Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation von Hanan, Emily J, Eigenbrot, Charles, Bryan, Marian C, Burdick, Daniel J, Chan, Bryan K, Chen, Yuan, Dotson, Jennafer, Heald, Robert A, Jackson, Philip S, La, Hank, Lainchbury, Michael D, Malek, Shiva, Purkey, Hans E, Schaefer, Gabriele, Schmidt, Stephen, Seward, Eileen M, Sideris, Steve, Tam, Christine, Wang, Shumei, Yeap, Siew Kuen, Yen, Ivana, Yin, Jianping, Yu, Christine, Zilberleyb, Inna, Heffron, Timothy P

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Potent and Highly Selective Benzimidazole Inhibitors of PI3-Kinase Delta von Murray, Jeremy M, Sweeney, Zachary K, Chan, Bryan K, Balazs, Mercedesz, Bradley, Erin, Castanedo, Georgette, Chabot, Christine, Chantry, David, Flagella, Michael, Goldstein, David M, Kondru, Rama, Lesnick, John, Li, Jun, Lucas, Matthew C, Nonomiya, Jim, Pang, Jodie, Price, Stephen, Salphati, Laurent, Safina, Brian, Savy, Pascal P. A, Seward, Eileen M, Ultsch, Mark, Sutherlin, Daniel P

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Discovery of a Noncovalent, Mutant-Selective Epidermal Growth Factor Receptor Inhibitor von Chan, Bryan K, Hanan, Emily J, Bowman, Krista K, Bryan, Marian C, Burdick, Daniel, Chan, Emily, Chen, Yuan, Clausen, Saundra, Dela Vega, Trisha, Dotson, Jennafer, Eigenbrot, Charles, Elliott, Richard L, Heald, Robert A, Jackson, Philip S, Knight, Jamie D, La, Hank, Lainchbury, Michael D, Malek, Shiva, Purkey, Hans E, Schaefer, Gabriele, Schmidt, Stephen, Seward, Eileen M, Sideris, Steve, Shao, Lily, Wang, Shumei, Yeap, Siew Kuen, Yen, Ivana, Yu, Christine, Heffron, Timothy P

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Discovery of Novel PI3-Kinase δ Specific Inhibitors for the Treatment of Rheumatoid Arthritis: Taming CYP3A4 Time-Dependent Inhibition von Safina, Brian S, Baker, Stewart, Baumgardner, Matt, Blaney, Paul M, Chan, Bryan K, Chen, Yung-Hsiang, Cartwright, Matthew W, Castanedo, Georgette, Chabot, Christine, Cheguillaume, Arnaud J, Goldsmith, Paul, Goldstein, David M, Goyal, Bindu, Hancox, Timothy, Handa, Raj K, Iyer, Pravin S, Kaur, Jasmit, Kondru, Rama, Kenny, Jane R, Krintel, Sussie L, Li, Jun, Lesnick, John, Lucas, Matthew C, Lewis, Cristina, Mukadam, Sophie, Murray, Jeremy, Nadin, Alan J, Nonomiya, Jim, Padilla, Fernando, Palmer, Wylie S, Pang, Jodie, Pegg, Neil, Price, Steve, Reif, Karin, Salphati, Laurent, Savy, Pascal A, Seward, Eileen M, Shuttleworth, Stephen, Sohal, Sukhjit, Sweeney, Zachary K, Tay, Suzanne, Tivitmahaisoon, Parcharee, Waszkowycz, Bohdan, Wei, Binqing, Yue, Qin, Zhang, Chenghong, Sutherlin, Daniel P

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Design of Selective Benzoxazepin PI3Kδ Inhibitors Through Control of Dihedral Angles von Safina, Brian S, Elliott, Richard L, Forrest, Andrew K, Heald, Robert A, Murray, Jeremy M, Nonomiya, Jim, Pang, Jodie, Salphati, Laurent, Seward, Eileen M, Staben, Steven T, Ultsch, Mark, Wei, Binqing, Yang, Wenqian, Sutherlin, Daniel P

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Potent and selective inhibitors of PI3Kδ: Obtaining isoform selectivity from the affinity pocket and tryptophan shelf von Sutherlin, Daniel P., Baker, Stewart, Bisconte, Angelina, Blaney, Paul M., Brown, Anthony, Chan, Bryan K., Chantry, David, Castanedo, Georgette, DePledge, Paul, Goldsmith, Paul, Goldstein, David M., Hancox, Timothy, Kaur, Jasmit, Knowles, David, Kondru, Rama, Lesnick, John, Lucas, Matthew C., Lewis, Cristina, Murray, Jeremy, Nadin, Alan J., Nonomiya, Jim, Pang, Jodie, Pegg, Neil, Price, Steve, Reif, Karin, Safina, Brian S., Salphati, Laurent, Staben, Steven, Seward, Eileen M., Shuttleworth, Stephen, Sohal, Sukhjit, Sweeney, Zachary K., Ultsch, Mark, Waszkowycz, Bohdan, Wei, Binqing

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Identification of GNE-293, a potent and selective PI3Kδ inhibitor: Navigating in vitro genotoxicity while improving potency and selectivity von Safina, Brian S., Sweeney, Zachary K., Li, Jun, Chan, Bryan K., Bisconte, Angelina, Carrera, Diane, Castanedo, Georgette, Flagella, Michael, Heald, Robert, Lewis, Cristina, Murray, Jeremy M., Nonomiya, Jim, Pang, Jodie, Price, Steve, Reif, Karin, Salphati, Laurent, Seward, Eileen M., Wei, Binqing, Sutherlin, Daniel P.

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Cyclophane-arene inclusion complexation in protic solvents: solvent effects versus electron donor-acceptor interactions von Ferguson, Stephen B, Sanford, Elizabeth M, Seward, Eileen M, Diederich, Francois

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Substituent Effects on Edge-to-Face Aromatic Interactions von Carver, Fiona J., Hunter, Christopher A., Livingstone, David J., McCabe, James F., Seward, Eileen M.

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Redox-dependent binding ability of a flavin cyclophane in aqueous solution: hydrophobic stacking versus cavity-inclusion complexation von Seward, Eileen M, Hopkins, R. Bruce, Sauerer, Wolfgang, Tam, Suk Wah, Diederich, Francois

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Molecular receptors. Synthesis and x-ray crystal structure of a calix[4] arene tetracarbonate-acetonitrile (1:1) clathrate von McKervey, M. Anthony, Seward, Eileen M, Ferguson, George, Ruhl, Barbara L

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Spirocyclic NK1 antagonists I:[4.5] and [5.5]-spiroketals von SEWARD, Eileen M, CARLSON, Emma, SADOWSKI, Sharon J, SWAIN, Christopher J, WILLIAMS, Brian J, HARRISON, Timothy, HAWORTH, Karen E, HERBERT, Richard, KELLEHER, Fintan J, KURTZ, Marc M, MOSELEY, Jonathan, OWEN, Simon N, OWENS, Andrew P

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Substituent effects on edge-to-face aromatic interactions von Carver, Fiona J, Hunter, Christopher A, Livingstone, David J, McCabe, James F, Seward, Eileen M

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Caesium-selective poly(vinyl chloride) membrane electrodes based on calix[6]arene esters von Cadogan, Aodhmar, Diamond, Dermot, Smyth, Malcolm R., Svehla, Gyula, McKervey, M. Anthony, Seward, Eileen M., Harris, Stephen J.

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Potent and selective inhibitors of PI3KI': Obtaining isoform selectivity from the affinity pocket and tryptophan shelf von Sutherlin, Daniel P, Baker, Stewart, Bisconte, Angelina, Blaney, Paul M, Brown, Anthony, Chan, Bryan K, Chantry, David, Castanedo, Georgette, DePledge, Paul, Goldsmith, Paul, Goldstein, David M, Hancox, Timothy, Kaur, Jasmit, Knowles, David, Kondru, Rama, Lesnick, John, Lucas, Matthew C, Lewis, Cristina, Murray, Jeremy, Nadin, Alan J, Nonomiya, Jim, Pang, Jodie, Pegg, Neil, Price, Steve, Reif, Karin, Safina, Brian S, Salphati, Laurent, Staben, Steven, Seward, Eileen M, Shuttleworth, Stephen, Sohal, Sukhjit, Sweeney, Zachary K, Ultsch, Mark, Waszkowycz, Bohdan, Wei, Binqing

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Structure–activity relationship for quantifying aromatic interactions von Carver, Fiona J., Hunter, Christopher A., Seward, Eileen M.

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Cation complexation by chemically modified calixarenes. Part 7. Transport of alkali cations by p-tert-butylcalix[n]arene esters and amides von Arnaud-Neu, Fran oise, Fanni, Stefano, Guerra, Lourdes, McGregor, William, Ziat, Khadija, Schwing-Weill, Marie-Jos, Barrett, Geraldine, McKervey, M. Anthony, Marrs, Deborah, Seward, Eileen M.

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Synthesis, X-ray crystal structures, and cation transfer properties of alkyl calixaryl acetates, a new series of molecular receptors von MCKERVEY, M. A, SEWARD, E. M, FERGUSON, G, RUHL, B, HARRIS, S. J

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Synthesis, X-ray crystal structure, and cation transfer properties of a Calix[4]arene tetraketone, a new versatile molecular receptor von FERGUSON, G, KAITNER, B, MCKERVEY, M. A, SEWARD, E. M

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Quantitative Measurements of Edge-to-Face Aromatic Interactions by Using Chemical Double-Mutant Cycles von Carver, Fiona J., Hunter, Christopher A., Jones, Philip S., Livingstone, David J., McCabe, James F., Seward, Eileen M., Tiger, Pascale, Spey, Sharon E.

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