Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma von Mazur, Pawel K, Herner, Alexander, Mello, Stephano S, Wirth, Matthias, Hausmann, Simone, Sánchez-Rivera, Francisco J, Lofgren, Shane M, Kuschma, Timo, Hahn, Stephan A, Vangala, Deepak, Trajkovic-Arsic, Marija, Gupta, Aayush, Heid, Irina, Noël, Peter B, Braren, Rickmer, Erkan, Mert, Kleeff, Jörg, Sipos, Bence, Sayles, Leanne C, Heikenwalder, Mathias, Heßmann, Elisabeth, Ellenrieder, Volker, Esposito, Irene, Jacks, Tyler, Bradner, James E, Khatri, Purvesh, Sweet-Cordero, E Alejandro, Attardi, Laura D, Schmid, Roland M, Schneider, Guenter, Sage, Julien, Siveke, Jens T

Volltext

Genome-Informed Targeted Therapy for Osteosarcoma von Sayles, Leanne C, Breese, Marcus R, Koehne, Amanda L, Leung, Stanley G, Lee, Alex G, Liu, Heng-Yi, Spillinger, Aviv, Shah, Avanthi T, Tanasa, Bogdan, Straessler, Krystal, Hazard, Florette K, Spunt, Sheri L, Marina, Neyssa, Kim, Grace E, Cho, Soo-Jin, Avedian, Raffi S, Mohler, David G, Kim, Mi-Ok, DuBois, Steven G, Hawkins, Douglas S, Sweet-Cordero, E Alejandro

Volltext

A Rare Population of CD24+ITGB4+Notchhi Cells Drives Tumor Propagation in NSCLC and Requires Notch3 for Self-Renewal von Zheng, Yanyan, de la Cruz, Cecile C., Sayles, Leanne C., Alleyne-Chin, Chris, Vaka, Dedeepya, Knaak, Tim D., Bigos, Marty, Xu, Yue, Hoang, Chuong D., Shrager, Joseph B., Fehling, Hans Joerg, French, Dorothy, Forrest, William, Jiang, Zhaoshi, Carano, Richard A.D., Barck, Kai H., Jackson, Erica L., Sweet-Cordero, E. Alejandro

Volltext

Molecular definition of a metastatic lung cancer state reveals a targetable CD109–Janus kinase–Stat axis von Chuang, Chen-Hua, Greenside, Peyton G, Rogers, Zoë N, Brady, Jennifer J, Yang, Dian, Ma, Rosanna K, Caswell, Deborah R, Chiou, Shin-Heng, Winters, Aidan F, Grüner, Barbara M, Ramaswami, Gokul, Spencley, Andrew L, Kopecky, Kimberly E, Sayles, Leanne C, Sweet-Cordero, E Alejandro, Li, Jin Billy, Kundaje, Anshul, Winslow, Monte M

Volltext

An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer von Vallejo, Adrian, Perurena, Naiara, Guruceaga, Elisabet, Mazur, Pawel K., Martinez-Canarias, Susana, Zandueta, Carolina, Valencia, Karmele, Arricibita, Andrea, Gwinn, Dana, Sayles, Leanne C., Chuang, Chen-Hua, Guembe, Laura, Bailey, Peter, Chang, David K., Biankin, Andrew, Ponz-Sarvise, Mariano, Andersen, Jesper B., Khatri, Purvesh, Bozec, Aline, Sweet-Cordero, E. Alejandro, Sage, Julien, Lecanda, Fernando, Vicent, Silve

Volltext

Antitumor activity of an engineered decoy receptor targeting CLCF1–CNTFR signaling in lung adenocarcinoma von Kim, Jun W., Marquez, Cesar P., Kostyrko, Kaja, Koehne, Amanda L., Marini, Kieren, Simpson, David R., Lee, Alex G., Leung, Stanley G., Sayles, Leanne C., Shrager, Joseph, Ferrer, Irene, Paz-Ares, Luis, Gephart, Melanie Hayden, Vicent, Silvestre, Cochran, Jennifer R., Sweet-Cordero, E. Alejandro

Volltext

Cross-Species Functional Analysis of Cancer-Associated Fibroblasts Identifies a Critical Role for CLCF1 and IL-6 in Non-Small Cell Lung Cancer In Vivo von VICENT, Silvestre, SAYLES, Leanne C, SHRAGER, Joseph, HOANG, Chuong D, PLEVRITIS, Sylvia, BUTTE, Atul J, ALEJANDRO SWEET-CORDERO, E, VAKA, Dedeepya, KHATRI, Purvesh, GEVAERT, Olivier, CHEN, Ron, ZHENG, Yanyan, GILLESPIE, Anna K, CLARKE, Nicole, YUE XU

Volltext

Direct transposition of native DNA for sensitive multimodal single-molecule sequencing von Nanda, Arjun S., Wu, Ke, Irkliyenko, Iryna, Woo, Brian, Ostrowski, Megan S., Clugston, Andrew S., Sayles, Leanne C., Xu, Lingru, Satpathy, Ansuman T., Nguyen, Hao G., Alejandro Sweet-Cordero, E., Goodarzi, Hani, Kasinathan, Sivakanthan, Ramani, Vijay

Volltext

Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer von Oliver, Trudy G, Mercer, Kim L, Sayles, Leanne C, Burke, James R, Mendus, Diana, Lovejoy, Katherine S, Cheng, Mei-Hsin, Subramanian, Aravind, Mu, David, Powers, Scott, Crowley, Denise, Bronson, Roderick T, Whittaker, Charles A, Bhutkar, Arjun, Lippard, Stephen J, Golub, Todd, Thomale, Juergen, Jacks, Tyler, Sweet-Cordero, E Alejandro

Volltext

Generation and multi-dimensional profiling of a childhood cancer cell line atlas defines new therapeutic opportunities von Sun, Claire Xin, Daniel, Paul, Bradshaw, Gabrielle, Shi, Hui, Loi, Melissa, Chew, Nicole, Parackal, Sarah, Tsui, Vanessa, Liang, Yuqing, Koptyra, Mateusz, Adjumain, Shazia, Sun, Christie, Chong, Wai Chin, Fernando, Dasun, Drinkwater, Caroline, Tourchi, Motahhareh, Habarakada, Dilru, Sooraj, Dhanya, Carvalho, Diana, Storm, Phillip B., Baubet, Valerie, Sayles, Leanne C., Fernandez, Elisabet, Nguyen, Thy, Pörksen, Mia, Doan, Anh, Crombie, Duncan E., Panday, Monty, Zhukova, Nataliya, Dun, Matthew D., Ludlow, Louise E., Day, Bryan, Stringer, Brett W., Neeman, Naama, Rubens, Jeffrey A., Raabe, Eric H., Vinci, Maria, Tyrrell, Vanessa, Fletcher, Jamie I., Ekert, Paul G., Dumevska, Biljana, Ziegler, David S., Tsoli, Maria, Syed Sulaiman, Nur Farhana, Loh, Amos Hong Pheng, Low, Sharon Yin Yee, Sweet-Cordero, E. Alejandro, Monje, Michelle, Resnick, Adam, Jones, Chris, Downie, Peter, Williams, Bryan, Rosenbluh, Joseph, Gough, Daniel, Cain, Jason E., Firestein, Ron

Volltext

The Mir181ab1 cluster promotes KRAS-driven oncogenesis and progression in lung and pancreas von Valencia, Karmele, Erice, Oihane, Kostyrko, Kaja, Hausmann, Simone, Guruceaga, Elizabeth, Tathireddy, Anuradha, Flores, Natasha M, Sayles, Leanne C, Lee, Alex G, Fragoso, Rita, Sun, Tian-Qiang, Vallejo, Adrian, Roman, Marta, Entrialgo-Cadierno, Rodrigo, Migueliz, Itziar, Razquin, Nerea, Fortes, Puri, Lecanda, Fernando, Lu, Jun, Ponz-Sarvise, Mariano, Chen, Chang-Zheng, Mazur, Pawel K, Sweet-Cordero, E Alejandro, Vicent, Silvestre

Volltext

Discovery Proteomics Analysis Determines That Driver Oncogenes Suppress Antiviral Defense Pathways Through Reduction in Interferon-β Autocrine Stimulation von Solomon, Paige E., Kirkemo, Lisa L., Wilson, Gary M., Leung, Kevin K., Almond, Mark H., Sayles, Leanne C., Sweet-Cordero, E. Alejandro, Rosenberg, Oren S., Coon, Joshua J., Wells, James A.

Volltext

Author Correction: Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma von Mazur, Pawel K., Herner, Alexander, Mello, Stephano S., Wirth, Matthias, Hausmann, Simone, Sánchez-Rivera, Francisco J., Lofgren, Shane M., Kuschma, Timo, Hahn, Stephan A., Vangala, Deepak, Trajkovic-Arsic, Marija, Gupta, Aayush, Heid, Irina, Noël, Peter B., Braren, Rickmer, Erkan, Mert, Kleeff, Jörg, Sipos, Bence, Sayles, Leanne C., Heikenwalder, Mathias, Heßmann, Elisabeth, Ellenrieder, Volker, Esposito, Irene, Jacks, Tyler, Bradner, James E., Khatri, Purvesh, Sweet-Cordero, E. Alejandro, Attardi, Laura D., Schmid, Roland M., Schneider, Guenter, Sage, Julien, Siveke, Jens T.

Volltext

Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models von Vicent, Silvestre, Chen, Ron, Sayles, Leanne C, Lin, Chenwei, Walker, Randal G, Gillespie, Anna K, Subramanian, Aravind, Hinkle, Gregory, Yang, Xiaoping, Saif, Sakina, Root, David E, Huff, Vicki, Hahn, William C, Sweet-Cordero, E Alejandro

Volltext

A 3D Osteosarcoma Model with Bone‐Mimicking Cues Reveals a Critical Role of Bone Mineral and Informs Drug Discovery von González Díaz, Eva C., Lee, Alex G., Sayles, Leanne C., Feria, Criselle, Sweet‐Cordero, E. Alejandro, Yang, Fan

Volltext

An integrative cross-tumors approach identifies FOSL1 as an oncogene dependency in KRAS-driven lung cancer von Vallejo, Adrian, Perurena, Naiara, Guruceaga, Elizabeth, Mazur, Pawel K., Martinez-Canarias, Susana, Zandueta, Carolina, Gwinn, Dana, Sayles, Leanne C., Chuang, Chen-Hua, Andersen, Jesper B., Bozec, Aline, Sweet-Cordero, Alejandro, Sage, Julien, Lecanda, Fernando, Vicent, Silvestre

Volltext

Introduction of an Additional Pathway for Lactate Oxidation in the Treatment of Lactic Acidosis and Mitochondrial Dysfunction in Caenorhabditis elegans von Leslie I. Grad, Leanne C. Sayles, Lemire, Bernard D., Schatz, Gottfried

Volltext

Expression of Ndi1p, an alternative NADH:ubiquinone oxidoreductase, increases mitochondrial membrane potential in a C. elegans model of mitochondrial disease von DeCorby, Adrienne, Gášková, Dana, Sayles, Leanne C., Lemire, Bernard D.

Volltext

Isolation and Functional Analysis of Mitochondria From the Nematode Caenorhabditis elegans von Grad, Leslie I., Sayles, Leanne C., Lemire, Bernard D.

Volltext

Abstract B09: Lineage tracing of tumor-propagating cells in LUAD von Marini, Kieren D., Hwang, Elizabeth, Lee, Alex, Sayles, Leanne, Sweet-Cordero, Alejandro

Volltext