Metabolic aspects of neuronal degeneration: From a NAD+ point of view von Sasaki, Yo

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NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD + depletion von Sasaki, Yo, Nakagawa, Takashi, Mao, Xianrong, DiAntonio, Aaron, Milbrandt, Jeffrey

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SARM1 activation triggers axon degeneration locally via NAD+destruction von Gerdts, Josiah, Brace, E.J., Sasaki, Yo, DiAntonio, Aaron, Milbrandt, Jeffrey

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Live imaging reveals the cellular events downstream of SARM1 activation von Ko, Kwang Woo, Devault, Laura, Sasaki, Yo, Milbrandt, Jeffrey, DiAntonio, Aaron

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TIR Domain Proteins Are an Ancient Family of NAD+-Consuming Enzymes von Essuman, Kow, Summers, Daniel W., Sasaki, Yo, Mao, Xianrong, Yim, Aldrin Kay Yuen, DiAntonio, Aaron, Milbrandt, Jeffrey

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Sarm1-mediated axon degeneration requires both SAM and TIR interactions von Gerdts, Josiah, Summers, Daniel W, Sasaki, Yo, DiAntonio, Aaron, Milbrandt, Jeffrey

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Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice von Mills, Kathryn F., Yoshida, Shohei, Stein, Liana R., Grozio, Alessia, Kubota, Shunsuke, Sasaki, Yo, Redpath, Philip, Migaud, Marie E., Apte, Rajendra S., Uchida, Koji, Yoshino, Jun, Imai, Shin-ichiro

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MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2 von Walker, Lauren J, Summers, Daniel W, Sasaki, Yo, Brace, E J, Milbrandt, Jeffrey, DiAntonio, Aaron

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A SARM1-mitochondrial feedback loop drives neuropathogenesis in a Charcot-Marie-Tooth disease type 2A rat model von Sato-Yamada, Yurie, Strickland, Amy, Sasaki, Yo, Bloom, Joseph, DiAntonio, Aaron, Milbrandt, Jeffrey

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Increased Nuclear NAD Biosynthesis and SIRT1 Activation Prevent Axonal Degeneration von Araki, Toshiyuki, Sasaki, Yo, Milbrandt, Jeffrey

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SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration von Figley, Matthew D., Gu, Weixi, Nanson, Jeffrey D., Shi, Yun, Sasaki, Yo, Cunnea, Katie, Malde, Alpeshkumar K., Jia, Xinying, Luo, Zhenyao, Saikot, Forhad K., Mosaiab, Tamim, Masic, Veronika, Holt, Stephanie, Hartley-Tassell, Lauren, McGuinness, Helen Y., Manik, Mohammad K., Bosanac, Todd, Landsberg, Michael J., Kerry, Philip S., Mobli, Mehdi, Hughes, Robert O., Milbrandt, Jeffrey, Kobe, Bostjan, DiAntonio, Aaron, Ve, Thomas

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Distinct developmental and degenerative functions of SARM1 require NAD+ hydrolase activity von Brace, E. J., Essuman, Kow, Mao, Xianrong, Palucki, John, Sasaki, Yo, Milbrandt, Jeff, DiAntonio, Aaron

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Stimulation of Nicotinamide Adenine Dinucleotide Biosynthetic Pathways Delays Axonal Degeneration after Axotomy von Sasaki, Yo, Araki, Toshiyuki, Milbrandt, Jeffrey

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Constitutively active SARM1 variants that induce neuropathy are enriched in ALS patients von Bloom, A Joseph, Mao, Xianrong, Strickland, Amy, Sasaki, Yo, Milbrandt, Jeffrey, DiAntonio, Aaron

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Mitofusin2 mutations disrupt axonal mitochondrial positioning and promote axon degeneration von Misko, Albert L, Sasaki, Yo, Tuck, Elizabeth, Milbrandt, Jeffrey, Baloh, Robert H

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Aberrant Schwann Cell Lipid Metabolism Linked to Mitochondrial Deficits Leads to Axon Degeneration and Neuropathy von Viader, Andreu, Sasaki, Yo, Kim, Sungsu, Strickland, Amy, Workman, Cayce S., Yang, Kui, Gross, Richard W., Milbrandt, Jeffrey

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Dysregulation of NAD + Metabolism Induces a Schwann Cell Dedifferentiation Program von Sasaki, Yo, Hackett, Amber R, Kim, Sungsu, Strickland, Amy, Milbrandt, Jeffrey

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Adipose tissue NAD⁺ biosynthesis is required for regulating adaptive thermogenesis and whole-body energy homeostasis in mice von Yamaguchi, Shintaro, Franczyk, Michael P., Chondronikola, Maria, Qi, Nathan, Gunawardana, Subhadra C., Stromsdorfer, Kelly L., Porter, Lane C., Wozniak, David F., Sasaki, Yo, Rensing, Nicholas, Wong, Michael, Piston, David W., Klein, Samuel, Yoshino, Jun

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An NAD⁺-dependent transcriptional program governs self-renewal and radiation resistance in glioblastoma von Gujar, Amit D., Le, Son, Mao, Diane D., Dadey, David Y. A., Turski, Alice, Sasaki, Yo, Aum, Diane, Luo, Jingqin, Dahiya, Sonika, Yuan, Liya, Rich, Keith M., Milbrandt, Jeffrey, Hallahan, Dennis E., Yano, Hiroko, Tran, David D., Kim, Albert H.

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SCG10 is a JNK target in the axonal degeneration pathway von Shin, Jung Eun, Miller, Bradley R., Babetto, Elisabetta, Cho, Yongcheol, Sasaki, Yo, Qayum, Shehzad, Russler, Emilie V., Cavalli, Valeria, Milbrandt, Jeffrey, DiAntonio, Aaron

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