Genetics, Cell Biology, and Pathophysiology of Pancreatitis von Mayerle, Julia, Sendler, Matthias, Hegyi, Eszter, Beyer, Georg, Lerch, Markus M., Sahin-Tóth, Miklós

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Cathepsin B-Mediated Activation of Trypsinogen in Endocytosing Macrophages Increases Severity of Pancreatitis in Mice von Sendler, Matthias, Weiss, Frank-Ulrich, Golchert, Janine, Homuth, Georg, van den Brandt, Cindy, Mahajan, Ujjwal M., Partecke, Lars-Ivo, Döring, Paula, Gukovsky, Ilya, Gukovskaya, Anna S., Wagh, Preshit R., Lerch, Markus M., Mayerle, Julia

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Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic cancer von Aghdassi, Ali, Sendler, Matthias, Guenther, Annett, Mayerle, Julia, Behn, Claas-Olsen, Heidecke, Claus-Dieter, Friess, Helmut, Büchler, Markus, Evert, Matthias, Lerch, Markus M, Weiss, Frank Ulrich

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Carrying asymptomatic gallstones is not associated with changes in intestinal microbiota composition and diversity but cholecystectomy with significant dysbiosis von Frost, Fabian, Kacprowski, Tim, Rühlemann, Malte, Weiss, Stefan, Bang, Corinna, Franke, Andre, Pietzner, Maik, Aghdassi, Ali A., Sendler, Matthias, Völker, Uwe, Völzke, Henry, Mayerle, Julia, Weiss, Frank U., Homuth, Georg, Lerch, Markus M.

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Examination of duodenal and colonic microbiome changes in mouse models of acute and chronic pancreatitis von Lange, Rabea, Glaubitz, Juliane, Frost, Fabian, Geisz, Andreas, Aghdassi, Ali A., Weiss, F. Ulrich, Sendler, Matthias

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Cathepsin B Activity Initiates Apoptosis via Digestive Protease Activation in Pancreatic Acinar Cells and Experimental Pancreatitis von Sendler, Matthias, Maertin, Sandrina, John, Daniel, Persike, Maria, Weiss, F.Ulrich, Krüger, Burkhard, Wartmann, Thomas, Wagh, Preshit, Halangk, Walter, Schaschke, Norbert, Mayerle, Julia, Lerch, Markus M.

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IRAK3-mediated suppression of pro-inflammatory MyD88/IRAK signaling affects disease severity in acute pancreatitis von Thiel, Franziska G., Asgarbeik, Saeedeh, Glaubitz, Juliane, Wilden, Anika, Lerch, Markus M., Weiss, Frank Ulrich, Sendler, Matthias

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In mouse chronic pancreatitis CD25+FOXP3+ regulatory T cells control pancreatic fibrosis by suppression of the type 2 immune response von Glaubitz, Juliane, Wilden, Anika, Golchert, Janine, Homuth, Georg, Völker, Uwe, Bröker, Barbara M., Thiele, Thomas, Lerch, Markus M., Mayerle, Julia, Aghdassi, Ali A., Weiss, Frank U., Sendler, Matthias

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Cathepsin D regulates cathepsin B activation and disease severity predominantly in inflammatory cells during experimental pancreatitis von Aghdassi, Ali A., John, Daniel S., Sendler, Matthias, Weiss, F. Ulrich, Reinheckel, Thomas, Mayerle, Julia, Lerch, Markus M.

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Alcohol Disrupts Levels and Function of the Cystic Fibrosis Transmembrane Conductance Regulator to Promote Development of Pancreatitis von Maléth, József, Balázs, Anita, Pallagi, Petra, Balla, Zsolt, Kui, Balázs, Katona, Máté, Judák, Linda, Németh, István, Kemény, Lajos V., Rakonczay, Zoltán, Venglovecz, Viktória, Földesi, Imre, Pető, Zoltán, Somorácz, Áron, Borka, Katalin, Perdomo, Doranda, Lukacs, Gergely L., Gray, Mike A., Monterisi, Stefania, Zaccolo, Manuela, Sendler, Matthias, Mayerle, Julia, Kühn, Jens-Peter, Lerch, Markus M., Sahin-Tóth, Miklós, Hegyi, Péter

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Immune response mechanisms in acute and chronic pancreatitis: strategies for therapeutic intervention von Glaubitz, Juliane, Asgarbeik, Saeedeh, Lange, Rabea, Mazloum, Hala, Elsheikh, Hager, Weiss, Frank Ulrich, Sendler, Matthias

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A recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis von Fjeld, Karianne, Weiss, Frank Ulrich, Lasher, Denise, Rosendahl, Jonas, Chen, Jian-Min, Johansson, Bente B, Kirsten, Holger, Ruffert, Claudia, Masson, Emmanuelle, Steine, Solrun J, Bugert, Peter, Cnop, Miriam, Grützmann, Robert, Mayerle, Julia, Mössner, Joachim, Ringdal, Monika, Schulz, Hans-Ulrich, Sendler, Matthias, Simon, Peter, Sztromwasser, Paweł, Torsvik, Janniche, Scholz, Markus, Tjora, Erling, Férec, Claude, Witt, Heiko, Lerch, Markus M, Njølstad, Pål R, Johansson, Stefan, Molven, Anders

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Tumor-Specific Delivery of 5-Fluorouracil–Incorporated Epidermal Growth Factor Receptor–Targeted Aptamers as an Efficient Treatment in Pancreatic Ductal Adenocarcinoma Models von Mahajan, Ujjwal M., Li, Qi, Alnatsha, Ahmed, Maas, Jessica, Orth, Michael, Maier, Sebastian Hubertus, Peterhansl, Julian, Regel, Ivonne, Sendler, Matthias, Wagh, Preshit R., Mishra, Neha, Xue, Yonggan, Allawadhi, Prince, Beyer, Georg, Kühn, Jens-Peter, Marshall, Thomas, Appel, Bettina, Lämmerhirt, Felix, Belka, Claus, Müller, Sabine, Weiss, Frank-Ulrich, Lauber, Kirsten, Lerch, Markus M., Mayerle, Julia

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The Gut Microbiome in Patients With Chronic Pancreatitis Is Characterized by Significant Dysbiosis and Overgrowth by Opportunistic Pathogens von Frost, Fabian, Weiss, Frank U., Sendler, Matthias, Kacprowski, Tim, Rühlemann, Malte, Bang, Corinna, Franke, Andre, Völker, Uwe, Völzke, Henry, Lamprecht, Georg, Mayerle, Julia, Aghdassi, Ali A., Homuth, Georg, Lerch, Markus M.

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Early trypsin activation develops independently of autophagy in caerulein-induced pancreatitis in mice von Malla, Sudarshan R., Krueger, Burkhard, Wartmann, Thomas, Sendler, Matthias, Mahajan, Ujjwal M., Weiss, F. Ulrich, Thiel, Franziska G., De Boni, Carina, Gorelick, Fred S., Halangk, Walter, Aghdassi, Ali A., Reinheckel, Thomas, Gukovskaya, Anna S., Lerch, Markus M., Mayerle, Julia

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Mobilization of CD11b+/Ly6chi monocytes causes multi organ dysfunction syndrome in acute pancreatitis von Wilden, Anika, Glaubitz, Juliane, Otto, Oliver, Biedenweg, Doreen, Nauck, Matthias, Mack, Matthias, Ribback, Silvia, Bröker, Barbara M., Rheinbaben, Sabrina Freiin von, Lerch, Markus M., Aghdassi, Ali Alexander, Weiss, Frank Ulrich, Sendler, Matthias

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Systemic Bile Acids Affect the Severity of Acute Pancreatitis in Mice Depending on Their Hydrophobicity and the Disease Pathogenesis von Tran, Quang Trung, Sendler, Matthias, Wiese, Mats L., Doller, Julia, Zierke, Lukas, Gischke, Marcel, Glaubitz, Juliane, Tran, Van Huy, Lalk, Michael, Bornscheuer, Uwe T., Weiss, Frank Ulrich, Lerch, Markus M., Aghdassi, Ali A.

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Cathepsin L Inactivates Human Trypsinogen, Whereas Cathepsin L-Deletion Reduces the Severity of Pancreatitis in Mice von Wartmann, Thomas, Mayerle, Julia, Kähne, Thilo, Sahin–Tóth, Miklós, Ruthenbürger, Manuel, Matthias, Rainer, Kruse, Anne, Reinheckel, Thomas, Peters, Christoph, Weiss, F. Ulrich, Sendler, Matthias, Lippert, Hans, Schulz, Hans–Ulrich, Aghdassi, Ali, Dummer, Annegret, Teller, Steffen, Halangk, Walter, Lerch, Markus M

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Roles of autophagy and metabolism in pancreatic cancer cell adaptation to environmental challenges von Maertin, Sandrina, Elperin, Jason M, Lotshaw, Ethan, Sendler, Matthias, Speakman, Steven D, Takakura, Kazuki, Reicher, Benjamin M, Mareninova, Olga A, Grippo, Paul J, Mayerle, Julia, Lerch, Markus M, Gukovskaya, Anna S

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Fecal glycoprotein 2 is a marker of gut microbiota dysbiosis and systemic inflammation von Frost, Fabian, Weiss, Stefan, Hertel, Johannes, Rühlemann, Malte, Bang, Corinna, Franke, Andre, Nauck, Matthias, Dörr, Marcus, Völzke, Henry, Roggenbuck, Dirk, Schierack, Peter, Völker, Uwe, Homuth, Georg, Aghdassi, Ali A, Sendler, Matthias, Lerch, Markus M, Weiss, Frank U

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