Chemical activation of the mechanotransduction channel Piezo1 von Syeda, Ruhma, Xu, Jie, Dubin, Adrienne E, Coste, Bertrand, Mathur, Jayanti, Huynh, Truc, Matzen, Jason, Lao, Jianmin, Tully, David C, Engels, Ingo H, Petrassi, H Michael, Schumacher, Andrew M, Montal, Mauricio, Bandell, Michael, Patapoutian, Ardem

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Englerin A Agonizes the TRPC4/C5 Cation Channels to Inhibit Tumor Cell Line Proliferation von Carson, Cheryl, Raman, Pichai, Tullai, Jennifer, Xu, Lei, Henault, Martin, Thomas, Emily, Yeola, Sarita, Lao, Jianmin, McPate, Mark, Verkuyl, J Martin, Marsh, George, Sarber, Jason, Amaral, Adam, Bailey, Scott, Lubicka, Danuta, Pham, Helen, Miranda, Nicolette, Ding, Jian, Tang, Hai-Ming, Ju, Haisong, Tranter, Pamela, Ji, Nan, Krastel, Philipp, Jain, Rishi K, Schumacher, Andrew M, Loureiro, Joseph J, George, Elizabeth, Berellini, Giuliano, Ross, Nathan T, Bushell, Simon M, Erdemli, Gül, Solomon, Jonathan M

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Tau overexpression exacerbates neuropathology after repeated mild head impacts in male mice von Cheng, Hank, Deaton, Lisa M., Qiu, Minhua, Ha, Sukwon, Pacoma, Reynand, Lao, Jianmin, Tolley, Valerie, Moran, Rita, Keeton, Amber, Lamb, John R., Fathman, John, Walker, John R., Schumacher, Andrew M.

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Discovery of a Small-Molecule Modulator of Glycosaminoglycan Sulfation von Cheung, Sheldon T, Miller, Michelle S, Pacoma, Reynand, Roland, Jason, Liu, Jian, Schumacher, Andrew M, Hsieh-Wilson, Linda C

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Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA von Owen, Kate A, Qiu, Deyi, Alves, Juliano, Schumacher, Andrew M, Kilpatrick, Lynette M, Li, Jun, Harris, Jennifer L, Ellis, Vincent

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Discovery, Optimization, and Biological Evaluation of 5‑(2-(Trifluoromethyl)phenyl)­indazoles as a Novel Class of Transient Receptor Potential A1 (TRPA1) Antagonists von Rooney, Lisa, Vidal, Agnès, D’Souza, Anne-Marie, Devereux, Nick, Masick, Brian, Boissel, Valerie, West, Ryan, Head, Victoria, Stringer, Rowan, Lao, Jianmin, Petrus, Matt J, Patapoutian, Ardem, Nash, Mark, Stoakley, Natalie, Panesar, Moh, Verkuyl, J. Martin, Schumacher, Andrew M, Petrassi, H. Michael, Tully, David C

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3D inversion recovery ultrashort echo time MRI can detect demyelination in cuprizone-treated mice von Searleman, Adam C, Ma, Yajun, Sampath, Srihari, Sampath, Srinath, Bussell, Robert, Chang, Eric Y, Deaton, Lisa, Schumacher, Andrew M, Du, Jiang

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Selective DYRK1A Inhibitor for the Treatment of Type 1 Diabetes: Discovery of 6‑Azaindole Derivative GNF2133 von Liu, Yahu A, Jin, Qihui, Zou, Yefen, Ding, Qiang, Yan, Shanshan, Wang, Zhicheng, Hao, Xueshi, Nguyen, Bao, Zhang, Xiaoyue, Pan, Jianfeng, Mo, Tingting, Jacobsen, Kate, Lam, Thanh, Wu, Tom Y.-H, Petrassi, H. Michael, Bursulaya, Badry, DiDonato, Michael, Gordon, W. Perry, Liu, Bo, Baaten, Janine, Hill, Robert, Nguyen-Tran, Vân, Qiu, Minhua, Zhang, You-Qing, Kamireddy, Anwesh, Espinola, Sheryll, Deaton, Lisa, Ha, Sukwon, Harb, George, Jia, Yong, Li, Jing, Shen, Weijun, Schumacher, Andrew M, Colman, Karyn, Glynne, Richard, Pan, Shifeng, McNamara, Peter, Laffitte, Bryan, Meeusen, Shelly, Molteni, Valentina, Loren, Jon

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An aminopyridazine-based inhibitor of a pro-apoptotic protein kinase attenuates hypoxia-ischemia induced acute brain injury von VELENTZA, Anastasia V, WAINWRIGHT, Mark S, ZASADZKI, Magdalena, MIRZOEVA, Salida, SCHUMACHER, Andrew M, HAIECH, Jacques, FOCIA, Pamela J, EGLI, Martin, WATTERSON, D. Martin

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Enhanced proteolytic clearance of plasma Aβ by peripherally administered neprilysin does not result in reduced levels of brain Aβ in mice von Walker, John R, Pacoma, Reynand, Watson, James, Ou, Weijia, Alves, Juliano, Mason, Daniel E, Peters, Eric C, Urbina, Hugo D, Welzel, Gus, Althage, Alana, Liu, Bo, Tuntland, Tove, Jacobson, Laura H, Harris, Jennifer L, Schumacher, Andrew M

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A Calmodulin-Regulated Protein Kinase Linked to Neuron Survival Is a Substrate for the Calmodulin-Regulated Death-Associated Protein Kinase von Schumacher, Andrew M, Schavocky, James P, Velentza, Anastasia V, Mirzoeva, Salida, Watterson, D. Martin

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A Dual Inhibitor of DYRK1A and GSK3β for β‐Cell Proliferation: Aminopyrazine Derivative GNF4877 von Liu, Yahu A., Jin, Qihui, Ding, Qiang, Hao, Xueshi, Mo, Tingting, Yan, Shanshan, Zou, Yefen, Huang, Zhihong, Zhang, Xiaoyue, Gao, Wenqi, Wu, Tom Y.‐H., Li, Chun, Bursalaya, Badry, Di Donato, Michael, Zhang, You‐Qing, Deaton, Lisa, Shen, Weijun, Taylor, Brandon, Kamireddy, Anwesh, Harb, George, Li, Jing, Jia, Yong, Schumacher, Andrew M., Laffitte, Bryan, Glynne, Richard, Pan, Shifeng, McNamara, Peter, Molteni, Valentina, Loren, Jon

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Death associated protein kinase as a potential therapeutic target von Schumacher, Andrew M, Velentza, Anastasia V, Watterson, D Martin

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Death-Associated Protein Kinase Phosphorylates Mammalian Ribosomal Protein S6 and Reduces Protein Synthesis von Schumacher, Andrew M, Velentza, Anastasia V, Watterson, D. Martin, Dresios, John

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Discovery of inhibitors of the channel-activating protease prostasin (CAP1/PRSS8) utilizing structure-based design von Tully, David C., Vidal, Agnès, Chatterjee, Arnab K., Williams, Jennifer A., Roberts, Michael J., Petrassi, H. Michael, Spraggon, Glen, Bursulaya, Badry, Pacoma, Reynand, Shipway, Aaron, Schumacher, Andrew M., Danahay, Henry, Harris, Jennifer L.

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DAPK catalytic activity in the hippocampus increases during the recovery phase in an animal model of brain hypoxic-ischemic injury von Schumacher, Andrew M, Velentza, Anastasia V, Watterson, D.Martin, Wainwright, Mark S

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Structure, activity, regulation, and inhibitor discovery for a protein kinase associated with apoptosis and neuronal death von Velentza, Anastasia V., Schumacher, Andrew M., Watterson, D.Martin

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A Protein Kinase Associated with Apoptosis and Tumor Suppression von Velentza, Anastasia V., Schumacher, Andrew M., Weiss, Curtis, Egli, Martin, Watterson, D. Martin

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A protein kinase associated with apoptosis and tumor suppression: structure, activity, and discovery of peptide substrates von Velentza, A V, Schumacher, A M, Weiss, C, Egli, M, Watterson, D M

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Lactate dehydrogenase as a selection criterion for ipilimumab treatment in metastatic melanoma von Kelderman, Sander, Heemskerk, Bianca, van Tinteren, Harm, van den Brom, Rob R. H., Hospers, Geke A. P., van den Eertwegh, Alfonsus J. M., Kapiteijn, Ellen W., de Groot, Jan Willem B., Soetekouw, Patricia, Jansen, Rob L., Fiets, Edward, Furness, Andrew J. S., Renn, Alexandra, Krzystanek, Marcin, Szallasi, Zoltan, Lorigan, Paul, Gore, Martin E., Schumacher, Ton N. M., Haanen, John B. A. G., Larkin, James M. G., Blank, Christian U.

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