Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance von Shaqra, Ala M., Zvornicanin, Sarah N., Huang, Qiu Yu J., Lockbaum, Gordon J., Knapp, Mark, Tandeske, Laura, Bakan, David T., Flynn, Julia, Bolon, Daniel N. A., Moquin, Stephanie, Dovala, Dustin, Kurt Yilmaz, Nese, Schiffer, Celia A.

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The molecular basis of drug resistance against hepatitis C virus NS3/4A protease inhibitors von Romano, Keith P, Ali, Akbar, Aydin, Cihan, Soumana, Djade, Ozen, Ayşegül, Deveau, Laura M, Silver, Casey, Cao, Hong, Newton, Alicia, Petropoulos, Christos J, Huang, Wei, Schiffer, Celia A

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Crystal Structure of SARS-CoV-2 Main Protease in Complex with the Non-Covalent Inhibitor ML188 von Lockbaum, Gordon J, Reyes, Archie C, Lee, Jeong Min, Tilvawala, Ronak, Nalivaika, Ellen A, Ali, Akbar, Kurt Yilmaz, Nese, Thompson, Paul R, Schiffer, Celia A

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Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms von Flynn, Julia M, Samant, Neha, Schneider-Nachum, Gily, Barkan, David T, Yilmaz, Nese Kurt, Schiffer, Celia A, Moquin, Stephanie A, Dovala, Dustin, Bolon, Daniel NA

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Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity von Kouno, Takahide, Silvas, Tania V., Hilbert, Brendan J., Shandilya, Shivender M. D., Bohn, Markus F., Kelch, Brian A., Royer, William E., Somasundaran, Mohan, Kurt Yilmaz, Nese, Matsuo, Hiroshi, Schiffer, Celia A.

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Structural basis of substrate specificity in human cytidine deaminase family APOBEC3s von Hou, Shurong, Lee, Jeong Min, Myint, Wazo, Matsuo, Hiroshi, Kurt Yilmaz, Nese, Schiffer, Celia A.

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Crystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with ssDNA von Maiti, Atanu, Myint, Wazo, Kanai, Tapan, Delviks-Frankenberry, Krista, Sierra Rodriguez, Christina, Pathak, Vinay K., Schiffer, Celia A., Matsuo, Hiroshi

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Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding von Romano, Keith P., Ali, Akbar, Royer, William E., Schiffer, Celia A., Coffin, John M.

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The ssDNA Mutator APOBEC3A Is Regulated by Cooperative Dimerization von Bohn, Markus-Frederik, Shandilya, Shivender M D, Silvas, Tania V, Nalivaika, Ellen A, Kouno, Takahide, Kelch, Brian A, Ryder, Sean P, Kurt-Yilmaz, Nese, Somasundaran, Mohan, Schiffer, Celia A

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Structure of the catalytically active APOBEC3G bound to a DNA oligonucleotide inhibitor reveals tetrahedral geometry of the transition state von Maiti, Atanu, Hedger, Adam K., Myint, Wazo, Balachandran, Vanivilasini, Watts, Jonathan K., Schiffer, Celia A., Matsuo, Hiroshi

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Substrate sequence selectivity of APOBEC3A implicates intra-DNA interactions von Silvas, Tania V., Hou, Shurong, Myint, Wazo, Nalivaika, Ellen, Somasundaran, Mohan, Kelch, Brian A., Matsuo, Hiroshi, Kurt Yilmaz, Nese, Schiffer, Celia A.

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Structure of the Vif-binding domain of the antiviral enzyme APOBEC3G von Kouno, Takahide, Luengas, Elizabeth M, Shigematsu, Megumi, Shandilya, Shivender M D, Zhang, JingYing, Chen, Luan, Hara, Mayuko, Schiffer, Celia A, Harris, Reuben S, Matsuo, Hiroshi

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Hydration Structure and Dynamics of Inhibitor-Bound HIV‑1 Protease von Leidner, Florian, Kurt Yilmaz, Nese, Paulsen, Janet, Muller, Yves A, Schiffer, Celia A

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Crystal Structure of the DNA Cytosine Deaminase APOBEC3F: The Catalytically Active and HIV-1 Vif-Binding Domain von Bohn, Markus-Frederik, Shandilya, Shivender M.D., Albin, John S., Kouno, Takahide, Anderson, Brett D., McDougle, Rebecca M., Carpenter, Michael A., Rathore, Anurag, Evans, Leah, Davis, Ahkillah N., Zhang, JingYing, Lu, Yongjian, Somasundaran, Mohan, Matsuo, Hiroshi, Harris, Reuben S., Schiffer, Celia A.

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Influenza virus drug resistance: a time-sampled population genetics perspective von Foll, Matthieu, Poh, Yu-Ping, Renzette, Nicholas, Ferrer-Admetlla, Anna, Bank, Claudia, Shim, Hyunjin, Malaspinas, Anna-Sapfo, Ewing, Gregory, Liu, Ping, Wegmann, Daniel, Caffrey, Daniel R, Zeldovich, Konstantin B, Bolon, Daniel N, Wang, Jennifer P, Kowalik, Timothy F, Schiffer, Celia A, Finberg, Robert W, Jensen, Jeffrey D

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Structural basis for mutation-induced destabilization of profilin 1 in ALS von Boopathy, Sivakumar, Tania V. Silvas, Maeve Tischbein, Silvia Jansen, Shivender M. Shandilya, Jill A. Zitzewitz, John E. Landers, Bruce L. Goode, Celia A. Schiffer, Daryl A. Bosco

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Methylcytosine and Normal Cytosine Deamination by the Foreign DNA Restriction Enzyme APOBEC3A von Carpenter, Michael A., Li, Ming, Rathore, Anurag, Lackey, Lela, Law, Emily K., Land, Allison M., Leonard, Brandon, Shandilya, Shivender M.D., Bohn, Markus-Frederik, Schiffer, Celia A., Brown, William L., Harris, Reuben S.

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Hepatitis C Virus NS3/4A Protease Inhibitors Incorporating Flexible P2 Quinoxalines Target Drug Resistant Viral Variants von Matthew, Ashley N, Zephyr, Jacqueto, Hill, Caitlin. J, Jahangir, Muhammad, Newton, Alicia, Petropoulos, Christos J, Huang, Wei, Kurt-Yilmaz, Nese, Schiffer, Celia A, Ali, Akbar

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Selection of HIV-1 for resistance to fifth-generation protease inhibitors reveals two independent pathways to high-level resistance von Spielvogel, Ean, Lee, Sook-Kyung, Zhou, Shuntai, Lockbaum, Gordon J, Henes, Mina, Sondgeroth, Amy, Kosovrasti, Klajdi, Nalivaika, Ellen A, Ali, Akbar, Yilmaz, Nese Kurt, Schiffer, Celia A, Swanstrom, Ronald

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Elucidating the Substrate Envelope of Enterovirus 68-3C Protease: Structural Basis of Specificity and Potential Resistance von Azzolino, Vincent N, Shaqra, Ala M, Ali, Akbar, Kurt Yilmaz, Nese, Schiffer, Celia A

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