Involvement of the central nervous system in acute lymphoblastic leukemia: opinions on molecular mechanisms and clinical implications based on recent data von Lenk, Lennart, Alsadeq, Ameera, Schewe, Denis M.

Volltext

TGF-β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling von Bragado, Paloma, Estrada, Yeriel, Parikh, Falguni, Krause, Sarah, Capobianco, Carla, Farina, Hernan G., Schewe, Denis M., Aguirre-Ghiso, Julio A.

Volltext

ATF6α-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo von Schewe, Denis M, Aguirre-Ghiso, Julio A

Volltext

Combining daratumumab with CD47 blockade prolongs survival in preclinical models of pediatric T-ALL von Müller, Kristina, Vogiatzi, Fotini, Winterberg, Dorothee, Rösner, Thies, Lenk, Lennart, Bastian, Lorenz, Gehlert, Carina L, Autenrieb, Marie Pauline, Brüggemann, Monika, Cario, Gunnar, Schrappe, Martin, Kulozik, Andreas E, Eckert, Cornelia, Bergmann, Anke K, Bornhauser, Beat, Bourquin, Jean-Pierre, Valerius, Thomas, Peipp, Matthias, Kellner, Christian, Schewe, Denis Martin

Volltext

Acute lymphoblastic leukemia of the central nervous system: on the role of PBX1 von Alsadeq, Ameera, Schewe, Denis M

Volltext

Perspectives of targeting LILRB1 in innate and adaptive immune checkpoint therapy of cancer von Zeller, Tobias, Münnich, Ira A., Windisch, Roland, Hilger, Patricia, Schewe, Denis M., Humpe, Andreas, Kellner, Christian

Volltext

When the bond breaks - targeting adhesion of leukemia cells to the meninges von Lenk, Lennart, Vogiatzi, Fotini, Schewe, Denis M

Volltext

Inhibition of eIF2α Dephosphorylation Maximizes Bortezomib Efficiency and Eliminates Quiescent Multiple Myeloma Cells Surviving Proteasome Inhibitor Therapy von SCHEWE, Denis M, AGUIRRE-GHISO, Julio A

Volltext

The role of ZAP70 kinase in acute lymphoblastic leukemia infiltration into the central nervous system von Alsadeq, Ameera, Fedders, Henning, Vokuhl, Christian, Belau, Nele M, Zimmermann, Martin, Wirbelauer, Tim, Spielberg, Steffi, Vossen-Gajcy, Michaela, Cario, Gunnar, Schrappe, Martin, Schewe, Denis M

Volltext

Molecular complete remission following combination treatment of daratumumab and venetoclax in an adolescent with relapsed mixed phenotype acute leukemia von Stanulla, Martin, Schewe, Denis M., Bornhauser, Beat, Bourquin, Jean-Pierre, Eckert, Cornelia, Eberl, Wolfgang, Wolf, Saskia, Wolf, Julian, Vogiatzi, Fotini, Bergmann, Anke K., Cario, Gunnar, Beier, Rita, Sauer, Martin, Kratz, Christian P., Maecker-Kolhoff, Britta

Volltext

Daratumumab eradicates minimal residual disease in a preclinical model of pediatric T-cell acute lymphoblastic leukemia von Vogiatzi, Fotini, Winterberg, Dorothee, Lenk, Lennart, Buchmann, Swantje, Cario, Gunnar, Schrappe, Martin, Peipp, Matthias, Richter-Pechanska, Paulina, Kulozik, Andreas E., Lentes, Jana, Bergmann, Anke K., Valerius, Thomas, Frielitz, Fabian-Simon, Kellner, Christian, Schewe, Denis M.

Volltext

Enhancement of epidermal growth factor receptor antibody tumor immunotherapy by glutaminyl cyclase inhibition to interfere with CD47/signal regulatory protein alpha interactions von Baumann, Niklas, Rösner, Thies, Jansen, J. H. Marco, Chan, Chilam, Marie Eichholz, Klara, Klausz, Katja, Winterberg, Dorothee, Müller, Kristina, Humpe, Andreas, Burger, Renate, Peipp, Matthias, Schewe, Denis M., Kellner, Christian, Leusen, Jeanette H. W., Valerius, Thomas

Volltext

Dual checkpoint blockade of CD47 and LILRB1 enhances CD20 antibody-dependent phagocytosis of lymphoma cells by macrophages von Zeller, Tobias, Lutz, Sebastian, Münnich, Ira A., Windisch, Roland, Hilger, Patricia, Herold, Tobias, Tahiri, Natyra, Banck, Jan C., Weigert, Oliver, Moosmann, Andreas, von Bergwelt-Baildon, Michael, Flamann, Cindy, Bruns, Heiko, Wichmann, Christian, Baumann, Niklas, Valerius, Thomas, Schewe, Denis M., Peipp, Matthias, Rösner, Thies, Humpe, Andreas, Kellner, Christian

Volltext

Myeloid checkpoint blockade improves killing of T-acute lymphoblastic leukemia cells by an IgA2 variant of daratumumab von Baumann, Niklas, Arndt, Christian, Petersen, Judith, Lustig, Marta, Rösner, Thies, Klausz, Katja, Kellner, Christian, Bultmann, Miriam, Bastian, Lorenz, Vogiatzi, Fotini, Leusen, Jeanette H. W., Burger, Renate, Schewe, Denis M., Peipp, Matthias, Valerius, Thomas

Volltext

“Mouse‐MRD” in central nervous system acute lymphoblastic leukaemia: assessing bone marrow minimal residual disease using a xenograft model – from bedside to the bench and back aga... von Alten, Julia, Claviez, Alexander, Vieth, Simon, Cario, Gunnar, Schewe, Denis M.

Volltext

IL7R is associated with CNS infiltration and relapse in pediatric B-cell precursor acute lymphoblastic leukemia von Alsadeq, Ameera, Lenk, Lennart, Vadakumchery, Anila, Cousins, Antony, Vokuhl, Christian, Khadour, Ahmad, Vogiatzi, Fotini, Seyfried, Felix, Meyer, Lueder-Hinrich, Cario, Gunnar, Hobeika, Elias, Debatin, Klaus-Michael, Halsey, Christina, Schrappe, Martin, Schewe, Denis M., Jumaa, Hassan

Volltext

In vivo inducible reverse genetics in patients’ tumors to identify individual therapeutic targets von Carlet, Michela, Völse, Kerstin, Vergalli, Jenny, Becker, Martin, Herold, Tobias, Arner, Anja, Senft, Daniela, Jurinovic, Vindi, Liu, Wen-Hsin, Gao, Yuqiao, Dill, Veronika, Fehse, Boris, Baldus, Claudia D., Bastian, Lorenz, Lenk, Lennart, Schewe, Denis M., Bagnoli, Johannes W., Vick, Binje, Schmid, Jan Philipp, Wilhelm, Alexander, Marschalek, Rolf, Jost, Philipp J., Miething, Cornelius, Riecken, Kristoffer, Schmidt-Supprian, Marc, Binder, Vera, Jeremias, Irmela

Volltext

Synergism between IL7R and CXCR4 drives BCR-ABL induced transformation in Philadelphia chromosome-positive acute lymphoblastic leukemia von Abdelrasoul, Hend, Vadakumchery, Anila, Werner, Markus, Lenk, Lennart, Khadour, Ahmad, Young, Marc, El Ayoubi, Omar, Vogiatzi, Fotini, Krämer, Markus, Schmid, Vera, Chen, Zhengshan, Yousafzai, Yasar, Cario, Gunnar, Schrappe, Martin, Müschen, Markus, Halsey, Christina, Mulaw, Medhanie A., Schewe, Denis M., Hobeika, Elias, Alsadeq, Ameera, Jumaa, Hassan

Volltext

An Fc-engineered CD19 antibody eradicates MRD in patient-derived MLL-rearranged acute lymphoblastic leukemia xenografts von Schewe, Denis M., Alsadeq, Ameera, Sattler, Cornelia, Lenk, Lennart, Vogiatzi, Fotini, Cario, Gunnar, Vieth, Simon, Valerius, Thomas, Rosskopf, Sophia, Meyersieck, Fabian, Alten, Julia, Schrappe, Martin, Gramatzki, Martin, Peipp, Matthias, Kellner, Christian

Volltext

Key factors for effective mitotane therapy in children with adrenocortical carcinoma von Kuhlen, Michaela, Mier, Pascal, Kunstreich, Marina, Lessel, Lienhard, Schneider, Dominik, Brecht, Ines, Schewe, Denis M, Frühwald, Michael C, Vorwerk, Peter, Redlich, Antje

Volltext