Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin von Leiman, Petr G, Basler, Marek, Ramagopal, Udupi A, Bonanno, Jeffrey B, Sauder, J. Michael, Pukatzki, Stefan, Burley, Stephen K, Almo, Steven C, Mekalanos, John J

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Crystal structure of the human PRMT5:MEP50 complex von Antonysamy, Stephen, Bonday, Zahid, Campbell, Robert M, Doyle, Brandon, Druzina, Zhanna, Gheyi, Tarun, Han, Bomie, Jungheim, Louis N, Qian, Yuewei, Rauch, Charles, Russell, Marijane, Sauder, J. Michael, Wasserman, Stephen R, Weichert, Kenneth, Willard, Francis S, Zhang, Aiping, Emtage, Spencer

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Discovery of potent small-molecule inhibitors of lipoprotein(a) formation von Diaz, Nuria, Perez, Carlos, Escribano, Ana Maria, Sanz, Gema, Priego, Julian, Lafuente, Celia, Barberis, Mario, Calle, Luis, Espinosa, Juan Felix, Priest, Birgit T., Zhang, Hong Y., Nosie, Amanda K., Haas, Joseph V., Cannady, Ellen, Borel, Anthony, Schultze, Albert E., Sauder, J. Michael, Hendle, Jörg, Weichert, Ken, Nicholls, Stephen J., Michael, Laura F.

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Integrative Structure–Function Mapping of the Nucleoporin Nup133 Suggests a Conserved Mechanism for Membrane Anchoring of the Nuclear Pore Complex von Kim, Seung Joong, Fernandez-Martinez, Javier, Sampathkumar, Parthasarathy, Martel, Anne, Matsui, Tsutomu, Tsuruta, Hiro, Weiss, Thomas M., Shi, Yi, Markina-Inarrairaegui, Ane, Bonanno, Jeffery B., Sauder, J. Michael, Burley, Stephen K., Chait, Brian T., Almo, Steven C., Rout, Michael P., Sali, Andrej

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Combined inhibition of PIM and CDK4/6 suppresses both mTOR signaling and Rb phosphorylation and potentiates PI3K inhibition in cancer cells von Litchfield, Lacey M, Boehnke, Karsten, Brahmachary, Manisha, Mur, Cecilia, Bi, Chen, Stephens, Jennifer R, Sauder, J Michael, Gutiérrez, Sonia M, McNulty, Ann M, Ye, Xiang S, Wu, Wenjuan, Lallena, María José, Gong, Xueqian, Merzoug, Farhana F, Jansen, Valerie M, Buchanan, Sean G

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Structure, Dynamics, Evolution, and Function of a Major Scaffold Component in the Nuclear Pore Complex von Sampathkumar, Parthasarathy, Kim, Seung Joong, Upla, Paula, Rice, William J., Phillips, Jeremy, Timney, Benjamin L., Pieper, Ursula, Bonanno, Jeffrey B., Fernandez-Martinez, Javier, Hakhverdyan, Zhanna, Ketaren, Natalia E., Matsui, Tsutomu, Weiss, Thomas M., Stokes, David L., Sauder, J. Michael, Burley, Stephen K., Sali, Andrej, Rout, Michael P., Almo, Steven C.

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SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo von Buchanan, Sean G, Hendle, Jorg, Lee, Patrick S, Smith, Christopher R, Bounaud, Pierre-Yves, Jessen, Katti A, Tang, Crystal M, Huser, Nanni H, Felce, Jeremy D, Froning, Karen J, Peterman, Marshall C, Aubol, Brandon E, Gessert, Steve F, Sauder, J Michael, Schwinn, Kenneth D, Russell, Marijane, Rooney, Isabelle A, Adams, Jason, Leon, Barbara C, Do, Tuan H, Blaney, Jeff M, Sprengeler, Paul A, Thompson, Devon A, Smyth, Lydia, Pelletier, Laura A, Atwell, Shane, Holme, Kevin, Wasserman, Stephen R, Emtage, Spencer, Burley, Stephen K, Reich, Siegfried H

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Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator von Lewis, Hal A, Buchanan, Sean G, Burley, Stephen K, Conners, Kris, Dickey, Mark, Dorwart, Michael, Fowler, Richard, Gao, Xia, Guggino, William B, Hendrickson, Wayne A, Hunt, John F, Kearins, Margaret C, Lorimer, Don, Maloney, Peter C, Post, Kai W, Rajashankar, Kanagalaghatta R, Rutter, Marc E, Sauder, J Michael, Shriver, Stephanie, Thibodeau, Patrick H, Thomas, Philip J, Zhang, Marie, Zhao, Xun, Emtage, Spencer

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Structural and Functional Studies of Fatty Acyl Adenylate Ligases from E. coli and L. pneumophila von Zhang, Zhening, Zhou, Rong, Sauder, J. Michael, Tonge, Peter J., Burley, Stephen K., Swaminathan, Subramanyam

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Loss of quaternary structure is associated with rapid sequence divergence in the OSBS family von Odokonyero, Denis, Sakai, Ayano, Patskovsky, Yury, Malashkevich, Vladimir N., Fedorov, Alexander A., Bonanno, Jeffrey B., Fedorov, Elena V., Toro, Rafael, Agarwal, Rakhi, Wang, Chenxi, Ozerova, Nicole D. S., Yew, Wen Shan, Sauder, J. Michael, Swaminathan, Subramanyam, Burley, Stephen K., Almo, Steven C., Glasner, Margaret E.

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Structural Basis for the Divergence of Substrate Specificity and Biological Function within HAD Phosphatases in Lipopolysaccharide and Sialic Acid Biosynthesis von Daughtry, Kelly D, Huang, Hua, Malashkevich, Vladimir, Patskovsky, Yury, Liu, Weifeng, Ramagopal, Udupi, Sauder, J. Michael, Burley, Stephen K, Almo, Steven C, Dunaway-Mariano, Debra, Allen, Karen N

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Catalytic Mechanism and Three-Dimensional Structure of Adenine Deaminase von Kamat, Siddhesh S, Bagaria, Ashima, Kumaran, Desigan, Holmes-Hampton, Gregory P, Fan, Hao, Sali, Andrej, Sauder, J. Michael, Burley, Stephen K, Lindahl, Paul A, Swaminathan, Subramanyam, Raushel, Frank M

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Caspase‐8 Variant G Regulates Rheumatoid Arthritis Fibroblast‐Like Synoviocyte Aggressive Behavior von Ansalone, Cecilia, Ainsworth, Richard I., Nygaard, Gyrid, Ai, Rizi, Prideaux, Edward B., Hammaker, Deepa, Perumal, Narayanan B., Weichert, Ken, Tung, Frances, Kodandapani, Lalitha, Sauder, J. Michael, Mertsching, Elisabeth C., Benschop, Robert J., Boyle, David L., Wang, Wei, Firestein, Gary S.

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Enzymatic Deamination of the Epigenetic Base N-6-Methyladenine von Kamat, Siddhesh S, Fan, Hao, Sauder, J. Michael, Burley, Stephen K, Shoichet, Brian K, Sali, Andrej, Raushel, Frank M

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Pa0148 from Pseudomonas aeruginosa Catalyzes the Deamination of Adenine von Goble, Alissa M, Zhang, Zhening, Sauder, J. Michael, Burley, Stephen K, Swaminathan, Subramanyam, Raushel, Frank M

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Difficult-to-express antigen generation through a co-expression and disassociation methodology von Lieu, Ricky, Chao, Grace, Kennedy, Emma, Sauder, J Michael, Narayanasamy, Prabakaran, Pustilnik, Anna, Thangaraju, Adithi, Ho, Carolyn, Pedroza, Mariah J, Ruiz, Diana, Yang, Xiaomin

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Mass Spectrometry Guided In Situ Proteolysis to Obtain Crystals for X-Ray Structure Determination von Gheyi, Tarun, Rodgers, Logan, Romero, Richard, Sauder, J. Michael, Burley, Stephen K.

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Functional Identification and Structure Determination of Two Novel Prolidases from cog1228 in the Amidohydrolase Superfamily von Xiang, Dao Feng, Patskovsky, Yury, Xu, Chengfu, Fedorov, Alexander A, Fedorov, Elena V, Sisco, Abby A, Sauder, J. Michael, Burley, Stephen K, Almo, Steven C, Raushel, Frank M

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Evolution of Enzymatic Activities in the Enolase Superfamily: Stereochemically Distinct Mechanisms in Two Families of cis,cis-Muconate Lactonizing Enzymes von Sakai, Ayano, Fedorov, Alexander A, Fedorov, Elena V, Schnoes, Alexandra M, Glasner, Margaret E, Brown, Shoshana, Rutter, Marc E, Bain, Kevin, Chang, Shawn, Gheyi, Tarun, Sauder, J. Michael, Burley, Stephen K, Babbitt, Patricia C, Almo, Steven C, Gerlt, John A

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Synthetic protease-activated class B GPCRs von Willard, Francis S., Meredith, Tamika D., Showalter, Aaron D., Ma, Wenzhen, Ho, Joseph D., Sauder, J. Michael, Sloop, Kyle W.

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