Cell line-based platforms to evaluate the therapeutic efficacy of candidate anticancer agents von Sharma, Sreenath V, Haber, Daniel A, Settleman, Jeff

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The Cancer Stem Cell Marker Aldehyde Dehydrogenase Is Required to Maintain a Drug-Tolerant Tumor Cell Subpopulation von RAHA, Debasish, WILSON, Timothy R, JING PENG, PETERSON, David, PENG YUE, EVANGELISTA, Marie, WILSON, Catherine, MERCHANT, Mark, SETTLEMAN, Jeff

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Personalized Cancer Therapy With Selective Kinase Inhibitors: An Emerging Paradigm in Medical Oncology von MCDERMOTT, Ultan, SETTLEMAN, Jeff

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Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors von Wilson, Timothy R., Fridlyand, Jane, Yan, Yibing, Penuel, Elicia, Burton, Luciana, Chan, Emily, Peng, Jing, Lin, Eva, Wang, Yulei, Sosman, Jeff, Ribas, Antoni, Li, Jiang, Moffat, John, Sutherlin, Daniel P., Koeppen, Hartmut, Merchant, Mark, Neve, Richard, Settleman, Jeff

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Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism von Perera, Rushika M., Stoykova, Svetlana, Nicolay, Brandon N., Ross, Kenneth N., Fitamant, Julien, Boukhali, Myriam, Lengrand, Justine, Deshpande, Vikram, Selig, Martin K., Ferrone, Cristina R., Settleman, Jeff, Stephanopoulos, Gregory, Dyson, Nicholas J., Zoncu, Roberto, Ramaswamy, Sridhar, Haas, Wilhelm, Bardeesy, Nabeel

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Unprovoked Stabilization and Nuclear Accumulation of the Naked Mole-Rat p53 Protein von Deuker, Marian M., Lewis, Kaitlyn N., Ingaramo, Maria, Kimmel, Jacob, Buffenstein, Rochelle, Settleman, Jeff

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A Therapeutic Opportunity in Melanoma: ErbB4 Makes a Mark on Skin von Settleman, Jeff

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A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations von Sharma, Sreenath V., Lee, Diana Y., Li, Bihua, Quinlan, Margaret P., Takahashi, Fumiyuki, Maheswaran, Shyamala, McDermott, Ultan, Azizian, Nancy, Zou, Lee, Fischbach, Michael A., Wong, Kwok-Kin, Brandstetter, Kathleyn, Wittner, Ben, Ramaswamy, Sridhar, Classon, Marie, Settleman, Jeff

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Repression of Stress-Induced LINE-1 Expression Protects Cancer Cell Subpopulations from Lethal Drug Exposure von Guler, Gulfem Dilek, Tindell, Charles Albert, Pitti, Robert, Wilson, Catherine, Nichols, Katrina, KaiWai Cheung, Tommy, Kim, Hyo-Jin, Wongchenko, Matthew, Yan, Yibing, Haley, Benjamin, Cuellar, Trinna, Webster, Joshua, Alag, Navneet, Hegde, Ganapati, Jackson, Erica, Nance, Tracy Leah, Giresi, Paul Garrett, Chen, Kuan-Bei, Liu, Jinfeng, Jhunjhunwala, Suchit, Settleman, Jeff, Stephan, Jean-Philippe, Arnott, David, Classon, Marie

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Overcoming EMT-associated resistance to anti-cancer drugs via Src/FAK pathway inhibition von Wilson, Catherine, Nicholes, Katrina, Bustos, Daisy, Lin, Eva, Song, Qinghua, Stephan, Jean-Philippe, Kirkpatrick, Donald S, Settleman, Jeff

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Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers von Sulahian, Rita, Kwon, Jason J., Walsh, Katherine H., Pailler, Emma, Bosse, Timothy L., Thaker, Maneesha, Almanza, Diego, Dempster, Joshua M., Pan, Joshua, Piccioni, Federica, Dumont, Nancy, Gonzalez, Alfredo, Rennhack, Jonathan, Nabet, Behnam, Bachman, John A., Goodale, Amy, Lee, Yenarae, Bagul, Mukta, Liao, Rosy, Navarro, Adrija, Yuan, Tina L., Ng, Raymond W.S., Raghavan, Srivatsan, Gray, Nathanael S., Tsherniak, Aviad, Vazquez, Francisca, Root, David E., Firestone, Ari J., Settleman, Jeff, Hahn, William C., Aguirre, Andrew J.

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Functional screening implicates miR-371-3p and peroxiredoxin 6 in reversible tolerance to cancer drugs von Sahu, Nisebita, Stephan, Jean-Philippe, Cruz, Darlene Dela, Merchant, Mark, Haley, Benjamin, Bourgon, Richard, Classon, Marie, Settleman, Jeff

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Regulation of autophagy, NF-κB signaling, and cell viability by miR-124 in KRAS mutant mesenchymal-like NSCLC cells von Mehta, Anita K, Hua, Kevin, Whipple, William, Nguyen, Minh-Thuy, Liu, Ching-Ti, Haybaeck, Johannes, Weidhaas, Joanne, Settleman, Jeff, Singh, Anurag

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Abstract A1-19: A comprehensive transcriptional portrait of human cancer cell lines von Klijn, Christiaan, Settleman, Jeff, Seshagiri, Somasekar, Zhang, Zemin

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Metabolic and transcriptional profiling reveals pyruvate dehydrogenase kinase 4 as a mediator of epithelial-mesenchymal transition and drug resistance in tumor cells von Sun, Yuting, Daemen, Anneleen, Hatzivassiliou, Georgia, Arnott, David, Wilson, Catherine, Zhuang, Guanglei, Gao, Min, Liu, Peter, Boudreau, Aaron, Johnson, Leisa, Settleman, Jeff

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Epidermal Growth Factor Receptor Kinase Domain Mutations in Esophageal and Pancreatic Adenocarcinomas von KWAK, Eunice L, JANKOWSKI, Janusz, MUIR, Beth, SETTLEMAN, Jeff, FUCHS, Charles S, KULKE, Matthew H, RYAN, David P, CLARK, Jeff W, SGROI, Dennis C, HABER, Daniel A, BELL, Daphne W, THAYER, Sarah P, LAUWERS, Gregory Y, BRANNIGAN, Brian W, HARRIS, Patricia L, OKIMOTO, Ross A, HASERLAT, Sara M, DRISCOLL, David R, FERRY, David

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Emerging Trends in Cancer Drug Discovery-From Drugging the "Undruggable" to Overcoming Resistance von Rudolph, Joachim, Settleman, Jeff, Malek, Shiva

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DOCK4, a GTPase Activator, Is Disrupted during Tumorigenesis von Yajnik, Vijay, Paulding, Charles, Sordella, Raffaella, McClatchey, Andrea I., Saito, Mako, Wahrer, Doke C.R., Reynolds, Paul, Bell, Daphne W., Lake, Robert, van den Heuvel, Sander, Settleman, Jeff, Haber, Daniel A.

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Predicting response to HER2 kinase inhibition von Settleman, Jeff

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Integrating complex genomic datasets and tumour cell sensitivity profiles to address a 'simple' question: which patients should get this drug? von Benes, Cyril, Settleman, Jeff

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