Cancer and the Circadian Clock von Shafi, Ayesha A, Knudsen, Karen E

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The circadian cryptochrome, CRY1, is a pro-tumorigenic factor that rhythmically modulates DNA repair von Shafi, Ayesha A., McNair, Chris M., McCann, Jennifer J., Alshalalfa, Mohammed, Shostak, Anton, Severson, Tesa M., Zhu, Yanyun, Bergman, Andre, Gordon, Nicolas, Mandigo, Amy C., Chand, Saswati N., Gallagher, Peter, Dylgjeri, Emanuela, Laufer, Talya S., Vasilevskaya, Irina A., Schiewer, Matthew J., Brunner, Michael, Feng, Felix Y., Zwart, Wilbert, Knudsen, Karen E.

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RB/E2F1 as a Master Regulator of Cancer Cell Metabolism in Advanced Disease von Mandigo, Amy C, Yuan, Wei, Xu, Kexin, Gallagher, Peter, Pang, Angel, Guan, Yi Fang, Shafi, Ayesha A, Thangavel, Chellappagounder, Sheehan, Beshara, Bogdan, Denisa, Paschalis, Alec, McCann, Jennifer J, Laufer, Talya S, Gordon, Nicolas, Vasilevskaya, Irina A, Dylgjeri, Emanuela, Chand, Saswati N, Schiewer, Matthew J, Domingo-Domenech, Josep, Den, Robert B, Holst, Jeff, McCue, Peter A, de Bono, Johann S, McNair, Christopher, Knudsen, Karen E

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Androgen receptor and its splice variant, AR-V7, differentially regulate FOXA1 sensitive genes in LNCaP prostate cancer cells von Krause, William C., Shafi, Ayesha A., Nakka, Manjula, Weigel, Nancy L.

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USP22 Functions as an Oncogenic Driver in Prostate Cancer by Regulating Cell Proliferation and DNA Repair von McCann, Jennifer J, Vasilevskaya, Irina A, Poudel Neupane, Neermala, Shafi, Ayesha A, McNair, Christopher, Dylgjeri, Emanuela, Mandigo, Amy C, Schiewer, Matthew J, Schrecengost, Randy S, Gallagher, Peter, Stanek, Timothy J, McMahon, Steven B, Berman-Booty, Lisa D, Ostrander, Jr, William F, Knudsen, Karen E

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Mutant p53 elicits context-dependent pro-tumorigenic phenotypes von McCann, Jennifer J., Vasilevskaya, Irina A., McNair, Christopher, Gallagher, Peter, Neupane, Neermala Poudel, de Leeuw, Renée, Shafi, Ayesha A., Dylgjeri, Emanuela, Mandigo, Amy C., Schiewer, Matthew J., Knudsen, Karen E.

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Cistrome and transcriptome analysis identifies unique androgen receptor (AR) and AR-V7 splice variant chromatin binding and transcriptional activities von Basil, Paul, Robertson, Matthew J., Bingman, William E., Dash, Amit K., Krause, William C., Shafi, Ayesha A., Piyarathna, Badrajee, Coarfa, Cristian, Weigel, Nancy L.

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Differential regulation of metabolic pathways by androgen receptor (AR) and its constitutively active splice variant, AR-V7, in prostate cancer cells von Shafi, Ayesha A, Putluri, Vasanta, Arnold, James M, Tsouko, Efrosini, Maity, Suman, Roberts, Justin M, Coarfa, Cristian, Frigo, Daniel E, Putluri, Nagireddy, Sreekumar, Arun, Weigel, Nancy L

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Androgen receptor splice variants are resistant to inhibitors of Hsp90 and FKBP52, which alter androgen receptor activity and expression von Shafi, Ayesha A., Cox, Marc B., Weigel, Nancy L.

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Androgen receptors in hormone-dependent and castration-resistant prostate cancer von SHAFI, Ayesha A, YEN, Aihua E, WEIGEL, Nancy L

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Potent activity of the Hsp90 inhibitor ganetespib in prostate cancer cells irrespective of androgen receptor status or variant receptor expression von HE, SUQIN, ZHANG, CHAOHUA, SHAFI, AYESHA A, SEQUEIRA, MANUEL, ACQUAVIVA, JAIME, FRIEDLAND, JULIE C, SANG, JIM, SMITH, DONALD L, WEIGEL, NANCY L, WADA, YUMIKO, PROIA, DAVID A

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Temporal Considerations in Brain Metastases Radiation Therapy: The Intersection of Chronobiology and Patient Profiles von Nelson, Nicolas G, Burke, Sara E, Cappelli, Louis, Matlack, Lauren E, Smith, Alexandria P, Francois, Noelle, Lombardo, Joseph F, Shah, Yash B, Wen, Kuang-Yi, Shafi, Ayesha A, Simone, Nicole L

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Time Matters: Importance of Circadian Rhythms, Disruption, and Chronotherapy in Urologic Malignancies von Pence, Sierra T., Chesnut, Gregory T., Shafi, Ayesha A.

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Novel Oncogenic Transcription Factor Cooperation in RB-Deficient Cancer von Mandigo, Amy C, Shafi, Ayesha A, McCann, Jennifer J, Yuan, Wei, Laufer, Talya S, Bogdan, Denisa, Gallagher, Lewis, Dylgjeri, Emanuela, Semenova, Galina, Vasilevskaya, Irina A, Schiewer, Matthew J, McNair, Chris M, de Bono, Johann S, Knudsen, Karen E

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A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer von Dylgjeri, Emanuela, Kothari, Vishal, Shafi, Ayesha A, Semenova, Galina, Gallagher, Peter T, Guan, Yi F, Pang, Angel, Goodwin, Jonathan F, Irani, Swati, McCann, Jennifer J, Mandigo, Amy C, Chand, Saswati, McNair, Christopher M, Vasilevskaya, Irina, Schiewer, Matthew J, Lallas, Costas D, McCue, Peter A, Gomella, Leonard G, Seifert, Erin L, Carroll, Jason S, Butler, Lisa M, Holst, Jeff, Kelly, William K, Knudsen, Karen E

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AR coactivators, CBP/p300, are critical mediators of DNA repair in prostate cancer von Sardar, Sumaira, McNair, Christopher M., Ravindranath, Lakshmi, Chand, Saswati N., Yuan, Wei, Bogdan, Denisa, Welti, Jon, Sharp, Adam, Ryan, Natalie K., Knudsen, Liam A., Schiewer, Matthew J., DeArment, Elise G., Janas, Thomas, Su, Xiaofeng A., Butler, Lisa M., de Bono, Johann S., Frese, Kris, Brooks, Nigel, Pegg, Neil, Knudsen, Karen E., Shafi, Ayesha A.

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Pleiotropic Impact of DNA-PK in Cancer and Implications for Therapeutic Strategies von Dylgjeri, Emanuela, McNair, Christopher, Goodwin, Jonathan F, Raymon, Heather K, McCue, Peter A, Shafi, Ayesha A, Leiby, Benjamin E, de Leeuw, Renée, Kothari, Vishal, McCann, Jennifer J, Mandigo, Amy C, Chand, Saswati N, Schiewer, Matthew J, Brand, Lucas J, Vasilevskaya, Irina, Gordon, Nicolas, Laufer, Talya S, Gomella, Leonard G, Lallas, Costas D, Trabulsi, Edouard J, Feng, Felix Y, Filvaroff, Ellen H, Hege, Kristin, Rathkopf, Dana, Knudsen, Karen E

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Patient-derived Models Reveal Impact of the Tumor Microenvironment on Therapeutic Response von Shafi, Ayesha A., Schiewer, Matthew J., de Leeuw, Renée, Dylgjeri, Emanuela, McCue, Peter A., Shah, Neelima, Gomella, Leonard G., Lallas, Costas D., Trabulsi, Edouard J., Centenera, Margaret M., Hickey, Theresa E., Butler, Lisa M., Raj, Ganesh V., Tilley, Wayne D., Cukierman, Edna, Knudsen, Karen E.

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Abstract A048: The importance of time: Circadian rhythm disruption and prostate cancer von Pence, Sierra T., Shafi, Ayesha A.

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PARP‐1 regulates DNA repair factor availability von Schiewer, Matthew J, Mandigo, Amy C, Gordon, Nicolas, Huang, Fangjin, Gaur, Sanchaika, de Leeuw, Renée, Zhao, Shuang G, Evans, Joseph, Han, Sumin, Parsons, Theodore, Birbe, Ruth, McCue, Peter, McNair, Christopher, Chand, Saswati N, Cendon‐Florez, Ylenia, Gallagher, Peter, McCann, Jennifer J, Poudel Neupane, Neermala, Shafi, Ayesha A, Dylgjeri, Emanuela, Brand, Lucas J, Visakorpi, Tapio, Raj, Ganesh V, Lallas, Costas D, Trabulsi, Edouard J, Gomella, Leonard G, Dicker, Adam P, Kelly, Wm. Kevin, Leiby, Benjamin E, Knudsen, Beatrice, Feng, Felix Y, Knudsen, Karen E

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