Inhibition of phosphodiesterase 10A has differential effects on dopamine D1 and D2 receptor modulation of sensorimotor gating von Gresack, Jodi E., Seymour, Patricia A., Schmidt, Christopher J., Risbrough, Victoria B.

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Phosphodiesterase 9A Regulates Central cGMP and Modulates Responses to Cholinergic and Monoaminergic Perturbation In Vivo von Kleiman, Robin J., Chapin, Douglas S., Christoffersen, Curt, Freeman, Jody, Fonseca, Kari R., Geoghegan, Kieran F., Grimwood, Sarah, Guanowsky, Victor, Hajós, Mihály, Harms, John F., Helal, Christopher J., Hoffmann, William E., Kocan, Geralyn P., Majchrzak, Mark J., McGinnis, Dina, McLean, Stafford, Menniti, Frank S., Nelson, Fredrick, Roof, Robin, Schmidt, Anne W., Seymour, Patricia A., Stephenson, Diane T., Tingley, Francis David, Vanase-Frawley, Michelle, Verhoest, Patrick R., Schmidt, Christopher J.

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Pharmacological disruption of mouse social approach behavior: Relevance to negative symptoms of schizophrenia von Hanks, Ashley N., Dlugolenski, Keith, Hughes, Zoë A., Seymour, Patricia A., Majchrzak, Mark J.

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CP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychotic activity von Siuciak, Judith A, Chapin, Douglas S, McCarthy, Sheryl A, Guanowsky, Victor, Brown, Janice, Chiang, Phoebe, Marala, Ravi, Patterson, Terrell, Seymour, Patricia A, Swick, Andrew, Iredale, Philip A

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Prevention of ketamine-induced working memory impairments by AMPA potentiators in a nonhuman primate model of cognitive dysfunction von Roberts, Brooke M., Holden, Daniel E., Shaffer, Christopher L., Seymour, Patricia A., Menniti, Frank S., Schmidt, Christopher J., Williams, Graham V., Castner, Stacy A.

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Modulation of NMDA receptor function by inhibition of d-amino acid oxidase in rodent brain von Strick, Christine A., Li, Cheryl, Scott, Liam, Harvey, Brian, Hajós, Mihály, Steyn, Stefanus J., Piotrowski, Mary A., James, Larry C., Downs, James T., Rago, Brian, Becker, Stacey L., El-Kattan, Ayman, Xu, Youfen, Ganong, Alan H., Tingley, F. David, Ramirez, Andres D., Seymour, Patricia A., Guanowsky, Victor, Majchrzak, Mark J., Fox, Carol B., Schmidt, Christopher J., Duplantier, Allen J.

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Reduction of brain kynurenic acid improves cognitive function von Kozak, Rouba, Campbell, Brian M, Strick, Christine A, Horner, Weldon, Hoffmann, William E, Kiss, Tamas, Chapin, Douglas S, McGinnis, Dina, Abbott, Amanda L, Roberts, Brooke M, Fonseca, Kari, Guanowsky, Victor, Young, Damon A, Seymour, Patricia A, Dounay, Amy, Hajos, Mihaly, Williams, Graham V, Castner, Stacy A

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Preclinical pharmacology of the α4β2 nAChR partial agonist varenicline related to effects on reward, mood and cognition von Rollema, Hans, Hajós, Mihály, Seymour, Patricia A., Kozak, Rouba, Majchrzak, Mark J., Guanowsky, Victor, Horner, Weldon E., Chapin, Doug S., Hoffmann, William E., Johnson, David E., Mclean, Stafford, Freeman, Jody, Williams, Kathryn E.

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Preclinical pharmacology of the alpha 4 beta 2 nAChR partial agonist varenicline related to effects on reward, mood and cognition von Rollema, Hans, Hajos, Mihaly, Seymour, Patricia A, Kozak, Rouba, Majchrzak, Mark J, Guanowsky, Victor, Horner, Weldon E, Chapin, Doug S, Hoffmann, William E, Johnson, David E, Mclean, Stafford, Freeman, Jody, Williams, Kathryn E

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Identification of a Potent, Highly Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor Clinical Candidate von Helal, Christopher J, Arnold, Eric, Boyden, Tracey, Chang, Cheng, Chappie, Thomas A, Fisher, Ethan, Hajos, Mihaly, Harms, John F, Hoffman, William E, Humphrey, John M, Pandit, Jayvardhan, Kang, Zhijun, Kleiman, Robin J, Kormos, Bethany L, Lee, Che-Wah, Lu, Jiemin, Maklad, Noha, McDowell, Laura, McGinnis, Dina, O’Connor, Rebecca E, O’Donnell, Christopher J, Ogden, Adam, Piotrowski, Mary, Schmidt, Christopher J, Seymour, Patricia A, Ueno, Hirokazu, Vansell, Nichole, Verhoest, Patrick R, Yang, Edward X

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Varenicline has antidepressant-like activity in the forced swim test and augments sertraline's effect von Rollema, Hans, Guanowsky, Victor, Mineur, Yann S., Shrikhande, Alka, Coe, Jotham W., Seymour, Patricia A., Picciotto, Marina R.

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The Discovery and Characterization of the α‑Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Potentiator N‑{(3S,4S)‑4-[4-(5-Cyano-2-thienyl)phenoxy]tetrahydrofura... von Shaffer, Christopher L, Patel, Nandini C, Schwarz, Jacob, Scialis, Renato J, Wei, Yunjing, Hou, Xinjun J, Xie, Longfei, Karki, Kapil, Bryce, Dianne K, Osgood, Sarah M, Hoffmann, William E, Lazzaro, John T, Chang, Cheng, McGinnis, Dina F, Lotarski, Susan M, Liu, JianHua, Obach, R. Scott, Weber, Mark L, Chen, Laigao, Zasadny, Kenneth R, Seymour, Patricia A, Schmidt, Christopher J, Hajós, Mihály, Hurst, Raymond S, Pandit, Jayvardhan, O’Donnell, Christopher J

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Amelioration of ketamine-induced working memory deficits by dopamine D1 receptor agonists von Roberts, Brooke M., Seymour, Patricia A., Schmidt, Christopher J., Williams, Graham V., Castner, Stacy A.

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Glycine transporter inhibition reverses ketamine-induced working memory deficits von Roberts, Brooke M, Shaffer, Christopher L, Seymour, Patricia A, Schmidt, Christopher J, Williams, Graham V, Castner, Stacy A

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Hyperphosphorylated Tau and Neurofilament and Cytoskeletal Disruptions in Mice Overexpressing Human p25, an Activator of cdk5 von Ahlijanian, M K, Barrezueta, N X, Williams, R D, Jakowski, A, Kowsz, K P, McCarthy, S, Coskran, T, Carlo, A, Seymour, P A, Burkhardt, J E, Nelson, R B, McNeish, J D

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Cdk5 as a drug target for the treatment of Alzheimer's disease von Lau, Lit-Fui, Seymour, Patricia A, Sanner, Mark A, Schachter, Joel B

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4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants von Sarges, Reinhard, Howard, Harry R, Browne, Ronald G, Lebel, Lorraine A, Seymour, Patricia A, Koe, B. Kenneth

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Dendritic spine density deficits in the hippocampal CA1 region of young Tg2576 mice are ameliorated with the PDE9A inhibitor PF-04447943 von Kleiman, Robin J, Lanz, Thomas A, Finley, James E, Bove, Susan E, Majchrzak, Mark J, Becker, Stacey L, Carvajal-Gonzales, Santos, Kuhn, A. Max, Wood, Kathleen M, Mariga, Abigail, Nelson, Frederick R, Verhoest, Patrick R, Seymour, Patricia A, Stephenson, Diane T

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CP-465,022, a selective noncompetitive AMPA receptor antagonist, blocks AMPA receptors but is not neuroprotective in vivo von MENNITI, Frank S, BUCHAN, Alistair M, CHENARD, Bertrand L, CRITCHETT, Donald J, GANONG, Alan H, GUANOWSKY, Victor, SEYMOUR, Patricia A, WELCH, Willard M

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The Pharmacology of CP‐154,526, a Non‐Peptide Antagonist of the CRH1 Receptor: A Review von Seymour, Patricia A., Schmidt, Anne W., Schulz, David W.

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