of PI3K-p110β as a potential anticancer agent von Ni, Jing, Liu, Qingsong, Xie, Shaozhen, Carlson, Coby, Von, Thanh, Vogel, Kurt, Riddle, Steve, Benes, Cyril, Eck, Michael, Roberts, Thomas, Gray, Nathanael, Zhao, Jean

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Abstract LB159: Overcoming immunosuppression and therapeutic resistance to PARP inhibition in BRCA1-deficient breast cancer with STING agonists von Wang, Qiwei, Bergholz, Johann S., Ding, Liya, Lin, Ziying, Xie, Shaozhen, Jiang, Tao, Kim, Hye-Jung, Roberts, Thomas M., Zhao, Jean J.

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