Increased oral availability and brain accumulation of the ALK inhibitor crizotinib by coadministration of the P‐glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) in... von Chuan Tang, Seng, Nguyen, Luan N., Sparidans, Rolf W., Wagenaar, Els, Beijnen, Jos H., Schinkel, Alfred H.

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Super-Enhancers, Phase-Separated Condensates, and 3D Genome Organization in Cancer von Tang, Seng Chuan, Vijayakumar, Udhaya, Zhang, Ying, Fullwood, Melissa Jane

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The Endosomal Protein CEMIP Links WNT Signaling to MEK1-ERK1/2 Activation in Selumetinib-Resistant Intestinal Organoids von Duong, Hong Quan, Nemazanyy, Ivan, Rambow, Florian, Tang, Seng Chuan, Delaunay, Sylvain, Tharun, Lars, Florin, Alexandra, Büttner, Reinhard, Vandaele, Daniel, Close, Pierre, Marine, Jean-Christophe, Shostak, Kateryna, Chariot, Alain

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Brain accumulation of sunitinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elacridar and sunitinib coadministr... von Tang, Seng Chuan, Lagas, Jurjen S., Lankheet, Nienke A.G., Poller, Birk, Hillebrand, Michel J., Rosing, Hilde, Beijnen, Jos H., Schinkel, Alfred H.

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Double-Transduced MDCKII Cells To Study Human P-Glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) Interplay in Drug Transport across the Blood−Brain Barrier von Poller, Birk, Wagenaar, Els, Tang, Seng Chuan, Schinkel, Alfred H

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Impact of P-Glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) Gene Dosage on Plasma Pharmacokinetics and Brain Accumulation of Dasatinib, Sorafenib, and Sunitinib von Tang, Seng Chuan, de Vries, Niels, Sparidans, Rolf W., Wagenaar, Els, Beijnen, Jos H., Schinkel, Alfred H.

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P-Glycoprotein, CYP3A, and Plasma Carboxylesterase Determine Brain and Blood Disposition of the mTOR Inhibitor Everolimus (Afinitor) in Mice von SENG CHUAN TANG, SPARIDANS, Rolf W, KA LEI CHEUNG, FUKAMI, Tatsuki, DURMUS, Selvi, WAGENAAR, Els, YOKOI, Tsuyoshi, VAN VLIJMEN, Bart J. M, BEIJNEN, Jos H, SCHINKEL, Alfred H

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Liquid chromatography–tandem mass spectrometric assay for the ALK inhibitor crizotinib in mouse plasma von Sparidans, Rolf W., Tang, Seng Chuan, Nguyen, Luan N., Schinkel, Alfred H., Schellens, Jan H.M., Beijnen, Jos H.

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Elp3‐mediated codon‐dependent translation promotes mTORC2 activation and regulates macrophage polarization von Chen, Dawei, Nemazanyy, Ivan, Peulen, Olivier, Shostak, Kateryna, Xu, Xinyi, Tang, Seng Chuan, Wathieu, Caroline, Turchetto, Silvia, Tielens, Sylvia, Nguyen, Laurent, Close, Pierre, Desmet, Christophe, Klein, Sebastian, Florin, Alexandra, Büttner, Reinhard, Petrellis, Georgios, Dewals, Benjamin, Chariot, Alain

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Super-silencer perturbation by EZH2 and REST inhibition leads to large loss of chromatin interactions and reduction in cancer growth von Zhang, Ying, Chen, Kaijing, Tang, Seng Chuan, Cai, Yichao, Nambu, Akiko, See, Yi Xiang, Fu, Chaoyu, Raju, Anandhkumar, Lebeau, Benjamin, Ling, Zixun, Chan, Jia Jia, Tay, Yvonne, Mutwil, Marek, Lakshmanan, Manikandan, Tucker-Kellogg, Greg, Chng, Wee Joo, Tenen, Daniel G, Osato, Motomi, Tergaonkar, Vinay, Fullwood, Melissa Jane

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The E3 ligase COP1 promotes ERα signaling and suppresses EMT in breast cancer von Tang, Seng Chuan, Lion, Quentin, Peulen, Olivier, Chariot, Philippe, Lavergne, Arnaud, Mayer, Alice, Fuster, Paula Allepuz, Close, Pierre, Klein, Sebastian, Florin, Alexandra, Büttner, Reinhard, Nemazanyy, Ivan, Shostak, Kateryna, Chariot, Alain

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P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) restrict brain accumulation of the active sunitinib metabolite N-desethyl sunitinib von Tang, Seng Chuan, Lankheet, Nienke A G, Poller, Birk, Wagenaar, Els, Beijnen, Jos H, Schinkel, Alfred H

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Genetically modified mouse models for oral drug absorption and disposition von Tang, Seng Chuan, Hendrikx, Jeroen JMA, Beijnen, Jos H, Schinkel, Alfred H

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P‑glycoprotein, CYP3A, and Plasma Carboxylesterase Determine Brain Disposition and Oral Availability of the Novel Taxane Cabazitaxel (Jevtana) in Mice von Tang, Seng Chuan, Kort, Anita, Cheung, Ka Lei, Rosing, Hilde, Fukami, Tatsuki, Durmus, Selvi, Wagenaar, Els, Hendrikx, Jeroen J. M. A, Nakajima, Miki, van Vlijmen, Bart J. M, Beijnen, Jos H, Schinkel, Alfred H

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Abstract 1518: P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) limit sunitinib brain accumulation which can be enhanced by oral elacridar treatment von Tang, Seng Chuan, Lagas, Jurjen S., Lankheet, Nienke, Rosing, Hilde, Beijnen, Jos H., Schinkel, Alfred H.

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Source Data Extended Data Figure 6a-DKO von Zhang, Ying, Chen, Kaijing, Tang, Seng Chuan, Cai, Yichao, Nambu, Akiko, See, Yi Xiang, Fu, Chaoyu, Raju, Anandhkumar, Lebeau, Benjamin, Ling, Zixun, Jia Chan, Jia, Tay, Yvonne, Mutwil, Marek, Lakshmanan, Manikandan, Tucker-Kellogg, Greg, Chng, Wee Joo, Tenen, Daniel G., Osato, Motomi, Tergaonkar, Vinay, Fullwood, Melissa

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Source Data Extended Data Figures 6b and 6c-S1KO von Zhang, Ying, Chen, Kaijing, Tang, Seng Chuan, Cai, Yichao, Nambu, Akiko, See, Yi Xiang, Fu, Chaoyu, Raju, Anandhkumar, Lebeau, Benjamin, Ling, Zixun, Jia Chan, Jia, Tay, Yvonne, Mutwil, Marek, Lakshmanan, Manikandan, Tucker-Kellogg, Greg, Chng, Wee Joo, Tenen, Daniel G., Osato, Motomi, Tergaonkar, Vinay, Fullwood, Melissa

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Source Data Extended Data Figures 8a and 8c von Zhang, Ying, Chen, Kaijing, Tang, Seng Chuan, Cai, Yichao, Nambu, Akiko, See, Yi Xiang, Fu, Chaoyu, Raju, Anandhkumar, Lebeau, Benjamin, Ling, Zixun, Jia Chan, Jia, Tay, Yvonne, Mutwil, Marek, Lakshmanan, Manikandan, Tucker-Kellogg, Greg, Chng, Wee Joo, Tenen, Daniel G., Osato, Motomi, Tergaonkar, Vinay, Fullwood, Melissa

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Source Data Fig 3 von Zhang, Ying, Chen, Kaijing, Tang, Seng Chuan, Cai, Yichao, Nambu, Akiko, See, Yi Xiang, Fu, Chaoyu, Raju, Anandhkumar, Lebeau, Benjamin, Ling, Zixun, Jia Chan, Jia, Tay, Yvonne, Mutwil, Marek, Lakshmanan, Manikandan, Tucker-Kellogg, Greg, Chng, Wee Joo, Tenen, Daniel G., Osato, Motomi, Tergaonkar, Vinay, Fullwood, Melissa

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Source Data Fig 2 von Zhang, Ying, Chen, Kaijing, Tang, Seng Chuan, Cai, Yichao, Nambu, Akiko, See, Yi Xiang, Fu, Chaoyu, Raju, Anandhkumar, Lebeau, Benjamin, Ling, Zixun, Jia Chan, Jia, Tay, Yvonne, Mutwil, Marek, Lakshmanan, Manikandan, Tucker-Kellogg, Greg, Chng, Wee Joo, Tenen, Daniel G., Osato, Motomi, Tergaonkar, Vinay, Fullwood, Melissa

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