Application of quantitative protein mass spectrometric data in the early predictive analysis of membrane-bound target engagement by monoclonal antibodies von Sepp, Armin, Muliaditan, Morris

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Predictive modelling and simulation for taming the chance and luck in biologics drug discovery von Sepp, A

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Application of quantitative protein mass spectrometric data in the early predictive analysis of target engagement by monoclonal antibodies von Muliaditan, Morris, Sepp, Armin

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Cross-species/cross-modality physiologically based pharmacokinetics for biologics: 89Zr-labelled albumin-binding domain antibody GSK3128349 in humans von Sepp, Armin, Bergström, Mats, Davies, Marie

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Predictive modelling and simulation for taming the chance and luck in biologics drug discovery/Bioloogiliste makromolekulide fusioloogiline farmakokineetika von Sepp, Armin

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A Physiologically Based Pharmacokinetic Model Relates the Subcutaneous Bioavailability of Monoclonal Antibodies to the Saturation of FcRn-Mediated Recycling in Injection-Site-Drain... von Stader, Felix, Liu, Cong, Derbalah, Abdallah, Momiji, Hiroshi, Pan, Xian, Gardner, Iain, Jamei, Masoud, Sepp, Armin

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Development of a physiologically based pharmacokinetic model for a domain antibody in mice using the two-pore theory von Sepp, Armin, Berges, Alienor, Sanderson, Andrew, Meno-Tetang, Guy

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Pharmacokinetic characteristics, pharmacodynamic effect and in vivo antiviral efficacy of liver-targeted interferon alpha von Rycroft, Daniel, Sosabowski, Jane, Coulstock, Edward, Davies, Marie, Morrey, John, Friel, Sarah, Kelly, Fiona, Hamatake, Robert, Ovečka, Milan, Prince, Rob, Goodall, Laura, Sepp, Armin, Walker, Adam

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The biodistribution and clearance of AlbudAb, a novel biopharmaceutical medicine platform, assessed via PET imaging in humans von Thorneloe, Kevin S., Sepp, Armin, Zhang, Sean, Galinanes-Garcia, Laura, Galette, Paul, Al-Azzam, Wasfi, Vugts, Danielle J., van Dongen, Guus, Elsinga, Phillip, Wiegers, Johan, Glaudemans, Andor W. J. M., Vincent, Veena, Renaux, Jessica, Szapacs, Matt, Birchler, Mary, Cleveland, Matthew, Bergstrom, Mats, Davies, Marie

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Liver-targeting of interferon-alpha with tissue-specific domain antibodies von Coulstock, Edward, Sosabowski, Jane, Ovečka, Milan, Prince, Rob, Goodall, Laura, Mudd, Clare, Sepp, Armin, Davies, Marie, Foster, Julie, Burnet, Jerome, Dunlevy, Gráinne, Walker, Adam

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Cell-free Selection of Zinc Finger DNA-binding Proteins Using In Vitro Compartmentalization von Sepp, Armin, Choo, Yen

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Novel Selection Approaches to Identify Antibodies Targeting Neoepitopes on the C5b6 Intermediate Complex to Inhibit Membrane Attack Complex Formation von Stach, Lasse, Dinley, Emily K. H., Tournier, Nadia, Bingham, Ryan P., Gormley, Darren A., Bramhall, Jo L., Taylor, Adam, Clarkson, Jane E., Welbeck, Katherine A., Harris, Claire L., Feeney, Maria, Hughes, Jane P., Sepp, Armin, Batuwangala, Thil D., Kitchen, Semra J., Nichols, Eva-Maria

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Physiologically-based pharmacokinetic model for pulmonary disposition of protein therapeutics in humans von Jagdale, Prabhas, Sepp, Armin, Shah, Dhaval K.

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Computer-assembled cross-species/cross-modalities two-pore physiologically based pharmacokinetic model for biologics in mice and rats von Sepp, Armin, Meno-Tetang, Guy, Weber, Andrew, Sanderson, Andrew, Schon, Oliver, Berges, Alienor

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Toward systems-informed models for biologics disposition: covariates of the abundance of the neonatal Fc Receptor (FcRn) in human tissues and implications for pharmacokinetic model... von Barber, Jill, Al-Majdoub, Zubida M., Couto, Narciso, Howard, Martyn, Elmorsi, Yasmine, Scotcher, Daniel, Alizai, Naved, de Wildt, Saskia, Stader, Felix, Sepp, Armin, Rostami-Hodjegan, Amin, Achour, Brahim

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In vivo biodistribution and pharmacokinetics of sotrovimab, a SARS-CoV-2 monoclonal antibody, in healthy cynomolgus monkeys von Aweda, Tolulope A., Cheng, Shih-Hsun, Lenhard, Stephen C., Sepp, Armin, Skedzielewski, Tinamarie, Hsu, Chih-Yang, Marshall, Shelly, Haag, Heather, Kehler, Jonathan, Jagdale, Prabhas, Peter, Alessia, Schmid, Michael A., Gehman, Andrew, Doan, Minh, Mayer, Andrew P., Gorycki, Peter, Fanget, Marie, Colas, Christophe, Smith, Brenda, Maier, Curtis C., Alsaid, Hasan

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Next generation immunotherapeutics—honing the magic bullet von Enever, Carrie, Batuwangala, Thil, Plummer, Chris, Sepp, Armin

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Modeling bispecific monoclonal antibody interaction with two cell membrane targets indicates the importance of surface diffusion von Sengers, Bram G, McGinty, Sean, Nouri, Fatma Z, Argungu, Maryam, Hawkins, Emma, Hadji, Aymen, Weber, Andrew, Taylor, Adam, Sepp, Armin

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Cell-Free Selection of Domain Antibodies by In Vitro Compartmentalization von Sepp, Armin, Griffiths, Andrew

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Microbead display by in vitro compartmentalisation: selection for binding using flow cytometry von Sepp, Armin, Tawfik, Dan S, Griffiths, Andrew D

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