PDIA1/P4HB is required for efficient proinsulin maturation and ß cell health in response to diet induced obesity von Jang, Insook, Pottekat, Anita, Poothong, Juthakorn, Yong, Jing, Lagunas-Acosta, Jacqueline, Charbono, Adriana, Chen, Zhouji, Scheuner, Donalyn L, Liu, Ming, Itkin-Ansari, Pamela, Arvan, Peter, Kaufman, Randal J

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The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells von Hassler, Justin R, Scheuner, Donalyn L, Wang, Shiyu, Han, Jaeseok, Kodali, Vamsi K, Li, Philip, Nguyen, Julie, George, Jenny S, Davis, Cory, Wu, Shengyang P, Bai, Yongsheng, Sartor, Maureen, Cavalcoli, James, Malhi, Harmeet, Baudouin, Gregory, Zhang, Yaoyang, Yates, III, John R, Itkin-Ansari, Pamela, Volkmann, Niels, Kaufman, Randal J

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Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2α) dephosphorylation in mammalian development von Harding, Heather P, Zhang, Yuhong, Scheuner, Donalyn, Chen, Jane-Jane, Kaufman, Randal J, Ron, David

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Stress granules and processing bodies are dynamically linked sites of mRNP remodeling von Kedersha, Nancy, Stoecklin, Georg, Ayodele, Maranatha, Yacono, Patrick, Lykke-Andersen, Jens, Fitzler, Marvin J, Scheuner, Donalyn, Kaufman, Randal J, Golan, David E, Anderson, Paul

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ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth von Bi, Meixia, Naczki, Christine, Koritzinsky, Marianne, Fels, Diane, Blais, Jaime, Hu, Nianping, Harding, Heather, Novoa, Isabelle, Varia, Mahesh, Raleigh, James, Scheuner, Donalyn, Kaufman, Randal J, Bell, John, Ron, David, Wouters, Bradly G, Koumenis, Constantinos

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Translational Repression Mediates Activation of Nuclear Factor Kappa B by Phosphorylated Translation Initiation Factor 2 von Deng, Jing, Lu, Phoebe D., Zhang, Yuhong, Scheuner, Donalyn, Kaufman, Randal J., Sonenberg, Nahum, Harding, Heather P., Ron, David

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Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity von Schulz, Oliver, Pichlmair, Andreas, Rehwinkel, Jan, Rogers, Neil C, Scheuner, Donalyn, Kato, Hiroki, Takeuchi, Osamu, Akira, Shizuo, Kaufman, Randal J, Reis e Sousa, Caetano

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Phosphorylation of Eukaryotic Translation Initiation Factor 2α Coordinates rRNA Transcription and Translation Inhibition during Endoplasmic Reticulum Stress von DuRose, Jenny B., Scheuner, Donalyn, Kaufman, Randal J., Rothblum, Lawrence I., Niwa, Maho

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Heme-regulated Inhibitor Kinase-mediated Phosphorylation of Eukaryotic Translation Initiation Factor 2 Inhibits Translation, Induces Stress Granule Formation, and Mediates Survival... von McEwen, Edward, Kedersha, Nancy, Song, Benbo, Scheuner, Donalyn, Gilks, Natalie, Han, Anping, Chen, Jane-Jane, Anderson, Paul, Kaufman, Randal J.

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Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis von Scheuner, Donalyn, Mierde, Dirk Vander, Song, Benbo, Flamez, Daisy, Creemers, John W M, Tsukamoto, Katsura, Ribick, Mark, Schuit, Frans C, Kaufman, Randal J

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Phosphorylation of the α Subunit of Eukaryotic Initiation Factor 2 Is Required for Activation of NF-κB in Response to Diverse Cellular Stresses von Jiang, Hao-Yuan, Wek, Sheree A., McGrath, Barbara C., Scheuner, Donalyn, Kaufman, Randal J., Cavener, Douglas R., Wek, Ronald C.

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Translational Control Is Required for the Unfolded Protein Response and In Vivo Glucose Homeostasis von Scheuner, Donalyn, Song, Benbo, McEwen, Edward, Liu, Chuan, Laybutt, Ross, Gillespie, Patrick, Saunders, Thom, Bonner-Weir, Susan, Kaufman, Randal J

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The unfolded protein response in nutrient sensing and differentiation von Kaufman, Randal J., Scheuner, Donalyn, Schröder, Martin, Shen, Xiaohua, Lee, Kyungho, Liu, Chuan Yin, Arnold, Stacey M.

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Regulation of starvation- and virus-induced autophagy by the eIF2α kinase signaling pathway von Talloczy, Z, Jiang, W, Virgin IV, HW, Leib, DA, Scheuner, D, Kaufman, R J, Eskelinen, E, Levine, B

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Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2 von Lu, Phoebe D, Jousse, Céline, Marciniak, Stefan J, Zhang, Yuhong, Novoa, Isabel, Scheuner, Donalyn, Kaufman, Randal J, Ron, David, Harding, Heather P

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Activation of GCN2 in UV-Irradiated Cells Inhibits Translation von Deng, Jing, Harding, Heather P., Raught, Brian, Gingras, Anne-Claude, Berlanga, Juan Jose, Scheuner, Donalyn, Kaufman, Randal J., Ron, David, Sonenberg, Nahum

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The Unfolded Protein Response: A Pathway That Links Insulin Demand with β-Cell Failure and Diabetes von Scheuner, Donalyn, Kaufman, Randal J

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Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression von Harding, Heather P., Zhang, Yuhong, Khersonsky, Sonya, Marciniak, Stefan, Scheuner, Donalyn, Kaufman, Randal J., Javitt, Norman, Chang, Young-Tae, Ron, David

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Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes von Song, Benbo, Scheuner, Donalyn, Ron, David, Pennathur, Subramaniam, Kaufman, Randal J

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Novel Function of PERK as a Mediator of Force-induced Apoptosis von Mak, Baldwin C., Wang, Qin, Laschinger, Carol, Lee, Wilson, Ron, David, Harding, Heather P., Kaufman, Randal J., Scheuner, Donalyn, Austin, Richard C., McCulloch, Christopher A.

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