Regulation of Ferroptotic Cancer Cell Death by GPX4 von Yang, Wan Seok, SriRamaratnam, Rohitha, Welsch, Matthew E., Shimada, Kenichi, Skouta, Rachid, Viswanathan, Vasanthi S., Cheah, Jaime H., Clemons, Paul A., Shamji, Alykhan F., Clish, Clary B., Brown, Lewis M., Girotti, Albert W., Cornish, Virginia W., Schreiber, Stuart L., Stockwell, Brent R.

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A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles von Subramanian, Aravind, Narayan, Rajiv, Corsello, Steven M., Peck, David D., Natoli, Ted E., Lu, Xiaodong, Gould, Joshua, Davis, John F., Tubelli, Andrew A., Asiedu, Jacob K., Lahr, David L., Hirschman, Jodi E., Liu, Zihan, Donahue, Melanie, Julian, Bina, Khan, Mariya, Wadden, David, Smith, Ian C., Lam, Daniel, Liberzon, Arthur, Toder, Courtney, Bagul, Mukta, Orzechowski, Marek, Enache, Oana M., Piccioni, Federica, Johnson, Sarah A., Lyons, Nicholas J., Berger, Alice H., Shamji, Alykhan F., Brooks, Angela N., Vrcic, Anita, Flynn, Corey, Rosains, Jacqueline, Takeda, David Y., Hu, Roger, Davison, Desiree, Lamb, Justin, Ardlie, Kristin, Hogstrom, Larson, Greenside, Peyton, Gray, Nathanael S., Clemons, Paul A., Silver, Serena, Wu, Xiaoyun, Zhao, Wen-Ning, Read-Button, Willis, Wu, Xiaohua, Haggarty, Stephen J., Ronco, Lucienne V., Boehm, Jesse S., Schreiber, Stuart L., Doench, John G., Bittker, Joshua A., Root, David E., Wong, Bang, Golub, Todd R.

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Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway von Viswanathan, Vasanthi S., Ryan, Matthew J., Dhruv, Harshil D., Gill, Shubhroz, Eichhoff, Ossia M., Seashore-Ludlow, Brinton, Kaffenberger, Samuel D., Eaton, John K., Shimada, Kenichi, Aguirre, Andrew J., Viswanathan, Srinivas R., Chattopadhyay, Shrikanta, Tamayo, Pablo, Yang, Wan Seok, Rees, Matthew G., Chen, Sixun, Boskovic, Zarko V., Javaid, Sarah, Huang, Cherrie, Wu, Xiaoyun, Tseng, Yuen-Yi, Roider, Elisabeth M., Gao, Dong, Cleary, James M., Wolpin, Brian M., Mesirov, Jill P., Haber, Daniel A., Engelman, Jeffrey A., Boehm, Jesse S., Kotz, Joanne D., Hon, Cindy S., Chen, Yu, Hahn, William C., Levesque, Mitchell P., Doench, John G., Berens, Michael E., Shamji, Alykhan F., Clemons, Paul A., Stockwell, Brent R., Schreiber, Stuart L.

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Multiplex cytological profiling assay to measure diverse cellular states von Gustafsdottir, Sigrun M, Ljosa, Vebjorn, Sokolnicki, Katherine L, Anthony Wilson, J, Walpita, Deepika, Kemp, Melissa M, Petri Seiler, Kathleen, Carrel, Hyman A, Golub, Todd R, Schreiber, Stuart L, Clemons, Paul A, Carpenter, Anne E, Shamji, Alykhan F

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Correlating chemical sensitivity and basal gene expression reveals mechanism of action von Rees, Matthew G, Seashore-Ludlow, Brinton, Cheah, Jaime H, Adams, Drew J, Price, Edmund V, Gill, Shubhroz, Javaid, Sarah, Coletti, Matthew E, Jones, Victor L, Bodycombe, Nicole E, Soule, Christian K, Alexander, Benjamin, Li, Ava, Montgomery, Philip, Kotz, Joanne D, Hon, C Suk-Yee, Munoz, Benito, Liefeld, Ted, Dančík, Vlado, Haber, Daniel A, Clish, Clary B, Bittker, Joshua A, Palmer, Michelle, Wagner, Bridget K, Clemons, Paul A, Shamji, Alykhan F, Schreiber, Stuart L

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Selective killing of cancer cells by a small molecule targeting the stress response to ROS von Raj, Lakshmi, Ide, Takao, Gurkar, Aditi U., Foley, Michael, Schenone, Monica, Li, Xiaoyu, Tolliday, Nicola J., Golub, Todd R., Carr, Steven A., Shamji, Alykhan F., Stern, Andrew M., Mandinova, Anna, Schreiber, Stuart L., Lee, Sam W.

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An Interactive Resource to Identify Cancer Genetic and Lineage Dependencies Targeted by Small Molecules von Basu, Amrita, Bodycombe, Nicole E., Cheah, Jaime H., Price, Edmund V., Liu, Ke, Schaefer, Giannina I., Ebright, Richard Y., Stewart, Michelle L., Ito, Daisuke, Wang, Stephanie, Bracha, Abigail L., Liefeld, Ted, Wawer, Mathias, Gilbert, Joshua C., Wilson, Andrew J., Stransky, Nicolas, Kryukov, Gregory V., Dancik, Vlado, Barretina, Jordi, Garraway, Levi A., Hon, C. Suk-Yee, Munoz, Benito, Bittker, Joshua A., Stockwell, Brent R., Khabele, Dineo, Stern, Andrew M., Clemons, Paul A., Shamji, Alykhan F., Schreiber, Stuart L.

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High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines von Yu, Channing, Mannan, Aristotle M, Yvone, Griselda Metta, Ross, Kenneth N, Zhang, Yan-Ling, Marton, Melissa A, Taylor, Bradley R, Crenshaw, Andrew, Gould, Joshua Z, Tamayo, Pablo, Weir, Barbara A, Tsherniak, Aviad, Wong, Bang, Garraway, Levi A, Shamji, Alykhan F, Palmer, Michelle A, Foley, Michael A, Winckler, Wendy, Schreiber, Stuart L, Kung, Andrew L, Golub, Todd R

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Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset von Seashore-Ludlow, Brinton, Rees, Matthew G, Cheah, Jaime H, Cokol, Murat, Price, Edmund V, Coletti, Matthew E, Jones, Victor, Bodycombe, Nicole E, Soule, Christian K, Gould, Joshua, Alexander, Benjamin, Li, Ava, Montgomery, Philip, Wawer, Mathias J, Kuru, Nurdan, Kotz, Joanne D, Hon, C Suk-Yee, Munoz, Benito, Liefeld, Ted, Dančík, Vlado, Bittker, Joshua A, Palmer, Michelle, Bradner, James E, Shamji, Alykhan F, Clemons, Paul A, Schreiber, Stuart L

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Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs von Adams, Drew J, Dai, Mingji, Pellegrino, Giovanni, Wagner, Bridget K, Stern, Andrew M, Shamji, Alykhan F, Schreiber, Stuart L

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Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense von Lassen, Kara G., Kuballa, Petric, Conway, Kara L., Patel, Khushbu K., Becker, Christine E., Peloquin, Joanna M., Villablanca, Eduardo J., Norman, Jason M., Liu, Ta-Chiang, Heath, Robert J., Becker, Morgan L., Fagbami, Lola, Horn, Heiko, Mercer, Johnathan, Yilmaz, Omer H., Jaffe, Jacob D., Shamji, Alykhan F., Bhan, Atul K., Carr, Steven A., Daly, Mark J., Virgin, Herbert W., Schreiber, Stuart L., Stappenbeck, Thaddeus S., Xavier, Ramnik J.

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Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles von Clemons, Paul A., Bodycombe, Nicole E., Carrinski, Hyman A., Wilson, J. Anthony, Shamji, Alykhan F., Wagner, Bridget K., Koehler, Angela N., Schreiber, Stuart L.

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Ubiquitin Ligase TRIM62 Regulates CARD9-Mediated Anti-fungal Immunity and Intestinal Inflammation von Cao, Zhifang, Conway, Kara L., Heath, Robert J., Rush, Jason S., Leshchiner, Elizaveta S., Ramirez-Ortiz, Zaida G., Nedelsky, Natalia B., Huang, Hailiang, Ng, Aylwin, Gardet, Agnès, Cheng, Shih-Chin, Shamji, Alykhan F., Rioux, John D., Wijmenga, Cisca, Netea, Mihai G., Means, Terry K., Daly, Mark J., Xavier, Ramnik J.

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Atg16l1 is Required for Autophagy in Intestinal Epithelial Cells and Protection of Mice From Salmonella Infection von Conway, Kara L, Kuballa, Petric, Song, Joo–Hye, Patel, Khushbu K, Castoreno, Adam B, Yilmaz, Omer H, Jijon, Humberto B, Zhang, Mei, Aldrich, Leslie N, Villablanca, Eduardo J, Peloquin, Joanna M, Goel, Gautam, Lee, In–Ah, Mizoguchi, Emiko, Shi, Hai Ning, Bhan, Atul K, Shaw, Stanley Y, Schreiber, Stuart L, Virgin, Herbert W, Shamji, Alykhan F, Stappenbeck, Thaddeus S, Reinecker, Hans–Christian, Xavier, Ramnik J

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Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling von Wawer, Mathias J., Li, Kejie, Gustafsdottir, Sigrun M., Ljos, Vebjorn, Bodycombe, Nicole E., Marton, Melissa A., Sokolnicki, Katherine L., Bray, Mark-Anthony, Kemp, Melissa M., Winchester, Ellen, Taylor, Bradley, Grant, George B., Hon, C. Suk-Yee, Duvall, Jeremy R., Wilson, J. Anthony, Bittker, Joshua A., Dančík, Vlado, Narayan, Rajiv, Subramanian, Aravind, Winckler, Wendy, Golub, Todd R., Carpenter, Anne E., Shamji, Alykhan F., Schreiber, Stuart L., Clemons, Paul A.

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A Small-Molecule Probe of the Histone Methyltransferase G9a Induces Cellular Senescence in Pancreatic Adenocarcinoma von Yuan, Yuan, Wang, Qiu, Paulk, Joshiawa, Kubicek, Stefan, Kemp, Melissa M, Adams, Drew J, Shamji, Alykhan F, Wagner, Bridget K, Schreiber, Stuart L

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A dataset of images and morphological profiles of 30 000 small-molecule treatments using the Cell Painting assay von Bray, Mark-Anthony, Gustafsdottir, Sigrun M, Rohban, Mohammad H, Singh, Shantanu, Ljosa, Vebjorn, Sokolnicki, Katherine L, Bittker, Joshua A, Bodycombe, Nicole E, Dančík, Vlado, Hasaka, Thomas P, Hon, Cindy S, Kemp, Melissa M, Li, Kejie, Walpita, Deepika, Wawer, Mathias J, Golub, Todd R, Schreiber, Stuart L, Clemons, Paul A, Shamji, Alykhan F, Carpenter, Anne E

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Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease von Leshchiner, Elizaveta S., Rush, Jason S., Durney, Michael A., Cao, Zhifang, Dančík, Vlado, Chittick, Benjamin, Wu, Huixian, Petrone, Adam, Bittker, Joshua A., Phillips, Andrew, Perez, Jose R., Shamji, Alykhan F., Kaushik, Virendar K., Daly, Mark J., Graham, Daniel B., Schreiber, Stuart L., Xavier, Ramnik J.

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Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics von Kuo, Szu-Yu, Castoreno, Adam B., Aldrich, Leslie N., Lassen, Kara G., Goel, Gautam, Dančík, Vlado, Kuballa, Petric, Latorre, Isabel, Conway, Kara L., Sarkar, Sovan, Maetzel, Dorothea, Jaenisch, Rudolf, Clemons, Paul A., Schreiber, Stuart L., Shamji, Alykhan F., Xavier, Ramnik J.

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A genetic basis for the variation in the vulnerability of cancer to DNA damage von Yard, Brian D., Adams, Drew J., Chie, Eui Kyu, Tamayo, Pablo, Battaglia, Jessica S., Gopal, Priyanka, Rogacki, Kevin, Pearson, Bradley E., Phillips, James, Raymond, Daniel P., Pennell, Nathan A., Almeida, Francisco, Cheah, Jaime H., Clemons, Paul A., Shamji, Alykhan, Peacock, Craig D., Schreiber, Stuart L., Hammerman, Peter S., Abazeed, Mohamed E.

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