5′-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates von Parmar, Rubina, Willoughby, Jennifer L. S., Liu, Jingxuan, Foster, Donald J., Brigham, Benjamin, Theile, Christopher S., Charisse, Klaus, Akinc, Akin, Guidry, Erin, Pei, Yi, Strapps, Walter, Cancilla, Mark, Stanton, Matthew G., Rajeev, Kallanthottathil G., Sepp-Lorenzino, Laura, Manoharan, Muthiah, Meyers, Rachel, Maier, Martin A., Jadhav, Vasant

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Knockdown of Virus Antigen Expression Increases Therapeutic Vaccine Efficacy in High-Titer Hepatitis B Virus Carrier Mice von Michler, Thomas, Kosinska, Anna D., Festag, Julia, Bunse, Till, Su, Jinpeng, Ringelhan, Marc, Imhof, Hortenzia, Grimm, Dirk, Steiger, Katja, Mogler, Carolin, Heikenwalder, Mathias, Michel, Marie-Louise, Guzman, Carlos A., Milstein, Stuart, Sepp-Lorenzino, Laura, Knolle, Percy, Protzer, Ulrike

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Micro RNA 145 Targets the Insulin Receptor Substrate-1 and Inhibits the Growth of Colon Cancer Cells von Shi, Bin, Sepp-Lorenzino, Laura, Prisco, Marco, Linsley, Peter, deAngelis, Tiziana, Baserga, Renato

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Evaluation of Efficacy, Biodistribution, and Inflammation for a Potent siRNA Nanoparticle: Effect of Dexamethasone Co-treatment von Abrams, Marc T, Koser, Martin L, Seitzer, Jessica, Williams, Stephanie C, DiPietro, Martha A, Wang, Weimin, Shaw, Andrew W, Mao, Xianzhi, Jadhav, Vasant, Davide, Joseph P, Burke, Paul A, Sachs, Alan B, Stirdivant, Steven M, Sepp-Lorenzino, Laura

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Induction of apoptosis by an inhibitor of the mitotic kinesin KSP requires both activation of the spindle assembly checkpoint and mitotic slippage von Tao, Weikang, South, Victoria J., Zhang, Yun, Davide, Joseph P., Farrell, Linda, Kohl, Nancy E., Sepp-Lorenzino, Laura, Lobell, Robert B.

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Silencing Myostatin Using Cholesterol-conjugated siRNAs Induces Muscle Growth von Khan, Tayeba, Weber, Hans, DiMuzio, Jillian, Matter, Andrea, Dogdas, Belma, Shah, Tosha, Thankappan, Anil, Disa, Jyoti, Jadhav, Vasant, Lubbers, Laura, Sepp-Lorenzino, Laura, Strapps, Walter R, Tadin-Strapps, Marija

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Intratracheal Administration of siRNA Triggers mRNA Silencing in the Lung to Modulate T Cell Immune Response and Lung Inflammation von Ng, Bruce, Cash-Mason, Tanesha, Wang, Yi, Seitzer, Jessica, Burchard, Julja, Brown, Duncan, Dudkin, Vadim, Davide, Joseph, Jadhav, Vasant, Sepp-Lorenzino, Laura, Cejas, Pedro J.

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Mechanistically Probing Lipid-siRNA Nanoparticle-associated Toxicities Identifies Jak Inhibitors Effective in Mitigating Multifaceted Toxic Responses von Tao, Weikang, Mao, Xianzhi, Davide, Joseph P, Ng, Bruce, Cai, Mingmei, Burke, Paul A, Sachs, Alan B, Sepp-Lorenzino, Laura

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Quantitative evaluation of siRNA delivery in vivo von Pei, Yi, Hancock, Paula J, Zhang, Hangchun, Bartz, René, Cherrin, Craig, Innocent, Nathalie, Pomerantz, Colin J, Seitzer, Jessica, Koser, Martin L, Abrams, Marc T, Xu, Yan, Kuklin, Nelly A, Burke, Paul A, Sachs, Alan B, Sepp-Lorenzino, Laura, Barnett, Stanley F

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Effective siRNA delivery and target mRNA degradation using an amphipathic peptide to facilitate pH-dependent endosomal escape von Bartz, René, Fan, Haihong, Zhang, Jingtao, Innocent, Nathalie, Cherrin, Craig, Beck, Stephen C, Pei, Yi, Momose, Aaron, Jadhav, Vasant, Tellers, David M, Meng, Fanyu, Crocker, Louis S, Sepp-Lorenzino, Laura, Barnett, Stanley F

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Expression of Micro-RNA-145 is regulated by a highly conserved genomic sequence 3′ to the pre-miR von La Rocca, Gaspare, Shi, Bin, Sepp-Lorenzino, Laura, Baserga, Renato

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Systematic chemical modifications of single stranded siRNAs significantly improved CTNNB1 mRNA silencing von Chang, Wonsuk, Pei, Yi, Guidry, Erin N., Zewge, Daniel, Parish, Craig A., Sherer, Edward C., DiMuzio, Jillian, Zhang, Hangchun, South, Victoria J., Strapps, Walter R., Sepp-Lorenzino, Laura, Colletti, Steven L., Stanton, Matthew G.

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An allosteric Akt inhibitor effectively blocks Akt signaling and tumor growth with only transient effects on glucose and insulin levels in vivo von Cherrin, Craig, Haskell, Kathleen, Howell, Bonnie, Jones, Raymond, Leander, Karen, Robinson, Ronald, Watkins, Aubrey, Bilodeau, Mark, Hoffman, Jacob, Sanderson, Philip, Hartman, George, Mahan, Elizabeth, Prueksaritanont, Thomayant, Jiang, Guoqiang, She, Qing-Bai, Rosen, Neal, Sepp-Lorenzino, Laura, Defeo-Jones, Deborah, Huber, Hans E.

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Inside Cover: 5′-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates (ChemBioChem 11/2016) von Parmar, Rubina, Willoughby, Jennifer L. S., Liu, Jingxuan, Foster, Donald J., Brigham, Benjamin, Theile, Christopher S., Charisse, Klaus, Akinc, Akin, Guidry, Erin, Pei, Yi, Strapps, Walter, Cancilla, Mark, Stanton, Matthew G., Rajeev, Kallanthottathil G., Sepp-Lorenzino, Laura, Manoharan, Muthiah, Meyers, Rachel, Maier, Martin A., Jadhav, Vasant

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Pharmacologic Shifting of a Balance between Protein Refolding and Degradation Mediated by Hsp90 von Schneider, Christine, Sepp-Lorenzino, Laura, Nimmesgern, Elmar, Ouerfelli, Ouathek, Danishefsky, Samuel, Rosen, Neal, Hartl, F. Ulrich

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A Farnesyl-Protein Transferase Inhibitor Induces p21 Expression and G1 Block in p53 Wild Type Tumor Cells von Sepp-Lorenzino, Laura, Rosen, Neal

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An Inhibitor of the Kinesin Spindle Protein Activates the Intrinsic Apoptotic Pathway Independently of p53 and De Novo Protein Synthesis von Tao, Weikang, South, Victoria J., Diehl, Ronald E., Davide, Joseph P., Sepp-Lorenzino, Laura, Fraley, Mark E., Arrington, Kenneth L., Lobell, Robert B.

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Structure and function of the insulin-like growth factor I receptor von Sepp-Lorenzino, L

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Proof-of-concept Studies for siRNA-mediated Gene Silencing for Coagulation Factors in Rat and Rabbit von Chen, Zhu, Luo, Bin, Cai, Tian-Quan, Thankappan, Anil, Xu, Yiming, Wu, Weizhen, DiMuzio, Jillian, Lifsted, Traci, DiPietro, Marty, Disa, Jyoti, Ng, Bruce, Leander, Karen, Clark, Seth, Hoos, Lizbeth, Zhou, Yuchen, Jochnowitz, Nina, Jachec, Christine, Szczerba, Peter, Gindy, Marian E, Strapps, Walter, Sepp-Lorenzino, Laura, Seiffert, Dietmar A, Lubbers, Laura, Tadin-Strapps, Marija

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Growth inhibition by microRNAs that target the insulin receptor substrate-1 von La Rocca, Gaspare, Shi, Bin, Badin, Margherita, De Angelis, Tiziana, Sepp-Lorenzino, Laura, Baserga, Renato

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