Amyloid-Beta Peptides Trigger Aggregation of Alpha-Synuclein In Vitro von Koeppen, Janett, Schulze, Anja, Machner, Lisa, Wermann, Michael, Eichentopf, Rico, Guthardt, Max, Haehnel, Angelika, Klehm, Jessica, Kriegeskorte, Marie-Christin, Hartlage-Ruebsamen, Maike, Morawski, Markus, von Hoersten, Stephan, Demuth, Hans-Ulrich, Rossner, Steffen, Schilling, Stephan

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Passive Aβ Immunotherapy: Current Achievements and Future Perspectives von Schilling, Stephan, Rahfeld, Jens-Ulrich, Lues, Inge, Lemere, Cynthia A

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Dipeptidyl peptidase 4 deficiency improves survival after focal cerebral ischemia in mice and ameliorates microglia activation and specific inflammatory markers von Höfling, Corinna, Donkersloot, Philippa, Ulrich, Luise, Burghardt, Sina, Opitz, Michael, Geissler, Stefanie, Schilling, Stephan, Cynis, Holger, Michalski, Dominik, Roßner, Steffen

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Natural Products from Plants and Algae for Treatment of Alzheimer's Disease: A Review von Klose, Jana, Griehl, Carola, Roßner, Steffen, Schilling, Stephan

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Helical ultrastructure of the metalloprotease meprin α in complex with a small molecule inhibitor von Bayly-Jones, Charles, Lupton, Christopher J., Fritz, Claudia, Venugopal, Hariprasad, Ramsbeck, Daniel, Wermann, Michael, Jäger, Christian, de Marco, Alex, Schilling, Stephan, Schlenzig, Dagmar, Whisstock, James C.

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Development of the clinical candidate PBD-C06, a humanized pGlu3-Aβ-specific antibody against Alzheimer’s disease with reduced complement activation von Hettmann, Thore, Gillies, Stephen D., Kleinschmidt, Martin, Piechotta, Anke, Makioka, Koki, Lemere, Cynthia A., Schilling, Stephan, Rahfeld, Jens-Ulrich, Lues, Inge

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Combination of the Glutaminyl Cyclase Inhibitor PQ912 (Varoglutamstat) and the Murine Monoclonal Antibody PBD-C06 (m6) Shows Additive Effects on Brain A beta Pathology in Transgeni... von Hoffmann, Torsten, Rahfeld, Jens-Ulrich, Schenk, Mathias, Ponath, Falk, Makioka, Koki, Hutter-Paier, Birgit, Lues, Inge, Lemere, Cynthia A., Schilling, Stephan

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Pyroglutamate Formation Influences Solubility and Amyloidogenicity of Amyloid Peptides von Schlenzig, Dagmar, Manhart, Susanne, Cinar, Yeliz, Kleinschmidt, Martin, Hause, Gerd, Willbold, Dieter, Funke, Susanne Aileen, Schilling, Stephan, Demuth, Hans-Ulrich

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Structure and Dynamics of Meprin β in Complex with a Hydroxamate-Based Inhibitor von Linnert, Miriam, Fritz, Claudia, Jaeger, Christian, Schlenzig, Dagmar, Ramsbeck, Daniel, Kleinschmidt, Martin, Wermann, Michael, Demuth, Hans-Ulrich, Parthier, Christoph, Schilling, Stephan

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Immunohistochemical Demonstration of the pGlu79 α-Synuclein Fragment in Alzheimer’s Disease and Its Tg2576 Mouse Model von Bluhm, Alexandra, Schrempel, Sarah, Schilling, Stephan, von Hörsten, Stephan, Schulze, Anja, Roßner, Steffen, Hartlage-Rübsamen, Maike

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N-Terminal pyroglutamate formation of Aβ38 and Aβ40 enforces oligomer formation and potency to disrupt hippocampal long-term potentiation von Schlenzig, Dagmar, Rönicke, Raik, Cynis, Holger, Ludwig, Hans-Henning, Scheel, Eike, Reymann, Klaus, Saido, Takaomi, Hause, Gerd, Schilling, Stephan, Demuth, Hans-Ulrich

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Acute Effects of Focused Ultrasound-Induced Blood-Brain Barrier Opening on Anti-Pyroglu3 Abeta Antibody Delivery and Immune Responses von Bathini, Praveen, Sun, Tao, Schenk, Mathias, Schilling, Stephan, McDannold, Nathan J, Lemere, Cynthia A

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Glutaminyl cyclases from animals and plants: a case of functionally convergent protein evolution von Schilling, Stephan, Wasternack, Claus, Demuth, Hans-Ulrich

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IsoQC (QPCTL) knock-out mice suggest differential substrate conversion by glutaminyl cyclase isoenzymes von Becker, Andreas, Eichentopf, Rico, Sedlmeier, Reinhard, Waniek, Alexander, Cynis, Holger, Koch, Birgit, Stephan, Anett, Bäuscher, Christoph, Kohlmann, Stephanie, Hoffmann, Torsten, Kehlen, Astrid, Berg, Sabine, Freyse, Ernst-Joachim, Osmand, Alexander, Plank, Anne-Christine, Roßner, Steffen, von Hörsten, Stephan, Graubner, Sigrid, Demuth, Hans-Ulrich, Schilling, Stephan

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Effector function of anti-pyroglutamate-3 A beta antibodies affects cognitive benefit, glial activation and amyloid clearance in Alzheimer's-like mice von Crehan, Helen, Liu, Bin, Kleinschmidt, Martin, Rahfeld, Jens-Ulrich, Le, Kevin X., Caldarone, Barbara J., Frost, Jeffrey L., Hettmann, Thore, Hutter-Paier, Birgit, O'Nuallain, Brian, Park, Mi-Ae, DiCarli, Marcelo F., Lues, Inge, Schilling, Stephan, Lemere, Cynthia A.

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A novel human tau knock-in mouse model reveals interaction of Abeta and human tau under progressing cerebral amyloidosis in 5xFAD mice von Barendrecht, Susan, Schreurs, An, Geissler, Stefanie, Sabanov, Victor, Ilse, Victoria, Rieckmann, Vera, Eichentopf, Rico, Künemund, Anja, Hietel, Benjamin, Wussow, Sebastian, Hoffmann, Katrin, Körber-Ferl, Kerstin, Pandey, Ravi, Carter, Gregory W, Demuth, Hans-Ulrich, Holzer, Max, Roßner, Steffen, Schilling, Stephan, Preuss, Christoph, Balschun, Detlef, Cynis, Holger

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Focal Cerebral Ischemia Induces Expression of Glutaminyl Cyclase along with Downstream Molecular and Cellular Inflammatory Responses von Höfling, Corinna, Ulrich, Luise, Burghardt, Sina, Donkersloot, Philippa, Opitz, Michael, Geissler, Stefanie, Schilling, Stephan, Cynis, Holger, Michalski, Dominik, Roßner, Steffen

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Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions von Schilling, Stephan, Hoffmann, Torsten, Manhart, Susanne, Hoffmann, Matthias, Demuth, Hans-Ulrich

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Isolation of an Isoenzyme of Human Glutaminyl Cyclase: Retention in the Golgi Complex Suggests Involvement in the Protein Maturation Machinery von Cynis, Holger, Rahfeld, Jens-Ulrich, Stephan, Anett, Kehlen, Astrid, Koch, Birgit, Wermann, Michael, Demuth, Hans-Ulrich, Schilling, Stephan

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Targeting isoaspartate-modified A beta rescues behavioral deficits in transgenic mice with Alzheimer's disease-like pathology von Gnoth, Kathrin, Piechotta, Anke, Kleinschmidt, Martin, Konrath, Sandra, Schenk, Mathias, Taudte, Nadine, Ramsbeck, Daniel, Rieckmann, Vera, Geissler, Stefanie, Eichentopf, Rico, Barendrecht, Susan, Hartlage-Ruebsamen, Maike, Demuth, Hans-Ulrich, Rossner, Steffen, Cynis, Holger, Rahfeld, Jens-Ulrich, Schilling, Stephan

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