Discovery and characterization of COVA322, a clinical-stage bispecific TNF/IL-17A inhibitor for the treatment of inflammatory diseases von Silacci, Michela, Lembke, Wibke, Woods, Richard, Attinger-Toller, Isabella, Baenziger-Tobler, Nadja, Batey, Sarah, Santimaria, Roger, von der Bey, Ulrike, Koenig-Friedrich, Susann, Zha, Wenjuan, Schlereth, Bernd, Locher, Mathias, Bertschinger, Julian, Grabulovski, Dragan

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Eradication of tumors from a human colon cancer cell line and from ovarian cancer metastases in immunodeficient mice by a single-chain Ep-CAM-/CD3-bispecific antibody construct von SCHLERETH, Bernd, FICHTNER, Iduna, WIMBERGER, Pauline, KIMMIG, Rainer, BAEUERLE, Patrick A, LORENCZEWSKI, Grit, KLEINDIENST, Petra, BRISCHWEIN, Klaus, DA SILVA, Antonio, KUFER, Peter, LUTTERBUESE, Ralf, JUNGHAHN, Ilse, KASIMIR-BAUER, Sabine

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Selective targeting and potent control of tumor growth using an EphA2/CD3-Bispecific single-chain antibody construct von HAMMOND, Scott A, LUTTERBUESE, Ralf, KIENER, Peter A, ROFF, Shannon, LUTTERBUESE, Petra, SCHLERETH, Bernd, BRUCKHEIMER, Elizabeth, KINCH, Michael S, COATS, Steve, BAEUERLE, Patrick A, KUFER, Peter

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Potent inhibition of local and disseminated tumor growth in immunocompetent mouse models by a bispecific antibody construct specific for Murine CD3 von SCHLERETH, Bernd, KLEINDIENST, Petra, KUFER, Peter, BAEUERLE, Patrick A, FICHTNER, Iduna, LORENCZEWSKI, Grit, BRISCHWEIN, Klaus, LIPPOLD, Sandra, DA SILVA, Antonio, LOCHER, Mathias, KISCHEL, Roman, LUTTERBIISE, Ralf

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Successful Vaccine-Induced Seroconversion by Single-Dose Immunization in the Presence of Measles Virus-Specific Maternal Antibodies von Schlereth, B, Rose, J K, Buonocore, L, ter Meulen, V, Niewiesk, S

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A CD79b Targeting ADC with Superior Anti-Tumor Activity and Safety Resulting in Significantly Improved Therapeutic Index (TI): Safe and Efficacious CD79b ADC von Schlereth, Bernd, Attinger-toller, Isabella, Probst, Philipp, Bertrand, Romain, Stark, Ramona, Santimaria, Roger, Renard, Emma, Fay, Rachael, Sharman, Jeff P., Grabulovski, Dragan, Spycher, Philipp

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Abstract 525: Novel DARPin multi-specific T-cell engager with an improved therapeutic window to overcome dose limiting toxicities in AML therapies von Reschke, Nina, Looser, Thamar, Krieg, Jennifer, Bianchi, Matteo, Schildknecht, Patricia, Bassler, Nicole, Gruebler, Yvonne, Grimm, Sebastian, Jeanbart, Laura, Hospodarsch, Tanja, Neculcea, Alexandra, Steiner, Daniel, Schlereth, Bernd, Reichen, Christian

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Abstract 1890: A solution to T-cell engager toxicity: An anti-CD3 Prodrug DARPin (CD3-PDD) shows no toxicity, but potent anti-tumor activity in a humanized mouse model von Bosshart, Andreas, Ahlskog, Julia Katharina, Eggenschwiler, Aline, Schiegg, Dieter, Grübler, Yvonne, Wandel, Sandra, Fontaine, Simon, Paladino, Maria, Mangold, Susanne, Hospodarsch, Tanja, Neculcea, Alexandra, Iss, Chloé, Herzog, Christel, Schlereth, Bernd

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Mode of cytotoxic action of T cell-engaging BiTE antibody MT110 von Haas, Cornelia, Krinner, Eva, Brischwein, Klaus, Hoffmann, Patrick, Lutterbüse, Ralf, Schlereth, Bernd, Kufer, Peter, Baeuerle, Patrick A

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BiTEs: bispecific antibody constructs with unique anti-tumor activity von Wolf, Evelyn, Hofmeister, Robert, Kufer, Peter, Schlereth, Bernd, Baeuerle, Patrick A.

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Avidity-Engineered CD3 Engaging DARPin ® Targeting Three Tumor Associated Antigens Induce Strong and Specific T Cell Dependent Killing of AML Cells with Potential for Improved Safe... von Bianchi, Matteo, Reschke, Nina, Reichen, Christian, Fischer, Stefanie, Grübler, Yvonne, Eggenschwiler, Aline, Krieg, Jennifer, Ioannou, Kyriaki, Ragusa, Simone, Looser, Thamar, Spitzli, Patricia, Herzog, Christel, Villemagne, Denis, Kaufmann, Yvonne, Matzner, Mirela, Auge, Alienor, Hänggi, Martin, Ali, Waleed, Franchini, Marco, Kirkin, Vladimir, Schlereth, Bernd, Luethi, Ursina, Ochsenbein, Adrian, Riether, Carsten, Steiner, Daniel, Goubier, Anne

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Abstract LB221: Novel peptide linker-based nectin-4 targeting ADC shows improved tolerability with long-lasting anti-tumor efficacy at low doses von Attinger-Toller, Isabella, Probst, Philipp, Bertrand, Romain, Renard, Emma, Stark, Ramona, Santimaria, Roger, Grabulovski, Dragan, Schlereth, Bernd, Spycher, Philipp Rene

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Abstract LB219: Inducing significant and efficient tumor growth inhibition vs trastuzumab deruxtecan with low drug-load topoisomerase 1 inhibitor ADC using novel peptide linkers fo... von Attinger-Toller, Isabella, Fay, Rachael, Bertrand, Romain, Probst, Philipp, Stark, Ramona, Santimaria, Roger, Grabulovski, Dragan, Schlereth, Bernd, Spycher, Philipp Rene

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Abstract LB174: Inducing complete and long-lasting tumor eradications at safe and well tolerated doses of a nectin-4 ADC generated with novel peptide linkers for payload conjugatio... von Attinger-Toller, Isabella, Probst, Philipp, Bertrand, Romain, Stark, Ramona, Santimaria, Roger, Grabulovski, Dragan, Schlereth, Bernd, Spycher, Philipp

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Strictly Target Cell-dependent Activation of T Cells by Bispecific Single-chain Antibody Constructs of the BiTE Class von BRISCHWEIN, Klaus, PARR, Larissa, SCHLERETH, Bernd, BAEUERLE, Patrick A, PFLANZ, Stefan, VOLKLAND, Jörg, LUMSDEN, John, KLINGER, Matthias, LOCHER, Mathias, HAMMOND, Scott A, KIENER, Peter, KUFER, Peter

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Safety and immunogenicity of IMVAMUNE, a promising candidate as a third generation smallpox vaccine von Vollmar, Jens, Arndtz, Nathaly, Eckl, Karl M., Thomsen, Torben, Petzold, Barbara, Mateo, Luis, Schlereth, Bernd, Handley, Amanda, King, Lynette, Hülsemann, Vanessa, Tzatzaris, Maria, Merkl, Karin, Wulff, Niels, Chaplin, Paul

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MT110: A novel bispecific single-chain antibody construct with high efficacy in eradicating established tumors von Brischwein, Klaus, Schlereth, Bernd, Guller, Benjamin, Steiger, Carola, Wolf, Andreas, Lutterbuese, Ralf, Offner, Sonja, Locher, Mathias, Urbig, Thomas, Raum, Tobias, Kleindienst, Petra, Wimberger, Pauline, Kimmig, Rainer, Fichtner, Iduna, Kufer, Peter, Hofmeister, Robert, da Silva, Antonio J., Baeuerle, Patrick A.

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Abstract 2910: A CD79b targeting ADC with superior anti-tumor activity and therapeutic index von Attinger-Toller, Isabella, Probst, Philipp, Bertrand, Romain, Stark, Ramona, Santimaria, Roger, Renard, Emma, Fay, Rachael, Grabulovski, Dragan, Schlereth, Bernd, Spycher, Philipp René

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Therapeutic Window of MuS110, a Single-Chain Antibody Construct Bispecific for Murine EpCAM and Murine CD3 von AMANN, Maria, BRISCHWEIN, Klaus, LUTTERBUESE, Ralf, KUFER, Peter, BAEUERLE, Patrick A, SCHLERETH, Bernd, LUTTERBUESE, Petra, PARR, Larissa, PETERSEN, Laetitia, LORENCZEWSKI, Grit, KRINNER, Eva, BRUCKMEIER, Sandra, LIPPOLD, Sandra, KISCHEL, Roman

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T Cell Costimulus-Independent and Very Efficacious Inhibition of Tumor Growth in Mice Bearing Subcutaneous or Leukemic Human B Cell Lymphoma Xenografts by a CD19-/CD3- Bispecific S... von Dreier, Torsten, Baeuerle, Patrick A, Fichtner, Iduna, Grun, Michael, Schlereth, Bernd, Lorenczewski, Grit, Kufer, Peter, Lutterbuse, Ralf, Riethmuller, Gert, Gjorstrup, Per, Bargou, Ralf C

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