Therapeutic strategies for targeting neurodegenerative protein misfolding disorders von Scannevin, Robert H

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Dimethyl fumarate and monoethyl fumarate exhibit differential effects on KEAP1, NRF2 activation, and glutathione depletion in vitro von Brennan, Melanie S, Matos, Maria F, Li, Bing, Hronowski, Xiaoping, Gao, Benbo, Juhasz, Peter, Rhodes, Kenneth J, Scannevin, Robert H

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Repurposing the NRF2 Activator Dimethyl Fumarate as Therapy Against Synucleinopathy in Parkinson's Disease von Lastres-Becker, Isabel, García-Yagüe, Angel J, Scannevin, Robert H, Casarejos, María J, Kügler, Sebastian, Rábano, Alberto, Cuadrado, Antonio

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The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease von Sevigny, Jeff, Chiao, Ping, Bussière, Thierry, Weinreb, Paul H., Williams, Leslie, Maier, Marcel, Dunstan, Robert, Salloway, Stephen, Chen, Tianle, Ling, Yan, O’Gorman, John, Qian, Fang, Arastu, Mahin, Li, Mingwei, Chollate, Sowmya, Brennan, Melanie S., Quintero-Monzon, Omar, Scannevin, Robert H., Arnold, H. Moore, Engber, Thomas, Rhodes, Kenneth, Ferrero, James, Hang, Yaming, Mikulskis, Alvydas, Grimm, Jan, Hock, Christoph, Nitsch, Roger M., Sandrock, Alfred

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Dimethyl fumarate treatment induces adaptive and innate immune modulation independent of Nrf2 von Schulze-Topphoff, Ulf, Varrin-Doyer, Michel, Pekarek, Kara, Spencer, Collin M., Shetty, Aparna, Sagan, Sharon A., Cree, Bruce A. C., Sobel, Raymond A., Wipke, Brian T., Steinman, Lawrence, Scannevin, Robert H., Zamvil, Scott S.

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Fumarates Promote Cytoprotection of Central Nervous System Cells against Oxidative Stress via the Nuclear Factor (Erythroid-Derived 2)-Like 2 Pathway von Scannevin, Robert H., Chollate, Sowmya, Jung, Mi-young, Shackett, Melanie, Patel, Hiral, Bista, Pradeep, Zeng, Weike, Ryan, Sarah, Yamamoto, Masayuki, Lukashev, Matvey, Rhodes, Kenneth J.

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Fumarates modulate microglia activation through a novel HCAR2 signaling pathway and rescue synaptic dysregulation in inflamed CNS von Parodi, Benedetta, Rossi, Silvia, Morando, Sara, Cordano, Christian, Bragoni, Alberto, Motta, Caterina, Usai, Cesare, Wipke, Brian T., Scannevin, Robert H., Mancardi, Giovanni L., Centonze, Diego, Kerlero de Rosbo, Nicole, Uccelli, Antonio

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Dimethyl fumarate alters microglia phenotype and protects neurons against proinflammatory toxic microenvironments von Peng, Haiyan, Li, Huo, Sheehy, Adam, Cullen, Patrick, Allaire, Norm, Scannevin, Robert H

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Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway von Linker, Ralf A, Lee, De-Hyung, Ryan, Sarah, van Dam, Anne M, Conrad, Rebecca, Bista, Pradeep, Zeng, Weike, Hronowsky, Xiaoping, Buko, Alex, Chollate, Sowmya, Ellrichmann, Gisa, Brück, Wolfgang, Dawson, Kate, Goelz, Susan, Wiese, Stefan, Scannevin, Robert H, Lukashev, Matvey, Gold, Ralf

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Dimethyl fumarate improves white matter function following severe hypoperfusion: Involvement of microglia/macrophages and inflammatory mediators von Fowler, Jill H, McQueen, Jamie, Holland, Philip R, Manso, Yasmina, Marangoni, Martina, Scott, Fiona, Chisholm, Emma, Scannevin, Robert H, Hardingham, Giles E, Horsburgh, Karen

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Inhibiting Stearoyl-CoA Desaturase Ameliorates α-Synuclein Cytotoxicity von Vincent, Benjamin M., Tardiff, Daniel F., Piotrowski, Jeff S., Aron, Rebecca, Lucas, Matthew C., Chung, Chee Yeun, Bacherman, Helene, Chen, YiQun, Pires, Michelle, Subramaniam, Radha, Doshi, Dimple B., Sadlish, Heather, Raja, Waseem K., Solís, Eric J., Khurana, Vikram, Le Bourdonnec, Bertrand, Scannevin, Robert H., Rhodes, Kenneth J.

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DMF, but not other fumarates, inhibits NF-κB activity in vitro in an Nrf2-independent manner von Gillard, Geoffrey O, Collette, Brian, Anderson, John, Chao, Jianhua, Scannevin, Robert H, Huss, David J, Fontenot, Jason D

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Heat Shock Protein 90: Inhibitors in Clinical Trials von Biamonte, Marco A, Van de Water, Ryan, Arndt, Joseph W, Scannevin, Robert H, Perret, Daniel, Lee, Wen-Cherng

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Patient-derived three-dimensional cortical neurospheres to model Parkinson's disease von Raja, Waseem K, Neves, Esther, Burke, Christopher, Jiang, Xin, Xu, Ping, Rhodes, Kenneth J, Khurana, Vikram, Scannevin, Robert H, Chung, Chee Yeun

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Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation von Scannevin, Robert H., Alexander, Richard, Haarlander, Tara Mezzasalma, Burke, Sharon L., Singer, Monica, Huo, Cuifen, Zhang, Yue-Mei, Maguire, Diane, Spurlino, John, Deckman, Ingrid, Carroll, Karen I., Lewandowski, Frank, Devine, Eric, Dzordzorme, Keli, Tounge, Brett, Milligan, Cindy, Bayoumy, Shariff, Williams, Robyn, Schalk-Hihi, Celine, Leonard, Kristi, Jackson, Paul, Todd, Matthew, Kuo, Lawrence C., Rhodes, Kenneth J.

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The NRF2 transcriptional target, OSGIN1, contributes to monomethyl fumarate-mediated cytoprotection in human astrocytes von Brennan, Melanie S., Matos, Maria F., Richter, Karl E., Li, Bing, Scannevin, Robert H.

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Extension of the Thrombolytic Time Window With Minocycline in Experimental Stroke von MURATA, Yoshihiro, ROSELL, Anna, SCANNEVIN, Robert H, RHODES, Kenneth J, XIAOYING WANG, LO, Eng H

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Pharmacodynamics of Dimethyl Fumarate Are Tissue Specific and Involve NRF2-Dependent and -Independent Mechanisms von Brennan, Melanie S, Patel, Hiral, Allaire, Norm, Thai, Alice, Cullen, Patrick, Ryan, Sarah, Lukashev, Matvey, Bista, Pradeep, Huang, Ron, Rhodes, Kenneth J, Scannevin, Robert H

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Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2 von Bell, Karen F.S., Al-Mubarak, Bashayer, Martel, Marc-André, McKay, Sean, Wheelan, Nicola, Hasel, Philip, Márkus, Nóra M., Baxter, Paul, Deighton, Ruth F., Serio, Andrea, Bilican, Bilada, Chowdhry, Sudhir, Meakin, Paul J., Ashford, Michael L.J., Wyllie, David J.A., Scannevin, Robert H., Chandran, Siddharthan, Hayes, John D., Hardingham, Giles E.

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Non-clinical Pharmacology of YTX-7739: a Clinical Stage Stearoyl-CoA Desaturase Inhibitor Being Developed for Parkinson’s Disease von Tardiff, Daniel F., Lucas, Matthew, Wrona, Iwona, Chang, Belle, Chung, Chee Yeun, Le Bourdonnec, Bertrand, Rhodes, Kenneth J., Scannevin, Robert H.

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