Extension of in vivo half-life of biologically active molecules by XTEN protein polymers von Podust, Vladimir N., Balan, Sibu, Sim, Bee-Cheng, Coyle, Michael P., Ernst, Ulrich, Peters, Robert T., Schellenberger, Volker

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A recombinant polypeptide extends the in vivo half-life of peptides and proteins in a tunable manner von Stemmer, Willem P C, Schellenberger, Volker, Wang, Chia-wei, Geething, Nathan C, Spink, Benjamin J, Campbell, Andrew, To, Wayne, Scholle, Michael D, Yin, Yong, Yao, Yi, Bogin, Oren, Cleland, Jeffrey L, Silverman, Joshua

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GLP2-2G-XTEN: a pharmaceutical protein with improved serum half-life and efficacy in a rat Crohn's disease model von Alters, Susan E, McLaughlin, Bryant, Spink, Benjamin, Lachinyan, Tigran, Wang, Chia-wei, Podust, Vladimir, Schellenberger, Volker, Stemmer, Willem P C

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Gcg-XTEN: an improved glucagon capable of preventing hypoglycemia without increasing baseline blood glucose von Geething, Nathan C, To, Wayne, Spink, Benjamin J, Scholle, Michael D, Wang, Chia-wei, Yin, Yong, Yao, Yi, Schellenberger, Volker, Cleland, Jeffrey L, Stemmer, Willem P C, Silverman, Joshua

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613 HER2-XPAT, a novel protease-activatable prodrug T cell engager (TCE), with potent T-cell activation and efficacy in solid tumors and large predicted safety margins in non-human... von Cattaruzza, Fiore, Nazeer, Ayesha, Lange, Zachary, Koski, Caitlin, Hammond, Mikhail, Dao-Pick, Trang, Henkensiefken, Angela, Derynck, Mika, Schellenberger, Volker, Irving, Bryan

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Rapid Evolution of Novel Traits in Microorganisms von SELIFONOVA, Olga, VALLE, Fernando, SCHELLENBERGER, Volker

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A β-lactamase with reduced immunogenicity for the targeted delivery of chemotherapeutics using antibody-directed enzyme prodrug therapy von Harding, Fiona A, Liu, Amy D, Stickler, Marcia, Razo, O Jennifer, Chin, Regina, Faravashi, Nargol, Viola, Wendy, Graycar, Tom, Yeung, V Pete, Aehle, Wolfgang, Meijer, Daan, Wong, Stephanie, Rashid, M Harunur, Valdes, Ana M, Schellenberger, Volker

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GLP2-2G-XTEN: a pharmaceutical protein with improved serum half-life and efficacy in a rat Crohn's. PLoS One. 2012; 7(11): e50630 von Alters, Susan E, McLaughlin, Bryant, Spink, Benjamin, Lachinyan, Tigran, Wang, Chia-Wei, Podust, Vladimir, Schellenberger, Volker, Stemmer, Willem P C

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BIVV001, a new class of factor VIII replacement for hemophilia A that is independent of von Willebrand factor in primates and mice von Seth Chhabra, Ekta, Liu, Tongyao, Kulman, John, Patarroyo-White, Susannah, Yang, Buyue, Lu, Qi, Drager, Douglas, Moore, Nancy, Liu, Jiayun, Holthaus, Amy M., Sommer, Jurg M., Ismail, Ayman, Rabinovich, Deana, Liu, Zhan, van der Flier, Arjan, Goodman, Allison, Furcht, Chris, Tie, Mark, Carlage, Tyler, Mauldin, Randy, Dobrowsky, Terrence M., Liu, Zhiqian, Mercury, Oblaise, Zhu, Lily, Mei, Baisong, Schellenberger, Volker, Jiang, Haiyan, Pierce, Glenn F., Salas, Joe, Peters, Robert

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Generation of large libraries of random mutants in Bacillus subtilis by PCR-based plasmid multimerization von SHAFIKHANI, S, SIEGEL, R. A, FERRARI, E, SCHELLENBERGER, V

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Abstract 3376: HER2-XPAT and EGFR-XPAT: Pro-drug T-cell engagers (TCEs) engineered to address o n -target, o ff -tumor toxicity with potent efficacy in vitro and in vivo and large... von Cattaruzza, Fiore, Nazeer, Ayesha, Lange, Zachary, Hammond, Mikhail, Koski, Caitlin, Henkensiefken, Angela, Derynck, Mika K., Irving, Bryan, Schellenberger, Volker

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Abstract 1824: HER2-XPAT, a novel protease-activatable T-cell engager (TCE) with potent T-cell activation and efficacy in solid tumors and large safety margins in non-human primate... von Cattaruzza, Fiore, Nazeer, Ayesha, Lange, Zachary, Koski, Caitlin, Hammond, Mikhail, To, Milton, Yeung, Pete, Lam, Sharon, Derynck, Mika K., Irving, Bryan, Schellenberger, Volker

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Abstract PS17-11: Her2-xpat, a novel protease-activatable prodrug t-cell engager (tce), exhibits potent t-cell activation and efficacy in her2 tumors, yielding large predicted safe... von Cattaruzza, Fiore, Nazeer, Ayesha, Lange, Zachary, Koski, Caitlin, Hammond, Mikhail, Henkensiefken, Angela, Dao-Pick, Trang, Derynck, Mika K, Irving, Bryan, Schellenberger, Volker

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A homogeneous high-DAR antibody-drug conjugate platform combining THIOMAB antibodies and XTEN polypeptides von Zacharias, Neelie, Podust, Vladimir N, Kajihara, Kimberly K, Leipold, Douglas, Del Rosario, Geoffrey, Thayer, Desiree, Dong, Emily, Paluch, Maciej, Fischer, David, Zheng, Kai, Lei, Corinna, He, Jintang, Ng, Carl, Su, Dian, Liu, Luna, Masih, Shabkhaiz, Sawyer, William, Tinianow, Jeff, Marik, Jan, Yip, Victor, Li, Guangmin, Chuh, Josefa, Morisaki, J Hiroshi, Park, Summer, Zheng, Bing, Hernandez-Barry, Hilda, Loyet, Kelly M, Xu, Min, Kozak, Katherine R, Phillips, Gail Lewis, Shen, Ben-Quan, Wu, Cong, Xu, Keyang, Yu, Shang-Fan, Kamath, Amrita, Rowntree, Rebecca K, Reilly, Dorothea, Pillow, Thomas, Polson, Andrew, Schellenberger, Volker, Hazenbos, Wouter L W, Sadowsky, Jack

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Abstract P193: AMX-818, a novel prodrug HER2-XPAT T-cell engager (TCE) with potent T cell activation, proteolytic cleavage and efficacy in xenograft tumors, and wide safety margins... von To, Milton, Yeung, Pete, Fox, Michael, Hammond, Mikhail, Cattaruzza, Fiore, Nazeer, Ayesha, Koski, Caitlin, Liu, Lucas, Khorsand, Sina, Rennerfeldt, Deena, Morrissey, Kari, Lange, Zachary, Dong, Ming, Lam, Sharon, Derynck, Mika K., Irving, Bryan A., Schellenberger, Volker

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Platelet-Targeted rFVIIa-Xten Improves Thrombin Generation and Fibrin Formation Compared to Recombinant FVIIa von Aleman, Maria M., Kistanova, Elena N., Moore, Nancy, Schellenberger, Volker, Peters, Robert, Salas, Joe

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Evaluation of Recombinant Fixfc-Xten Bleeding Efficacy in Hemophilia-B Mouse Models von Liu, Zhan, van der Flier, Arjan, Ismail, Ayman, Simpson, Allison, Kurt, Lutfiye, Schellenberger, Volker, Loh, Christine, Peters, Robert

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Multivalent Antiviral XTEN–Peptide Conjugates with Long in Vivo Half-Life and Enhanced Solubility von Ding, Sheng, Song, Michael, Sim, Bee-Cheng, Gu, Chen, Podust, Vladimir N, Wang, Chia-Wei, McLaughlin, Bryant, Shah, Trishul P, Lax, Rodney, Gast, Rainer, Sharan, Rahul, Vasek, Arthur, Hartman, M. Amanda, Deniston, Colin, Srinivas, Prathna, Schellenberger, Volker

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Willem 'Pim' Stemmer 1957–2013 von Larrick, James W, Schellenberger, Volker, Barbas III, Carlos F

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Willem 'Pim' Stemmer 1957-2013: a truly original thinker and pioneering entrepreneur von Larrick, James W, Schellenberger, Volker, Barbas, III, Carlos F

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