Dinaciclib (SCH 727965), a novel and potent cyclin-dependent kinase inhibitor von Parry, David, Guzi, Timothy, Shanahan, Frances, Davis, Nicole, Prabhavalkar, Deepa, Wiswell, Derek, Seghezzi, Wolfgang, Paruch, Kamil, Dwyer, Michael P, Doll, Ronald, Nomeir, Amin, Windsor, William, Fischmann, Thierry, Wang, Yaolin, Oft, Martin, Chen, Taiying, Kirschmeier, Paul, Lees, Emma M

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CRAF dimerization with ARAF regulates KRAS-driven tumor growth von Venkatanarayan, Avinashnarayan, Liang, Jason, Yen, Ivana, Shanahan, Frances, Haley, Benjamin, Phu, Lilian, Verschueren, Erik, Hinkle, Trent B., Kan, David, Segal, Ehud, Long, Jason E., Lima, Tony, Liau, Nicholas P.D., Sudhamsu, Jawahar, Li, Jason, Klijn, Christiaan, Piskol, Robert, Junttila, Melissa R., Shaw, Andrey S., Merchant, Mark, Chang, Matthew T., Kirkpatrick, Donald S., Malek, Shiva

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Role for BRG1 in Cell Cycle Control and Tumor Suppression von Hendricks, Kristin B., Shanahan, Frances, Lees, Emma

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Replication stress activates DNA polymerase alpha-associated Chk1 von Taricani, Lorena, Shanahan, Frances, Parry, David

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Phenotypic enhancement of thymidylate synthetase pathway inhibitors following ablation of Neil1 DNA glycosylase/lyase von Taricani, Lorena, Shanahan, Frances, Pierce, Rob H., Guzi, Timothy J., Parry, David

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Cyclin E Associates with BAF155 and BRG1, Components of the Mammalian SWI-SNF Complex, and Alters the Ability of BRG1 To Induce Growth Arrest von Shanahan, Frances, Seghezzi, Wolfgang, Parry, David, Mahony, Daniel, Lees, Emma

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Pharmacological Induction of RAS-GTP Confers RAF Inhibitor Sensitivity in KRAS Mutant Tumors von Yen, Ivana, Shanahan, Frances, Merchant, Mark, Orr, Christine, Hunsaker, Thomas, Durk, Matthew, La, Hank, Zhang, Xiaolin, Martin, Scott E., Lin, Eva, Chan, John, Yu, Yihong, Amin, Dhara, Neve, Richard M., Gustafson, Amy, Venkatanarayan, Avinashnarayan, Foster, Scott A., Rudolph, Joachim, Klijn, Christiaan, Malek, Shiva

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Identifying transcriptional programs underlying cancer drug response with TraCe-seq von Chang, Matthew T., Shanahan, Frances, Nguyen, Thi Thu Thao, Staben, Steven T., Gazzard, Lewis, Yamazoe, Sayumi, Wertz, Ingrid E., Piskol, Robert, Yang, Yeqing Angela, Modrusan, Zora, Haley, Benjamin, Evangelista, Marie, Malek, Shiva, Foster, Scott A., Ye, Xin

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Allosteric Inhibitors of the SARS-COV‑2 Papain-like Protease Domain Induce Proteasomal Degradation of Its Parent Protein NSP3 von Cockram, Peter E., Walters, Benjamin T., Lictao, Aaron, Shanahan, Frances, Wertz, Ingrid E., Foster, Scott A., Rudolph, Joachim

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Ternary complex dissociation kinetics contribute to mutant-selective EGFR degradation von Rosenberg, Scott C., Shanahan, Frances, Yamazoe, Sayumi, Kschonsak, Marc, Zeng, Yi J., Lee, James, Plise, Emile, Yen, Ivana, Rose, Christopher M., Quinn, John G., Gazzard, Lewis J., Walters, Benjamin T., Kirkpatrick, Donald S., Staben, Steven T., Foster, Scott A., Malek, Shiva

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Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a 5‑Fluoro-4-(3H)‑quinazolinone Aryl Urea pan-RAF Kinase Inhibitor von Huestis, Malcolm P, Dela Cruz, Darlene, DiPasquale, Antonio G, Durk, Matthew R, Eigenbrot, Charles, Gibbons, Paul, Gobbi, Alberto, Hunsaker, Thomas L, La, Hank, Leung, Dennis H, Liu, Wendy, Malek, Shiva, Merchant, Mark, Moffat, John G, Muli, Christine S, Orr, Christine J, Parr, Brendan T, Shanahan, Frances, Sneeringer, Christopher J, Wang, Weiru, Yen, Ivana, Yin, Jianping, Siu, Michael, Rudolph, Joachim

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ARAF mutations confer resistance to the RAF inhibitobelvarafenib in melanoma von Yen, Ivana, Shanahan, Frances, Lee, Jeeyun, Hong, Yong Sang, Shin, Sang Joon, Moore, Amanda R, Sudhamsu, Jawahar, Chang, Matthew T, Bae, Inhwan, Dela Cruz, Darlene, Hunsaker, Thomas, Klijn, Christiaan, Liau, Nicholas P D, Lin, Eva, Martin, Scott E, Modrusan, Zora, Piskol, Robert, Segal, Ehud, Venkatanarayan, Avinashnarayan, Ye, Xin, Yin, Jianping, Zhang, Liangxuan, Kim, JIN-SOO, Lim, HYEONG-SEOK, Kim, KYU-PYO, Kim, Yu Jung, Han, Hye Sook, Lee, Soo Jung, Kim, Seung Tae, Jung, Minkyu, Hong, Yoon-hee, Noh, Young Su, Choi, Munjeong, Han, Oakpil, Nowicka, Malgorzata, Srinivasan, Shrividhya, Yan, Yibing, Kim, Tae Won, Malek, Shiva

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Abstract 874: Pharmacologically induced RAS-GTP levels and CRAF-BRAF hetero-dimerization drive sensitization to Type II pan-RAF inhibitors in KRAS mutant cancer von Klijn, Christiaan N., Yen, Ivana, Shanahan, Frances, Merchant, Mark, Orr, Christine, Hunsaker, Thomas, Durk, Matthew, La, Hank, Zhang, Xiaoling, Martin, Scott, Lin, Eva, Chan, John, Yu, Yihong, Amin, Dhara, Gustafson, Amy, Foster, Scott, Rudolph, Joachim, Malek, Shiva

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Abstract 4967: RAF kinase inhibition synergizes with MEK inhibitors in KRAS mutant tumors von Yen, Ivana, Klijn, Christiaan, Shanahan, Frances, Merchant, Mark, Orr, Christine, Hunsaker, Thomas, Durk, Matthew, La, Hank, Zhang, Xiaolin, Martin, Scott, Lin, Eva, Chan, John, Yu, Yihong, Gustafson, Amy, Rudolph, Joachim, Malek, Shiva

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Discovery of Dinaciclib (SCH 727965): A Potent and Selective Inhibitor of Cyclin-Dependent Kinases von Paruch, Kamil, Dwyer, Michael P, Alvarez, Carmen, Brown, Courtney, Chan, Tin-Yau, Doll, Ronald J, Keertikar, Kerry, Knutson, Chad, McKittrick, Brian, Rivera, Jocelyn, Rossman, Randall, Tucker, Greg, Fischmann, Thierry, Hruza, Alan, Madison, Vincent, Nomeir, Amin A, Wang, Yaolin, Kirschmeier, Paul, Lees, Emma, Parry, David, Sgambellone, Nicole, Seghezzi, Wolfgang, Schultz, Lesley, Shanahan, Frances, Wiswell, Derek, Xu, Xiaoying, Zhou, Quiao, James, Ray A, Paradkar, Vidyadhar M, Park, Haengsoon, Rokosz, Laura R, Stauffer, Tara M, Guzi, Timothy J

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BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines von WONG, Alexander K. C, SHANAHAN, Frances, SMITH, Richard, SALADA, Grant, CARILLO, Arlene, LAITY, Kirsten, GUPTE, Jamila, SWEDLUND, Brad, TAVTIGIAN, Sean V, TENG, David H-F, LEES, Emma, YUAN CHEN, LUBING LIAN, PHUONG HA, HENDRICKS, Kristin, GHAFFARI, Siavash, ILIEV, Diana, PENN, Brandon, WOODLAND, Anne-Marie

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The identification of novel 5′-amino gemcitabine analogs as potent RRM1 inhibitors von Labroli, Marc A., Dwyer, Michael P., Shen, Ruichao, Popovici-Muller, Janeta, Pu, Qinglin, Wyss, Daniel, McCoy, Mark, Barrett, Dianah, Davis, Nicole, Seghezzi, Wolfgang, Shanahan, Frances, Taricani, Lorena, Beaumont, Maribel, Malinao, Maria-Christina, Parry, David, Guzi, Timothy J.

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Versatile templates for the development of novel kinase inhibitors: Discovery of novel CDK inhibitors von Dwyer, Michael P., Paruch, Kamil, Alvarez, Carmen, Doll, Ronald J., Keertikar, Kerry, Duca, Jose, Fischmann, Thierry O., Hruza, Alan, Madison, Vincent, Lees, Emma, Parry, David, Seghezzi, Wolfgang, Sgambellone, Nicole, Shanahan, Frances, Wiswell, Derek, Guzi, Timothy J.

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Pathways of activation of the Epstein-Barr virus productive cycle von SINCLAIR, A. J, BRIMMELL, M, SHANAHAN, F, FARRELL, P. J

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Regulation of G1/S transition in mammalian cells von Guevara, Claudia, Korver, Wouter, Mahony, Daniel, Parry, David, Seghezzi, Wolfgang, Shanahan, Frances, Lees, Emma

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