Preclinical development of a high affinity α-synuclein antibody, MEDI1341, that can enter the brain, sequester extracellular α-synuclein and attenuate α-synuclein spreading in vivo... von Schofield, Darren J., Irving, Lorraine, Calo, Laura, Bogstedt, Anna, Rees, Gareth, Nuccitelli, Annalisa, Narwal, Rajesh, Petrone, Marcella, Roberts, Jennifer, Brown, Lee, Cusdin, Fiona, Dosanjh, Bhupinder, Lloyd, Christopher, Dobson, Claire, Gurrell, Ian, Fraser, Graham, McFarlane, Mary, Rockenstein, Edward, Spencer, Brian, Masliah, Eliezer, Spillantini, Maria Grazia, Tan, Keith, Billinton, Andrew, Vaughan, Tris, Chessell, Iain, Perkinton, Michael S.

Volltext

Generating therapeutic monoclonal antibodies to complex multi-spanning membrane targets: Overcoming the antigen challenge and enabling discovery strategies von Dodd, Roger, Schofield, Darren J., Wilkinson, Trevor, Britton, Zachary T.

Volltext

Identification of optimal protein binders through the use of large genetically encoded display libraries von McCafferty, John, Schofield, Darren

Volltext

Therapeutic Monoclonal Antibodies to Complex Membrane Protein Targets: Antigen Generation and Antibody Discovery Strategies von Dodd, Roger B., Wilkinson, Trevor, Schofield, Darren J.

Volltext

Antibodies binding the head domain of P2X4 inhibit channel function and reverse neuropathic pain von Williams, Wendy A., Linley, John E., Jones, Clare A., Shibata, Yoko, Snijder, Arjan, Button, James, Hatcher, Jon P., Huang, Ling, Taddese, Bruck, Thornton, Peter, Schofield, Darren J., Thom, George, Popovic, Bojana, Dosanjh, Bhupinder, Wilkinson, Trevor, Hughes, Jane, Dobson, Claire L., Groves, Maria A., Webster, Carl I., Billinton, Andy, Vaughan, Tristan J., Chessell, Iain

Volltext

A roadmap to generate renewable protein binders to the human proteome von Colwill, Karen, Gräslund, Susanne

Volltext

Rituximab causes a polarization of B cells that augments its therapeutic function in NK-cell–mediated antibody-dependent cellular cytotoxicity von Rudnicka, Dominika, Oszmiana, Anna, Finch, Donna K., Strickland, Ian, Schofield, Darren J., Lowe, David C., Sleeman, Matthew A., Davis, Daniel M.

Volltext

Activity of murine surrogate antibodies for durvalumab and tremelimumab lacking effector function and the ability to deplete regulatory T cells in mouse models of cancer von Schofield, Darren J, Percival-Alwyn, Jennifer, Rytelewski, Mateusz, Hood, John, Rothstein, Raymond, Wetzel, Leslie, McGlinchey, Kelly, Adjei, Grace, Watkins, Amanda, Machiesky, LeeAnn, Chen, Weimin, Andrews, John, Groves, Maria, Morrow, Michelle, Stewart, Ross A, Leinster, Andrew, Wilkinson, Robert W, Hammond, Scott A, Luheshi, Nadia, Dobson, Claire, Oberst, Michael

Volltext

Immunomodulation of T- and NK-cell Responses by a Bispecific Antibody Targeting CD28 Homolog and PD-L1 von Ramaswamy, Madhu, Kim, Taeil, Jones, Des C, Ghadially, Hormas, Mahmoud, Tamer I, Garcia, Andrew, Browne, Gareth, Zenonos, Zenon, Puplampu-Dove, Yvonne, Riggs, Jeffrey M, Bhat, Geetha K, Herbst, Ronald, Schofield, Darren J, Carlesso, Gianluca

Volltext

Spatial Configuration of Hepatitis E Virus Antigenic Domain von LI XING, WANG, Joseph C, MIYAMURA, Tatsuo, HOLLAND CHENG, R, LI, Tian-Cheng, YASUTOMI, Yasuhiro, LARA, James, KHUDYAKOV, Yury, SCHOFIELD, Darren, EMERSON, Suzanne U, PURCELL, Robert H, TAKEDA, Naokazu

Volltext

Genetic methods of antibody generation and their use in immunohistochemistry von Schofield, Darren J., Lewis, Arthur R., Austin, Mark J.

Volltext

Application of phage display to high throughput antibody generation and characterization von Schofield, Darren J, Pope, Anthony R, Clementel, Veronica, Buckell, Jenny, Chapple, Susan Dj, Clarke, Kay F, Conquer, Jennie S, Crofts, Anna M, Crowther, Sandra R E, Dyson, Michael R, Flack, Gillian, Griffin, Gareth J, Hooks, Yvette, Howat, William J, Kolb-Kokocinski, Anja, Kunze, Susan, Martin, Cecile D, Maslen, Gareth L, Mitchell, Joanne N, O'Sullivan, Maureen, Perera, Rajika L, Roake, Wendy, Shadbolt, S Paul, Vincent, Karen J, Warford, Anthony, Wilson, Wendy E, Xie, Jane, Young, Joyce L, McCafferty, John

Volltext

A simple vector system to improve performance and utilisation of recombinant antibodies von Martin, Cecile D, Rojas, Gertrudis, Mitchell, Joanne N, Vincent, Karen J, Wu, Jiahua, McCafferty, John, Schofield, Darren J

Volltext

Human monoclonal antibodies that react with the E2 glycoprotein of hepatitis C virus and possess neutralizing activity von SCHOFIELD, Darren J, BARTOSCH, Birke, SHIMIZU, Yohko K, ALLANDER, Tobias, ALTER, Harvey J, EMERSON, Suzanne U, COSSET, Francois-Loic, PURCELL, Robert H

Volltext

Biochemical characterization of the active heterodimer form of human heparanase (Hpa1) protein expressed in insect cells von McKenzie, Edward, Young, Kathryn, Hircock, Margaret, Bennett, James, Bhaman, Maina, Felix, Robert, Turner, Paul, Stamps, Alasdair, McMillan, David, Saville, Giles, Ng, Stanley, Mason, Sean, Snell, Daniel, Schofield, Darren, Gong, Haiping, Townsend, Reid, Gallagher, John, Page, Martin, Parekh, Raj, Stubberfield, Colin

Volltext

Identification of Chimpanzee Fab Fragments by Repertoire Cloning and Production of a Full-Length Humanized Immunoglobulin G1 Antibody That Is Highly Efficient for Neutralization of... von Men, Ruhe, Yamashiro, Tetsu, Goncalvez, Ana P, Wernly, Claire, Schofield, Darren J, Emerson, Suzanne U, Purcell, Robert H, Lai, Ching-Juh

Volltext

Monoclonal antibodies that neutralize HEV recognize an antigenic site at the carboxyterminus of an ORF2 protein vaccine von Schofield, Darren J, Purcell, Robert H, Nguyen, Hanh T, Emerson, Suzanne U

Volltext

Abstract 4438: A bispecific antibody targeting CD28H and PDL-1 is a novel and potent immunomodulator of T cell responses von Ramaswamy, Madhu, Kim, Taeil, Jones, Desmond, Ghadially, Hormas, Mahmoud, Tamer, Garcia, Andrew, Wilson, Susan, Riggs, Jeffrey, Schofield, Darren, Carlesso, GIanluca

Volltext

Su1770 AZD7798: A NEW CCR9 DEPLETING ANTIBODY TO TREAT CROHN'S DISEASE von Nys, Josquin, Thom, George, Cariuk, Peter, Riley, Aidan, Kelly, Aoife, Swieboda, Dawid P., Huntington, Catherine, Rees, D.G., Irving, Lorraine M., Schofield, Darren, Daramola, Lekan, Stebbings, Richard, Marks, Daniel J.

Volltext

IL-33 is associated with alveolar dysfunction in patients with viral lower respiratory tract disease von Scott, Ian C., Zuydam, Natalie van, Cann, Jennifer A., Negri, Victor Augusti, Tsafou, Kalliopi, Killick, Helen, Liu, Zhi, McCrae, Christopher, Rees, D. Gareth, England, Elizabeth, Guscott, Molly A., Houslay, Kirsty, McCormick, Dominique, Freeman, Anna, Schofield, Darren, Freeman, Adrian, Cohen, E. Suzanne, Thwaites, Ryan, Brohawn, Zach, Platt, Adam, Openshaw, Peter J.M., Semple, Malcolm G., Baillie, J. Kenneth, Wilkinson, Tom

Volltext