Improved vectors and genome-wide libraries for CRISPR screening von Sanjana, Neville E, Shalem, Ophir, Zhang, Feng

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High-throughput functional genomics using CRISPR–Cas9 von Shalem, Ophir, Sanjana, Neville E., Zhang, Feng

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High-resolution interrogation of functional elements in the noncoding genome von Sanjana, Neville E., Wright, Jason, Zheng, Kaijie, Shalem, Ophir, Fontanillas, Pierre, Joung, Julia, Cheng, Christine, Regev, Aviv, Zhang, Feng

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Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells von Shalem, Ophir, Sanjana, Neville E., Hartenian, Ella, Shi, Xi, Scott, David A., Mikkelsen, Tarjei S., Heckl, Dirk, Ebert, Benjamin L., Root, David E., Doench, John G., Zhang, Feng

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Hypoxia as a therapy for mitochondrial disease von Jain, Isha H., Zazzeron, Luca, Goli, Rahul, Alexa, Kristen, Schatzman-Bone, Stephanie, Dhillon, Harveen, Goldberger, Olga, Peng, Jun, Shalem, Ophir, Sanjana, Neville E., Zhang, Feng, Goessling, Wolfram, Zapol, Warren M., Mootha, Vamsi K.

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Identification of essential genes for cancer immunotherapy von Patel, Shashank J., Sanjana, Neville E., Kishton, Rigel J., Eidizadeh, Arash, Vodnala, Suman K., Cam, Maggie, Gartner, Jared J., Jia, Li, Steinberg, Seth M., Yamamoto, Tori N., Merchant, Anand S., Mehta, Gautam U., Chichura, Anna, Shalem, Ophir, Tran, Eric, Eil, Robert, Sukumar, Madhusudhanan, Guijarro, Eva Perez, Day, Chi-Ping, Robbins, Paul, Feldman, Steve, Merlino, Glenn, Zhang, Feng, Restifo, Nicholas P.

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DNA targeting specificity of RNA-guided Cas9 nucleases von Hsu, Patrick D, Scott, David A, Weinstein, Joshua A, Ran, F Ann, Konermann, Silvana, Agarwala, Vineeta, Li, Yinqing, Fine, Eli J, Wu, Xuebing, Shalem, Ophir, Cradick, Thomas J, Marraffini, Luciano A, Bao, Gang, Zhang, Feng

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BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis von Canver, Matthew C., Smith, Elenoe C., Sher, Falak, Pinello, Luca, Sanjana, Neville E., Shalem, Ophir, Chen, Diane D., Schupp, Patrick G., Vinjamur, Divya S., Garcia, Sara P., Luc, Sidinh, Kurita, Ryo, Nakamura, Yukio, Fujiwara, Yuko, Maeda, Takahiro, Yuan, Guo-Cheng, Zhang, Feng, Orkin, Stuart H., Bauer, Daniel E.

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Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia von Tam, Oliver H., Rozhkov, Nikolay V., Shaw, Regina, Kim, Duyang, Hubbard, Isabel, Fennessey, Samantha, Propp, Nadia, Phatnani, Hemali, Kwan, Justin, Sareen, Dhruv, Broach, James R., Simmons, Zachary, Arcila-Londono, Ximena, Lee, Edward B., Van Deerlin, Vivianna M., Shneider, Neil A., Fraenkel, Ernest, Ostrow, Lyle W., Baas, Frank, Zaitlen, Noah, Berry, James D., Malaspina, Andrea, Fratta, Pietro, Cox, Gregory A., Thompson, Leslie M., Finkbeiner, Steve, Dardiotis, Efthimios, Miller, Timothy M., Chandran, Siddharthan, Pal, Suvankar, Hornstein, Eran, MacGowan, Daniel J., Heiman-Patterson, Terry, Hammell, Molly G., Patsopoulos, Nikolaos.A., Butovsky, Oleg, Dubnau, Joshua, Nath, Avindra, Bowser, Robert, Harms, Matt, Aronica, Eleonora, Poss, Mary, Phillips-Cremins, Jennifer, Crary, John, Atassi, Nazem, Lange, Dale J., Adams, Darius J., Stefanis, Leonidas, Gotkine, Marc, Baloh, Robert, Babu, Suma, Raj, Towfique, Paganoni, Sabrina, Shalem, Ophir, Smith, Colin, Zhang, Bin, Harris, Brent T., Fagegaltier, Delphine, Harris, Brent T., Ostrow, Lyle W., Phatnani, Hemali, Ravits, John, Dubnau, Josh, Gale Hammell, Molly

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The Hyaluronidase, TMEM2, Promotes ER Homeostasis and Longevity Independent of the UPRER von Schinzel, Robert Thomas, Higuchi-Sanabria, Ryo, Shalem, Ophir, Moehle, Erica Ann, Webster, Brant Michael, Joe, Larry, Bar-Ziv, Raz, Frankino, Phillip Andrew, Durieux, Jenni, Pender, Corinne, Kelet, Naame, Kumar, Saranya Santhosh, Savalia, Nupur, Chi, Hannah, Simic, Milos, Nguyen, Ngoc-Tram, Dillin, Andrew

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Axonal transcription factors signal retrogradely in lesioned peripheral nerve von Ben-Yaakov, Keren, Dagan, Shachar Y, Segal-Ruder, Yael, Shalem, Ophir, Vuppalanchi, Deepika, Willis, Dianna E, Yudin, Dmitry, Rishal, Ida, Rother, Franziska, Bader, Michael, Blesch, Armin, Pilpel, Yitzhak, Twiss, Jeffery L, Fainzilber, Mike

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Integrated design, execution, and analysis of arrayed and pooled CRISPR genome-editing experiments von Canver, Matthew C, Haeussler, Maximilian, Bauer, Daniel E, Orkin, Stuart H, Sanjana, Neville E, Shalem, Ophir, Yuan, Guo-Cheng, Zhang, Feng, Concordet, Jean-Paul, Pinello, Luca

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Transcriptome kinetics is governed by a genome-wide coupling of mRNA production and degradation: a role for RNA Pol II von Shalem, Ophir, Groisman, Bella, Choder, Mordechai, Dahan, Orna, Pilpel, Yitzhak

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CRISPR screen for protein inclusion formation uncovers a role for SRRD in the regulation of intermediate filament dynamics and aggresome assembly von Sweeney, Katelyn M, Chantarawong, Sapanna, Barbieri, Edward M, Cajka, Greg, Liu, Matthew, Spruce, Lynn, Fazelinia, Hossein, Portz, Bede, Copley, Katie, Lapidot, Tomer, Duhamel, Lauren, Greenwald, Phoebe, Saida, Naseeb, Shalgi, Reut, Shorter, James, Shalem, Ophir

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Systematic dissection of the sequence determinants of gene 3' end mediated expression control von Shalem, Ophir, Sharon, Eilon, Lubliner, Shai, Regev, Ifat, Lotan-Pompan, Maya, Yakhini, Zohar, Segal, Eran

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Population-scale longitudinal mapping of COVID-19 symptoms, behaviour and testing von Allen, William E., Altae-Tran, Han, Briggs, James, Jin, Xin, McGee, Glen, Shi, Andy, Raghavan, Rumya, Kamariza, Mireille, Nova, Nicole, Pereta, Albert, Danford, Chris, Kamel, Amine, Gothe, Patrik, Milam, Evrhet, Aurambault, Jean, Primke, Thorben, Li, Weijie, Inkenbrandt, Josh, Huynh, Tuan, Chen, Evan, Lee, Christina, Croatto, Michael, Bentley, Helen, Lu, Wendy, Murray, Robert, Travassos, Mark, Coull, Brent A., Openshaw, John, Greene, Casey S., Shalem, Ophir, King, Gary, Probasco, Ryan, Cheng, David R., Silbermann, Ben, Zhang, Feng, Lin, Xihong

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Transient transcriptional responses to stress are generated by opposing effects of mRNA production and degradation von Segal, Eran, Pilpel, Yitzhak, Shalem, Ophir, Dahan, Orna, Levo, Michal, Martinez, Maria Rodriguez, Furman, Itay

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Widespread promoter-mediated coordination of transcription and mRNA degradation von Dori-Bachash, Mally, Shalem, Ophir, Manor, Yair S, Pilpel, Yitzhak, Tirosh, Itay

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Therapeutic genetic variation revealed in diverse Hsp104 homologs von March, Zachary M, Sweeney, Katelyn, Kim, Hanna, Yan, Xiaohui, Castellano, Laura M, Jackrel, Meredith E, Lin, JiaBei, Chuang, Edward, Gomes, Edward, Willicott, Corey W, Michalska, Karolina, Jedrzejczak, Robert P, Joachimiak, Andrzej, Caldwell, Kim A, Caldwell, Guy A, Shalem, Ophir, Shorter, James

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An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients von Phatnani, Hemali, Kwan, Justin, Sareen, Dhruv, Broach, James R., Simmons, Zachary, Arcila-Londono, Ximena, Lee, Edward B., Van Deerlin, Vivianna M., Shneider, Neil A., Fraenkel, Ernest, Ostrow, Lyle W., Baas, Frank, Zaitlen, Noah, Malaspina, Andrea, Fratta, Pietro, Cox, Gregory A., Thompson, Leslie M., Finkbeiner, Steve, Dardiotis, Efthimios, Chandran, Siddharthan, Pal, Suvankar, Hornstein, Eran, MacGowan, Daniel J., Heiman-Patterson, Terry, Hammell, Molly G., Patsopoulos, Nikolaos.A., Butovsky, Oleg, Dubnau, Joshua, Nath, Avindra, Bowser, Robert, Harms, Matt, Poss, Mary, Phillips-Cremins, Jennifer, Crary, John, Atassi, Nazem, Lange, Dale J., Adams, Darius J., Stefanis, Leonidas, Gotkine, Marc, Baloh, Robert H., Babu, Suma, Raj, Towfique, Paganoni, Sabrina, Shalem, Ophir, Smith, Colin, Zhang, Bin, Harris, Brent, Broce, Iris, Drory, Vivian, Ravits, John, McMillan, Corey, Menon, Vilas, Wu, Lani, Altschuler, Steven, Li, Jonathan, Lim, Ryan G., Kaye, Julia A., Dardov, Victoria, Coyne, Alyssa N., Wu, Jie, Milani, Pamela, Cheng, Andrew, Thompson, Terri G., Ornelas, Loren, Frank, Aaron, Adam, Miriam, Banuelos, Maria G., Casale, Malcolm, Cox, Veerle, Escalante-Chong, Renan, Daigle, J. Gavin, Gomez, Emilda, Hayes, Lindsey, Holewenski, Ronald, Lei, Susan, Lenail, Alex, Lima, Leandro, Mandefro, Berhan, Matlock, Andrea, Panther, Lindsay, Patel-Murray, Natasha Leanna, Pham, Jacqueline, Ramamoorthy, Divya, Sachs, Karen, Shelley, Brandon, Stocksdale, Jennifer, Trost, Hannah, Wilhelm, Mark, Venkatraman, Vidya, Wassie, Brook T., Wyman, Stacia, Yang, Stephanie, Van Eyk, Jennifer E., Lloyd, Thomas E., Finkbeiner, Steven, Fraenkel, Ernest, Rothstein, Jeffrey D., Sareen, Dhruv, Svendsen, Clive N., Thompson, Leslie M.

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