European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender von Seppälä, T T, Latchford, A, Negoi, I, Sampaio Soares, A, Jimenez-Rodriguez, R, Sánchez-Guillén, L, Evans, D G, Ryan, N, Crosbie, E J, Dominguez-Valentin, M, Burn, J, Kloor, M, Knebel Doeberitz, M von, Duijnhoven, F J B van, Quirke, P, Sampson, J R, Møller, P, Möslein, G

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Lynch Syndrome Genetics and Clinical Implications von Peltomäki, Päivi, Nyström, Minna, Mecklin, Jukka-Pekka, Seppälä, Toni T.

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CSF biomarkers for Alzheimer disease correlate with cortical brain biopsy findings von SEPPÄLÄ, T. T, NERG, O, JÄÄSKELÄINEN, J. E, RINNE, J, SOININEN, H, LEINONEN, V, HERUKKA, S.-K, KOIVISTO, A. M, RUMMUKAINEN, J, PULI, L, ZETTERBERG, H, PYYKKÖ, O. T, HELISALMI, S, ALAFUZOFF, I, HILTUNEN, M

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Cerebrospinal fluid biomarker and brain biopsy findings in idiopathic normal pressure hydrocephalus von Pyykkö, Okko T, Lumela, Miikka, Rummukainen, Jaana, Nerg, Ossi, Seppälä, Toni T, Herukka, Sanna-Kaisa, Koivisto, Anne M, Alafuzoff, Irina, Puli, Lakshman, Savolainen, Sakari, Soininen, Hilkka, Jääskeläinen, Juha E, Hiltunen, Mikko, Zetterberg, Henrik, Leinonen, Ville

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Pretibial lacerations among elderly patients: A province-wide study from Kymenlaakso, Finland, 2015–2019 von Seppälä, T., Grünthal, V., Koljonen, V.

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Editorial: Identification, risk stratification, and optimized management for Lynch Syndrome von Bernstein, Inge, Therkildsen, Christina, Seppälä, Toni T

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Epidemiological, clinical and molecular characterization of Lynch‐like syndrome: A population‐based study von Porkka, Noora, Lahtinen, Laura, Ahtiainen, Maarit, Böhm, Jan P., Kuopio, Teijo, Eldfors, Samuli, Mecklin, Jukka‐Pekka, Seppälä, Toni T., Peltomäki, Päivi

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Genetic and Epigenetic Characteristics of Inflammatory Bowel Disease–Associated Colorectal Cancer von Rajamäki, Kristiina, Taira, Aurora, Katainen, Riku, Välimäki, Niko, Kuosmanen, Anna, Plaketti, Roosa-Maria, Seppälä, Toni T., Ahtiainen, Maarit, Wirta, Erkki-Ville, Vartiainen, Emilia, Sulo, Päivi, Ravantti, Janne, Lehtipuro, Suvi, Granberg, Kirsi J., Nykter, Matti, Tanskanen, Tomas, Ristimäki, Ari, Koskensalo, Selja, Renkonen-Sinisalo, Laura, Lepistö, Anna, Böhm, Jan, Taipale, Jussi, Mecklin, Jukka-Pekka, Aavikko, Mervi, Palin, Kimmo, Aaltonen, Lauri A.

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Subtotal Colectomy for Colon Cancer Reduces the Need for Subsequent Surgery in Lynch Syndrome von Renkonen-Sinisalo, Laura, Seppälä, Toni T, Järvinen, Heikki J, Mecklin, Jukka-Pekka

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Mortality and Length of Stay of Very Low Birth Weight and Very Preterm Infants: A EuroHOPE Study von Numerato, Dino, Fattore, Giovanni, Tediosi, Fabrizio, Zanini, Rinaldo, Peltola, Mikko, Banks, Helen, Mihalicza, Péter, Lehtonen, Liisa, Sveréus, Sofia, Heijink, Richard, Klitkou, Søren Toksvig, Fletcher, Eilidh, Heijden, Amber van der, Lundberg, Fredrik, Over, Eelco, Häkkinen, Unto, Seppälä, Timo T

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Indoor air problems and experiences of injustice in the workplace: A quantitative and a qualitative study von Finell, E., Seppälä, T.

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Clinical characteristics of pancreatic and biliary tract cancers in Lynch syndrome: A retrospective analysis from the Finnish National Lynch Syndrome Research Registry von Zalevskaja, Kristina, Mecklin, Jukka-Pekka, Seppälä, Toni T

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Patient-derived Organoid Pharmacotyping is a Clinically Tractable Strategy for Precision Medicine in Pancreatic Cancer von Seppälä, Toni T., Zimmerman, Jacquelyn W., Sereni, Elisabetta, Plenker, Dennis, Suri, Reecha, Rozich, Noah, Blair, Alex, Thomas, Dwayne L., Teinor, Jonathan, Javed, Ammar, Patel, Hardik, Cameron, John L., Burns, William R., He, Jin, Tuveson, David A., Jaffee, Elizabeth M., Eshleman, James, Szabolcs, Annamaria, Ryan, David P., Ting, David T., Wolfgang, Christopher L., Burkhart, Richard A.

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Precision Medicine in Pancreatic Cancer: Patient-Derived Organoid Pharmacotyping Is a Predictive Biomarker of Clinical Treatment Response von Seppälä, Toni T, Zimmerman, Jacquelyn W, Suri, Reecha, Zlomke, Haley, Ivey, Gabriel D, Szabolcs, Annamaria, Shubert, Christopher R, Cameron, John L, Burns, William R, Lafaro, Kelly J, He, Jin, Wolfgang, Christopher L, Zou, Ying S, Zheng, Lei, Tuveson, David A, Eshlemann, James R, Ryan, David P, Kimmelman, Alec C, Hong, Theodore S, Ting, David T, Jaffee, Elizabeth M, Burkhart, Richard A

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The “unnatural” history of colorectal cancer in Lynch syndrome: Lessons from colonoscopy surveillance von Ahadova, Aysel, Seppälä, Toni T., Engel, Christoph, Gallon, Richard, Burn, John, Holinski‐Feder, Elke, Steinke‐Lange, Verena, Möslein, Gabriela, Nielsen, Maartje, Broeke, Sanne W., Laghi, Luigi, Dominguez‐Valentin, Mev, Capella, Gabriel, Macrae, Finlay, Scott, Rodney, Hüneburg, Robert, Nattermann, Jacob, Hoffmeister, Michael, Brenner, Hermann, Bläker, Hendrik, Knebel Doeberitz, Magnus, Sampson, Julian R., Vasen, Hans, Mecklin, Jukka‐Pekka, Møller, Pål, Kloor, Matthias

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Delphi Initiative for Early-Onset Colorectal Cancer (DIRECt) International Management Guidelines von Cavestro, Giulia Martina, Mannucci, Alessandro, Balaguer, Francesc, Hampel, Heather, Kupfer, Sonia S., Repici, Alessandro, Sartore-Bianchi, Andrea, Seppälä, Toni T., Valentini, Vincenzo, Boland, Clement Richard, Brand, Randall E., Buffart, Tineke E., Burke, Carol A., Caccialanza, Riccardo, Cannizzaro, Renato, Cascinu, Stefano, Cercek, Andrea, Crosbie, Emma J., Danese, Silvio, Dekker, Evelien, Daca-Alvarez, Maria, Deni, Francesco, Dominguez-Valentin, Mev, Eng, Cathy, Goel, Ajay, Guillem, Josè G., Houwen, Britt B.S.L., Kahi, Charles, Kalady, Matthew F., Kastrinos, Fay, Kühn, Florian, Laghi, Luigi, Latchford, Andrew, Liska, David, Lynch, Patrick, Malesci, Alberto, Mauri, Gianluca, Meldolesi, Elisa, Møller, Pål, Monahan, Kevin J., Möslein, Gabriela, Murphy, Caitlin C., Nass, Karlijn, Ng, Kimmie, Oliani, Cristina, Papaleo, Enrico, Patel, Swati G., Puzzono, Marta, Remo, Andrea, Ricciardiello, Luigi, Ripamonti, Carla Ida, Siena, Salvatore, Singh, Satish K., Stadler, Zsofia K., Stanich, Peter P., Syngal, Sapna, Turi, Stefano, Urso, Emanuele Damiano, Valle, Laura, Vanni, Valeria Stella, Vilar, Eduardo, Vitellaro, Marco, You, Yi-Qian Nancy, Yurgelun, Matthew B., Zuppardo, Raffaella Alessia, Stoffel, Elena M.

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Prognostic significance of spatial and density analysis of T lymphocytes in colorectal cancer von Elomaa, Hanna, Ahtiainen, Maarit, Väyrynen, Sara A., Ogino, Shuji, Nowak, Jonathan A., Friman, Marjukka, Helminen, Olli, Wirta, Erkki-Ville, Seppälä, Toni T., Böhm, Jan, Mäkinen, Markus J., Mecklin, Jukka-Pekka, Kuopio, Teijo, Väyrynen, Juha P.

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The Different Immune Profiles of Normal Colonic Mucosa in Cancer-Free Lynch Syndrome Carriers and Lynch Syndrome Colorectal Cancer Patients von Bohaumilitzky, Lena, Kluck, Klaus, Hüneburg, Robert, Gallon, Richard, Nattermann, Jacob, Kirchner, Martina, Kristiansen, Glen, Hommerding, Oliver, Pfuderer, Pauline L., Wagner, Lelia, Echterdiek, Fabian, Kösegi, Svenja, Müller, Nico, Fischer, Konstantin, Nelius, Nina, Hartog, Ben, Borthwick, Gillian, Busch, Elena, Haag, Georg Martin, Bläker, Hendrik, Möslein, Gabriela, von Knebel Doeberitz, Magnus, Seppälä, Toni T., Ahtiainen, Maarit, Mecklin, Jukka-Pekka, Bishop, D. Timothy, Burn, John, Stenzinger, Albrecht, Budczies, Jan, Kloor, Matthias, Ahadova, Aysel

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Associations of Pathogenic Variants in MLH1, MSH2, and MSH6 With Risk of Colorectal Adenomas and Tumors and With Somatic Mutations in Patients With Lynch Syndrome von Engel, Christoph, Ahadova, Aysel, Seppälä, Toni T., Aretz, Stefan, Bigirwamungu-Bargeman, Marloes, Bläker, Hendrik, Bucksch, Karolin, Büttner, Reinhard, de Vos tot Nederveen Cappel, Wouter T., Endris, Volker, Holinski-Feder, Elke, Holzapfel, Stefanie, Hüneburg, Robert, Jacobs, Maarten A.J.M., Koornstra, Jan J., Langers, Alexandra M., Lepistö, Anna, Morak, Monika, Möslein, Gabriela, Peltomäki, Päivi, Pylvänäinen, Kirsi, Rahner, Nils, Renkonen-Sinisalo, Laura, Schulmann, Karsten, Steinke-Lange, Verena, Stenzinger, Albrecht, Strassburg, Christian P., van de Meeberg, Paul C., van Kouwen, Mariette, van Leerdam, Monique, Vangala, Deepak B., Vecht, Juda, Verhulst, Marie-Louise, von Knebel Doeberitz, Magnus, Weitz, Jürgen, Zachariae, Silke, Loeffler, Markus, Mecklin, Jukka-Pekka, Kloor, Matthias, Vasen, Hans F.

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Pretibial hematomas – A real-world single-center study von Seppälä, T., Grünthal, V., Koljonen, V.

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