Invention of MK-8262, a Cholesteryl Ester Transfer Protein (CETP) Inhibitor Backup to Anacetrapib with Best-in-Class Properties von Vachal, Petr, Duffy, Joseph L, Campeau, Louis-Charles, Amin, Rupesh P, Mitra, Kaushik, Murphy, Beth Ann, Shao, Pengcheng P, Sinclair, Peter J, Ye, Feng, Katipally, Revathi, Lu, Zhijian, Ondeyka, Debra, Chen, Yi-Heng, Zhao, Kake, Sun, Wanying, Tyagarajan, Sriram, Bao, Jianming, Wang, Sheng-Ping, Cote, Josee, Lipardi, Concetta, Metzger, Daniel, Leung, Dennis, Hartmann, Georgy, Wollenberg, Gordon K, Liu, Jian, Tan, Lushi, Xu, Yingju, Chen, Qinghao, Liu, Guiquan, Blaustein, Robert O, Johns, Douglas G

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Block of Peripheral Nerve Sodium Channels Selectively Inhibits Features of Neuropathic Pain in Rats von Brochu, Richard M., Dick, Ivy E., Tarpley, Jason W., McGowan, Erin, Gunner, David, Herrington, James, Shao, Pengcheng P., Ok, Dong, Li, Chunshi, Parsons, William H., Stump, Gary L., Regan, Christopher P., Lynch, Joseph J., Lyons, Kathryn A., McManus, Owen B., Clark, Samantha, Ali, Zahid, Kaczorowski, Gregory J., Martin, William J., Priest, Birgit T.

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Discovery of isoxazole voltage gated sodium channel blockers for treatment of chronic pain von Shao, Pengcheng P., Ye, Feng, Weber, Ann E., Li, Xiaohua, Lyons, Kathryn A., Parsons, William H., Garcia, Maria L., Priest, Birgit T., Smith, McHardy M., Felix, John P., Williams, Brande S., Kaczorowski, Gregory J., McGowan, Erin, Abbadie, Catherine, Martin, William J., McMasters, Daniel R., Gao, Ying-Duo

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Discovery and Pharmacology of a Novel Somatostatin Subtype 5 (SSTR5) Antagonist: Synergy with DPP‑4 Inhibition von Liu, Weiguo, Shao, Pengcheng P, Liang, Gui-Bai, Bawiec, John, He, Jiafang, Aster, Susan D, Wu, Margaret, Chicchi, Garry, Wang, John, Tsao, Kwei-Lan, Shang, Jin, Salituro, Gino, Zhou, Yun-Ping, Li, Cai, Akiyama, Taro E, Metzger, Daniel E, Murphy, Beth Ann, Howard, Andrew D, Weber, Ann E, Duffy, Joseph L

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Aminopiperidine Sulfonamide Cav2.2 Channel Inhibitors for the Treatment of Chronic Pain von Shao, Pengcheng P, Ye, Feng, Chakravarty, Prasun K, Varughese, Deepu J, Herrington, James B, Dai, Ge, Bugianesi, Randal M, Haedo, Rodolfo J, Swensen, Andrew M, Warren, Vivien A, Smith, McHardy M, Garcia, Maria L, McManus, Owen B, Lyons, Kathryn A, Li, Xiaohua, Green, Mitchell, Jochnowitz, Nina, McGowan, Erin, Mistry, Shruti, Sun, Shu-Yu, Abbadie, Catherine, Kaczorowski, Gregory J, Duffy, Joseph L

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Improved Cav2.2 Channel Inhibitors through a gem-Dimethylsulfone Bioisostere Replacement of a Labile Sulfonamide von Shao, Pengcheng P, Ye, Feng, Chakravarty, Prasun K, Herrington, James B, Dai, Ge, Bugianesi, Randal M, Haedo, Rodolfo J, Swensen, Andrew M, Warren, Vivien A, Smith, McHardy M, Garcia, Maria L, McManus, Owen B, Lyons, Kathryn A, Li, Xiaohua, Green, Mitchell, Jochnowitz, Nina, McGowan, Erin, Mistry, Shruti, Sun, Shu-Yu, Abbadie, Catherine, Kaczorowski, Gregory J, Duffy, Joseph L

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Discovery of a novel class of isoxazoline voltage gated sodium channel blockers von Shao, Pengcheng P., Ye, Feng, Weber, Ann E., Li, Xiaohua, Lyons, Kathryn A., Parsons, William H., Garcia, Maria L., Priest, Birgit T., Smith, McHardy M., Felix, John P., Williams, Brande S., Kaczorowski, Gregory J., McGowan, Erin, Abbadie, Catherine, Martin, William J., McMasters, Daniel R., Gao, Ying-Duo

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A Disubstituted Succinamide Is a Potent Sodium Channel Blocker with Efficacy in a Rat Pain Model von Priest, Birgit T, Garcia, Maria L, Middleton, Richard E, Brochu, Richard M, Clark, Samantha, Dai, Ge, Dick, Ivy E, Felix, John P, Liu, Chou J, Reiseter, Brita S, Schmalhofer, William A, Shao, Pengcheng P, Tang, Yui S, Chou, Margaret Z, Kohler, Martin G, Smith, McHardy M, Warren, Vivien A, Williams, Brande S, Cohen, Charles J, Martin, William J, Meinke, Peter T, Parsons, William H, Wafford, Keith A, Kaczorowski, Gregory J

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Stereoselective synthesis of cis- and trans-3-fluoro-1-phenylcyclobutyl amine von Shao, Pengcheng P., Ye, Feng

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Aminopiperidine Sulfonamide Ca v 2.2 Channel Inhibitors for the Treatment of Chronic Pain von Shao, Pengcheng P., Ye, Feng, Chakravarty, Prasun K., Varughese, Deepu J., Herrington, James B., Dai, Ge, Bugianesi, Randal M., Haedo, Rodolfo J., Swensen, Andrew M., Warren, Vivien A., Smith, McHardy M., Garcia, Maria L., McManus, Owen B., Lyons, Kathryn A., Li, Xiaohua, Green, Mitchell, Jochnowitz, Nina, McGowan, Erin, Mistry, Shruti, Sun, Shu-Yu, Abbadie, Catherine, Kaczorowski, Gregory J., Duffy, Joseph L.

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Improved Ca v 2.2 Channel Inhibitors through a gem -Dimethylsulfone Bioisostere Replacement of a Labile Sulfonamide von Shao, Pengcheng P., Ye, Feng, Chakravarty, Prasun K., Herrington, James B., Dai, Ge, Bugianesi, Randal M., Haedo, Rodolfo J., Swensen, Andrew M., Warren, Vivien A., Smith, McHardy M., Garcia, Maria L., McManus, Owen B., Lyons, Kathryn A., Li, Xiaohua, Green, Mitchell, Jochnowitz, Nina, McGowan, Erin, Mistry, Shruti, Sun, Shu-Yu, Abbadie, Catherine, Kaczorowski, Gregory J., Duffy, Joseph L.

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TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES von HUANG, Chunhui, ELLIS, J. Michael, ESPOSITE, Sara, UJJAINWALLA, Feroze, CHILDERS, Matthew, L, SCIAMMETTA, Nunzio, FISCHER, Christian, LAMPE, John, W, OTTE, Ryan, D, SLOMAN, David, L, PARKER, Dann, L., Jr, REUTERSHAN, Michael, WHITE, Catherine, BOGEN, Stephane, L, LLINAS, Francesc Xavier Fradera, HONG, Qingmei, MACHACEK, Michelle, R, WU, Zhicai, SHAO, Pengcheng, P, MCMASTERS, Daniel, R, KIM, Alexander, J

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NOVEL TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES von HUANG, Chunhui, UJJAINWALLA, Feroze, CHILDERS, Matthew, L, SCIAMMETTA, Nunzio, FISCHER, Christian, LAMPE, John, W, SUN, Wanying, SLOMAN, David, L, PARKER, Dann, L., Jr, BOGEN, Stephane, L, LLINAS, Francesc Xavier Fradera, MACHACEK, Michelle, R, SHAO, Pengcheng, P, MCMASTERS, Daniel, R, KIM, Alexander, J

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ChemInform Abstract: Discovery of Isoxazole Voltage Gated Sodium Channel Blockers for Treatment of Chronic Pain von Shao, Pengcheng P., ., et al

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NOVEL TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES von HUANG, Chunhui, ELLIS, J. Michael, ESPOSITE, Sara, UJJAINWALLA, Feroze, CHILDERS, Matthew, L, SCIAMMETTA, Nunzio, FISCHER, Christian, LAMPE, John, W, SUN, Wanying, HOFFMAN, Dawn, M, SLOMAN, David, L, PARKER, Dann, L., Jr, REUTERSHAN, Michael, BOGEN, Stephane, L, LLINAS, Francesc Xavier Fradera, KATTAR, Solomon, MACHACEK, Michelle, R, WU, Zhicai, SHAO, Pengcheng, P, MCMASTERS, Daniel, R, KIM, Alexander, J

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Tricyclic compounds as inhibitors of mutant IDH enzymes von Sciammetta, Nunzio, Reutershan, Michael H, Fischer, Christian, Ellis, J. Michael, Gibeau, Craig R, Wu, Zhicai, Kim, Alexander J, Bogen, Stephane L, Shao, Pengcheng P, Fradera Llinas, Francesc Xavier, Parker, Jr., Dann L, Esposite, Sara, Sun, Wanying, Hoffman, Dawn M, Huang, Chunhui, Lampe, John W, Machacek, Michelle R, Yu, Yang, Childers, Matthew L, Sloman, David L, Kattar, Solomon D, Ujjainwalla, Feroze, McMasters, Daniel R

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Tricyclic compounds as inhibitors of mutant IDH enzymes von Sciammetta, Nunzio, Fischer, Christian, Kim, Alexander J, Bogen, Stephane L, Shao, Pengcheng P, Fradera Llinas, Francesc Xavier, Parker, Jr., Dann L, Sun, Wanying, Huang, Chunhui, Lampe, John W, Machacek, Michelle R, Childers, Matthew L, Sloman, David L, Ujjainwalla, Feroze, McMasters, Daniel R

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Tricyclic compounds as inhibitors of mutant IDH enzymes von Sciammetta, Nunzio, Fischer, Christian, Zhang, Hongjun, Bogen, Stephane L, Shao, Pengcheng P, Fradera Llinas, Francesc Xavier, Huang, Chunhui, Biftu, Tesfaye, Huang, Xianhai, Yu, Yang, Simov, Valdimir, Biju, Purakkattle, McMasters, Daniel R, Hong, Qingmei, Ellis, J. Michael, Wu, Zhicai, Kim, Alexander J, Zhao, Kake, Chen, Lei, Gibeau, Craig, Parker, Jr., Dann L, Esposite, Sara, Fuller, Peter H, Witter, David J, Lampe, John W, White, Catherine, Machacek, Michelle R, Park, Min K, Reutershan, Michael, Close, Joshua, Childers, Matthew L, Sloman, David L, Ujjainwalla, Feroze, Otte, Ryan D

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NOVEL TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES von HUANG, Chunhui, ELLIS, J. Michael, ESPOSITE, Sara, UJJAINWALLA, Feroze, CHILDERS, Matthew, L, SCIAMMETTA, Nunzio, FISCHER, Christian, LAMPE, John, W, OTTE, Ryan, D, SLOMAN, David, L, PARKER, Dann, L., Jr, REUTERSHAN, Michael, WHITE, Catherine, BOGEN, Stephane, L, LLINAS, Francesc Xavier Fradera, HONG, Qingmei, MACHACEK, Michelle, R, WU, Zhicai, SHAO, Pengcheng, P, MCMASTERS, Daniel, R, KIM, Alexander, J

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NOVEL TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES von HUANG, Chunhui, UJJAINWALLA, Feroze, CHILDERS, Matthew, L, SCIAMMETTA, Nunzio, FISCHER, Christian, LAMPE, John, W, SUN, Wanying, SLOMAN, David, L, PARKER, Dann, L., Jr, BOGEN, Stephane, L, LLINAS, Francesc Xavier Fradera, MACHACEK, Michelle, R, SHAO, Pengcheng, P, MCMASTERS, Daniel, R, KIM, Alexander, J

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