Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials von Johnson, J I, Decker, S, Zaharevitz, D, Rubinstein, L V, Venditti, J M, Schepartz, S, Kalyandrug, S, Christian, M, Arbuck, S, Hollingshead, M, Sausville, E A

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Developmental Therapeutics Program at the NCI: molecular target and drug discovery process von MONGA, M, SAUSVILLE, E. A

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Major clinical response to nivolumab in relapsed/refractory Hodgkin lymphoma after allogeneic stem cell transplantation von Yared, J A, Hardy, N, Singh, Z, Hajj, S, Badros, A Z, Kocoglu, M, Yanovich, S, Sausville, E A, Ujjani, C, Ruehle, K, Goecke, C, Landau, M, Rapoport, A P

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Proteasome inhibitors : A novel class of potent and effective antitumor agents von ADAMS, J, PALOMBELLA, V. J, SAUSVILLE, E. A, JOHNSON, J, DESTREE, A, LAZARUS, D. D, MAAS, J, PIEN, C. S, PRAKASH, S, ELLIOTT, P. J

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Preclinical and Clinical Development of Cyclin-Dependent Kinase Modulators von Senderowicz, Adrian M., Sausville, Edward A.

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A gene expression database for the molecular pharmacology of cancer von Scherf, Uwe, Ross, Douglas T., Waltham, Mark, Smith, Lawrence H., Lee, Jae K., Tanabe, Lorraine, Kohn, Kurt W., Reinhold, William C., Myers, Timothy G., Andrews, Darren T., Scudiero, Dominic A., Eisen, Michael B., Sausville, Edward A., Pommier, Yves, Botstein, David, Brown, Patrick O., Weinstein, John N.

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Phase I Trial of 72-Hour Continuous Infusion UCN-01 in Patients With Refractory Neoplasms von SAUSVILLE, Edward A, ARBUCK, Susan G, JING, Xiu-Xian, ROBERGE, Michel, FUSE, Eiichi, KUWABARA, Takashi, SENDEROWICZ, Adrian M, MESSMANN, Richard, HEADLEE, Donna, BAUER, Kenneth S, LUSH, Richard M, MURGO, Anthony, FIGG, William D, LAHUSEN, Tyler, JAKEN, Susan

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Paullones, a Series of Cyclin-Dependent Kinase Inhibitors:  Synthesis, Evaluation of CDK1/Cyclin B Inhibition, and in Vitro Antitumor Activity von Schultz, Christiane, Link, Andreas, Leost, Maryse, Zaharevitz, Daniel W, Gussio, Rick, Sausville, Edward A, Meijer, Laurent, Kunick, Conrad

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Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 12... von O'CONNOR, P. M, JACKMAN, J, FRIEND, S, FORNACE, A. J, KOHN, K. W, BAE, I, MYERS, T. G, FAN, S, MUTOH, M, SCUDIERO, D. A, MONKS, A, SAUSVILLE, E. A, WEINSTEIN, J. N

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Contributions of human tumor xenografts to anticancer drug development von Sausville, Edward A, Burger, Angelika M

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Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin von BUBB, M. R, SENDEROVICZ, A. M. J, SAUSVILLE, E. A, DUNCAN, K. L. K, KORN, E. D

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Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms von SENDEROWICZ, A. M, HEADLEE, D, ARBUCK, S. G, SAUSVILLE, E. A, STINSON, S. F, LUSH, R. M, KALIL, N, VILLALBA, L, HILL, K, STEINBERG, S. M, FIGG, W. D, TOMPKINS, A

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Antitumor Benzothiazoles. 8. Synthesis, Metabolic Formation, and Biological Properties of the C- and N-Oxidation Products of Antitumor 2-(4-Aminophenyl)benzothiazoles von Kashiyama, Eiji, Hutchinson, Ian, Chua, Mei-Sze, Stinson, Sherman F, Phillips, Lawrence R, Kaur, Gurmeet, Sausville, Edward A, Bradshaw, Tracey D, Westwell, Andrew D, Stevens, Malcolm F. G

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DNA damage and cell cycle arrest induced by 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203, NSC 703786) is attenuated in aryl hydrocarbon receptor deficient MCF-7 cells von Trapani, V, Patel, V, Leong, C-O, Ciolino, H P, Yeh, G C, Hose, C, Trepel, J B, Stevens, M F G, Sausville, E A, Loaiza-Pérez, A I

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Down-regulation of cyclin D1 by transcriptional repression in MCF-7 human breast carcinoma cells induced by flavopiridol von CARLSON, B, LAHUSEN, T, SINGH, S, LOAIZA-PEREZ, A, WORLAND, P. J, PESTELL, R, ALBANESE, C, SAUSVILLE, E. A, SENDEROWICZ, A. M

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Identification of Novel Purine and Pyrimidine Cyclin-Dependent Kinase Inhibitors with Distinct Molecular Interactions and Tumor Cell Growth Inhibition Profiles von Arris, Christine E, Boyle, F. Thomas, Calvert, A. Hilary, Curtin, Nicola J, Endicott, Jane A, Garman, Elspeth F, Gibson, Ashleigh E, Golding, Bernard T, Grant, Sharon, Griffin, Roger J, Jewsbury, Philip, Johnson, Louise N, Lawrie, Alison M, Newell, David R, Noble, Martin E. M, Sausville, Edward A, Schultz, Robert, Yu, Wyatt

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Targeted Toxins von FRANKEL, A. E, KREITMAN, R. J, SAUSVILLE, E. A

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Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases von ZAHAREVITZ, D. W, GUSSIO, R, LEOST, M, SENDEROWICZ, A. M, LAHUSEN, T, KUNICK, C, MEIJER, L, SAUSVILLE, E. A

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UCN-01: a Potent Abrogator of G2 Checkpoint Function in Cancer Cells With Disrupted p53 von Wang, Qizhi, Fan, Saijun, Eastman, Alan, Worland, Peter J., Sausville, Edward A., O'Connor, Patrick M.

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In vitro evaluation of amino acid prodrugs of novel antitumour 2-(4-amino-3-methylphenyl)benzothiazoles von Bradshaw, T D, Chua, M-S, Browne, H L, Trapani, V, Sausville, E A, Stevens, M F G

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