Rapid assessment of conformational preferences in biaryl and aryl carbonyl fragments von Gutiérrez Sanfeliciano, Sonia Maria, Schaus, John M

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Intracellular Binding Site for a Positive Allosteric Modulator of the Dopamine D1 Receptor von Wang, Xushan, Heinz, Beverly A., Qian, Yue-Wei, Carter, Joan H., Gadski, Robert A., Beavers, Lisa S., Little, Sheila P., Yang, Charles R., Beck, James P., Hao, Junliang, Schaus, John M., Svensson, Kjell A., Bruns, Robert F.

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The role of 5-HT1A receptors in control of lower urinary tract function in cats von THOR, Karl B, KATOFIASC, Mary A, DANUSER, Hansjorg, SPRINGER, Johannes, SCHAUS, John M

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Preclinical profile of a dopamine D1 potentiator suggests therapeutic utility in neurological and psychiatric disorders von Bruns, Robert F., Mitchell, Stephen N., Wafford, Keith A., Harper, Alex J., Shanks, Elaine A., Carter, Guy, O'Neill, Michael J., Murray, Tracey K., Eastwood, Brian J., Schaus, John M., Beck, James P., Hao, Junliang, Witkin, Jeffrey M., Li, Xia, Chernet, Eyassu, Katner, Jason S., Wang, Hong, Ryder, John W., Masquelin, Meghane E., Thompson, Linda K., Love, Patrick L., Maren, Deanna L., Falcone, Julie F., Menezes, Michelle M., Zhang, Linli, Yang, Charles R., Svensson, Kjell A.

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An Allosteric Potentiator of the Dopamine D1 Receptor Increases Locomotor Activity in Human D1 Knock-In Mice without Causing Stereotypy or Tachyphylaxis von Svensson, Kjell A, Heinz, Beverly A, Schaus, John M, Beck, James P, Hao, Junliang, Krushinski, Joseph H, Reinhard, Matthew R, Cohen, Michael P, Hellman, Sarah L, Getman, Brian G, Wang, Xushan, Menezes, Michelle M, Maren, Deanna L, Falcone, Julie F, Anderson, Wesley H, Wright, Rebecca A, Morin, S Michelle, Knopp, Kelly L, Adams, Benjamin L, Rogovoy, Borys, Okun, Ilya, Suter, Todd M, Statnick, Michael A, Gehlert, Donald R, Nelson, David L, Lucaites, Virginia L, Emkey, Renee, DeLapp, Neil W, Wiernicki, Todd R, Cramer, Jeffrey W, Yang, Charles R, Bruns, Robert F

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[3H]LY334370, a novel radioligand for the 5-HT1F receptor. II. Autoradiographic localization in rat, guinea pig, monkey and human brain von Lucaites, Virginia L, Krushinski, Joseph H, Schaus, John M, Audia, James E, Nelson, David L

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Lu AE58054, a 5-HT6 antagonist, reverses cognitive impairment induced by subchronic phencyclidine in a novel object recognition test in rats von Arnt, Jorn, Bang-Andersen, Benny, Grayson, Ben, Bymaster, Franklin P., Cohen, Michael P., DeLapp, Neil W., Giethlen, Bruno, Kreilgaard, Mads, McKinzie, David L., Neill, Joanna C., Nelson, David L., Nielsen, Søren M., Poulsen, Mette N., Schaus, John M., Witten, Louise M.

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Imaging and quantitation of cannabinoid CB1 receptors in human and monkey brains using (18)F-labeled inverse agonist radioligands von Terry, Garth E, Hirvonen, Jussi, Liow, Jeih-San, Zoghbi, Sami S, Gladding, Robert, Tauscher, Johannes T, Schaus, John M, Phebus, Lee, Felder, Christian C, Morse, Cheryl L, Donohue, Sean R, Pike, Victor W, Halldin, Christer, Innis, Robert B

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Quantitation of cannabinoid CB1 receptors in healthy human brain using positron emission tomography and an inverse agonist radioligand von Terry, Garth E., Liow, Jeih-San, Zoghbi, Sami S., Hirvonen, Jussi, Farris, Amanda G., Lerner, Alicja, Tauscher, Johannes T., Schaus, John M., Phebus, Lee, Felder, Christian C., Morse, Cheryl L., Hong, Jinsoo S., Pike, Victor W., Halldin, Christer, Innis, Robert B.

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Synthesis, Ex Vivo Evaluation, and Radiolabeling of Potent 1,5-Diphenylpyrrolidin-2-one Cannabinoid Subtype-1 Receptor Ligands as Candidates for In Vivo Imaging von Donohue, Sean R, Krushinski, Joseph H, Pike, Victor W, Chernet, Eyassu, Phebus, Lee, Chesterfield, Amy K, Felder, Christian C, Halldin, Christer, Schaus, John M

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The PET Radioligand [11C]MePPEP Binds Reversibly and with High Specific Signal to Cannabinoid CB1 Receptors in Nonhuman Primate Brain von YASUNO, Fumihiko, BROWN, Amira K, GLADDING, Robert L, HONG, Jinsoo, HALLDIN, Christer, PIKE, Victor W, INNIS, Robert B, ZOGHBI, Sami S, KRUSHINSKI, Joseph H, CHERNET, Eyassu, TAUSCHER, Johannes, SCHAUS, John M, PHEBUS, Lee A, CHESTERFIELD, Amy K, FELDER, Christian C

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Positron emission tomography imaging using an inverse agonist radioligand to assess cannabinoid CB1 receptors in rodents von Terry, Garth, Liow, Jeih-San, Chernet, Eyassu, Zoghbi, Sami S, Phebus, Lee, Felder, Christian C, Tauscher, Johannes, Schaus, John M, Pike, Victor W, Halldin, Christer, Innis, Robert B

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Design, synthesis and evaluation of bicyclic benzamides as novel 5-HT1F receptor agonists von DEYI ZHANG, KOHLMAN, Dan, NELSON, David L. G, SCHAUS, John M, XU, Yao-Chang, KRUSHINSKI, Joseph, LIANG, Sidney, YING, Bai-Ping, REILLY, John E, DINN, Sean R, WAINSCOTT, David B, NUTTER, Suzanne, GOUGH, Wendy

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Biodistribution and dosimetry in humans of two inverse agonists to image cannabinoid CB1 receptors using positron emission tomography von Terry, Garth E., Hirvonen, Jussi, Liow, Jeih-San, Seneca, Nicholas, Tauscher, Johannes T., Schaus, John M., Phebus, Lee, Felder, Christian C., Morse, Cheryl L., Pike, Victor W., Halldin, Christer, Innis, Robert B.

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Synthesis and Structure−Activity Relationships of Potent and Orally Active 5-HT4 Receptor Antagonists:  Indazole and Benzimidazolone Derivatives von Schaus, John M, Thompson, Dennis C, Bloomquist, William E, Susemichel, Alice D, Calligaro, David O, Cohen, Marlene L

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Pharmacological characterization of the cannabinoid CB1 receptor PET ligand ortholog, [3H]MePPEP von SUTER, Todd M, CHESTERFIELD, Amy K, CHUN BAO, SCHAUS, John M, KRUSHINSKI, Joseph H, STATNICK, Michael A, FELDER, Christian C

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Pharmacological characterization of endocannabinoid transport and fatty acid amide hydrolase inhibitors von Dickason-Chesterfield, Amy K, Kidd, Stephanie R, Moore, Steven A, Schaus, John M, Liu, Bin, Nomikos, George G, Felder, Christian C

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5-HT1F receptor agonists inhibit neurogenic dural inflammation in guinea pigs von Johnson, Kirk W, Schaus, John M, Durkin, Margaret M, Audia, James E, Kaldor, Stephen W, Flaugh, Michael E, Adham, Nika, Zgombick, John M, Cohen, Marlene L, Branchek, Theresa A, Phebus, Lee A

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Imaging and Quantitation of Cannabinoid CB1 Receptors in Human and Monkey Brains Using 18F-Labeled Inverse Agonist Radioligands von Terry, Garth E, Hirvonen, Jussi, Liow, Jeih-San, Zoghbi, Sami S, Gladding, Robert, Tauscher, Johannes T, Schaus, John M, Phebus, Lee, Felder, Christian C, Morse, Cheryl L, Donohue, Sean R, Pike, Victor W, Halldin, Christer, Innis, Robert B

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Novel Potent 5-HT1F Receptor Agonists:  Structure−Activity Studies of a Series of Substituted N-[3-(1-Methyl-4-piperidinyl)-1H-pyrrolo[3,2-b]pyridin-5-yl]amides von Filla, Sandra A, Mathes, Brian M, Johnson, Kirk W, Phebus, Lee A, Cohen, Marlene L, Nelson, David L, Zgombick, John M, Erickson, Jon A, Schenck, Kathryn W, Wainscott, David B, Branchek, Theresa A, Schaus, John M

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