Drug discovery approaches targeting the PI3K Akt pathway in cancer von Garcia-Echeverria, C, Sellers, W R

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Complementary activities of DOT1L and Menin inhibitors in MLL-rearranged leukemia von Dafflon, C, Craig, V J, Méreau, H, Gräsel, J, Schacher Engstler, B, Hoffman, G, Nigsch, F, Gaulis, S, Barys, L, Ito, M, Aguadé-Gorgorió, J, Bornhauser, B, Bourquin, J-P, Proske, A, Stork-Fux, C, Murakami, M, Sellers, W R, Hofmann, F, Schwaller, J, Tiedt, R

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Integrated Genomic Profiling of Endometrial Carcinoma Associates Aggressive Tumors with Indicators of PI3 Kinase Activation von Salvesen, H. B., Carter, S. L., Mannelqvist, M., Dutt, A., Getz, G., Stefansson, I. M., Raeder, M. B., Sos, M. L., Engelsen, I. B., Trovik, J., Wik, E., Greulich, H., Bø, T. H., Jonassen, I., Thomas, R. K., Zander, T., Garraway, L. A., Øyan, A. M., Sellers, W. R., Kalland, K. H., Meyerson, M., Akslen, L. A., Beroukhim, R., Gray, Joe W.

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TERT promoter mutations and monoallelic activation of TERT in cancer von Huang, F W, Bielski, C M, Rinne, M L, Hahn, W C, Sellers, W R, Stegmeier, F, Garraway, L A, Kryukov, G V

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Forkhead Transcription Factors Are Critical Effectors of Cell Death and Cell Cycle Arrest Downstream of PTEN von Nakamura, Noriaki, Ramaswamy, Shivapriya, Vazquez, Francisca, Signoretti, Sabina, Loda, Massimo, Sellers, William R.

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Loss of PTEN expression in paraffin-embedded primary prostate Cancer correlates with high Gleason score and advanced stage von MCMENAMIN, M. E, SOUNG, P, PERERA, S, KAPLAN, I, LODA, M, SELLERS, W. R

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Role of the retinoblastoma protein in the pathogenesis of human cancer von SELLERS, W. R, KAELIN, W. G

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Targeted Cancer Therapies in the Twenty-First Century: Lessons From Imatinib von Stegmeier, F, Warmuth, M, Sellers, W R, Dorsch, M

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Somatic mutations are present in all members of the AKT family in endometrial carcinoma von Dutt, A, Salvesen, H B, Greulich, H, Sellers, W R, Beroukhim, R, Meyerson, M

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Akt-regulated pathways in prostate cancer von Majumder, Pradip K, Sellers, William R

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Identification of a cyclin-cdk2 recognition motif present in substrates and p21-like cyclin-dependent kinase inhibitors von Adams, Peter D., Sellers, William R., Sharma, Sushil K., Wu, Arthur D., Nalin, Carlo M., Kaelin, William G.

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Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis von Levine, Ross L., Wadleigh, Martha, Cools, Jan, Ebert, Benjamin L., Wernig, Gerlinde, Huntly, Brian J.P., Boggon, Titus J., Wlodarska, Iwona, Clark, Jennifer J., Moore, Sandra, Adelsperger, Jennifer, Koo, Sumin, Lee, Jeffrey C., Gabriel, Stacey, Mercher, Thomas, D’Andrea, Alan, Fröhling, Stefan, Döhner, Konstanze, Marynen, Peter, Vandenberghe, Peter, Mesa, Ruben A., Tefferi, Ayalew, Griffin, James D., Eck, Michael J., Sellers, William R., Meyerson, Matthew, Golub, Todd R., Lee, Stephanie J., Gilliland, D. Gary

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Molecular characterization of the tumor microenvironment in breast cancer von Allinen, Minna, Beroukhim, Rameen, Cai, Li, Brennan, Cameron, Lahti-Domenici, Jaana, Huang, Haiyan, Porter, Dale, Hu, Min, Chin, Lynda, Richardson, Andrea, Schnitt, Stuart, Sellers, William R, Polyak, Kornelia

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A Potent Transrepression Domain in the Retinoblastoma Protein Induces a Cell Cycle Arrest when Bound to E2F Sites von Sellers, William R., Rodgers, Jennifer W., Kaelin, William G.

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Gene expression correlates of clinical prostate cancer behavior von Singh, Dinesh, Febbo, Phillip G., Ross, Kenneth, Jackson, Donald G., Manola, Judith, Ladd, Christine, Tamayo, Pablo, Renshaw, Andrew A., D'Amico, Anthony V., Richie, Jerome P., Lander, Eric S., Loda, Massimo, Kantoff, Philip W., Golub, Todd R., Sellers, William R.

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TSC2 regulates VEGF through mTOR-dependent and -independent pathways von Brugarolas, James B, Vazquez, Francisca, Reddy, Archana, Sellers, William R, Kaelin, William G

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High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene von Torres-Arzayus, Maria I., de Mora, Jaime Font, Yuan, Jing, Vazquez, Francisca, Bronson, Roderick, Rue, Montserrat, Sellers, William R., Brown, Myles

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An integrated view of copy number and allelic alterations in the cancer genome using single nucleotide polymorphism arrays von XIAOJUN ZHAO, CHENG LI, GRAY, Joe W, SELLERS, William R, MEYERSON, Matthew, PAEZ, J. Guillermo, KOEI CHIN, JÄNNE, Pasi A, CHEN, Tzu-Hsiu, GIRARD, Luc, MINNA, John, CHRISTIANI, David, LEO, Chris

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A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR von Ramaswamy, Shivapriya, Nakamura, Noriaki, Sansal, Isabelle, Bergeron, Louise, Sellers, William R.

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Cells Degrade a Novel Inhibitor of Differentiation with E1A-Like Properties upon Exiting the Cell Cycle von Miyake, Satoshi, Sellers, William R., Safran, Michal, Li, Xiaotong, Zhao, Wenqing, Grossman, Steven R., Gan, Jianmin, DeCaprio, James A., Adams, Peter D., Kaelin, William G.

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