B(C6F5)3-Catalyzed Hydrosilation of Imines via Silyliminium Intermediates von Blackwell, James M, Sonmor, Eric R, Scoccitti, Tiziana, Piers, Warren E

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Identification of 2-oxo-N-(phenylmethyl)-4-imidazolidinecarboxamide antagonists of the P2X(7) receptor von Abberley, Lee, Bebius, Aude, Beswick, Paul J, Billinton, Andy, Collis, Katharine L, Dean, David K, Fonfria, Elena, Gleave, Robert J, Medhurst, Stephen J, Michel, Anton D, Moses, Andrew P, Patel, Sadhana, Roman, Shilina A, Scoccitti, Tiziana, Smith, Beverley, Steadman, Jon G A, Walter, Daryl S

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Discovery of a novel series of nonacidic benzofuran EP1 receptor antagonists von ALLAN, Amanda C, BILLINTON, Andy, NAYLOR, Alan, RAWLINGS, D. Anthony, SIME, Mairi, SCOCCITTI, Tiziana, THEOBALD, Pamela J, BROWN, Susan H, CHOWDHURY, Anita, EATHERTON, Andrew J, FIELDHOUSE, Charlotte, GIBLIN, Gerard M. P, GOLDSMITH, Paul, HALL, Adrian, HURST, David N

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Identification of 2-oxo-N-(phenylmethyl)-4-imidazolidinecarboxamide antagonists of the P2X7 receptor von Abberley, Lee, Bebius, Aude, Beswick, Paul J., Billinton, Andy, Collis, Katharine L., Dean, David K., Fonfria, Elena, Gleave, Robert J., Medhurst, Stephen J., Michel, Anton D., Moses, Andrew P., Patel, Sadhana, Roman, Shilina A., Scoccitti, Tiziana, Smith, Beverley, Steadman, Jon G.A., Walter, Daryl S.

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Discovery of a novel indole series of EP1 receptor antagonists by scaffold hopping von HALL, Adrian, BILLINTON, Andy, THEOBALD, Pamela J, BROWN, Susan H, CHOWDHURY, Anita, GIBLIN, Gerard M. P, GOLDSMITH, Paul, HURST, David N, NAYLOR, Alan, PATEL, Sadhana, SCOCCITTI, Tiziana

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The discovery of 2-fluoro-N-(3-fluoro-4-(5-((4-morpholinobutyl)amino)-1,3,4-oxadiazol-2-yl)phenyl)benzamide, a full agonist of the alpha-7 nicotinic acetylcholine receptor showing... von Skidmore, John, Atcha, Zeenat, Boucherat, Emmanuelle, Castelletti, Laura, Chen, Deborah W., Coppo, Frank T., Cutler, Leanne, Dunsdon, Rachel M., Heath, Bronagh M., Hutchings, Rio, Hurst, David N., Javed, Sahar, Martin, Samuel, Maskell, Emma S.L., Norton, David, Pemberton, Darrel J., Redshaw, Sally, Rutter, Richard, Sehmi, Sanjeet S., Scoccitti, Tiziana, Temple, Hannah E., Theobald, Pam, Ward, Robert W., Wilson, David M.

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Discovery of GSK345931A : An EP1 receptor antagonist with efficacy in preclinical models of inflammatory pain von HALL, Adrian, BROWN, Susan H, SCOCCITTI, Tiziana, WILSON, Alexander W, WINCHESTER, Wendy J, BUDD, Christopher, CLAYTON, Nicholas M, GIBLIN, Gerard M. P, GOLDSMITH, Paul, HAYHOW, Thomas G, HURST, David N, NAYLOR, Alan, RAWLINGS, D. Anthony

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Discovery of a novel series of nonacidic benzofuran EP sub(1 receptor antagonists) von Allan, Amanda C, Billinton, Andy, Brown, Susan H, Chowdhury, Anita, Eatherton, Andrew J, Fieldhouse, Charlotte, Giblin, Gerard MP, Goldsmith, Paul, Hall, Adrian, Hurst, David N, Naylor, Alan, Rawlings, DAnthony, Sime, Mairi, Scoccitti, Tiziana, Theobald, Pamela J

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Discovery of sodium 6-[(5-chloro-2-{[(4-chloro-2-fluorophenyl)-methyl]oxy}phenyl)methyl]-2-pyridinecarboxylate (GSK269984A) an EP1 receptor antagonist for the treatment of inflamma... von HALL, Adrian, BILLINTON, Andy, PEET, Caroline F, SCOCCITTI, Tiziana, WILSON, Alexander W, WINCHESTER, Wendy, BROWN, Susan H, CHOWDHURY, Anita, CLAYTON, Nicholas M, GIBLIN, Gerard M. P, GIBSON, Mairi, GOLDSMITH, Paul A, HURST, David N, NAYLOR, Alan

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The discovery of 6 -[2 -(5 -chloro -2 -{[ (2,4 -difluorophenyl )-methyl ]oxy}phenyl ) -1 -cyclopenten -1 -yl ] -2 -pyridinecarboxylic acid, GW848687X, a potent and selective prosta... von GIBLIN, Gerard M. P, BIT, Rino A, HURST, David N, MICHEL, Anton D, NAYLOR, Alan, NOVELLI, Riccardo, SCOCCITTI, Tiziana, SPALDING, David, TANG, Sac P, WILSON, Alex W, WILSON, Rich, BROWN, Susan H, CHAIGNOT, Hélène M, CHOWDHURY, Anita, CHESSELL, Iain P, CLAYTON, Nicholas M, COLEMAN, Tanya, HALL, Adrian, HAMMOND, Beverley

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The discovery of 2-fluoro-N-3-fluoro-4-5-((4-morpholinobutyl)amino)-1,3, 4-oxadiazol-2-ylphenylbenzamide, a full agonist of the alpha-7 nicotinic acetylcholine receptor showing eff... von SKIDMORE, John, ATCHA, Zeenat, HURST, David N, JAVED, Sahar, MARTIN, Samuel, MASKELL, Emma S. L, NORTON, David, PEMBERTON, Darrel J, REDSHAW, Sally, RUTTER, Richard, SEHMI, Sanjeet S, SCOCCITTI, Tiziana, BOUCHERAT, Emmanuelle, TEMPLE, Hannah E, THEOBALD, Pam, WARD, Robert W, WILSON, David M, CASTELLETTI, Laura, CHEN, Deborah W, COPPO, Frank T, CUTLER, Leanne, DUNSDON, Rachel M, HEATH, Bronagh M, HUTCHINGS, Rio

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Discovery of a novel series of nonacidic benzofuran EP 1 receptor antagonists von Allan, Amanda C., Billinton, Andy, Brown, Susan H., Chowdhury, Anita, Eatherton, Andrew J., Fieldhouse, Charlotte, Giblin, Gerard M.P., Goldsmith, Paul, Hall, Adrian, Hurst, David N., Naylor, Alan, Rawlings, D. Anthony, Sime, Mairi, Scoccitti, Tiziana, Theobald, Pamela J.

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Identification of a series of 1,3,4-oxadiazol-2-amines as potent alpha-7 agonists with efficacy in the novel object recognition model of cognition von Skidmore, John, Atcha, Zeenat, Boucherat, Emmanuelle, Castelletti, Laura, Chen, Deborah W., Coppo, Frank T., Cutler, Leanne, Dunsdon, Rachel M., Heath, Bronagh M., Hutchings, Rio, Hurst, David N., Javed, Sahar, Martin, Samuel, Maskell, Emma S.L., Norton, David, Pemberton, Darrel J., Redshaw, Sally, Rutter, Richard, Sehmi, Sanjeet S., Scoccitti, Tiziana, Temple, Hannah E., Theobald, Pam, Ward, Robert W., Wilson, David M.

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Identification of 2-oxo-N-(phenylmethyl)-4-imidazolidinecarboxamide antagonists of the P2X sub(7) receptor von Abberley, Lee, Bebius, Aude, Beswick, Paul J, Billinton, Andy, Collis, Katharine L, Dean, David K, Fonfria, Elena, Gleave, Robert J, Medhurst, Stephen J, Michel, Anton D, Moses, Andrew P, Patel, Sadhana, Roman, Shilina A, Scoccitti, Tiziana, Smith, Beverley, Steadman, Jon GA, Walter, Daryl S

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Discovery of sodium 6-[(5-chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)methyl ]-2-pyrid inecarboxylate (GSK269984A) an EP1 receptor antagonist for the treatment of inflamm... von Hall, Adrian, Billinton, Andy, Brown, Susan H, Chowdhury, Anita, Clayton, Nicholas M, Giblin, Gerard M P, Gibson, Mairi, Goldsmith, Paul A, Hurst, David N, Naylor, Alan, Peet, Caroline F, Scoccitti, Tiziana, Wilson, Alexander W, Winchester, Wendy

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Discovery of a novel indole series of EP sub(1) receptor antagonists by scaffold hopping von Hall, Adrian, Billinton, Andy, Brown, Susan H, Chowdhury, Anita, Giblin, Gerard MP, Goldsmith, Paul, Hurst, David N, Naylor, Alan, Patel, Sadhana, Scoccitti, Tiziana, Theobald, Pamela J

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Novel methylene-linked heterocyclic EP1 receptor antagonists von HALL, Adrian, BIT, Rino A, BROWN, Susan H, CHOWDHURY, Anita, GIBLIN, Gerard M. P, HURST, David N, KILFORD, Ian R, LEWELL, Xiao, NAYLOR, Alan, SCOCCITTI, Tiziana

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Novel methylene-linked heterocyclic EP sub(1) receptor antagonists von Hall, Adrian, Bit, Rino A, Brown, Susan H, Chowdhury, Anita, Giblin, Gerard MP, Hurst, David N, Kilford, Ian R, Lewell, Xiao, Naylor, Alan, Scoccitti, Tiziana

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Discovery of GSK345931A: An EP 1 receptor antagonist with efficacy in preclinical models of inflammatory pain von Hall, Adrian, Brown, Susan H., Budd, Christopher, Clayton, Nicholas M., Giblin, Gerard M.P., Goldsmith, Paul, Hayhow, Thomas G., Hurst, David N., Naylor, Alan, Anthony Rawlings, D., Scoccitti, Tiziana, Wilson, Alexander W., Winchester, Wendy J.

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Discovery of sodium 6-[(5-chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)methyl]-2-pyridinecarboxylate (GSK269984A) an EP 1 receptor antagonist for the treatment of inflamma... von Hall, Adrian, Billinton, Andy, Brown, Susan H., Chowdhury, Anita, Clayton, Nicholas M., Giblin, Gerard M.P., Gibson, Mairi, Goldsmith, Paul A., Hurst, David N., Naylor, Alan, Peet, Caroline F., Scoccitti, Tiziana, Wilson, Alexander W., Winchester, Wendy

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