Electroporation delivery of DNA vaccines: prospects for success von Sardesai, Niranjan Y, Weiner, David B

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Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neopl... von Trimble, Cornelia L, Prof, Morrow, Matthew P, PhD, Kraynyak, Kimberly A, PhD, Shen, Xuefei, PhD, Dallas, Michael, PhD, Yan, Jian, PhD, Edwards, Lance, MD, Parker, R Lamar, MD, Denny, Lynette, MD, Giffear, Mary, BS, Brown, Ami Shah, PhD, Marcozzi-Pierce, Kathleen, MA, Shah, Divya, MS, Slager, Anna M, MS, Sylvester, Albert J, MS, Khan, Amir, PhD, Broderick, Kate E, PhD, Juba, Robert J, MSCEP, Herring, Timothy A, MPH, Boyer, Jean, PhD, Lee, Jessica, MPH, Sardesai, Niranjan Y, PhD, Weiner, David B, Prof, Bagarazzi, Mark L, MD

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A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques von Mothe, Beatriz, Hu, Xintao, Llano, Anuska, Rosati, Margherita, Olvera, Alex, Kulkarni, Viraj, Valentin, Antonio, Alicea, Candido, Pilkington, Guy R, Sardesai, Niranjan Y, Rocafort, Muntsa, Crespo, Manel, Carrillo, Jorge, Marco, Andrés, Mullins, James I, Dorrell, Lucy, Hanke, Tomáš, Clotet, Bonaventura, Pavlakis, George N, Felber, Barbara K, Brander, Christian

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DNA vaccination protects mice against Zika virus-induced damage to the testes von Griffin, Bryan D., Muthumani, Kar, Warner, Bryce M., Majer, Anna, Hagan, Mable, Audet, Jonathan, Stein, Derek R., Ranadheera, Charlene, Racine, Trina, De La Vega, Marc-Antoine, Piret, Jocelyne, Kucas, Stephanie, Tran, Kaylie N., Frost, Kathy L., De Graff, Christine, Soule, Geoff, Scharikow, Leanne, Scott, Jennifer, McTavish, Gordon, Smid, Valerie, Park, Young K., Maslow, Joel N., Sardesai, Niranjan Y., Kim, J. Joseph, Yao, Xiao-jian, Bello, Alexander, Lindsay, Robbin, Boivin, Guy, Booth, Stephanie A., Kobasa, Darwyn, Embury-Hyatt, Carissa, Safronetz, David, Weiner, David B., Kobinger, Gary P.

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A DNA vaccine against chikungunya virus is protective in mice and induces neutralizing antibodies in mice and nonhuman primates von Mallilankaraman, Karthik, Shedlock, Devon J, Bao, Huihui, Kawalekar, Omkar U, Fagone, Paolo, Ramanathan, Aarthi A, Ferraro, Bernadette, Stabenow, Jennifer, Vijayachari, Paluru, Sundaram, Senthil G, Muruganandam, Nagarajan, Sarangan, Gopalsamy, Srikanth, Padma, Khan, Amir S, Lewis, Mark G, Kim, J Joseph, Sardesai, Niranjan Y, Muthumani, Karuppiah, Weiner, David B

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Intradermal SynCon® Ebola GP DNA Vaccine Is Temperature Stable and Safely Demonstrates Cellular and Humoral Immunogenicity Advantages in Healthy Volunteers von Tebas, Pablo, Kraynyak, Kimberly A, Patel, Ami, Maslow, Joel N, Morrow, Matthew P, Sylvester, Albert J, Knoblock, Dawson, Gillespie, Elisabeth, Amante, Dinah, Racine, Trina, McMullan, Trevor, Jeong, Moonsup, Roberts, Christine C, Park, Young K, Boyer, Jean, Broderick, Kate E, Kobinger, Gary P, Bagarazzi, Mark, Weiner, David B, Sardesai, Niranjan Y, White, Scott M

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Personalized neoantigen vaccine and pembrolizumab in advanced hepatocellular carcinoma: a phase 1/2 trial von Yarchoan, Mark, Gane, Edward J., Marron, Thomas U., Perales-Linares, Renzo, Yan, Jian, Cooch, Neil, Shu, Daniel H., Fertig, Elana J., Kagohara, Luciane T., Bartha, Gabor, Northcott, Josette, Lyle, John, Rochestie, Sarah, Peters, Joann, Connor, Jason T., Jaffee, Elizabeth M., Csiki, Ildiko, Weiner, David B., Perales-Puchalt, Alfredo, Sardesai, Niranjan Y.

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A Synthetic DNA, Multi-Neoantigen Vaccine Drives Predominately MHC Class I CD8 + T-cell Responses, Impacting Tumor Challenge von Duperret, Elizabeth K, Perales-Puchalt, Alfredo, Stoltz, Regina, G H, Hiranjith, Mandloi, Nitin, Barlow, James, Chaudhuri, Amitabha, Sardesai, Niranjan Y, Weiner, David B

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Altered response hierarchy and increased T-cell breadth upon HIV-1 conserved element DNA vaccination in macaques von Kulkarni, Viraj, Valentin, Antonio, Rosati, Margherita, Alicea, Candido, Singh, Ashish K, Jalah, Rashmi, Broderick, Kate E, Sardesai, Niranjan Y, Le Gall, Sylvie, Mothe, Beatriz, Brander, Christian, Rolland, Morgane, Mullins, James I, Pavlakis, George N, Felber, Barbara K

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Heterosubtypic protection against pathogenic human and avian influenza viruses via in vivo electroporation of synthetic consensus DNA antigens von Laddy, Dominick J, Yan, Jian, Kutzler, Michele, Kobasa, Darwyn, Kobinger, Gary P, Khan, Amir S, Greenhouse, Jack, Sardesai, Niranjan Y, Draghia-Akli, Ruxandra, Weiner, David B

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Protection against dengue disease by synthetic nucleic acid antibody prophylaxis/immunotherapy von Flingai, Seleeke, Plummer, Emily M., Patel, Ami, Shresta, Sujan, Mendoza, Janess M., Broderick, Kate E., Sardesai, Niranjan Y., Muthumani, Kar, Weiner, David B.

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Rapid and Long-Term Immunity Elicited by DNA-Encoded Antibody Prophylaxis and DNA Vaccination Against Chikungunya Virus von Muthumani, Karuppiah, Block, Peter, Flingai, Seleeke, Muruganantham, Nagarajan, Chaaithanya, Itta Krishna, Tingey, Colleen, Wise, Megan, Reuschel, Emma L., Chung, Christopher, Muthumani, Abirami, Sarangan, Gopalsamy, Srikanth, Padma, Khan, Amir S., Vijayachari, Paluru, Sardesai, Niranjan Y., Kim, J. Joseph, Ugen, Kenneth E., Weiner, David B.

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An engineered bispecific DNA-encoded IgG antibody protects against Pseudomonas aeruginosa in a pneumonia challenge model von Patel, Ami, DiGiandomenico, Antonio, Keller, Ashley E., Smith, Trevor R. F., Park, Daniel H., Ramos, Stephanie, Schultheis, Katherine, Elliott, Sarah T. C., Mendoza, Janess, Broderick, Kate E., Wise, Megan C., Yan, Jian, Jiang, Jingjing, Flingai, Seleeke, Khan, Amir S., Muthumani, Kar, Humeau, Laurent, Cheng, Lily I., Wachter-Rosati, Leslie, Stover, C. Kendall, Sardesai, Niranjan Y., Weiner, David B.

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Activated CD4⁺CCR5⁺ T cells in the rectum predict increased SIV acquisition in SIVGag/Tat-vaccinated rhesus macaques von Carnathan, Diane G., Wetzel, Katherine S., Yu, Joana, Lee, S. Thera, Johnson, Brent A., Paiardini, Mirko, Yan, Jian, Morrow, Matthew P., Sardesai, Niranjan Y., Weiner, David B., Ertl, Hildegund C. J., Silvestri, Guido

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DNA and protein co-immunization improves the magnitude and longevity of humoral immune responses in macaques von Jalah, Rashmi, Kulkarni, Viraj, Patel, Vainav, Rosati, Margherita, Alicea, Candido, Bear, Jenifer, Yu, Lei, Guan, Yongjun, Shen, Xiaoying, Tomaras, Georgia D, LaBranche, Celia, Montefiori, David C, Prattipati, Rajasekhar, Pinter, Abraham, Bess, Jr, Julian, Lifson, Jeffrey D, Reed, Steven G, Sardesai, Niranjan Y, Venzon, David J, Valentin, Antonio, Pavlakis, George N, Felber, Barbara K

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Safety and Comparative Immunogenicity of an HIV-1 DNA Vaccine in Combination with Plasmid Interleukin 12 and Impact of Intramuscular Electroporation for Delivery von Kalams, Spyros A., Parker, Scott D., Elizaga, Marnie, Metch, Barbara, Edupuganti, Srilatha, Hural, John, De Rosa, Stephen, Carter, Donald K., Rybczyk, Kyle, Frank, Ian, Fuchs, Jonathan, Koblin, Beryl, Kim, Denny H., Joseph, Patrice, Keefer, Michael C., Baden, Lindsey R., Eldridge, John, Boyer, Jean, Sherwat, Adam, Cardinali, Massimo, Allen, Mary, Pensiero, Michael, Butler, Chris, Khan, Amir S., Yan, Jian, Sardesai, Niranjan Y., Kublin, James G., Weiner, David B.

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In Vivo Delivery of Synthetic Human DNA-Encoded Monoclonal Antibodies Protect against Ebolavirus Infection in a Mouse Model von Patel, Ami, Park, Daniel H., Davis, Carl W., Smith, Trevor R.F., Leung, Anders, Tierney, Kevin, Bryan, Aubrey, Davidson, Edgar, Yu, Xiaoying, Racine, Trina, Reed, Charles, Gorman, Marguerite E., Wise, Megan C., Elliott, Sarah T.C., Esquivel, Rianne, Yan, Jian, Chen, Jing, Muthumani, Kar, Doranz, Benjamin J., Saphire, Erica Ollmann, Crowe, James E., Broderick, Kate E., Kobinger, Gary P., He, Shihua, Qiu, Xiangguo, Kobasa, Darwyn, Humeau, Laurent, Sardesai, Niranjan Y., Ahmed, Rafi, Weiner, David B.

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A DNA vaccine delivered by dermal electroporation fully protects cynomolgus macaques against Lassa fever von Cashman, Kathleen A., Wilkinson, Eric R., Shaia, Carl I., Facemire, Paul R., Bell, Todd M., Bearss, Jeremy J., Shamblin, Joshua D., Wollen, Suzanne E., Broderick, Kate E., Sardesai, Niranjan Y., Schmaljohn, Connie S.

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HIV-1 Env DNA vaccine plus protein boost delivered by EP expands B- and T-cell responses and neutralizing phenotype in vivo von Muthumani, Kar, Wise, Megan C, Broderick, Kate E, Hutnick, Natalie, Goodman, Jonathan, Flingai, Seleeke, Yan, Jian, Bian, Chaoran B, Mendoza, Janess, Tingey, Colleen, Wilson, Christine, Wojtak, Krzysztof, Sardesai, Niranjan Y, Weiner, David B

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Clinical and Immunologic Biomarkers for Histologic Regression of High-Grade Cervical Dysplasia and Clearance of HPV16 and HPV18 after Immunotherapy von Morrow, Matthew P, Kraynyak, Kimberly A, Sylvester, Albert J, Dallas, Michael, Knoblock, Dawson, Boyer, Jean D, Yan, Jian, Vang, Russell, Khan, Amir S, Humeau, Laurent, Sardesai, Niranjan Y, Kim, J Joseph, Plotkin, Stanley, Weiner, David B, Trimble, Cornelia L, Bagarazzi, Mark L

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