Phase I First-in-Human Dose Escalation Study of the oral SF3B1 modulator H3B-8800 in myeloid neoplasms von Steensma, David P., Wermke, Martin, Klimek, Virginia M., Greenberg, Peter L., Font, Patricia, Komrokji, Rami S., Yang, Jay, Brunner, Andrew M., Carraway, Hetty E., Ades, Lionel, Al-Kali, Aref, Alonso-Dominguez, Juan M., Alfonso-Piérola, Ana, Coombs, Catherine C., Deeg, H. Joachim, Flinn, Ian, Foran, James M., Garcia-Manero, Guillermo, Maris, Michael B., McMasters, Malgorzata, Micol, Jean-Baptiste, De Oteyza, Jaime Perez, Thol, Felicitas, Wang, Eunice S., Watts, Justin M., Taylor, Justin, Stone, Richard, Gourineni, Vikram, Marino, Alyssa J., Yao, Huilan, Destenaves, Benoit, Yuan, Xiaobin, Yu, Kun, Dar, Sara, Ohanjanian, Lernik, Kuida, Keisuke, Xiao, Jianjun, Scholz, Catherine, Gualberto, Antonio, Platzbecker, Uwe

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Vedolizumab for the treatment of active ulcerative colitis: A randomized controlled phase 2 dose‐ranging study von Parikh, Asit, Leach, Timothy, Wyant, Tim, Scholz, Catherine, Sankoh, Serap, Mould, Diane R., Ponich, Terry, Fox, Irving, Feagan, Brian G.

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Tipifarnib in recurrent, metastatic HRAS‐mutant salivary gland cancer von Hanna, Glenn J., Guenette, Jeffrey P., Chau, Nicole G., Sayehli, Cyrus M., Wilhelm, Christian, Metcalf, Robert, Wong, Deborah J., Brose, Marcia, Razaq, Mohammad, Pérez‐Ruiz, Elisabeth, Cohen, Ezra E. W., Aggarwal, Rahul, Scholz, Catherine, Gualberto, Antonio, Ho, Alan L.

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A Phase I and Pharmacokinetic Study of the Oral Histone Deacetylase Inhibitor, MS-275, in Patients with Refractory Solid Tumors and Lymphomas von Gore, Lia, Rothenberg, Mace L., O'Bryant, Cindy L., Schultz, Mary Kay, Sandler, Alan B., Coffin, Denise, McCoy, Candice, Schott, Astrid, Scholz, Catherine, Eckhardt, S. Gail

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Vedolizumab Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability Following Administration of a Single, Ascending, Intravenous Dose to Healthy Volunteers von Rosario, Maria, Wyant, Timothy, Leach, Timothy, Sankoh, Serap, Scholz, Catherine, Parikh, Asit, Fox, Irving, Feagan, Brian G.

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Abstract P110: Neandertal introgressions contribute to upper aero-digestive tract tumor patient survival and identify patients who may benefit from STING agonist treatment von Gualberto, Antonio, Chen, Tenghui, Scholz, Catherine, Luke, Jason

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Tipifarnib in Head and Neck Squamous Cell Carcinoma With HRAS Mutations von Ho, Alan L, Brana, Irene, Haddad, Robert, Bauman, Jessica, Bible, Keith, Oosting, Sjoukje, Wong, Deborah J, Ahn, Myung-Ju, Boni, Valentina, Even, Caroline, Fayette, Jerome, Flor, Maria José, Harrington, Kevin, Kim, Sung-Bae, Licitra, Lisa, Nixon, Ioanna, Saba, Nabil F, Hackenberg, Stephan, Specenier, Pol, Worden, Francis, Balsara, Binaifer, Leoni, Mollie, Martell, Bridget, Scholz, Catherine, Gualberto, Antonio

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A Phase II Trial of Tipifarnib for Patients with Previously Treated, Metastatic Urothelial Carcinoma Harboring HRAS Mutations von Lee, Hye Won, Sa, Jason K, Gualberto, Antonio, Scholz, Catherine, Sung, Hyun Hwan, Jeong, Byong Chang, Choi, Han Yong, Kwon, Ghee Young, Park, Se Hoon

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Patient reported abdominal pain as a surrogate of the clinical benefit of tipifarnib in pancreatic cancer patients von Gualberto, Antonio, Scholz, Catherine Rose, Van Cutsem, Eric

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Abstract 4917: Tipifarnib is highly active in HRAS mutant lung squamous carcinoma tumor models von Kessler, Linda, Scholz, Catherine, Gualberto, Antonio, Liu, Yi, Burrows, Francis

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Preliminary activity of tipifarnib in tumors of the head and neck, salivary gland and urothelial tract with HRAS mutations von Ho, Alan Loh, Hanna, Glenn J., Scholz, Catherine Rose, Gualberto, Antonio, Park, Se Hoon

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Tipifarnib, a farnesyltransferase inhibitor, for metastatic urothelial carcinoma harboring HRAS mutations von Lee, Jiyun, Kim, Hana, Gualberto, Antonio, Scholz, Catherine Rose, Park, Se Hoon

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Relative bioavailability of H3B-6545 tablets versus capsules and drug-drug interaction between H3B-6545 and pantoprazole von Xiao, Jianjun Alan, Coleman, Hugh A, Sahmoud, Tarek, Gao, Lei, Chong, Weili, McAuley, Sonja, Scholz, Catherine, Gualberto, Antonio

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Crosstalk between the IGF1 and CXCL12 Pathways Defines Objective Responses to the Farnesyl Transferase Inhibitor Tipifarnib in AML and PTCL Patients von Gualberto, Antonio, Scholz, Catherine, Mishra, Vishnu, Janes, Matthew R, Kessler, Linda

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Tipifarnib enhances eradication of acute myeloid leukemia by altering CXCL12/CXCR4 signaling in AML and by modifying the bone marrow microenvironment von Sterner, Rosalie, Greif, Lauren E, Khan, Rehan, Kwok, Tina, Peterson, Kevin L, Kaufmann, Scott H, Kessler, Linda, Scholz, Catherine, Gualberto, Antonio, Hedin, Karen E

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Long-term clinical experience with vedolizumab in patients with inflammatory bowel disease von Parikh, Asit, Fox, Irving, Leach, Timothy, Xu, Jing, Scholz, Catherine, Patella, Michael, Feagan, Brian G

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Abstract CT191: Mechanism of action of the farnesyltransferase inhibitor, tipifarnib, and its clinical applications von Gualberto, Antonio, Scholz, Catherine, Mishra, Vishnu, Janes, Matthew R., Kessler, Linda, Cutsem, Eric Van, Ho, Alan L., Witzig, Thomas

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Abstract P1-17-03: H3B-6545 in combination with palbociclib in women with metastatic estrogen receptor-positive (ER+), human epidermal growth factor receptor 2 (HER2)-negative brea... von Johnston, Stephen, Pluard, Timothy J, Wang, Judy S, Hamilton, Erika P, Juric, Dejan, Scholz, Catherine R, Hnitecki, Elizabeth, Dar, Sara, Gao, Lei, Cantagallo, Lisa, Korpal, Manav, Xiao, Jianjun Alan, Yu, Lihua, Sahmoud, Tarek, Gualberto, Antonio

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Killer Immunoglobulin-like Receptors (KIR) in Low-Risk Myelodysplastic Syndrome: Genotyping and Gene Expression Evaluation von Coutinho, Diego, Ali, Abdullah Mahmood, Gualberto, Antonio, Scholz, Catherine, Bracken, Karen, Jurcic, Joseph G., Raza, Azra

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The CXCL12/CXCR4 Pathway As a Potential Target of Tipifarnib in Acute Myeloid Leukemia and Myelodysplastic Syndromes von Gualberto, Antonio, Scholz, Catherine, Janes, Matthew R, Kessler, Linda, Raza, Azra

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