Electroporation delivery of DNA vaccines: prospects for success von Sardesai, Niranjan Y, Weiner, David B

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Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neopl... von Trimble, Cornelia L, Prof, Morrow, Matthew P, PhD, Kraynyak, Kimberly A, PhD, Shen, Xuefei, PhD, Dallas, Michael, PhD, Yan, Jian, PhD, Edwards, Lance, MD, Parker, R Lamar, MD, Denny, Lynette, MD, Giffear, Mary, BS, Brown, Ami Shah, PhD, Marcozzi-Pierce, Kathleen, MA, Shah, Divya, MS, Slager, Anna M, MS, Sylvester, Albert J, MS, Khan, Amir, PhD, Broderick, Kate E, PhD, Juba, Robert J, MSCEP, Herring, Timothy A, MPH, Boyer, Jean, PhD, Lee, Jessica, MPH, Sardesai, Niranjan Y, PhD, Weiner, David B, Prof, Bagarazzi, Mark L, MD

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DNA vaccination protects mice against Zika virus-induced damage to the testes von Griffin, Bryan D., Muthumani, Kar, Warner, Bryce M., Majer, Anna, Hagan, Mable, Audet, Jonathan, Stein, Derek R., Ranadheera, Charlene, Racine, Trina, De La Vega, Marc-Antoine, Piret, Jocelyne, Kucas, Stephanie, Tran, Kaylie N., Frost, Kathy L., De Graff, Christine, Soule, Geoff, Scharikow, Leanne, Scott, Jennifer, McTavish, Gordon, Smid, Valerie, Park, Young K., Maslow, Joel N., Sardesai, Niranjan Y., Kim, J. Joseph, Yao, Xiao-jian, Bello, Alexander, Lindsay, Robbin, Boivin, Guy, Booth, Stephanie A., Kobasa, Darwyn, Embury-Hyatt, Carissa, Safronetz, David, Weiner, David B., Kobinger, Gary P.

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Protection against dengue disease by synthetic nucleic acid antibody prophylaxis/immunotherapy von Flingai, Seleeke, Plummer, Emily M., Patel, Ami, Shresta, Sujan, Mendoza, Janess M., Broderick, Kate E., Sardesai, Niranjan Y., Muthumani, Kar, Weiner, David B.

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An engineered bispecific DNA-encoded IgG antibody protects against Pseudomonas aeruginosa in a pneumonia challenge model von Patel, Ami, DiGiandomenico, Antonio, Keller, Ashley E., Smith, Trevor R. F., Park, Daniel H., Ramos, Stephanie, Schultheis, Katherine, Elliott, Sarah T. C., Mendoza, Janess, Broderick, Kate E., Wise, Megan C., Yan, Jian, Jiang, Jingjing, Flingai, Seleeke, Khan, Amir S., Muthumani, Kar, Humeau, Laurent, Cheng, Lily I., Wachter-Rosati, Leslie, Stover, C. Kendall, Sardesai, Niranjan Y., Weiner, David B.

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Activated CD4⁺CCR5⁺ T cells in the rectum predict increased SIV acquisition in SIVGag/Tat-vaccinated rhesus macaques von Carnathan, Diane G., Wetzel, Katherine S., Yu, Joana, Lee, S. Thera, Johnson, Brent A., Paiardini, Mirko, Yan, Jian, Morrow, Matthew P., Sardesai, Niranjan Y., Weiner, David B., Ertl, Hildegund C. J., Silvestri, Guido

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A DNA vaccine against chikungunya virus is protective in mice and induces neutralizing antibodies in mice and nonhuman primates von Mallilankaraman, Karthik, Shedlock, Devon J, Bao, Huihui, Kawalekar, Omkar U, Fagone, Paolo, Ramanathan, Aarthi A, Ferraro, Bernadette, Stabenow, Jennifer, Vijayachari, Paluru, Sundaram, Senthil G, Muruganandam, Nagarajan, Sarangan, Gopalsamy, Srikanth, Padma, Khan, Amir S, Lewis, Mark G, Kim, J Joseph, Sardesai, Niranjan Y, Muthumani, Karuppiah, Weiner, David B

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Altered response hierarchy and increased T-cell breadth upon HIV-1 conserved element DNA vaccination in macaques von Kulkarni, Viraj, Valentin, Antonio, Rosati, Margherita, Alicea, Candido, Singh, Ashish K, Jalah, Rashmi, Broderick, Kate E, Sardesai, Niranjan Y, Le Gall, Sylvie, Mothe, Beatriz, Brander, Christian, Rolland, Morgane, Mullins, James I, Pavlakis, George N, Felber, Barbara K

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Heterosubtypic protection against pathogenic human and avian influenza viruses via in vivo electroporation of synthetic consensus DNA antigens von Laddy, Dominick J, Yan, Jian, Kutzler, Michele, Kobasa, Darwyn, Kobinger, Gary P, Khan, Amir S, Greenhouse, Jack, Sardesai, Niranjan Y, Draghia-Akli, Ruxandra, Weiner, David B

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In Vivo Delivery of Synthetic Human DNA-Encoded Monoclonal Antibodies Protect against Ebolavirus Infection in a Mouse Model von Patel, Ami, Park, Daniel H., Davis, Carl W., Smith, Trevor R.F., Leung, Anders, Tierney, Kevin, Bryan, Aubrey, Davidson, Edgar, Yu, Xiaoying, Racine, Trina, Reed, Charles, Gorman, Marguerite E., Wise, Megan C., Elliott, Sarah T.C., Esquivel, Rianne, Yan, Jian, Chen, Jing, Muthumani, Kar, Doranz, Benjamin J., Saphire, Erica Ollmann, Crowe, James E., Broderick, Kate E., Kobinger, Gary P., He, Shihua, Qiu, Xiangguo, Kobasa, Darwyn, Humeau, Laurent, Sardesai, Niranjan Y., Ahmed, Rafi, Weiner, David B.

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DNA and virus particle vaccination protects against acquisition and confers control of viremia upon heterologous simian immunodeficiency virus challenge von Patel, Vainav, Jalah, Rashmi, Kulkarni, Viraj, Valentin, Antonio, Rosati, Margherita, Alicea, Candido, von Gegerfelt, Agneta, Huang, Wensheng, Guan, Yongjun, Keele, Brandon F., Bess, Julian W., Piatak, Michael, Lifson, Jeffrey D., Williams, William T., Shen, Xiaoying, Tomaras, Georgia D., Amara, Rama R., Robinson, Harriet L., Johnson, Welkin, Broderick, Kate E., Sardesai, Niranjan Y., Venzon, David J., Hirsch, Vanessa M., Felber, Barbara K., Pavlakis, George N.

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A DNA vaccine delivered by dermal electroporation fully protects cynomolgus macaques against Lassa fever von Cashman, Kathleen A., Wilkinson, Eric R., Shaia, Carl I., Facemire, Paul R., Bell, Todd M., Bearss, Jeremy J., Shamblin, Joshua D., Wollen, Suzanne E., Broderick, Kate E., Sardesai, Niranjan Y., Schmaljohn, Connie S.

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Multivalent Smallpox DNA Vaccine Delivered by Intradermal Electroporation Drives Protective Immunity in Nonhuman Primates Against Lethal Monkeypox Challenge von Hirao, Lauren A., Draghia-Akli, Ruxandra, Prigge, Jonathan T., Yang, Maria, Satishchandran, Abhishek, Wu, Ling, Hammarlund, Erika, Khan, Amir S., Babas, Tahar, Rhodes, Lowrey, Silvera, Peter, Slifka, Mark, Sardesai, Niranjan Y., Weiner, David B.

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DNA and protein co-immunization improves the magnitude and longevity of humoral immune responses in macaques von Jalah, Rashmi, Kulkarni, Viraj, Patel, Vainav, Rosati, Margherita, Alicea, Candido, Bear, Jenifer, Yu, Lei, Guan, Yongjun, Shen, Xiaoying, Tomaras, Georgia D, LaBranche, Celia, Montefiori, David C, Prattipati, Rajasekhar, Pinter, Abraham, Bess, Jr, Julian, Lifson, Jeffrey D, Reed, Steven G, Sardesai, Niranjan Y, Venzon, David J, Valentin, Antonio, Pavlakis, George N, Felber, Barbara K

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A synDNA vaccine delivering neoAg collections controls heterogenous, multifocal murine lung and ovarian tumors via robust T cell generation von Bhojnagarwala, Pratik S., Perales-Puchalt, Alfredo, Cooch, Neil, Sardesai, Niranjan Y., Weiner, David B.

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HIV-1 Env DNA vaccine plus protein boost delivered by EP expands B- and T-cell responses and neutralizing phenotype in vivo von Muthumani, Kar, Wise, Megan C, Broderick, Kate E, Hutnick, Natalie, Goodman, Jonathan, Flingai, Seleeke, Yan, Jian, Bian, Chaoran B, Mendoza, Janess, Tingey, Colleen, Wilson, Christine, Wojtak, Krzysztof, Sardesai, Niranjan Y, Weiner, David B

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Mesothelin Variant 1 Is Released from Tumor Cells as a Diagnostic Marker von HELLSTROM, Ingegerd, RAYCRAFT, John, KANAN, Sandra, SARDESAI, Niranjan Y, VERCH, Thorsten, YI YANG, HELLSTROM, Karl Erik

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Gag and env conserved element CE DNA vaccines elicit broad cytotoxic T cell responses targeting subdominant epitopes of HIV and SIV Able to recognize virus-infected cells in macaqu... von Hu, Xintao, Lu, Zhongyan, Valentin, Antonio, Rosati, Margherita, Broderick, Kate E., Sardesai, Niranjan Y., Marx, Preston A., Mullins, James I., Pavlakis, George N., Felber, Barbara K.

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MESOMARK™ : A potential test for malignant pleural mesothelioma von BEYER, Heather L, GESCHWINDT, Ryan D, SARDESAI, Niranjan Y, GLOVER, Curtis L, TRAN, Ly, HELLSTROM, Ingegerd, HELLSTROM, Karl-Erik, MILLER, M. Craig, VERCH, Thorsten, ALLARD, W. Jeffrey, PASS, Harvey I

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HIV-1 p24(gag) derived conserved element DNA vaccine increases the breadth of immune response in mice von Kulkarni, Viraj, Rosati, Margherita, Valentin, Antonio, Ganneru, Brunda, Singh, Ashish K, Yan, Jian, Rolland, Morgane, Alicea, Candido, Beach, Rachel Kelly, Zhang, Gen-Mu, Le Gall, Sylvie, Broderick, Kate E, Sardesai, Niranjan Y, Heckerman, David, Mothe, Beatriz, Brander, Christian, Weiner, David B, Mullins, James I, Pavlakis, George N, Felber, Barbara K

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