Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates von Foster, Donald J., Brown, Christopher R., Shaikh, Sarfraz, Trapp, Casey, Schlegel, Mark K., Qian, Kun, Sehgal, Alfica, Rajeev, Kallanthottathil G., Jadhav, Vasant, Manoharan, Muthiah, Kuchimanchi, Satya, Maier, Martin A., Milstein, Stuart

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The Polyploid State Plays a Tumor-Suppressive Role in the Liver von Zhang, Shuyuan, Zhou, Kejin, Luo, Xin, Li, Lin, Tu, Ho-Chou, Sehgal, Alfica, Nguyen, Liem H., Zhang, Yu, Gopal, Purva, Tarlow, Branden D., Siegwart, Daniel J., Zhu, Hao

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Specific hepatic delivery of procollagen α1(I) small interfering RNA in lipid‐like nanoparticles resolves liver fibrosis von Jiménez Calvente, Carolina, Sehgal, Alfica, Popov, Yury, Kim, Yong Ook, Zevallos, Victor, Sahin, Ugur, Diken, Mustafa, Schuppan, Detlef

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Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc-siRNA conjugates von Nair, Jayaprakash K, Attarwala, Husain, Sehgal, Alfica, Wang, Qianfan, Aluri, Krishna, Zhang, Xuemei, Gao, Minggeng, Liu, Ju, Indrakanti, Ramesh, Schofield, Sally, Kretschmer, Philip, Brown, Christopher R, Gupta, Swati, Willoughby, Jennifer L S, Boshar, Julie A, Jadhav, Vasant, Charisse, Klaus, Zimmermann, Tracy, Fitzgerald, Kevin, Manoharan, Muthiah, Rajeev, Kallanthottathil G, Akinc, Akin, Hutabarat, Renta, Maier, Martin A

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Knockdown of Anillin Actin Binding Protein Blocks Cytokinesis in Hepatocytes and Reduces Liver Tumor Development in Mice Without Affecting Regeneration von Zhang, Shuyuan, Nguyen, Liem H., Zhou, Kejin, Tu, Ho-Chou, Sehgal, Alfica, Nassour, Ibrahim, Li, Lin, Gopal, Purva, Goodman, Joshua, Singal, Amit G., Yopp, Adam, Zhang, Yu, Siegwart, Daniel J., Zhu, Hao

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Safety and Efficacy of RNAi Therapy for Transthyretin Amyloidosis von Coelho, Teresa, Adams, David, Silva, Ana, Lozeron, Pierre, Hawkins, Philip N, Mant, Timothy, Perez, Javier, Chiesa, Joseph, Warrington, Steve, Tranter, Elizabeth, Munisamy, Malathy, Falzone, Rick, Harrop, Jamie, Cehelsky, Jeffrey, Bettencourt, Brian R, Geissler, Mary, Butler, James S, Sehgal, Alfica, Meyers, Rachel E, Chen, Qingmin, Borland, Todd, Hutabarat, Renta M, Clausen, Valerie A, Alvarez, Rene, Fitzgerald, Kevin, Gamba-Vitalo, Christina, Nochur, Saraswathy V, Vaishnaw, Akshay K, Sah, Dinah W.Y, Gollob, Jared A, Suhr, Ole B

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The Polyploid State Plays a Tumor-Suppressive Role in the Liver von Zhang, Shuyuan, Zhou, Kejin, Luo, Xin, Li, Lin, Tu, Ho-Chou, Sehgal, Alfica, Nguyen, Liem H, Zhang, Yu, Gopal, Purva, Tarlow, Branden D, Siegwart, Daniel J, Zhu, Hao

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Opportunities and challenges for innovative and equitable healthcare von Ecker, David J., Aiello, Clarice D., Arron, Joseph R., Bennett, C. Frank, Bernard, Amy, Breakefield, Xandra O., Broderick, Timothy J., Callier, Shawneequa L., Canton, Barry, Chen, Janice S., Fishburn, C. Simone, Garrett, Banning, Hecht, Sidney M., Janowitz, Tobias, Kliegman, Melinda, Krainer, Adrian, Louis, Chrystal U., Lowe, Christopher, Sehgal, Alfica, Tozan, Yesim, Tracey, Kevin J., Urnov, Fyodor, Wattendorf, Daniel, Williams, Thomas W., Zhao, Xuanhe, Hayden, Michael R.

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Transcriptional characterization of iPSC-derived microglia as a model for therapeutic development in neurodegeneration von Ramaswami, Gokul, Yuva-Aydemir, Yeliz, Akerberg, Brynn, Matthews, Bryan, Williams, Jenna, Golczer, Gabriel, Huang, Jiaqi, Al Abdullatif, Ali, Huh, Dann, Burkly, Linda C., Engle, Sandra J., Grossman, Iris, Sehgal, Alfica, Sigova, Alla A., Fremeau, Robert T., Liu, Yuting, Bumcrot, David

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Author Correction: Transcriptional characterization of iPSC-derived microglia as a model for therapeutic development in neurodegeneration von Ramaswami, Gokul, Yuva-Aydemir, Yeliz, Akerberg, Brynn, Matthews, Bryan, Williams, Jenna, Golczer, Gabriel, Huang, Jiaqi, Al Abdullatif, Ali, Huh, Dann, Burkly, Linda C., Engle, Sandra J., Grossman, Iris, Sehgal, Alfica, Sigova, Alla A., Fremeau, Robert T., Liu, Yuting, Bumcrot, David

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Preclinical Development of a Subcutaneous ALAS1 RNAi Therapeutic for Treatment of Hepatic Porphyrias Using Circulating RNA Quantification von Chan, Amy, Liebow, Abigail, Yasuda, Makiko, Gan, Lin, Racie, Tim, Maier, Martin, Kuchimanchi, Satya, Foster, Don, Milstein, Stuart, Charisse, Klaus, Sehgal, Alfica, Manoharan, Muthiah, Meyers, Rachel, Fitzgerald, Kevin, Simon, Amy, Desnick, Robert J, Querbes, William

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A rapid two-step method for isolation of functional primary mouse hepatocytes: cell characterization and asialoglycoprotein receptor based assay development von Severgnini, Mariano, Sherman, Jennifer, Sehgal, Alfica, Jayaprakash, Narayanannair K., Aubin, Justin, Wang, Gang, Zhang, Ligang, Peng, Chang G., Yucius, Kristina, Butler, Jim, Fitzgerald, Kevin

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Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery von Lee, Hyukjin, Lytton-Jean, Abigail K. R., Chen, Yi, Love, Kevin T., Park, Angela I., Karagiannis, Emmanouil D., Sehgal, Alfica, Querbes, William, Zurenko, Christopher S., Jayaraman, Muthusamy, Peng, Chang G., Charisse, Klaus, Borodovsky, Anna, Manoharan, Muthiah, Donahoe, Jessica S., Truelove, Jessica, Nahrendorf, Matthias, Langer, Robert, Anderson, Daniel G.

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Discovery and Targeting of the Signaling Controls of PNPLA3 to Effectively Reduce Transcription, Expression, and Function in Pre-Clinical NAFLD/NASH Settings von Schwartz, Brian E., Rajagopal, Vaishnavi, Smith, Cynthia, Cohick, Evan, Whissell, Gavin, Gamboa, Mario, Pai, Rutuja, Sigova, Alla, Grossman, Iris, Bumcrot, David, Sasidharan, Kavitha, Romeo, Stefano, Sehgal, Alfica, Pingitore, Piero

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The roles of individual mammalian argonautes in RNA interference in vivo von Ruda, Vera M, Chandwani, Rohit, Sehgal, Alfica, Bogorad, Roman L, Akinc, Akin, Charisse, Klaus, Tarakhovsky, Alexander, Novobrantseva, Tatiana I, Koteliansky, Victor

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Tissue-specific gene silencing monitored in circulating RNA von Sehgal, Alfica, Chen, Qingmin, Gibbings, Derrick, Sah, Dinah W Y, Bumcrot, David

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Novel roles for ATP-binding cassette G transporters in lipid redistribution in Toxoplasma von Ehrenman, Karen, Sehgal, Alfica, Lige, Bao, Stedman, Timothy T, Joiner, Keith A, Coppens, Isabelle

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SREBP controls oxygen-dependent mobilization of retrotransposons in fission yeast von Sehgal, Alfica, Lee, Chih-Yung S, Espenshade, Peter J

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Specific hepatic delivery of procollagen [alpha]1(I) small interfering RNA in lipid-like nanoparticles resolves liver fibrosis von Jimenez Calvente, Carolina, Sehgal, Alfica, Popov, Yury, Kim, Yong Ook, Zevallos, Victor, Sahin, Ugur, Diken, Mustafa, Schuppan, Detlef

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Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery von Lee, Hyukjin, Lytton-Jean, Abigail K. R., Chen, Yi, Love, Kevin T., Park, Angela I., Karagiannis, Emmanouil D., Sehgal, Alfica, Querbes, William, Zurenko, Christopher S., Jayaraman, Muthusamy, Peng, Chang G., Charisse, Klaus, Borodovsky, Anna, Manoharan, Muthiah, Donahoe, Jessica S., Truelove, Jessica, Nahrendorf, Matthias, Langer, Robert, Anderson, Daniel G.

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