Selective Inhibition of Bruton’s Tyrosine Kinase by a Designed Covalent Ligand Leads to Potent Therapeutic Efficacy in Blood Cancers Relative to Clinically Used Inhibitors von Sousa, Bárbara B., de Almeida, Cátia Rebelo, Barahona, Ana F., Lopes, Raquel, Martins-Logrado, Ana, Cavaco, Marco, Neves, Vera, Carvalho, Luís A. R., Labão-Almeida, Carlos, Coelho, Ana R., Leal Bento, Marta, Lopes, Ricardo M. R. M., Oliveira, Bruno L., Castanho, Miguel A. R. B., Neumeister, Peter, Deutsch, Alexander, Vladimer, Gregory I., Krall, Nikolaus, João, Cristina, Corzana, Francisco, Seixas, João D., Fior, Rita, Bernardes, Gonçalo J. L.

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Antimicrobial Action of Carbon Monoxide-Releasing Compounds von NOBRE, Ligia S, SEIXAS, Joao D, ROMAO, Carlos C, SARAIVA, Ligia M

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Developing drug molecules for therapy with carbon monoxide von Romo, Carlos C, Blttler, Walter A, Seixas, Joo D, Bernardes, Gonalo J. L

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CORM-3 Reactivity toward Proteins: The Crystal Structure of a Ru(II) Dicarbonyl−Lysozyme Complex von Santos-Silva, Teresa, Mukhopadhyay, Abhik, Seixas, João D, Bernardes, Gonçalo J. L, Romão, Carlos C, Romão, Maria J

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Reactive Oxygen Species Mediate Bactericidal Killing Elicited by Carbon Monoxide-releasing Molecules von Tavares, Ana Filipa N., Teixeira, Miguel, Romão, Carlos C., Seixas, João D., Nobre, Lígia S., Saraiva, Lígia M.

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Establishment of a Structure–Activity Relationship of 1H‑Imidazo[4,5‑c]quinoline-Based Kinase Inhibitor NVP-BEZ235 as a Lead for African Sleeping Sickness von Seixas, João D, Luengo-Arratta, Sandra A, Diaz, Rosario, Saldivia, Manuel, Rojas-Barros, Domingo I, Manzano, Pilar, Gonzalez, Silvia, Berlanga, Manuela, Smith, Terry K, Navarro, Miguel, Pollastri, Michael P

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A Novel Carbon Monoxide-Releasing Molecule Fully Protects Mice from Severe Malaria von PENA, Ana C, PENACHO, Nuno, MANCIO-SILVA, Liliana, NERES, Rita, SEIXAS, Joao D, FERNANDES, Afonso C, ROMAO, Carlos C, MOTA, Maria M, BERNARDES, Gonçalo J. L, PAMPLONA, Ana

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Identification and characterization of hundreds of potent and selective inhibitors of Trypanosoma brucei growth from a kinase-targeted library screening campaign von Diaz, Rosario, Luengo-Arratta, Sandra A, Seixas, João D, Amata, Emanuele, Devine, William, Cordon-Obras, Carlos, Rojas-Barros, Domingo I, Jimenez, Elena, Ortega, Fatima, Crouch, Sabrinia, Colmenarejo, Gonzalo, Fiandor, Jose Maria, Martin, Jose Julio, Berlanga, Manuela, Gonzalez, Silvia, Manzano, Pilar, Navarro, Miguel, Pollastri, Michael P

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A contribution to the rational design of Ru(CO)3Cl2L complexes for in vivo delivery of CO von Seixas, João D, Santos, Marino F A, Mukhopadhyay, Abhik, Coelho, Ana C, Reis, Patrícia M, Veiros, Luís F, Marques, Ana R, Penacho, Nuno, Gonçalves, Ana M L, Romão, Maria J, Bernardes, Gonçalo J L, Santos-Silva, Teresa, Romão, Carlos C

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Study of the interactions of bovine serum albumin with a molybdenum(II) carbonyl complex by spectroscopic and molecular simulation methods von Jeremias, Hélia F, Lousa, Diana, Hollmann, Axel, Coelho, Ana C, Baltazar, Carla S, Seixas, João D, Marques, Ana R, Santos, Nuno C, Romão, Carlos C, Soares, Cláudio M

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Enhanced Permeability and Binding Activity of Isobutylene‐Grafted Peptides von Sun, Shuang, Compañón, Ismael, Martínez‐Sáez, Nuria, Seixas, João D., Boutureira, Omar, Corzana, Francisco, Bernardes, Gonçalo J. L.

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Characterization of a versatile organometallic pro-drug (CORM) for experimental CO based therapeutics von Seixas, João D, Mukhopadhyay, Abhik, Santos-Silva, Teresa, Otterbein, Leo E, Gallo, David J, Rodrigues, Sandra S, Guerreiro, Bruno H, Gonçalves, Ana M L, Penacho, Nuno, Marques, Ana R, Coelho, Ana C, Reis, Patrícia M, Romão, Maria J, Romão, Carlos C

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Generation of Carbon Monoxide Releasing Molecules (CO-RMs) as Drug Candidates for the Treatment of Acute Liver Injury: Targeting of CO-RMs to the Liver von Marques, Ana R, Kromer, Lukas, Gallo, David J, Penacho, Nuno, Rodrigues, Sandra S, Seixas, João D, Bernardes, Gonçalo J. L, Reis, Patrícia M, Otterbein, Sherrie L, Ruggieri, Rachel A, Gonçalves, Ana S. G, Gonçalves, Ana M. L, Matos, Marta N. De, Bento, Isabel, Otterbein, Leo E, Blättler, Walter A, Romão, Carlos C

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An N-Acetyl Cysteine Ruthenium Tricarbonyl Conjugate Enables Simultaneous Release of CO and Ablation of Reactive Oxygen Species von Seixas, João D., Chaves-Ferreira, Miguel, Montes-Grajales, Diana, Gonçalves, Ana M., Marques, Ana R., Saraiva, Lígia M., Olivero-Verbel, Jesus, Romão, Carlos C., Bernardes, Gonçalo J. L.

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Inhibition of Nitric Oxide–Stimulated Vasorelaxation by Carbon Monoxide-Releasing Molecules von Marazioti, Antonia, Bucci, Mariarosaria, Coletta, Ciro, Vellecco, Valentina, Baskaran, Padmamalini, Szabó, Csaba, Cirino, Giuseppe, Marques, Ana Rita, Guerreiro, Bruno, Gonçalves, Ana M.L, Seixas, João D, Beuve, Annie, Romão, Carlos C, Papapetropoulos, Andreas

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A scalable insect cell-based production process of the human recombinant BMX for in-vitro covalent ligand high-throughput screening von Sousa, Bárbara B., Sousa, Marcos F. Q., Marques, Marta C., Seixas, João D., Brito, José A., Matias, Pedro M., Bernardes, Gonçalo J. L., Roldão, António

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Ibrutinib Inhibits BMX-Dependent Endothelial VCAM-1 Expression In Vitro and Pro-Atherosclerotic Endothelial Activation and Platelet Adhesion In Vivo von Kohs, Tia C. L., Olson, Sven R., Pang, Jiaqing, Jordan, Kelley R., Zheng, Tony J., Xie, Aris, Hodovan, James, Muller, Matthew, McArthur, Carrie, Johnson, Jennifer, Sousa, Bárbara B., Wallisch, Michael, Kievit, Paul, Aslan, Joseph E., Seixas, João D., Bernardes, Gonçalo J. L., Hinds, Monica T., Lindner, Jonathan R., McCarty, Owen J. T., Puy, Cristina, Shatzel, Joseph J.

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Structural and biophysical insights into the mode of covalent binding of rationally designed potent BMX inhibitors von Seixas, João D, Sousa, Bárbara B, Marques, Marta C, Guerreiro, Ana, Traquete, Rui, Rodrigues, Tiago, Albuquerque, Inês S, Sousa, Marcos F. Q, Lemos, Ana R, Sousa, Pedro M. F, Bandeiras, Tiago M, Wu, Di, Doyle, Shelby K, Robinson, Carol V, Koehler, Angela N, Corzana, Francisco, Matias, Pedro M, Bernardes, Gonçalo J. L

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CpMo(CO)3Cl as a precatalyst for the epoxidation of olefins von VALENTE, Anabela A, SEIXAS, Joao D, GONCALVES, Isabel S, ABRANTES, Marta, PILLINGER, Martyn, ROMAO, Carlos C

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β-Cyclodextrin and permethylated β-cyclodextrin inclusion compounds of a cyclopentadienyl molybdenum tricarbonyl complex and their use as cyclooctene epoxidation catalyst precursor... von Braga, Susana S., Gago, Sandra, Seixas, João D., Valente, Anabela A., Pillinger, Martyn, Santos, Teresa M., Gonçalves, Isabel S., Romão, Carlos C.

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