MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates von Dondelinger, Yves, Declercq, Wim, Montessuit, Sylvie, Roelandt, Ria, Goncalves, Amanda, Bruggeman, Inge, Hulpiau, Paco, Weber, Kathrin, Sehon, Clark A., Marquis, Robert W., Bertin, John, Gough, Peter J., Savvides, Savvas, Martinou, Jean-Claude, Bertrand, Mathieu J.M., Vandenabeele, Peter

Volltext

RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity von Mandal, Pratyusha, Berger, Scott B., Pillay, Sirika, Moriwaki, Kenta, Huang, Chunzi, Guo, Hongyan, Lich, John D., Finger, Joshua, Kasparcova, Viera, Votta, Bart, Ouellette, Michael, King, Bryan W., Wisnoski, David, Lakdawala, Ami S., DeMartino, Michael P., Casillas, Linda N., Haile, Pamela A., Sehon, Clark A., Marquis, Robert W., Upton, Jason, Daley-Bauer, Lisa P., Roback, Linda, Ramia, Nancy, Dovey, Cole M., Carette, Jan E., Chan, Francis Ka-Ming, Bertin, John, Gough, Peter J., Mocarski, Edward S., Kaiser, William J.

Volltext

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases von Harris, Philip A, Berger, Scott B, Jeong, Jae U, Nagilla, Rakesh, Bandyopadhyay, Deepak, Campobasso, Nino, Capriotti, Carol A, Cox, Julie A, Dare, Lauren, Dong, Xiaoyang, Eidam, Patrick M, Finger, Joshua N, Hoffman, Sandra J, Kang, James, Kasparcova, Viera, King, Bryan W, Lehr, Ruth, Lan, Yunfeng, Leister, Lara K, Lich, John D, MacDonald, Thomas T, Miller, Nathan A, Ouellette, Michael T, Pao, Christina S, Rahman, Attiq, Reilly, Michael A, Rendina, Alan R, Rivera, Elizabeth J, Schaeffer, Michelle C, Sehon, Clark A, Singhaus, Robert R, Sun, Helen H, Swift, Barbara A, Totoritis, Rachel D, Vossenkämper, Anna, Ward, Paris, Wisnoski, David D, Zhang, Daohua, Marquis, Robert W, Gough, Peter J, Bertin, John

Volltext

Identification of benzimidazole diamides as selective inhibitors of the nucleotide-binding oligomerization domain 2 (NOD2) signaling pathway von Rickard, David J, Sehon, Clark A, Kasparcova, Viera, Kallal, Lorena A, Zeng, Xin, Montoute, Monica N, Chordia, Tushar, Poore, Derek D, Li, Hu, Wu, Zining, Eidam, Patrick M, Haile, Pamela A, Yu, Jong, Emery, John G, Marquis, Robert W, Gough, Peter J, Bertin, John

Volltext

Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase von Harris, Philip A, Faucher, Nicolas, George, Nicolas, Eidam, Patrick M, King, Bryan W, White, Gemma V, Anderson, Niall A, Bandyopadhyay, Deepak, Beal, Allison M, Beneton, Veronique, Berger, Scott B, Campobasso, Nino, Campos, Sebastien, Capriotti, Carol A, Cox, Julie A, Daugan, Alain, Donche, Frederic, Fouchet, Marie-Hélène, Finger, Joshua N, Geddes, Brad, Gough, Peter J, Grondin, Pascal, Hoffman, Bonnie L, Hoffman, Sandra J, Hutchinson, Susan E, Jeong, Jae U, Jigorel, Emilie, Lamoureux, Pauline, Leister, Lara K, Lich, John D, Mahajan, Mukesh K, Meslamani, Jamel, Mosley, Julie E, Nagilla, Rakesh, Nassau, Pamela M, Ng, Sze-Ling, Ouellette, Michael T, Pasikanti, Kishore K, Potvain, Florent, Reilly, Michael A, Rivera, Elizabeth J, Sautet, Stéphane, Schaeffer, Michelle C, Sehon, Clark A, Sun, Helen, Thorpe, James H, Totoritis, Rachel D, Ward, Paris, Wellaway, Natalie, Wisnoski, David D, Woolven, James M, Bertin, John, Marquis, Robert W

Volltext

A key role for the endothelium in NOD1 mediated vascular inflammation: comparison to TLR4 responses von Gatheral, Timothy, Reed, Daniel M, Moreno, Laura, Gough, Peter J, Votta, Bart J, Sehon, Clark A, Rickard, David J, Bertin, John, Lim, Eric, Nicholson, Andrew G, Mitchell, Jane A

Volltext

Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL von Kaiser, William J., Sridharan, Haripriya, Huang, Chunzi, Mandal, Pratyusha, Upton, Jason W., Gough, Peter J., Sehon, Clark A., Marquis, Robert W., Bertin, John, Mocarski, Edward S.

Volltext

Identification of selective small molecule inhibitors of the nucleotide-binding oligomerization domain 1 (NOD1) signaling pathway von Rickard, David J, Sehon, Clark A, Kasparcova, Viera, Kallal, Lorena A, Haile, Pamela A, Zeng, Xin, Montoute, Monica N, Poore, Derek D, Li, Hu, Wu, Zining, Eidam, Patrick M, Emery, John G, Marquis, Robert W, Gough, Peter J, Bertin, John

Volltext

Total Syntheses of Ningalin A, Lamellarin O, Lukianol A, and Permethyl Storniamide A Utilizing Heterocyclic Azadiene Diels−Alder Reactions von Boger, Dale L, Boyce, Christopher W, Labroli, Marc A, Sehon, Clark A, Jin, Qing

Volltext

Potent, Selective and Orally Bioavailable Dihydropyrimidine Inhibitors of Rho Kinase (ROCK1) as Potential Therapeutic Agents for Cardiovascular Diseases von Sehon, Clark A, Wang, Gren Z, Viet, Andrew Q, Goodman, Krista B, Dowdell, Sarah E, Elkins, Patricia A, Semus, Simon F, Evans, Christopher, Jolivette, Larry J, Kirkpatrick, Robert B, Dul, Edward, Khandekar, Sanjay S, Yi, Tracey, Wright, Lois L, Smith, Gary K, Behm, David J, Bentley, Ross, Doe, Christopher P, Hu, Erding, Lee, Dennis

Volltext

Development of Dihydropyridone Indazole Amides as Selective Rho-Kinase Inhibitors von Goodman, Krista B, Cui, Haifeng, Dowdell, Sarah E, Gaitanopoulos, Dimitri E, Ivy, Robert L, Sehon, Clark A, Stavenger, Robert A, Wang, Gren Z, Viet, Andrew Q, Xu, Weiwei, Ye, Guosen, Semus, Simon F, Evans, Christopher, Fries, Harvey E, Jolivette, Larry J, Kirkpatrick, Robert B, Dul, Edward, Khandekar, Sanjay S, Yi, Tracey, Jung, David K, Wright, Lois L, Smith, Gary K, Behm, David J, Bentley, Ross, Doe, Christopher P, Hu, Erding, Lee, Dennis

Volltext

Pharmacological Inhibition of C-C Chemokine Receptor 2 Decreases Macrophage Infiltration in the Aortic Root of the Human C-C Chemokine Receptor 2/Apolipoprotein E−/− Mouse: Magneti... von Olzinski, Alan R, Turner, Gregory H, Bernard, Roberta E, Karr, Heather, Cornejo, Carla A, Aravindhan, Karpagam, Hoang, Bao, Ringenberg, Michael A, Qin, Pu, Goodman, Krista B, Willette, Robert N, Macphee, Colin H, Jucker, Beat M, Sehon, Clark A, Gough, Peter J

Volltext

Synthesis of Furans and 2,5-Dihydrofurans by Ag(I)-Catalyzed Isomerization of Allenones, Alkynyl Allylic Alcohols, and Allenylcarbinols von Marshall, James A, Sehon, Clark A

Volltext

CCR2 receptor antagonists: Optimization of biaryl sulfonamides to increase activity in whole blood von Wang, Gren Z., Haile, Pamela A., Daniel, Tom, Belot, Benjamin, Viet, Andrew Q., Goodman, Krista B., Sha, Deyou, Dowdell, Sarah E., Varga, Norbert, Hong, Xuan, Chakravorty, Subhas, Webb, Christine, Cornejo, Carla, Olzinski, Alan, Bernard, Roberta, Evans, Christopher, Emmons, Amanda, Briand, Jacques, Chung, Chun-Wa, Quek, Ruben, Lee, Dennis, Gough, Peter J., Sehon, Clark A.

Volltext

Practical and Scalable Synthesis of a Selective CCK1 Receptor Antagonist von Mapes, Christopher M, Mani, Neelakandha S, Deng, Xiaohu, Pandit, Chennagiri R, McClure, Kelly J, Pippel, Marna C. W, Sehon, Clark A, Gomez, Laurent, Shinde, Shirin, Breitenbucher, J. Guy, Jones, Todd K

Volltext

Discovery and SAR studies of a novel series of noncovalent cathepsin S inhibitors von Gustin, Darin J., Sehon, Clark A., Wei, Jianmei, Cai, Hui, Meduna, Steven P., Khatuya, Haripada, Sun, Siquan, Gu, Yin, Jiang, Wen, Thurmond, Robin L., Karlsson, Lars, Edwards, James P.

Volltext

Pyrazole CCK1 receptor antagonists. Part 2: SAR studies by solid-phase library synthesis and determination of Free-Wilson additivity von SEHON, Clark, MCCLURE, Kelly, HACK, Michael, MORTON, Magda, GOMEZ, Laurent, LI, Lina, BARRETT, Terrance D, SHANKLEY, Nigel, BREITENBUCHER, J. Guy

Volltext

Aminomethylpiperazines as selective urotensin antagonists von Hilfiker, Mark A., Zhang, Daohua, Dowdell, Sarah E., Goodman, Krista B., McAtee, John J., Dodson, Jason W., Viet, Andrew Q., Wang, Gren Z., Sehon, Clark A., Behm, David J., Wu, Zining, Carballo, Luz H., Douglas, Stephen A., Neeb, Michael J.

Volltext

Total Synthesis of the Enantiomer of the Furanocembrane Rubifolide von Marshall, James A, Sehon, Clark A

Volltext

The SAR of 4-substituted (6,6-bicyclic) piperidine cathepsin S inhibitors von Grice, Cheryl A., Tays, Kevin, Khatuya, Haripada, Gustin, Darin J., Butler, Christopher R., Wei, Jianmei, Sehon, Clark A., Sun, Siquan, Gu, Yin, Jiang, Wen, Thurmond, Robin L., Karlsson, Lars, Edwards, James P.

Volltext